| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huan. ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation. Brain, behavior, and immunity. 2022-08-22. PMID:35995236. |
these results suggest that increased bdnf synthesis through activation of erk1/2 caused by a single lps injection and subsequent trkb signaling are required for the antidepressant effect of hippocampal microglial stimulation. |
2022-08-22 |
2023-08-14 |
mouse |
| Camila Espasandín, Sofía Rivero, Laura Bengoa, Karina Cal, Gerardo Romanelli, Juan Claudio Benech, Juan Pablo Damiá. CaMKIV/CREB/BDNF signaling pathway expression in prefrontal cortex, amygdala, hippocampus and hypothalamus in streptozotocin-induced diabetic mice with anxious-like behavior. Experimental brain research. 2022-08-19. PMID:35984483. |
the objective of this study was to determine whether mice with type 1 diabetes (t1dm) induced with streptozotocin show a profile of anxious-type behaviors and alterations in the expression/activity of camkiv, creb, pcreb and bdnf in different regions of the brain (prefrontal cortex, amygdala, hippocampus and hypothalamus) in comparison to non-diabetic mice (ndb). |
2022-08-19 |
2023-08-14 |
mouse |
| Bongjun Sur, Bombi Le. Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder. Journal of natural medicines. 2022-08-18. PMID:35982366. |
it also increased the reduction in the brain-derived neurotrophic factor (bdnf) and tropomyosin-related kinase b (trkb) mrnas expression, and the ratio of p-akt/akt in the hippocampus. |
2022-08-18 |
2023-08-14 |
rat |
| Daria Savitska, Morgan Hess, Dila Calis, Philine Marchetta, Csaba Harasztosi, Stefan Fink, Philipp Eckert, Peter Ruth, Lukas Rüttiger, Marlies Knipper, Wibke Singe. Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way. Frontiers in neuroscience. vol 16. 2022-08-15. PMID:35968392. |
lower central compensation resulted in poorer temporal auditory processing, reduced hippocampal ltp, and decreased recruitment of activity-dependent brain-derived neurotrophic factor (bdnf) expression in hippocampal regions ( |
2022-08-15 |
2023-08-14 |
Not clear |
| Candan Sağlam, İnci Turan, Hale Sayan Özaçma. THE EFFECT OF GLUCAGON LIKE PEPTIDE -1 RECEPTOR AGONIST ON BEHAVIORAL DESPAIR AND ANXIETY-LIKE BEHAVIOR IN OVARIECTOMIZED RATS: MODULATION OF BDNF/CREB, NRF2 AND LIPOCALIN 2. Behavioural brain research. 2022-08-12. PMID:35961539. |
the objective of the present study is to evaluate the effect of glp-1ra, namely liraglutide, on emotional behaviors, and to identify the level of oxidative stress, neuroinflammation, and bdnf signaling in the hippocampus of ovx rats. |
2022-08-12 |
2023-08-14 |
rat |
| Candan Sağlam, İnci Turan, Hale Sayan Özaçma. THE EFFECT OF GLUCAGON LIKE PEPTIDE -1 RECEPTOR AGONIST ON BEHAVIORAL DESPAIR AND ANXIETY-LIKE BEHAVIOR IN OVARIECTOMIZED RATS: MODULATION OF BDNF/CREB, NRF2 AND LIPOCALIN 2. Behavioural brain research. 2022-08-12. PMID:35961539. |
the levels of bdnf, creb, nrf2, and lipocalin 2 in the hippocampal tissue were measured by elisa. |
2022-08-12 |
2023-08-14 |
rat |
| Candan Sağlam, İnci Turan, Hale Sayan Özaçma. THE EFFECT OF GLUCAGON LIKE PEPTIDE -1 RECEPTOR AGONIST ON BEHAVIORAL DESPAIR AND ANXIETY-LIKE BEHAVIOR IN OVARIECTOMIZED RATS: MODULATION OF BDNF/CREB, NRF2 AND LIPOCALIN 2. Behavioural brain research. 2022-08-12. PMID:35961539. |
moreover, bdnf, creb, and nrf2 levels decreased significantly in the hippocampus of ovx rats. |
2022-08-12 |
2023-08-14 |
rat |
| Candan Sağlam, İnci Turan, Hale Sayan Özaçma. THE EFFECT OF GLUCAGON LIKE PEPTIDE -1 RECEPTOR AGONIST ON BEHAVIORAL DESPAIR AND ANXIETY-LIKE BEHAVIOR IN OVARIECTOMIZED RATS: MODULATION OF BDNF/CREB, NRF2 AND LIPOCALIN 2. Behavioural brain research. 2022-08-12. PMID:35961539. |
liraglutide treatment limited the reduction of bdnf and nrf2 levels in the hippocampus, maintaining them at the control levels. |
2022-08-12 |
2023-08-14 |
rat |
| Wenjing Yan, Hulin Zhu, Pengbo Zhang, Ting Sun, Shuai Gong, Guoxiu Sun, Zeqiang Re. Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice. Metabolic brain disease. 2022-08-10. PMID:35947291. |
expression levels of monoaminergic system markers, brain-derived neurotrophic factor (bdnf), pro-inflammatory cytokines, and nuclear factor-kappa b (nfκb) in the hippocampus and serum were detected using immunochemistry and western and enzyme-linked immunosorbent assay analysis. |
2022-08-10 |
2023-08-14 |
mouse |
| Wenjing Yan, Hulin Zhu, Pengbo Zhang, Ting Sun, Shuai Gong, Guoxiu Sun, Zeqiang Re. Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice. Metabolic brain disease. 2022-08-10. PMID:35947291. |
immunohistochemistry studies revealed reduced levels of serotonin, norepinephrine, and bdnf in the hippocampus and serum. |
2022-08-10 |
2023-08-14 |
mouse |
| Suzuka Miura, Eri Oyanagi, Chihiro Watanabe, Hiroki Hamada, Takafumi Aoki, Michael J Kremenik, Hiromi Yan. Acetyl-L-carnitine attenuates Poly I: C- induced sickness behavior in mice. Bioscience, biotechnology, and biochemistry. 2022-08-09. PMID:35945649. |
the gene expression of brain-derived neurotrophic factor (bdnf) in the cerebrum and hippocampus, which is associated with physical activity, was higher in the alc-treated group. |
2022-08-09 |
2023-08-14 |
mouse |
| Nabila E Abdelmeguid, Tasneem M Hammad, Ashraf M Abdel-Moneim, Sherine Abdel Sala. Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor. Neurochemical research. 2022-08-08. PMID:35939172. |
in conclusion, our study demonstrates that the antidepressive action of egcg involves downregulation of serum il-1β, upregulation of bdnf mrna in the hippocampus, and reduction of ca3 neuronal lesions. |
2022-08-08 |
2023-08-14 |
mouse |
| Xinna Li, Xiaofang Shi, Madaline McPherson, Mary Hager, Gonzalo G Garcia, Richard A Mille. Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice. Aging cell. 2022-08-05. PMID:35930768. |
these mice also have elevated levels of hippocampal brain-derived neurotrophic factor (bdnf) and of doublecortin (dcx), suggesting a mechanism for maintenance of cognitive function at older ages. |
2022-08-05 |
2023-08-14 |
mouse |
| Mengxi Lu, Xia He, Zhexiao Jiao, Zewen Hu, Zijing Guo, Shiyun Dai, Hui Wang, Dan X. The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure. Environmental toxicology. 2022-08-02. PMID:35917217. |
these results indicated that pce inhibits the bdnf pathway and mediates the hippocampus's glutamate (glu) excitotoxicity. |
2022-08-02 |
2023-08-14 |
rat |
| Laura Musazzi, Paolo Tornese, Nathalie Sala, Francis S Lee, Maurizio Popoli, Alessandro Ierac. Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNF Journal of cellular physiology. 2022-07-31. PMID:35908196. |
acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of bdnf stressful life events are considered major risk factors for the development of several psychiatric disorders, though people differentially cope with stress. |
2022-07-31 |
2023-08-14 |
human |
| Tadahiro Numakawa, Haruki Odak. The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887075. |
brain-derived neurotrophic factor (bdnf) and its high affinity receptor trkb are highly expressed in the cortical and hippocampal areas and play an essential role in learning and memory. |
2022-07-27 |
2023-08-14 |
Not clear |
| Soraya Mansouri, Ali-Akbar Salari, Ali Abedi, Parham Mohammadi, Mohammad Aman. Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. Physiology & behavior. 2022-07-20. PMID:35858673. |
we measured inflammatory cytokines including tumor necrosis factor (tnf)-α, interferon (ifn)-γ, interleukin (il)-17a, and brain-derived neurotrophic factor (bdnf) in the hippocampus of obese mice. |
2022-07-20 |
2023-08-14 |
mouse |
| Soraya Mansouri, Ali-Akbar Salari, Ali Abedi, Parham Mohammadi, Mohammad Aman. Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. Physiology & behavior. 2022-07-20. PMID:35858673. |
our results show that hfd-induced obesity significantly impaired working, spatial and recognition memory by increasing ifn-γ and il-17a and decreasing bdnf levels in the hippocampus of mice. |
2022-07-20 |
2023-08-14 |
mouse |
| Soraya Mansouri, Ali-Akbar Salari, Ali Abedi, Parham Mohammadi, Mohammad Aman. Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. Physiology & behavior. 2022-07-20. PMID:35858673. |
on the other hand, melatonin treatment effectively improved all cognitive impairments and reduced tnf-α, ifn-γ, and il-17a and elevated bdnf levels in the hippocampus of obese mice. |
2022-07-20 |
2023-08-14 |
mouse |
| Jing-Yu Qi, Liu-Kun Yang, Xin-Shang Wang, Min Wang, Xu-Bo Li, Ban Feng, Yu-Mei Wu, Shui-Bing Liu, Kun Zhan. Mechanism of CNS regulation by irisin, a multifunctional protein. Brain research bulletin. 2022-07-19. PMID:35850187. |
it has been reported that irisin can cross the blood-brain barrier and increase the expression of a brain-derived neurotrophic factor (bdnf) in the hippocampus, which improves learning and memory. |
2022-07-19 |
2023-08-14 |
Not clear |