| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
therefore, the present study aimed to evaluate the influences of the ee housing (postnatal day: pnd21-60) following postnatal serotonin depletion (by para-chlorophenylalanine: pcpa, 100mg/kg, s.c, in pnd 10-20) on anxiety-related behaviors, cognitive functions, and brain-derived neurotrophic factor (bdnf) mrna expression in the hippocampus of male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Adriana L Silva, Joana L Oliveira, Ravena P do Nascimento, Letícia O Santos, Fillipe M de Araújo, Balbino L Dos Santos, Rejane C Santana, Eduardo Luiz T Moreira, Maria José M Batatinha, Iura M Alves, Eudes S Velozo, Mauricio M Victor, Adriano M Assis, Roberto F Almeida, Diogo O G de Souza, Victor Diógenes A Silva, Silvia L Cost. Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: a model of vascular damage in perspective. Neurotoxicology. 2022-11-06. PMID:36336098. |
additionally, it was demonstrated by rt-qpcr that mct induced up-regulation on mrna expression of neuroinflammatory mediator, especially il1β and ccl2 in the hippocampus and cortex, and down-regulation on mrna expression of neurotrophins hgdf and bdnf in the cortex. |
2022-11-06 |
2023-08-14 |
rat |
| Yan Sun, Haiyan Zhu, Rongrong Cheng, Zhengquan Tang, Min Zhan. Outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates antibiotic-induced anxiety and depression-like behavior in mice. Physiology & behavior. 2022-11-06. PMID:36336146. |
after treatment with a. muciniphila and amuc_1100, bdnf and trkb levels were restored in the hippocampus and cortex. |
2022-11-06 |
2023-08-14 |
mouse |
| Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmus. Differential regulation of the BDNF gene in cortical and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-31. PMID:36316156. |
differential regulation of the bdnf gene in cortical and hippocampal neurons. |
2022-10-31 |
2023-08-14 |
rat |
| Eli-Eelika Esvald, Jürgen Tuvikene, Andra Moistus, Käthy Rannaste, Susann Kõomägi, Tõnis Timmus. Differential regulation of the BDNF gene in cortical and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-31. PMID:36316156. |
first, we thoroughly characterized the role of the best-described regulators of bdnf gene - creb family transcription factors, and show that activity-dependent bdnf expression depends more on creb and the coactivators cbp and crtc1 in cortical than in hippocampal neurons. |
2022-10-31 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-κb pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. |
2022-10-29 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
inhibition of plasma exosomes or mir-182-5p could significantly ameliorate learning and memory disorders; decrease the levels of pro-inflammatory cytokines tnf-α, il-6, and il-1β; increase the expression of bdnf and ngf; and inhibit the activity of nf-κb signaling pathway in pocd rat hippocampus. |
2022-10-29 |
2023-08-14 |
rat |
| Gahyun Lim, Heaji Lee, Yunsook Li. Potential Effects of Resistant Exercise on Cognitive and Muscle Functions Mediated by Myokines in Sarcopenic Obese Mice. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289794. |
interestingly, the protein level of brain-derived neurotrophic factor (bdnf) in ex was simultaneously increased in all tissues including muscle, plasma, and hippocampus compared to that in ob. |
2022-10-27 |
2023-08-14 |
mouse |
| Narjes Baazaoui, Khalid Iqba. Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291618. |
the imbalance of neurotrophic factors with an increase in fgf-2 level and a decrease in brain derived neurotrophic factor (bdnf) and neurotrophin 4 (nt-4) in the hippocampus, frontal cortex and parietal cortex and disruption of the brain micro-environment are other characteristics of ad. |
2022-10-27 |
2023-08-14 |
Not clear |
| Bongjun Sur, Bombi Le. Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 6. 2022-10-27. PMID:36302617. |
in addition, myr enhanced the mrna expression of brain-derived neurotropic factor (bdnf) in the hippocampus. |
2022-10-27 |
2023-08-14 |
rat |
| Mario E Lloret-Torres, Roxsana N Ayala-Pagan, Freddyson J Martínez-Rivera, Pedro Bonilla, Jennifer L Barreto-Estrad. Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference. IBRO neuroscience reports. 2022-10-24. PMID:36275846. |
hippocampal and amygdalar increased bdnf expression in the extinction of opioid-induced place preference. |
2022-10-24 |
2023-08-14 |
human |
| Mario E Lloret-Torres, Roxsana N Ayala-Pagan, Freddyson J Martínez-Rivera, Pedro Bonilla, Jennifer L Barreto-Estrad. Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference. IBRO neuroscience reports. 2022-10-24. PMID:36275846. |
drug conditioning and extinction sessions were followed by western blots for bdnf in the hippocampus (hpc), amygdala (amy) and vs/nac. |
2022-10-24 |
2023-08-14 |
human |
| Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Alireza Samzadeh-Kermani, Bahareh Gholamigeravand, Kimia Amiri, Mahsa Majidi, Siamak Shahid. The effects of polyvinyl alcohol-coated selenium nanoparticles on memory impairment in rats. Metabolic brain disease. 2022-10-22. PMID:36271966. |
the expression of hippocampal brain-derived neurotrophic factor (bdnf) and stress oxidative markers (mda and tac), and the number of amyloid-beta (aβ) plaques were assessed using elisa kits, biochemical methods, and congo red staining, respectively. |
2022-10-22 |
2023-08-14 |
rat |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
the mrna expression of bdnf, psd-95, and syp in offspring hippocampus were detected by qrt-pcr, and the protein expression of bdnf, psd-95, syp, hdac2, ach3k9, and ach3k14 were measured by western blotting or immunohistochemistry. |
2022-10-20 |
2023-08-14 |
rat |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
the expression of hdac2 protein was significantly upregulated, while ach3k9, ach3k14, bdnf, psd-95, and syp protein levels were significantly downregulated in the hippocampus of b[a]p- exposed rats. |
2022-10-20 |
2023-08-14 |
rat |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
in addition, chip results showed that prenatal b[a]p exposure markedly decreased the level of ach3k9 and ach3k14 in the promoter region of bdnf and psd-95 gene in the hippocampus of pnd 45 and pnd 75 offspring. |
2022-10-20 |
2023-08-14 |
rat |
| Wen Zhang, Meng-Meng Ge, Long-Qing Zhang, Xiao-Man Yuan, Si-Yi Han, Anne Manyande, Yu-Ke Tian, Xue-Bi Tia. nDysfunction of the BDNF-TrkB signaling pathway contributes to learning and memory impairments induced by neuroinflammation in mice. Neuroscience. 2022-10-20. PMID:36265757. |
in addition, lps reduced the protein levels of bdnf, p-trkb, bcl-2, p-erk1/2, p-camk2, p-creb and p-glur1 and increased the expression of bax in the hippocampus and medial prefrontal cortex regions. |
2022-10-20 |
2023-08-14 |
mouse |
| Allison N Pullin, Victoria S Farrar, Jason W Loxterkamp, Claire T Jones, Rebecca M Calisi, Kristina Horback, Pamela J Lein, Maja M Makago. Providing height to pullets does not influence hippocampal dendritic morphology or brain-derived neurotrophic factor at the end of the rearing period. Poultry science. vol 101. issue 12. 2022-10-17. PMID:36252500. |
overall, providing height during rearing did not affect dendritic morphology or bdnf at 16 wk of age, but other metrics in the hippocampus or other brain regions warrant further investigation. |
2022-10-17 |
2023-08-14 |
Not clear |
| Hunter Franks, Ruishan Wang, Mingqi Li, Bin Wang, Ashton Wildmann, Tyler Ortyl, Shannon O'Brien, Deborah Young, Francesca-Fang Liao, Kazuko Sakat. Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB. Journal of neurochemistry. 2022-10-13. PMID:36227087. |
heat shock factor hsf1 regulates bdnf gene promoters upon acute stress in the hippocampus, together with pcreb. |
2022-10-13 |
2023-08-14 |
mouse |
| Hunter Franks, Ruishan Wang, Mingqi Li, Bin Wang, Ashton Wildmann, Tyler Ortyl, Shannon O'Brien, Deborah Young, Francesca-Fang Liao, Kazuko Sakat. Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB. Journal of neurochemistry. 2022-10-13. PMID:36227087. |
the results of immunohistochemistry and chromatin immunoprecipitation quantitative pcr (chip-qpcr) showed that administration of kainic acid (a glutamate receptor agonist inducing excitotoxity) to young adult mice induced hsf1 nuclear translocation and its binding to multiple bdnf promoters in the hippocampus. |
2022-10-13 |
2023-08-14 |
mouse |