| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porc. Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats. Hormones and behavior. vol 144. 2022-07-05. PMID:35785712. |
chronic treatment with hormonal contraceptives alters hippocampal bdnf and histone h3 post-translational modifications but not learning and memory in female rats. |
2022-07-05 |
2023-08-14 |
rat |
| Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porc. Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats. Hormones and behavior. vol 144. 2022-07-05. PMID:35785712. |
decreased hippocampal brain-derived neurotrophic factor (bdnf) levels and altered histone h3 post-translational modifications (ptms) were observed 14 days after discontinuation from chronic ee-lng treatment. |
2022-07-05 |
2023-08-14 |
rat |
| Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porc. Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats. Hormones and behavior. vol 144. 2022-07-05. PMID:35785712. |
these results provide the first evidence of hippocampal epigenetic changes induced by hormonal contraceptives and complement previous studies on the neurobiological actions of hormonal contraceptives; the finding that effects of chronic ee-lng treatment on bdnf content and histone ptms are observed 14 days after drug discontinuation warrants further investigation to better understand the implications of such long-term consequences for women's health. |
2022-07-05 |
2023-08-14 |
rat |
| Ya-Jing Zhu, Jun-Juan Fan, Fang-Yi Wu, Ming Zhang, Ao-Qi Song, Yong Li, Yan-Kun Li, Wen-Ning W. Aging Promotes Chronic Stress-Induced Depressive-Like Behavior by Activating NLRP1 Inflammasome-Driven Inflammatory Signaling in Mice. Inflammation. 2022-07-02. PMID:35779196. |
moreover, aged mice exhibited lower hippocampal bdnf levels compared to young mice. |
2022-07-02 |
2023-08-14 |
mouse |
| Ya-Jing Zhu, Jun-Juan Fan, Fang-Yi Wu, Ming Zhang, Ao-Qi Song, Yong Li, Yan-Kun Li, Wen-Ning W. Aging Promotes Chronic Stress-Induced Depressive-Like Behavior by Activating NLRP1 Inflammasome-Driven Inflammatory Signaling in Mice. Inflammation. 2022-07-02. PMID:35779196. |
hippocampal nlrp1a knockdown reduced the levels of pro-inflammatory cytokines and the expression of cxcl1/cxcr2, restored bdnf levels, and alleviated chronic stress-induced depressive-like behaviors in aged mice. |
2022-07-02 |
2023-08-14 |
mouse |
| Tessa J Helman, John P Headrick, Jason N Peart, Nicolas J C Stapelber. Central and cardiac stress resiliences consistently linked to integrated immuno-neuroendocrine responses across stress models in male mice. The European journal of neuroscience. 2022-06-28. PMID:35763309. |
highly integrated expression of hpa axis, neuro-inflammatory, bdnf, monoamine, gaba, cannabinoid and opioid signalling genes was confirmed across conditions, and consistent/potentially causal correlations identified for: i) locomotor activity (noradrenaline, ghrelin; fc crhr1, tnfrsf1b, il33, nfkb1, maoa, gabra1; hippocampal il33); ii) thigmotaxis (adrenaline, leptin); iii) anxiety-like behaviour (adrenaline, leptin; fc tnfrsf1a; hippocampal il33); iv) depressive-like behaviour (ghrelin; fc/hippocampal s100a8); and v) cardiac stress-resistance (noradrenaline, leptin; fc il33, tnfrsf1b, htr1a, gabra1, gabrg2; hippocampal il33, tnfrsf1a, maoa, drd2). |
2022-06-28 |
2023-08-14 |
mouse |
| Salvatore Saieva, Giulio Taglialatel. Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice. Scientific reports. vol 12. issue 1. 2022-06-27. PMID:35761012. |
lastly, hippocampal levels of the neurotrophic factor bdnf were increased in nir-treated hfd mice, compared to untreated hfd mice. |
2022-06-27 |
2023-08-14 |
mouse |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
here, we found that vad caused brain injury, lipid peroxidation, and neuronal death in the hippocampus, as well as astrocyte and microglial activation, and reduced bdnf neurotrophic factor expression together with behavioral alterations. |
2022-06-24 |
2023-08-14 |
mouse |
| Farid Farhani, Shahnaz Shahrbanian, Mohammad Auais, Amir Hossein Ahmadi Hekmatikar, Katsuhiko Suzuk. Effects of Aerobic Training on Brain Plasticity in Patients with Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741616. |
twelve studies with medium to high quality were included, of which five studies focused on brain-derived neurotrophic factor (four articles reported elevation and one article reported no changes in bdnf levels following the aerobic exercise), two studies focused on brain structures (both reported increases in hippocampus volume following the aerobic exercise), and five studies focused on brain activity (four articles reported positive changes, and one article reported no changes in brain activity following the aerobic exercise). |
2022-06-24 |
2023-08-14 |
Not clear |
| Hu Zhang, Ji-Ling Liang, Qiu-Yue Wu, Jin-Xiu Li, Ya Liu, Liang-Wen Wu, Jie-Lun Huang, Xiao-Wen Wu, Ming-Hui Wang, Ning Che. Swimming Suppresses Cognitive Decline of HFD-Induced Obese Mice through Reversing Hippocampal Inflammation, Insulin Resistance, and BDNF Level. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745162. |
swimming suppresses cognitive decline of hfd-induced obese mice through reversing hippocampal inflammation, insulin resistance, and bdnf level. |
2022-06-24 |
2023-08-14 |
mouse |
| Yating Zhang, Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You, Peng Yu, Yan-Zhong Chang, Guofen Ga. Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation. Molecular neurobiology. 2022-06-22. PMID:35732869. |
hippocampal iron accumulation impairs synapses and memory via suppressing furin expression and downregulating bdnf maturation. |
2022-06-22 |
2023-08-14 |
mouse |
| Yating Zhang, Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You, Peng Yu, Yan-Zhong Chang, Guofen Ga. Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation. Molecular neurobiology. 2022-06-22. PMID:35732869. |
regarding the changes of furin-mediated activities caused by hippocampal iron overload, we found that the maturation of brain-derived neurotrophic factor (bdnf) was impeded and the expression levels of synaptogenesis-related proteins were downregulated, leading to cognitive decline. |
2022-06-22 |
2023-08-14 |
mouse |
| Rosamaria Orlando, Roxana Paula Ginerete, Laura Cavalleri, Vincenza Aliperti, Tiziana Imbriglio, Giuseppe Battaglia, Anna Rita Zuena, Ferdinando Nicoletti, Emilio Merlo Pich, Ginetta Coll. Synergic action of L-acetylcarnitine and L-methylfolate in Mouse Models of Stress-Related Disorders and Human iPSC-Derived Dopaminergic Neurons. Frontiers in pharmacology. vol 13. 2022-06-20. PMID:35721218. |
in both stress paradigms, lac and mf acted synergistically in reducing the immobility time in the forced swim test and enhancing bdnf protein levels in the frontal cortex and hippocampus. |
2022-06-20 |
2023-08-14 |
mouse |
| Bongjun Sur, Bombi Le. Myricetin Inhibited Fear and Anxiety-Like Behaviors by HPA Axis Regulation and Activation of the BDNF-ERK Signaling Pathway in Posttraumatic Stress Disorder Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-06-20. PMID:35722162. |
it also increased the reduction in the brain-derived neurotrophic factor (bdnf) and tropomyosin-related kinase b mrna expression and the ratio of p-erk/extracellular signal-regulated kinase (erk) in the hippocampus. |
2022-06-20 |
2023-08-14 |
rat |
| Marco Pagliusi, Daniela Franco, Shannon Cole, Gessynger Morais-Silva, Ramesh Chandra, Megan E Fox, Sergio D Iñiguez, Cesar R Sartori, Mary Kay Lob. The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722560. |
in stress outcomes, bdnf acting in the hippocampus has a stress resilience effect, and, inversely, in the nucleus accumbens (nac), bdnf acts as a stress susceptible molecule. |
2022-06-20 |
2023-08-14 |
mouse |
| Seval Keloglan Musuroglu, Duygu Murat Ozturk, Leyla Sahin, Ozge Selin Cevik, Kenan Cevi. Environmental enrichment as a strategy: attenuates the anxiety and memory impairment in social isolation stress. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-06-20. PMID:35724417. |
this study was designed to examine how ee affects memory functions, anxiety level, and the expression levels of memory/anxiety-related genes such as nr2a, nr2b, bdnf, and cfos in the hippocampus of socially isolated rats. |
2022-06-20 |
2023-08-14 |
rat |
| Roberto Laureano-Melo, Raoni Conceição Dos-Santos, Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Claudio da Silva Almeida, Luís Carlos Reis, Bruno Guimarães Marinho, Gisele Giannocco, Ahmed Rg, Wellington da Silva Côrte. Neonatal D-fenfluramine Treatment Promotes Long-Term Behavioral Changes in Adult Mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-06-19. PMID:35718760. |
alternatively, there was a reduction only in the tryptophan hydroxylase (tph2) and bdnf expression in the hippocampus. |
2022-06-19 |
2023-08-14 |
mouse |
| Fabrizio Sanna, Maria Pina Serra, Marianna Boi, Jessica Bratzu, Laura Poddighe, Francesco Sanna, Antonella Carta, Maria Giuseppa Corda, Osvaldo Giorgi, Maria Rosaria Melis, Antonio Argiolas, Marina Quart. Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity. Hippocampus. 2022-06-18. PMID:35716117. |
neuroplastic changes in c-fos, Δfosb, bdnf, trkb, and arc expression in the hippocampus of male roman rats: differential effects of sexual activity. |
2022-06-18 |
2023-08-14 |
rat |
| Fabrizio Sanna, Maria Pina Serra, Marianna Boi, Jessica Bratzu, Laura Poddighe, Francesco Sanna, Antonella Carta, Maria Giuseppa Corda, Osvaldo Giorgi, Maria Rosaria Melis, Antonio Argiolas, Marina Quart. Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity. Hippocampus. 2022-06-18. PMID:35716117. |
sexual activity causes differential changes in the expression of markers of neural activation (c-fos and Δfosb) and neural plasticity (arc and bdnf/trkb), as determined either by western blot (bdnf, trkb, arc, and Δfosb) or immunohistochemistry (bdnf, trkb, arc, and c-fos), in the hippocampus of male roman high (rha) and low avoidance (rla) rats, two psychogenetically selected rat lines that display marked differences in sexual behavior (rha rats exhibit higher sexual motivation and better copulatory performance than rla rats). |
2022-06-18 |
2023-08-14 |
rat |
| Fabrizio Sanna, Maria Pina Serra, Marianna Boi, Jessica Bratzu, Laura Poddighe, Francesco Sanna, Antonella Carta, Maria Giuseppa Corda, Osvaldo Giorgi, Maria Rosaria Melis, Antonio Argiolas, Marina Quart. Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity. Hippocampus. 2022-06-18. PMID:35716117. |
both methods showed (with some differences) that sexual activity modifies the expression levels of these markers in the hippocampus of roman rats depending on: (i) the level of sexual experience, that is, changes were usually more evident in sexually naïve than in experienced rats; (ii) the hippocampal partition, that is, bdnf and arc increased in the dorsal but tended to decrease in the ventral hippocampus; (iii) the marker considered, that is, in sexually experienced animals bdnf, c-fos, and arc levels were similar to those of controls, while Δfosb levels increased; and (iv) the rat line, that is, changes were usually larger in rha than rla rats. |
2022-06-18 |
2023-08-14 |
rat |