| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu L. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022-02-20. PMID:35183538. |
results showed that chronic unpredictable stress (cus) markedly increased the expression levels of hippocampal nr6a1 protein, which reduced hippocampal creb phosphorylation and bdnf protein expression. |
2022-02-20 |
2023-08-13 |
mouse |
| Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu L. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022-02-20. PMID:35183538. |
furthermore, genetic knockdown of hippocampal creb or bdnf abrogated the preventive effect of hippocampal nr6a1 down-regulation on cus-induced depression-like behaviors in mice. |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
we analyzed corticosterone concentrations in serum, levels of grα isoforms (95, 67, 50, 40, and 25 kda), and mrna levels of gr-responsive genes (gr, fkbp5, bdnf, and il-1β) in the hippocampus and the prefrontal cortex (pfc). |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
changes in gene expression revealed that female depressive-like behavior could be related to increased levels of il-1β in hippocampus and reduced bdnf levels in both hippocampus and pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
however, in males, adolescent cus increased expression of gr in adult hippocampus and bdnf in pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Rukmani Pandey, Asmita Garg, Keerti Gupta, Pallavi Shukla, Kapil Mandrah, Somendu Roy, Naibedya Chattopadhyay, Sanghamitra Bandyopadhya. Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats. Molecular neurobiology. 2022-02-17. PMID:35175559. |
it also indicates that endogenous e2 regulates hippocampal bmp and bdnf signaling and restrains arsenic-induced neuronal dysfunctions in females, which may be inhibited in e2-deficient conditions, such as menopause or ovarian failure. |
2022-02-17 |
2023-08-13 |
rat |
| Ying-Xiao Li, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Cheng, Ting-Ting Yan. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. Plants (Basel, Switzerland). vol 11. issue 3. 2022-02-15. PMID:35161241. |
the expression levels of the serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) in the hippocampus of the rats with depression were markedly increased by gmdz. |
2022-02-15 |
2023-08-13 |
rat |
| Ying-Xiao Li, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Cheng, Ting-Ting Yan. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. Plants (Basel, Switzerland). vol 11. issue 3. 2022-02-15. PMID:35161241. |
these results suggest that gmdz may alleviate the depressive-like behaviors in depressive rats, possibly via licorice (gan cao), to increase 5-htt and bdnf signals in the hippocampus. |
2022-02-15 |
2023-08-13 |
rat |
| Sarah Thomas Broome, Alessandro Castorin. The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163768. |
buspirone attenuated the induction of interleukin-1β and interleukin-6 expression by rotenone, and this was paralleled by the upregulation of arginase-1, brain-derived neurotrophic factor (bdnf), and activity-dependent neuroprotective protein (adnp) in the midbrain, striatum, prefrontal cortex, amygdala, and hippocampus. |
2022-02-15 |
2023-08-13 |
mouse |
| Yosra A Hussien, Dina F Mansour, Somaia A Nada, Sahar S Abd El-Rahman, Rania M Abdelsalam, Amina S Attia, Dalia M El-Tanboul. Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: Modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects. Life sciences. 2022-02-08. PMID:35134437. |
lng modulated taa-induced disturbances in hippocampal amino acids; glutamate, and gaba with a significant increase in hippocampal bdnf. |
2022-02-08 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Differential effects of voluntary and forced exercise trainings on spatial learning ability and hippocampal biomarkers in aged female rats. Neuroscience letters. 2022-02-05. PMID:35121056. |
after the behavioral test, hippocampus tissues were taken for the analysis of synaptophysin, acetylcholinesterase (ache), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), malondialdehyde (mda), protein carbonyl (pc), glutathione (gsh) and superoxide dismutase (sod). |
2022-02-05 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Differential effects of voluntary and forced exercise trainings on spatial learning ability and hippocampal biomarkers in aged female rats. Neuroscience letters. 2022-02-05. PMID:35121056. |
in the hippocampus tissue, levels of the synaptophysin, bdnf, ngf and sod were higher, but mda levels were lower in the voluntary exercise group than in the control group (p < 0.05). |
2022-02-05 |
2023-08-13 |
rat |
| Ana Paula Moreira, Adriana Fernanda K Vizuete, Lisandra Eda Fusinato Zin, Charlanne Oliveira de Marques, Rafaela Ferreira Pacheco, Miriara B Leal, Carlos-Alberto Gonçalve. The Methylglyoxal/RAGE/NOX-2 Pathway is Persistently Activated in the Hippocampus of Rats with STZ-Induced Sporadic Alzheimer's Disease. Neurotoxicity research. 2022-02-02. PMID:35106732. |
furthermore, reinforcing this possibility, we found a reduction in cholinergic communication in the hippocampus (as shown by decreased choline acetyltransferase), a reduction in bdnf, and an increase in tgf-β, the combination of which may result in synaptic deterioration. |
2022-02-02 |
2023-08-13 |
rat |
| Bingyi Liu, Ning Zhang, Junrong Yang, Wei Sun, Ruiyan Zhang, Xuexing Zheng, Zhengping Wang, Hans-Christian Siebert, Jun Ha. Preparation, Characterization, Evaluation of Neuroprotective Effect, and Related Mechanisms of Phosphatidylserine Emulsion in 5- and 12-Week Old Mice. Journal of agricultural and food chemistry. 2022-02-02. PMID:35107277. |
western-blotting analysis displayed that the 2% (w/w) ps emulsion treated group upregulated bdnf, trkb, psd95, mtor, mbp, and erbb4 expression in the hippocampus of 5- and 12-week old mice. |
2022-02-02 |
2023-08-13 |
mouse |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
hippocampal tissues were used to assess expression of fndc5/irisin, bdnf and proteins related to insulin signalling, in addition to β-amyloid peptide and phosphorylated tau protein levels. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
exercise and carnosine intake almost normalized hippocampal fndc5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved bdnf and insulin signalling proteins, with corresponding mitigated cognitive impairments. |
2022-01-29 |
2023-08-13 |
rat |
| Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafaei, Ali Rashidy-Pou. Corrigendum "Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic- morphine treated male rats" [Behav. Brain Res. 421 (2022) 113732]. Behavioural brain research. vol 422. 2022-01-27. PMID:35085978. |
corrigendum "effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal bdnf decline, and bax/bcl-2 ratio alteration in chronic- morphine treated male rats" [behav. |
2022-01-27 |
2023-08-13 |
rat |
| Maryam Abdollahzadeh, Hamdollah Panahpour, Safa Ghaheri, Hakimeh Saadat. Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats. Brain research bulletin. 2022-01-22. PMID:35065185. |
therefore, the present study aims to examine the effects of calcitriol supplementation (100ng/kg /day for five weeks) on cognitive impairment, behavioral deficits, and hippocampal brain-derived neurotrophic factor (bdnf) changes following cisplatin treatment (5mg/kg/ once a week for five weeks). |
2022-01-22 |
2023-08-13 |
rat |
| Maryam Abdollahzadeh, Hamdollah Panahpour, Safa Ghaheri, Hakimeh Saadat. Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats. Brain research bulletin. 2022-01-22. PMID:35065185. |
besides, hippocampal bdnf levels were reduced in cisplatin-treated rats; however, calcitriol alleviated these effects of cisplatin and up-regulated bdnf mrna in the hippocampus. |
2022-01-22 |
2023-08-13 |
rat |
| Maryam Abdollahzadeh, Hamdollah Panahpour, Safa Ghaheri, Hakimeh Saadat. Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats. Brain research bulletin. 2022-01-22. PMID:35065185. |
we conclude that increased hippocampal bdnf mediates the beneficial effects of calcitriol against neurotoxicity in cisplatin-exposed rats. |
2022-01-22 |
2023-08-13 |
rat |