| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Ting Wang, Han Wang, Wu-Jiang Ren, Xue-Ling Dai, Qing Huo, Shuo Wang, Ya-Xuan Su. 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway. Journal of Asian natural products research. 2022-06-07. PMID:35672874. |
diss can regulate tyrosine kinase b (trkb)/brain-derived neurotrophic factor (bdnf) signaling in the hippocampus. |
2022-06-07 |
2023-08-14 |
mouse |
| Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopr. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochemical research. 2022-06-06. PMID:35665448. |
furthermore, treatment with tmp increased bdnf, p-akt, and p-creb levels, normalized cholinergic dysfunction, and suppressed oxidative, inflammatory, and apoptotic markers in the hippocampus. |
2022-06-06 |
2023-08-14 |
rat |
| Weisheng Li, Likui Lu, Dan Zhu, Jingliu Liu, Yajun Shi, Hongtao Zeng, Xi Yu, Jun Guo, Bin Wei, Yongle Cai, Miao Su. Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway. Ecotoxicology and environmental safety. vol 239. 2022-06-01. PMID:35643027. |
in addition, in vivo experiment demonstrated that the protein abundance of bdnf and the ratio of p-creb1 to creb1 were increased in the hippocampus of naf offspring, while the level of trkb was reduced. |
2022-06-01 |
2023-08-13 |
mouse |
| Youness Kadil, Houda Filal. Nigella Fixed Oil mitigates memory impairment in a rat aged model of cognitive decline, a pivotal role of BDNF and CREB signaling pathways in the hippocampus. CNS & neurological disorders drug targets. 2022-05-31. PMID:35638539. |
nigella fixed oil mitigates memory impairment in a rat aged model of cognitive decline, a pivotal role of bdnf and creb signaling pathways in the hippocampus. |
2022-05-31 |
2023-08-13 |
rat |
| Tae-Woon Kim, Sang-Seo Park, Hye-Sang Par. Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628329. |
we found that the offspring of mothers with ama without exercise training had decreased spatial learning and memory, brain-derived neurotrophic factor (bdnf) and postsynaptic density protein 95 (psd-95) protein levels, neurogenesis, and mitochondrial function, as well as hippocampal cell death. |
2022-05-28 |
2023-08-13 |
Not clear |
| Tae-Woon Kim, Sang-Seo Park, Hye-Sang Par. Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628329. |
the maternal exercises augmented the hippocampal levels of bdnf, which prevents decreased cognitive function in the offspring of mothers with ama. |
2022-05-28 |
2023-08-13 |
Not clear |
| Yaran Gao, Ming Hu, Xiaoli Niu, Meixi Li, Lili Xu, Yining Xiao, Jiawei Zhang, Hebo Wang, Litao Li, Bao Chu, Peiyuan L. Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF- Oxidative medicine and cellular longevity. vol 2022. 2022-05-26. PMID:35615581. |
additionally, nbp promoted both the expression of brain-derived neurotrophic factor (bdnf) and tyrosine receptor kinase b (trkb) in hippocampus tissue. |
2022-05-26 |
2023-08-13 |
mouse |
| Wei-Jia Gu, Chun-Rong Bao, Hong-Yu Xie, Bin Chen, Wan-Qing Lin, Yi Wu, Nian-Hong Wan. [Effect of electroacupuncture invention on activities of PGC-1α/Irisin (FNDC5)/BDNF signaling in cerebral cortex, hippocampus and muscles in focal cerebral ischemic/reperfusion injury rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 5. 2022-05-26. PMID:35616417. |
to observe the effect of electroacupuncture(ea) on the expression of peroxisome proliferator-activated receptor gamma coactivators-1-alpha (pgc-1α), irisin and brain-derived neurotrophic factor (bdnf) in the ischemic peripheral cortex, hippocampus and local skeletal muscle in rats with focal cerebral ischemic/reperfusion injury (ci/ri), so as to explore its underlying mechanism of improving of ci/ri. |
2022-05-26 |
2023-08-13 |
rat |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the hippocampal and prefrontal cortical (pfc) expression levels of bdnf and c-fos were also assessed to show whether the treatments affect the memory-related signaling pathway. |
2022-05-26 |
2023-08-13 |
rat |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the expression levels of bdnf and c-fos in the pfc and the hippocampus were significantly decreased in the stress animal group. |
2022-05-26 |
2023-08-13 |
rat |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the muscimol response was compounded with the decreased levels of bdnf and c-fos in the pfc and the hippocampus. |
2022-05-26 |
2023-08-13 |
rat |
| Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Li. Hippocampal F3/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice. Biochemical pharmacology. 2022-05-24. PMID:35609645. |
currently, it has been demonstrated that besides monoaminergic dysfunction, depression is accompanied by several other important pathological phenomena such as impaired neurogenesis and decreased brain-derived neurotrophic factor (bdnf)-camp response element binding protein (creb) signaling cascade in the hippocampus. |
2022-05-24 |
2023-08-13 |
mouse |
| Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimur. Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600081. |
the aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (bdnf) in patients experiencing a first episode of major depression (md) ( |
2022-05-23 |
2023-08-13 |
Not clear |
| Xiao-Bing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huan. Brain-Derived Neurotrophic Factor regulates LYN kinase mediated Myosin Light Chain Kinase activation to modulate non-muscle myosin II activity in hippocampal neurons. The Journal of biological chemistry. 2022-05-22. PMID:35598826. |
the role of bdnf on modulating the phosphorylation of mlc2 was validated by using western blotting (wb) in primary cultured hippocampal neurons. |
2022-05-22 |
2023-08-13 |
mouse |
| Xiao-Bing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huan. Brain-Derived Neurotrophic Factor regulates LYN kinase mediated Myosin Light Chain Kinase activation to modulate non-muscle myosin II activity in hippocampal neurons. The Journal of biological chemistry. 2022-05-22. PMID:35598826. |
this result was confirmed by injecting bdnf into the dorsal hippocampus of mice and detecting the phosphorylation level of mlc2 by wb. |
2022-05-22 |
2023-08-13 |
mouse |
| Mansour Sayyah, Mehdi Seydyousefi, Abdorreza Eghbal Moghanlou, Gerlinde A S Metz, Nabi Shamsaei, Mohammad Hasan Faghfoori, Zeinab Faghfoor. Activation of BDNF- and VEGF-mediated Neuroprotection by Treadmill Exercise Training in Experimental Stroke. Metabolic brain disease. 2022-05-21. PMID:35596908. |
this study was designed to examine the effect of aerobic exercise on post ischemia/reperfusion injury on concentration and expression of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) after inducing a neuronal loss in ca1 region of hippocampus in male wistar rats. |
2022-05-21 |
2023-08-13 |
rat |
| Soonil Pyo, Joohee Kim, Jihye Hwang, Jeong Hyun Heo, Kyungri Kim, Sung-Rae Ch. Environmental Enrichment and Estrogen Upregulate Beta-Hydroxybutyrate Underlying Functional Improvement. Frontiers in molecular neuroscience. vol 15. 2022-05-20. PMID:35592114. |
in cerebral cortex and hippocampus, ee resulted in a significant increase in the level of βhb and a significant reduction in hdac, consequently enhancing bdnf expression. |
2022-05-20 |
2023-08-13 |
mouse |
| Keren Nitzan, Dekel David, Motty Franko, Roni Toledano, Sharon Fidelman, Yaarit Simchon Tenenbaum, Maya Blonder, Shir Armoza-Eilat, Alon Shamir, Moshe Rehavi, Yair Ben-Chaim, Ravid Doro. Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms. Translational psychiatry. vol 12. issue 1. 2022-05-19. PMID:35589704. |
we show here that shan zha is sufficient to produce an anxiolytic and antidepressant-like effect similar to nht or the escitalopram through activation of 5-ht1a receptor and an elevation in bdnf levels in the hippocampus and pre-frontal cortex (pfc). |
2022-05-19 |
2023-08-13 |
mouse |
| Hanxue Wu, Jinzhu Zhuang, Jiawei Wang, Shenglan Yuan, Hui Sun, Jiaxi X. AT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556110. |
in both prefrontal cortex and hippocampus, the mrna levels of bdnf (brain-derived neurotrophic factor) and pi4kiiiβ (phosphatidylinositol 4-kinase iiiβ) were found to be significantly lower in hypertensive nt mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Jyotirmaya Behera, Rubins H Petit, Yu-Ting Zheng, Neetu Tyag. 1,3-Butanediol Mitigates High-Salt Diet Induced Cognitive Impairment in Aging Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556919. |
this mechanistic study shows that hsd+ 1,3-butanediol mice display an increased mitochondrial tfam dependent upregulation of brain-derived neurotrophic factor (bdnf) and nuclear receptor subfamily 4a (nr4a) in the mouse hippocampus via activation of the h3k27ac acetylation at the promoter. |
2022-05-13 |
2023-08-13 |
mouse |