| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Princewill Ikechukwu Ugwu, Benneth Ben-Azu, Sandra Ugonne Ugwu, Christian I Uruaka, Chinecherem Choice Nworgu, Pamela Onyinye Okorie, Kizito Oluchukwu Okafor, Kenneth Kelechi Anachuna, Melford Uche Elendu, Amogechukwu Onyinye Ugwu, Ugochukwu Bond Anyaehie, Azubuike A Nwankwo, Eme Effiom Osi. Putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin. Brain research bulletin. 2022-03-12. PMID:35278662. |
the decreased serotonin in the prefrontal-cortex and dopamine in the striatum, elevated levels of noradrenaline and acetylcholinesterase in the prefrontal-cortex and hippocampus with corresponding decrease in bdnf were reversed by quercetin. |
2022-03-12 |
2023-08-13 |
mouse |
| Emily J Jaehne, Jessica N Kent, Emily J Antolasic, Bradley J Wright, Jereme G Spiers, Kerstin C Creutzberg, Federico De Rosa, Marco A Riva, Caryl E Sortwell, Timothy J Collier, Maarten van den Buus. Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory. Translational psychiatry. vol 12. issue 1. 2022-03-08. PMID:35256586. |
bdnf exon vi expression in the dorsal hippocampus was higher and bdnf protein level in the ventral hippocampus was lower in female val/met rats than female val/val rats, with no other genotype differences, including in total bdnf, bdnf long, or bdnf iv mrna. |
2022-03-08 |
2023-08-13 |
rat |
| Shengying Pan, Yaoying Ma, Rongrong Yang, Xu Lu, Qingsheng You, Ting Ye, Chao Huan. Indole-3-Carbinol Selectively Prevents Chronic Stress-Induced Depression-but not Anxiety-Like Behaviors via Suppressing Pro-Inflammatory Cytokine Production and Oxido-Nitrosative Stress in the Brain. Frontiers in pharmacology. vol 13. 2022-03-04. PMID:35242039. |
further analysis showed that repeated i3c treatment (60 mg/kg, 10 days) prevented csds-induced increases in levels of nitrite and malondialdehyde (mda), decreases in contents of glutathione (gsh), and decreases in levels of brain derived neurotrophic factor (bdnf) protein in the hippocampus and prefrontal cortex. |
2022-03-04 |
2023-08-13 |
mouse |
| Teresa Cramer, Raminder Gill, Zahra S Thirouin, Markus Vaas, Suchita Sampath, Fanny Martineau, Sara B Noya, Patrizia Panzanelli, Tania J J Sudharshan, David Colameo, Philip K-Y Chang, Pei You Wu, Roy Shi, Philip A Barker, Steven A Brown, Rosa C Paolicelli, Jan Klohs, Rebecca Anne McKinney, Shiva K Tyagaraja. Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia. Science advances. vol 8. issue 9. 2022-03-04. PMID:35245123. |
here, using in vitro organotypic hippocampal slice cultures and transient middle cerebral artery occlusion (mcao) in genetically engineered mice in vivo, we report that at 24 hours after ischemia, microglia release brain-derived neurotrophic factor (bdnf) to downregulate glutamatergic and gabaergic synapses within the peri-infarct area. |
2022-03-04 |
2023-08-13 |
mouse |
| Che-Wen Tsai, Shih-Jen Tsai, Yi-Ju Pan, Hsin-Mei Lin, Tsung-Yu Pan, Feng-Yi Yan. Transcranial Ultrasound Stimulation Reverses Behavior Changes and the Expression of Calcium-Binding Protein in a Rodent Model of Schizophrenia. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-01. PMID:35229268. |
in addition, lipus stimulation rebalanced the bdnf levels in the hippocampus and medial prefrontal cortex. |
2022-03-01 |
2023-08-13 |
rat |
| Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koc. N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216241. |
the aim of our study was to compare the efficacy of chronic administration of the atypical antipsychotic drug aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butoxy}-3,4-dihydro-2(1h)-quinolinone; ari) and the well-known antioxidant n-acetylcysteine (nac) both in alleviating schizophrenia-like social and cognitive deficits and in reducing the decreases in the levels of the brain-derived neurotrophic factor (bdnf) in the prefrontal cortex (pfc) and hippocampus (hip) of adult sprague-dawley rats, that have been induced by chronic administration of the model compound l-buthionine-(s, r)-sulfoximine (bso) during the early postnatal development (p5-p16). |
2022-02-26 |
2023-08-13 |
rat |
| Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping X. The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. Brain research. 2022-02-26. PMID:35218705. |
moreover, fmn reduced the serum corticosterone levels, upregulated the protein expression levels of the glucocorticoid receptor (gr), and brain-derived neurotrophic factor (bdnf) in the hippocampus, protected against the cort-induced neuronal impairment, and promoted the neurogenesis in the hippocampus. |
2022-02-26 |
2023-08-13 |
mouse |
| Nayere Askari, Ali Mousavi, Mohammad Reza Vaez-Mahdav. Maternal deprivation effect on morphine-induced CPP is related to changes in Opioid receptors in selected rat brain regions (hippocampus, prefrontal cortex, and nucleus accumbens). Behavioural processes. 2022-02-26. PMID:35218881. |
a significant decrease was observed in the expression of bdnf gene (in all of the selected brain regions) and gr (glucocorticoid receptor) gene (in the hippocampus and nucleus accumbens) in md rats. |
2022-02-26 |
2023-08-13 |
rat |
| Matthew Marion, John Hamilton, Brittany Richardson, Nicole Roeder, Antonio Figueiredo, Amanda Nubelo, Eleftherios Hetelekides, Samantha Penman, Yuji Owada, Yoshiteru Kagawa, Panayotis K Thano. Environmental Enrichment Sex-dependently Rescues Memory Impairment in FABP5 KO Mice Not Mediated by Brain-Derived Neurotrophic Factor. Behavioural brain research. 2022-02-24. PMID:35202717. |
mice were then euthanized to assess hippocampal brain-dervied neurotrophic factor (bdnf) concentrations. |
2022-02-24 |
2023-08-13 |
mouse |
| Matthew Marion, John Hamilton, Brittany Richardson, Nicole Roeder, Antonio Figueiredo, Amanda Nubelo, Eleftherios Hetelekides, Samantha Penman, Yuji Owada, Yoshiteru Kagawa, Panayotis K Thano. Environmental Enrichment Sex-dependently Rescues Memory Impairment in FABP5 KO Mice Not Mediated by Brain-Derived Neurotrophic Factor. Behavioural brain research. 2022-02-24. PMID:35202717. |
lastly, environmental enrichment increased hippocampal bdnf levels in male wt mice only. |
2022-02-24 |
2023-08-13 |
mouse |
| Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu L. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022-02-20. PMID:35183538. |
chronic stress exposure is a risk factor that can induce the development of depression-like behaviors by impairing the hippocampal cyclic adenosine monophosphate-response element binding protein (creb)-brain-derived neurotrophic factor (bdnf) signaling, but its underlying mechanisms remain largely unknown. |
2022-02-20 |
2023-08-13 |
mouse |
| Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu L. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022-02-20. PMID:35183538. |
results showed that chronic unpredictable stress (cus) markedly increased the expression levels of hippocampal nr6a1 protein, which reduced hippocampal creb phosphorylation and bdnf protein expression. |
2022-02-20 |
2023-08-13 |
mouse |
| Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu L. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022-02-20. PMID:35183538. |
furthermore, genetic knockdown of hippocampal creb or bdnf abrogated the preventive effect of hippocampal nr6a1 down-regulation on cus-induced depression-like behaviors in mice. |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
we analyzed corticosterone concentrations in serum, levels of grα isoforms (95, 67, 50, 40, and 25 kda), and mrna levels of gr-responsive genes (gr, fkbp5, bdnf, and il-1β) in the hippocampus and the prefrontal cortex (pfc). |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
changes in gene expression revealed that female depressive-like behavior could be related to increased levels of il-1β in hippocampus and reduced bdnf levels in both hippocampus and pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
however, in males, adolescent cus increased expression of gr in adult hippocampus and bdnf in pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Rukmani Pandey, Asmita Garg, Keerti Gupta, Pallavi Shukla, Kapil Mandrah, Somendu Roy, Naibedya Chattopadhyay, Sanghamitra Bandyopadhya. Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats. Molecular neurobiology. 2022-02-17. PMID:35175559. |
it also indicates that endogenous e2 regulates hippocampal bmp and bdnf signaling and restrains arsenic-induced neuronal dysfunctions in females, which may be inhibited in e2-deficient conditions, such as menopause or ovarian failure. |
2022-02-17 |
2023-08-13 |
rat |
| Ying-Xiao Li, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Cheng, Ting-Ting Yan. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. Plants (Basel, Switzerland). vol 11. issue 3. 2022-02-15. PMID:35161241. |
the expression levels of the serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) in the hippocampus of the rats with depression were markedly increased by gmdz. |
2022-02-15 |
2023-08-13 |
rat |
| Ying-Xiao Li, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Cheng, Ting-Ting Yan. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. Plants (Basel, Switzerland). vol 11. issue 3. 2022-02-15. PMID:35161241. |
these results suggest that gmdz may alleviate the depressive-like behaviors in depressive rats, possibly via licorice (gan cao), to increase 5-htt and bdnf signals in the hippocampus. |
2022-02-15 |
2023-08-13 |
rat |
| Sarah Thomas Broome, Alessandro Castorin. The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163768. |
buspirone attenuated the induction of interleukin-1β and interleukin-6 expression by rotenone, and this was paralleled by the upregulation of arginase-1, brain-derived neurotrophic factor (bdnf), and activity-dependent neuroprotective protein (adnp) in the midbrain, striatum, prefrontal cortex, amygdala, and hippocampus. |
2022-02-15 |
2023-08-13 |
mouse |