| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Y. CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice. ACS chemical neuroscience. 2022-11-18. PMID:36399525. |
moreover, cy-09 increased the brain-derived neurotrophic factor (bdnf) only in microglia but not in the whole hippocampus. |
2022-11-18 |
2023-08-14 |
mouse |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
after 3 months, we evaluated zoometry, a serum bioclinical profile, and in the hippocampus and frontal cortex, we performed biochemical assays (concentration of lactate, glutamate, fatty acids, and asat, alat, and ldh activity), immunoreactivity tests (gfap, cox2, cd36, and bdnf), and immunoassays (tnf-α, il-1β, il-6, and pge2). |
2022-11-14 |
2023-08-14 |
rat |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
at the brain level, it is noteworthy that the hcd group had an increase in lactate and glutamate concentration, reactive astrogliosis, immunoreactive cox2 neurons in the ca1 subfield hippocampus and frontal cortex, and high levels of pge2, tnf-α, il-1β, and il-6, and low bdnf immunoreactivity. |
2022-11-14 |
2023-08-14 |
rat |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
meanwhile, the hfd is highlighted by increased fatty acid levels and cd36 expression in the hippocampus and frontal cortex, strong reactive astrogliosis and cox2 immunoreactivity, and the greatest inflammation with the lowest bdnf immunoreactivity. |
2022-11-14 |
2023-08-14 |
rat |
| Benneth Ben-Azu, Christian I Uruaka, Abayomi M Ajayi, Thiophilus Aghogho Jarikre, Kingsley E Nwangwa, Kingsley C Chilaka, Bienose S Chijioke, Marymagdalene G Omonyeme, Chineye B Ozege, Emmanuella C Ofili, Ebidenara B Warekoromor, Nwanneka L Edigbue, Ufoma V Esiekpe, Dabrechi E Akaenyi, Gladys O Ag. Reversal and Preventive Pleiotropic Mechanisms Involved in the Antipsychotic-Like Effect of Taurine, an Essential β-Amino Acid in Ketamine-Induced Experimental Schizophrenia in Mice. Neurochemical research. 2022-11-09. PMID:36350433. |
taurine reduced ketamine-induced dopamine and 5-hydroxytryptamine changes, and increased gad and bdnf levels in the striatum, prefrontal-cortex and hippocampus, suggesting increased gabaergic and neurotrophic transmissions. |
2022-11-09 |
2023-08-14 |
mouse |
| Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park, Pann-Ghill Suh, C Justin Le. Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus. Experimental neurobiology. vol 31. issue 5. 2022-11-09. PMID:36351843. |
because ca2 hippocampus has been reported as a critical brain region for social memory, we develop ca2-specific blockade of memory formation through deletion of phospholipase c gamma 1 (plcγ1), which is a key molecule in the brain-derived neurotrophic factor (bdnf) signaling pathway. |
2022-11-09 |
2023-08-14 |
mouse |
| Feng Gao, Juan Wang, Shaojie Yang, Manman Ji, Guoqi Zh. Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice. Neuropharmacology. vol 222. 2022-11-07. PMID:36341808. |
moreover, systemic application of rol before re-exposure improved hippocampal brain-derived neurotrophic factor (bdnf)/tyrosine kinase receptor b (trkb) signaling and calpain1/akt/mtor signaling. |
2022-11-07 |
2023-08-14 |
mouse |
| Wei Liu, Jiaxi Liu, Jie Gao, Xiaoxu Duan, Lifeng Zhan. Effects of Subchronic Aluminum Exposure on Learning, Memory, and Neurotrophic Factors in Rats. Neurotoxicity research. 2022-11-07. PMID:36342585. |
with hematoxylin and eosin staining, western blot, immunofluorescence, and rt-pcr, the morphology of nerve cells in the hippocampus of rat brain were observed, and the levels of activator protein-1 (ap-1) gene and protein, nerve growth factor (ngf), neurotrophin-3 (nt3), glial cell line-derived neurotrophic factor (gdnf), and brain-derived neurotrophic factor (bdnf) gene and protein level, etc. |
2022-11-07 |
2023-08-14 |
human |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal bdnf level following postnatal serotonin depletion in male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
therefore, the present study aimed to evaluate the influences of the ee housing (postnatal day: pnd21-60) following postnatal serotonin depletion (by para-chlorophenylalanine: pcpa, 100mg/kg, s.c, in pnd 10-20) on anxiety-related behaviors, cognitive functions, and brain-derived neurotrophic factor (bdnf) mrna expression in the hippocampus of male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Adriana L Silva, Joana L Oliveira, Ravena P do Nascimento, Letícia O Santos, Fillipe M de Araújo, Balbino L Dos Santos, Rejane C Santana, Eduardo Luiz T Moreira, Maria José M Batatinha, Iura M Alves, Eudes S Velozo, Mauricio M Victor, Adriano M Assis, Roberto F Almeida, Diogo O G de Souza, Victor Diógenes A Silva, Silvia L Cost. Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: a model of vascular damage in perspective. Neurotoxicology. 2022-11-06. PMID:36336098. |
additionally, it was demonstrated by rt-qpcr that mct induced up-regulation on mrna expression of neuroinflammatory mediator, especially il1β and ccl2 in the hippocampus and cortex, and down-regulation on mrna expression of neurotrophins hgdf and bdnf in the cortex. |
2022-11-06 |
2023-08-14 |
rat |
| Yan Sun, Haiyan Zhu, Rongrong Cheng, Zhengquan Tang, Min Zhan. Outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates antibiotic-induced anxiety and depression-like behavior in mice. Physiology & behavior. 2022-11-06. PMID:36336146. |
after treatment with a. muciniphila and amuc_1100, bdnf and trkb levels were restored in the hippocampus and cortex. |
2022-11-06 |
2023-08-14 |
mouse |
| Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmus. Differential regulation of the BDNF gene in cortical and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-31. PMID:36316156. |
differential regulation of the bdnf gene in cortical and hippocampal neurons. |
2022-10-31 |
2023-08-14 |
rat |
| Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmus. Differential regulation of the BDNF gene in cortical and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-31. PMID:36316156. |
first, we thoroughly characterized the role of the best-described regulators of bdnf gene - creb family transcription factors, and show that activity-dependent bdnf expression depends more on creb and the coactivators cbp and crtc1 in cortical than in hippocampal neurons. |
2022-10-31 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-κb pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. |
2022-10-29 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
inhibition of plasma exosomes or mir-182-5p could significantly ameliorate learning and memory disorders; decrease the levels of pro-inflammatory cytokines tnf-α, il-6, and il-1β; increase the expression of bdnf and ngf; and inhibit the activity of nf-κb signaling pathway in pocd rat hippocampus. |
2022-10-29 |
2023-08-14 |
rat |
| Gahyun Lim, Heaji Lee, Yunsook Li. Potential Effects of Resistant Exercise on Cognitive and Muscle Functions Mediated by Myokines in Sarcopenic Obese Mice. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289794. |
interestingly, the protein level of brain-derived neurotrophic factor (bdnf) in ex was simultaneously increased in all tissues including muscle, plasma, and hippocampus compared to that in ob. |
2022-10-27 |
2023-08-14 |
mouse |
| Narjes Baazaoui, Khalid Iqba. Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291618. |
the imbalance of neurotrophic factors with an increase in fgf-2 level and a decrease in brain derived neurotrophic factor (bdnf) and neurotrophin 4 (nt-4) in the hippocampus, frontal cortex and parietal cortex and disruption of the brain micro-environment are other characteristics of ad. |
2022-10-27 |
2023-08-14 |
Not clear |
| Bongjun Sur, Bombi Le. Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 6. 2022-10-27. PMID:36302617. |
in addition, myr enhanced the mrna expression of brain-derived neurotropic factor (bdnf) in the hippocampus. |
2022-10-27 |
2023-08-14 |
rat |
| Mario E Lloret-Torres, Roxsana N Ayala-Pagan, Freddyson J Martínez-Rivera, Pedro Bonilla, Jennifer L Barreto-Estrad. Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference. IBRO neuroscience reports. 2022-10-24. PMID:36275846. |
hippocampal and amygdalar increased bdnf expression in the extinction of opioid-induced place preference. |
2022-10-24 |
2023-08-14 |
human |