| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Li. Hippocampal F3/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice. Biochemical pharmacology. 2022-05-24. PMID:35609645. |
currently, it has been demonstrated that besides monoaminergic dysfunction, depression is accompanied by several other important pathological phenomena such as impaired neurogenesis and decreased brain-derived neurotrophic factor (bdnf)-camp response element binding protein (creb) signaling cascade in the hippocampus. |
2022-05-24 |
2023-08-13 |
mouse |
| Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimur. Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600081. |
the aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (bdnf) in patients experiencing a first episode of major depression (md) ( |
2022-05-23 |
2023-08-13 |
Not clear |
| Xiao-Bing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huan. Brain-Derived Neurotrophic Factor regulates LYN kinase mediated Myosin Light Chain Kinase activation to modulate non-muscle myosin II activity in hippocampal neurons. The Journal of biological chemistry. 2022-05-22. PMID:35598826. |
the role of bdnf on modulating the phosphorylation of mlc2 was validated by using western blotting (wb) in primary cultured hippocampal neurons. |
2022-05-22 |
2023-08-13 |
mouse |
| Xiao-Bing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huan. Brain-Derived Neurotrophic Factor regulates LYN kinase mediated Myosin Light Chain Kinase activation to modulate non-muscle myosin II activity in hippocampal neurons. The Journal of biological chemistry. 2022-05-22. PMID:35598826. |
this result was confirmed by injecting bdnf into the dorsal hippocampus of mice and detecting the phosphorylation level of mlc2 by wb. |
2022-05-22 |
2023-08-13 |
mouse |
| Mansour Sayyah, Mehdi Seydyousefi, Abdorreza Eghbal Moghanlou, Gerlinde A S Metz, Nabi Shamsaei, Mohammad Hasan Faghfoori, Zeinab Faghfoor. Activation of BDNF- and VEGF-mediated Neuroprotection by Treadmill Exercise Training in Experimental Stroke. Metabolic brain disease. 2022-05-21. PMID:35596908. |
this study was designed to examine the effect of aerobic exercise on post ischemia/reperfusion injury on concentration and expression of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) after inducing a neuronal loss in ca1 region of hippocampus in male wistar rats. |
2022-05-21 |
2023-08-13 |
rat |
| Soonil Pyo, Joohee Kim, Jihye Hwang, Jeong Hyun Heo, Kyungri Kim, Sung-Rae Ch. Environmental Enrichment and Estrogen Upregulate Beta-Hydroxybutyrate Underlying Functional Improvement. Frontiers in molecular neuroscience. vol 15. 2022-05-20. PMID:35592114. |
in cerebral cortex and hippocampus, ee resulted in a significant increase in the level of βhb and a significant reduction in hdac, consequently enhancing bdnf expression. |
2022-05-20 |
2023-08-13 |
mouse |
| Keren Nitzan, Dekel David, Motty Franko, Roni Toledano, Sharon Fidelman, Yaarit Simchon Tenenbaum, Maya Blonder, Shir Armoza-Eilat, Alon Shamir, Moshe Rehavi, Yair Ben-Chaim, Ravid Doro. Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms. Translational psychiatry. vol 12. issue 1. 2022-05-19. PMID:35589704. |
we show here that shan zha is sufficient to produce an anxiolytic and antidepressant-like effect similar to nht or the escitalopram through activation of 5-ht1a receptor and an elevation in bdnf levels in the hippocampus and pre-frontal cortex (pfc). |
2022-05-19 |
2023-08-13 |
mouse |
| Hanxue Wu, Jinzhu Zhuang, Jiawei Wang, Shenglan Yuan, Hui Sun, Jiaxi X. AT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556110. |
in both prefrontal cortex and hippocampus, the mrna levels of bdnf (brain-derived neurotrophic factor) and pi4kiiiβ (phosphatidylinositol 4-kinase iiiβ) were found to be significantly lower in hypertensive nt mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Jyotirmaya Behera, Rubins H Petit, Yu-Ting Zheng, Neetu Tyag. 1,3-Butanediol Mitigates High-Salt Diet Induced Cognitive Impairment in Aging Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556919. |
this mechanistic study shows that hsd+ 1,3-butanediol mice display an increased mitochondrial tfam dependent upregulation of brain-derived neurotrophic factor (bdnf) and nuclear receptor subfamily 4a (nr4a) in the mouse hippocampus via activation of the h3k27ac acetylation at the promoter. |
2022-05-13 |
2023-08-13 |
mouse |
| Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Hun-Young Park, Jisu Kim, Kiwon Li. The Effects of Exercise Training with Oral Intake of Lactate on Hippocampal Neurogenesis and Neurotrophic Factors in Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560403. |
after the experiment ended, hippocampal neurogenesis (ki67, neural stem cell proliferation marker; dcx, marker of differentiation to immature neurons) and neurotrophic factors (pgc1α, fndc5, vegfa, and bdnf) were evaluated respectively by immunohistochemistry (ihc) and by western blot (wb) on hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |
| Bing Su, Suohua Cheng, Lei Wang, Bing Wan. MicroRNA-139-5p acts as a suppressor gene for depression by targeting nuclear receptor subfamily 3, group C, member 1. Bioengineered. vol 13. issue 5. 2022-05-11. PMID:35543383. |
furthermore, compared with the antago-nc group, 3 weeks of antagomir-139-5p treatment significantly decreased mir-139-5p level in model group hippocampus, increased sucrose preference index, reduced neuron damages, and enhanced the levels of nuclear receptor subfamily 3 group c member 1 (nr3c1), brain-derived neurotrophic factor (bdnf), phosphorylated/total tyrosine kinase receptor b (p-trkb/trkb), phosphorylated/total camp-response element-binding protein (p-creb/creb) and phosphorylated/total extracellular regulated protein kinases (p-erk/erk). |
2022-05-11 |
2023-08-13 |
mouse |
| Robert S Gardner, Donna L Korol, Paul E Gol. Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats. Pharmacology, biochemistry, and behavior. 2022-05-05. PMID:35513118. |
exposure to morphine or cocaine did not significantly change levels of brain-derived neurotrophic factor (bdnf) or a downstream target of bdnf signaling, glycogen synthase kinase 3β (gsk3β), in the hippocampus or striatum. |
2022-05-05 |
2023-08-13 |
rat |
| Stefanie Rauskolb, Thomas Andreska, Sophie Fries, Cora Ruedt von Collenberg, Robert Blum, Camelia-Maria Monoranu, Carmen Villmann, Michael Sendtne. Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-05-05. PMID:35513854. |
neuronal overexpression of igfbp5 prevents the training-induced increase of hippocampal and cortical bdnf expression and reduces the effects of exercise on memory retention, but not on learning acquisition. |
2022-05-05 |
2023-08-13 |
mouse |
| Javad Riyahi, Behrouz Abdoli, Francesca Gelfo, Laura Petrosini, Leila Khatami, Gholam Hossein Meftahi, Abbas Haghparas. Multigenerational effects of paternal spatial training are lasting in the F1 and F2 male offspring. Behavioural pharmacology. 2022-05-03. PMID:35502983. |
further, to investigate the memory process in f1 and f2 male offspring, brain-derived neurotrophic factor (bdnf), p-erk1/2 and acetylated histone 3 lysine 14 (h3k14) expression levels in the hippocampus were analyzed. |
2022-05-03 |
2023-08-13 |
Not clear |
| Javad Riyahi, Behrouz Abdoli, Francesca Gelfo, Laura Petrosini, Leila Khatami, Gholam Hossein Meftahi, Abbas Haghparas. Multigenerational effects of paternal spatial training are lasting in the F1 and F2 male offspring. Behavioural pharmacology. 2022-05-03. PMID:35502983. |
these findings were supported by neurobiologic data showing that paternal training increased bdnf and p-erk1/2 in the hippocampus of f1 and f2 male offspring. |
2022-05-03 |
2023-08-13 |
Not clear |
| Ge Ou, Qian Li, Lin Zhu, Yuanyuan Zhang, Yijing Liu, Xin Li, Lina Du, Yiguang Ji. Intranasal hydrogel of armodafinil hydroxypropyl-β-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 3. 2022-05-02. PMID:35498223. |
besides, the western blot (wb) of hippocampal brain-derived neurotrophic factor (bdnf) and amygdala dopamine transporter (dat) immunohistochemistry sections indicated that aic hydrogel had a protective effect on the brain tissue of ptsd mice. |
2022-05-02 |
2023-08-13 |
mouse |
| Sonia Sanchez-Bezanilla, Daniel J Beard, Rebecca J Hood, N David Åberg, Patricia Crock, Frederick R Walker, Michael Nilsson, Jörgen Isgaard, Lin Kooi On. Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice. Neural plasticity. vol 2022. 2022-04-25. PMID:35465399. |
we aimed to explore the mechanisms of gh treatment by investigating how gh modulates pathways known to induce neuroplasticity, focusing on association between brain-derived neurotrophic factor (bdnf) and mammalian target of rapamycin (mtor) in the peri-infarct area, hippocampus, and thalamus. |
2022-04-25 |
2023-08-13 |
mouse |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
possible alterations in levels of brain-derived neurotrophic factor (bdnf) expression in the hippocampus and amygdala were also evaluated. |
2022-04-23 |
2023-08-13 |
mouse |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
in addition, we found decreased bdnf and enhanced gfap hippocampal expression levels, accompanied by elevations in glutamate amount, as well as reduction in gaba content in amygdala and hippocampus. |
2022-04-23 |
2023-08-13 |
mouse |
| Kanishk Luhach, Giriraj T Kulkarni, Vijay P Singh, Bhupesh Sharm. Vinpocetine ameliorates developmental hyperserotonemia induced behavioral and biochemical changes: role of neuronal function, inflammation, and oxidative stress. Acta neurobiologiae experimentalis. vol 82. issue 1. 2022-04-22. PMID:35451422. |
also, effects on biochemical markers related with neuronal function brain derived neurotrophic factor (bdnf) and phosphorylated camp response element binding protein (pcreb), inflammation interleukins (il‑6 and il‑10) and tumor necrosis factor-alpha (tnf‑α), and oxidative stress (tbars and gsh) were studied in important brain areas (frontal cortex, cerebellum, hippocampus, and striatum). |
2022-04-22 |
2023-08-13 |
rat |