| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp treatment greatly ameliorated the cognitive disability, reduced aβ1-40 and aβ1-42 levels and tau phosphorylation, and upregulated bace1, trk b, and bdnf expression in the hippocampus of 2vo rats. |
2023-01-31 |
2023-08-14 |
rat |
| Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Li. Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice. European journal of pharmacology. 2023-01-28. PMID:36708979. |
although ana-12 treatment had no significant effect on the expression of enk/δor, it blocked the promoting effects of brain-derived neurotrophic factor (bdnf)/tyrosine kinase b(trkb) signaling by snc80 in the hippocampus and amygdala. |
2023-01-28 |
2023-08-14 |
mouse |
| Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu, Bo Jian. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023-01-26. PMID:36702294. |
we have previously demonstrated that hippocampal salt-inducible kinase 2 (sik2) plays a role in the pathogenesis of depression via regulating the downstream creb-regulated transcription coactivator 1 (crtc1)-camp response element-binding protein (creb)-brain derived neurotrophic factor (bdnf) pathway. |
2023-01-26 |
2023-08-14 |
mouse |
| Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu, Bo Jian. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023-01-26. PMID:36702294. |
hg-9-91-01 treatment also reversed the decreasing effects of cums on the bdnf signaling cascade and adult neurogenesis in the hippocampus. |
2023-01-26 |
2023-08-14 |
mouse |
| Renrui Lu, Li Zhang, Huihui Wang, Meng Li, Weisheng Feng, Xiaoke Zhen. Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation Frontiers in pharmacology. vol 13. 2023-01-23. PMID:36686689. |
moreover, echinacoside significantly increased p-creb/creb ratio and bdnf level in hippocampus. |
2023-01-23 |
2023-08-14 |
mouse |
| Juliano Viana Borges, Vivian Naziaseno Pires, Betânia Souza de Freitas, Gabriel Rübensam, Vitória Corrêa Vieira, Cristophod de Souza Dos Santos, Nadja Schröder, Elke Bromber. Behavior, BDNF and epigenetic mechanisms in response to social isolation and social support in middle aged rats exposed to chronic stress. Behavioural brain research. 2023-01-19. PMID:36657665. |
more specifically, we investigated the behavioral responses, corticosterone levels, bdnf gene expression, and markers of hippocampal epigenetic alterations (levels of h3k9 acetylation and methylation, h3k27 methylation, hdac5, dnmt1, and dnmt3a gene expressions) in middle-aged adult rats maintained in different housing conditions (isolation or accompanied housing) and exposed to the chronic unpredictable stress protocol (cus). |
2023-01-19 |
2023-08-14 |
rat |
| Pan Meng, Xi Zhang, Dandan Li, Hui Yang, Xiaoyuan Lin, Hongqing Zhao, Ping Li, Yuhong Wang, Xiaoye Wang, Jinwen G. Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis. Neural plasticity. vol 2023. 2023-01-17. PMID:36647544. |
western blot was utilized to measure the expression of bdnf and 5-ht in the hippocampus. |
2023-01-17 |
2023-08-14 |
rat |
| Shuichi Chiba, Hikaru Asano, Shogo Moriya, Taichi Hatakeyama, Shohei Kobayashi, Ryo Ohta, Maiko Kawaguch. Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels. Neuropsychopharmacology reports. 2023-01-17. PMID:36649932. |
bidirectional effects of voluntary exercise on the expression of bdnf isoforms in the hippocampus of hatano rat strains displaying different activity levels. |
2023-01-17 |
2023-08-14 |
human |
| Shuichi Chiba, Hikaru Asano, Shogo Moriya, Taichi Hatakeyama, Shohei Kobayashi, Ryo Ohta, Maiko Kawaguch. Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels. Neuropsychopharmacology reports. 2023-01-17. PMID:36649932. |
the expression levels of bdnf isoforms and the corresponding coding sequences (cds) were measured in the hippocampus using real-time polymerase chain reaction (pcr). |
2023-01-17 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of ampk/akt/creb/ bdnf signaling cascades. |
2023-01-14 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Estêvão Scotti-Muzzi, Thais Chile, Homero Vallada, Maria Concepción Garcia Otaduy, Márcio Gerhardt Soeiro-de-Souz. BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects. Brain imaging and behavior. 2023-01-11. PMID:36630045. |
the single-nucleotide polymorphism in the bdnf gene (bdnf rs6265) has been associated with decreased hippocampal bdnf secretion and volume in met carriers in different populations, although the val allele has been reported to be more frequent in bd patients. |
2023-01-11 |
2023-08-14 |
human |
| Jeffrey J Moffat, Samuel A Sakhai, Zachary W Hoisington, Yann Ehinger, Dorit Ro. The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice. Psychopharmacology. 2023-01-09. PMID:36622381. |
the bdnf val68met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of bdnf in the ventral hippocampus of male mice. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
we evaluated whether sex and bdnf genotype (val66met polymorphism (met/met) versus wild-type (val/val)) influenced the ability of voluntary running to enhance cognition and hippocampal neurogenesis in mice. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
at increased neurogenesis in the ventral hippocampus of bdnf val/val mice of both sexes and increased the proportion of mature type 3 doublecortin-expressing cells in the dorsal hippocampus of female mice only. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
our results indicate at improved cognitive performance in bdnf met/met mice and increased hippocampal neurogenesis in bdnf val/val mice in middle age. |
2023-01-09 |
2023-08-14 |
mouse |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
galr2 and y1r agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving bdnf actions. |
2023-01-04 |
2023-08-14 |
Not clear |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
we studied their hippocampal proliferating actions using the proliferating cell nuclear antigen (pcna) on neuroblasts or stem cells and the expression of the brain-derived neurothrophic factor (bdnf). |
2023-01-04 |
2023-08-14 |
Not clear |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
we demonstrated that the intranasal infusion of galr2 and the y1r agonists promotes neuroblasts proliferation in the dentate gyrus of the ventral hippocampus and the induction of the neurotrophic factor bdnf. |
2023-01-04 |
2023-08-14 |
Not clear |