| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhang, Guiping Wang, Rui Li, Ruitong Liu, Zengli Yu, Zengli Zhang, Zhongxiao Wa. Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise. Neurochemistry international. 2022-12-02. PMID:36460238. |
tmao group has significantly upregulated bace1 from both hippocampus and cortex, also increased cathepsin b, p-tau at ser396&ser404, gfap, p-nf-κb p65 in cortex, while reduced bdnf, synaptophysin and psd95 in hippocampus, also reduced occludin and zo-1 from cortex, and reduced occludin from colon. |
2022-12-02 |
2023-08-14 |
mouse |
| Ying Zhang, Guiping Wang, Rui Li, Ruitong Liu, Zengli Yu, Zengli Zhang, Zhongxiao Wa. Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise. Neurochemistry international. 2022-12-02. PMID:36460238. |
in contrast, bace1 from both hippocampus and cortex, also cathepsin b and p-tauser396 from cortex were reduced, bdnf, snaptophysin, and psd95 from hippocampus, zo-1 from cortex, and occludin from colon were elevated post exercise compared to tmao group. |
2022-12-02 |
2023-08-14 |
mouse |
| Shuyue Cheng, Wei Wang, Zemeng Zhu, Mingyue Zhao, Hannao Li, Dexiang Liu, Fang Pa. Involvement of brain-derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice. Journal of neurochemistry. 2022-12-01. PMID:36453259. |
depression-like behaviors, bdnf promoter iv methylation, expression of dna methyltransferases (dnmts), demethylation machinery enzymes, bdnf protein levels, and neuronal development in the prefrontal cortex (pfc) and hippocampus (hip) were assessed in adolescent and adult mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Shuyue Cheng, Wei Wang, Zemeng Zhu, Mingyue Zhao, Hannao Li, Dexiang Liu, Fang Pa. Involvement of brain-derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice. Journal of neurochemistry. 2022-12-01. PMID:36453259. |
additionally, stress in adolescence induced lower levels of bdnf and abnormal hippocampal doublecortin (dcx) expression in adolescent and adult mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Junpei Matsubayashi, Yuki Kawaguchi, Yutaka Kawakami, Kohtaro Take. Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression. Journal of neurochemistry. 2022-11-30. PMID:36448220. |
this study examined molecular mechanism of regulation in lotus expression and found that brain-derived neurotrophic factor (bdnf) increased lotus expression in cultured hippocampal neurons. |
2022-11-30 |
2023-08-14 |
Not clear |
| Junpei Matsubayashi, Yuki Kawaguchi, Yutaka Kawakami, Kohtaro Take. Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression. Journal of neurochemistry. 2022-11-30. PMID:36448220. |
finally, neurite outgrowth assay in cultured hippocampal neurons revealed that bdnf treatment-induced antagonism for ngr1 by upregulating lotus expression. |
2022-11-30 |
2023-08-14 |
Not clear |
| Leandro Garbossa, Larissa Joaquim, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Richard Simon Machado, Kiuanne Metzker, Gabriela Bernades, Everton Lanzzarin, Erick Bagio, Adriele de Farias, Naiana da Rosa, Fabiana Durante de Medeiros, Raquel Jaconi de Carli, Bruna Hoffman Oliveira, Nivaldo Correia Ferreira, Juliete Palandi, Franciane Bobinski, Daniel Fernandes Martins, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilh. The effect of modafinil on passive avoidance memory, brain level of BDNF and oxidative stress markers in sepsis survivor rats. The International journal of neuroscience. 2022-11-30. PMID:36448768. |
the nitrite and nitrate (n/n) concentration, myeloperoxidase (mpo) and catalase (cat) activity, lipid and protein oxidative damage, and brain-derived neurotrophic factor (bdnf) levels were measured in the prefrontal cortex and hippocampus. |
2022-11-30 |
2023-08-14 |
rat |
| Leandro Garbossa, Larissa Joaquim, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Richard Simon Machado, Kiuanne Metzker, Gabriela Bernades, Everton Lanzzarin, Erick Bagio, Adriele de Farias, Naiana da Rosa, Fabiana Durante de Medeiros, Raquel Jaconi de Carli, Bruna Hoffman Oliveira, Nivaldo Correia Ferreira, Juliete Palandi, Franciane Bobinski, Daniel Fernandes Martins, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilh. The effect of modafinil on passive avoidance memory, brain level of BDNF and oxidative stress markers in sepsis survivor rats. The International journal of neuroscience. 2022-11-30. PMID:36448768. |
decreased n/n concentration and mpo activity were verified in the prefrontal cortex of rats submitted to clp and md treatment, as well as reduced protein and lipid oxidative damage in the hippocampus, which was accompanied by increased cat activity and bdnf levels. |
2022-11-30 |
2023-08-14 |
rat |
| Jamileh Gholami, Sajad Sahab Negah, Arezoo Rajabian, Ehsan Saburi, Vahid Hajal. The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model. Biochemistry and biophysics reports. vol 32. 2022-11-28. PMID:36438603. |
spatial learning and memory were assessed in the morris water maze (mwm) and real-time pcr was performed to assess the expression of brain-derived neurotrophic factor (bdnf) and m1 muscarinic acetylcholine receptor (achm1r) within the hippocampus. |
2022-11-28 |
2023-08-14 |
rat |
| Jamileh Gholami, Sajad Sahab Negah, Arezoo Rajabian, Ehsan Saburi, Vahid Hajal. The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model. Biochemistry and biophysics reports. vol 32. 2022-11-28. PMID:36438603. |
this additive protective effect may be in part due to the augmented influence of this combination on bdnf levels and cholinergic neuronal system within the hippocampus. |
2022-11-28 |
2023-08-14 |
rat |
| Mengyu Cai, Yicui Qu, Zifu Ren, Xin Xu, Chuyang Ye, Hongtao Lu, Yinyin Zhang, Wenlan Pan, Hui Shen, Hongxia L. Nutritional supplements formulated to prevent cognitive impairment in animals. Current research in food science. vol 5. 2022-11-28. PMID:36439642. |
likewise, western blot results showed that the formula could activate the camp pathway and increase the expression of phosphorylated pka and bdnf in hippocampal cells. |
2022-11-28 |
2023-08-14 |
Not clear |
| Dawei Dong, Aihui Ren, Ying Yang, Jiayi Su, Libin Liu, Wenyan Zhuo, Yubin Lian. VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats. Journal of molecular neuroscience : MN. 2022-11-28. PMID:36441377. |
in addition, vx-765 treatment increased bdnf levels and normalized synaptophysin protein levels in the hippocampus after cortical infarction. |
2022-11-28 |
2023-08-14 |
rat |
| Muhammad Zahid Khan, Yong-Bo Zheng, Kai Yuan, Ying Han, Lin L. Extracellular zinc regulates contextual fear memory formation in male rats through MMP-BDNF-TrkB pathway in dorsal hippocampus and basolateral amygdala. Behavioural brain research. 2022-11-28. PMID:36442645. |
extracellular zinc chelator caedta, bdnf scavenger trkb-fc, exogenous 7,8-dhf and matrix metalloproteinases (mmp) inhibitor were infused into the ca1 and ca3 regions of hippocampus and bla after cfc. |
2022-11-28 |
2023-08-14 |
rat |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430520. |
bdnf levels were significantly increased in pfcx and hippocampus by trazodone and in the nac and hypothalamus by citalopram. |
2022-11-26 |
2023-08-14 |
rat |
| Verona E Mulgrave, Abdulrahman A Alsayegh, Aida Jaldi, DianneMarie T Omire-Mayor, Niaya James, Oyonumo Ntekim, Eric Walters, Emanuel O Akala, Joanne S Allar. Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice. Neuropeptides. vol 97. 2022-11-26. PMID:36434832. |
hippocampal bdnf protein were similar between genotypes and was not significantly modulated by treadmill running. |
2022-11-26 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in this preclinical experimental study, we investigated in the offspring of c57bl/6 female mice submitted to mia with lipopolysaccharide (lps), typically altered behaviors in asd, such as social interaction and stereotyped self-grooming movement, as well as the levels of the brain-derived neurotrophic factor (bdnf) and interleukin 17a (il-17a) in the hippocampus and cortex, at 28 and 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in the hippocampus of the offspring of females submitted to mia, a decrease in bdnf levels was found at 28 days and 60 days of life, and a decrease in il-17a levels only at 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in the neurochemical issues of the hippocampal region, impairment of bdnf levels has already been demonstrated, which may be an important factor for the observation of asd-like behaviors in adult mice at 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
the neurotrophic hypothesis of depression proposes that reduced levels of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) contribute to neuronal atrophy or loss in the prefrontal cortex (pfc) and hippocampus and impaired hippocampal adult neurogenesis, which are associated with depressive symptoms. |
2022-11-20 |
2023-08-14 |
mouse |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
rodent studies have revealed that ketamine rapidly increases bdnf and vegf release and/or expression in the pfc and hippocampus, which in turn increases the number and function of spine synapses in the pfc and hippocampal neurogenesis. |
2022-11-20 |
2023-08-14 |
mouse |