| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
in this review, we give an overview of the current status in the regulation of central bdnf expression by peripheral signalling, with a special interest in the regulation of hippocampal bdnf levels by signals via the vagus nerve. |
2023-02-25 |
2023-08-14 |
Not clear |
| Łukasz Zapała, Grzegorz Niemczyk, Piotr Zapała, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wróbe. The Cannabinoid Ligand Arachidonyl-2'-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835228. |
acea restored the cort-induced changes in the biomarkers in urine (bdnf, ngf), bladder detrusor (vacht, rho kinase), bladder urothelium (cgrp, atp, crf, oct-3, trpv1), and hippocampus (tnf-α, il-1β and il-6, crf, il-10, bdnf, ngf). |
2023-02-25 |
2023-08-14 |
rat |
| Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. |
serum levels of brain-derived neurotrophic factor (bdnf), numerous endocannabinoids and hippocampal fatty acid amide hydrolase (faah) levels were assessed. |
2023-02-25 |
2023-08-14 |
human |
| Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. |
the effect of cbda-me in females was accompanied by elevated serum bdnf and some endocannabinoids and low hippocampal expression of faah. |
2023-02-25 |
2023-08-14 |
human |
| Ying Zhang, Qian Zhou, Lu Lu, Yu Su, Wei Shi, Hu Zhang, Ran Liu, Yuepu Pu, Lihong Yi. Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling. Nutrients. vol 15. issue 4. 2023-02-25. PMID:36839332. |
cu also suppresses phosphorylation levels in creb and decreases the expression of bdnf and trkb in the mouse hippocampus. |
2023-02-25 |
2023-08-14 |
mouse |
| Hailing Zhao, Xiuxiu Zhao, Yue Sun, Xiaomei Yao, Wanqi Zhan. Iodide intake during pregnancy and lactation stimulates KLF9, BDNF expression in offspring brain with elevated DHA, EPA metabolites. Heliyon. vol 9. issue 2. 2023-02-23. PMID:36816261. |
in both male and female offspring rats, serum ft3, ft4 levels and the expression of klf9, thyroid hormone receptors (tr)α, trβ and bdnf in the hippocampal region and cerebellum were significantly increased in 5 times higher-than-normal pregnant iodide intake (5 hi) and 10 times higher-than-normal pregnant iodide intake (10 hi) group. |
2023-02-23 |
2023-08-14 |
rat |
| Yahui Wang, Zehuai Liang, Wenyue Song, Yu Qin, Noah Todd, Mingqi Ga. Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway. Oxidative medicine and cellular longevity. vol 2023. 2023-02-23. PMID:36819781. |
compared with the control group, cums treatment increased immobility time; decreased sucrose preference; reduced expression of bdnf, p-erk1/2, and p-creb; and increased expression of akt, foxo, and bim in the hippocampus. |
2023-02-23 |
2023-08-14 |
mouse |
| P Stepanova, D Kumar, K Cavonius, J Korpikoski, J Sirjala, D Lindholm, M H Voutilaine. Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington's disease. Scientific reports. vol 13. issue 1. 2023-02-22. PMID:36807563. |
furthermore, cdnf increased bdnf mrna level in hippocampus in vivo in the n171-82q model and bdnf protein level in cultured striatal neurons. |
2023-02-22 |
2023-08-14 |
mouse |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
male and female ee mice displayed greater bdnf and psd-95 expressions in the medial prefrontal cortex and hippocampus compared to socially housed and deprived housed mice. |
2023-02-21 |
2023-08-14 |
mouse |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
lps treatment decreased bdnf expression in all the brain regions examined in ee mice, except for the ca3 region of the hippocampus, where ee housing successfully mitigated the pubertal lps-induced decrease in bdnf expression. |
2023-02-21 |
2023-08-14 |
mouse |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
interestingly, lps-treated mice housed in deprived conditions displayed unexpected increases in bdnf and psd-95 expressions throughout the medial prefrontal cortex and hippocampus. |
2023-02-21 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
synaptic function was determined by the levels of brain-derived neurotrophic factor (bdnf), postsynaptic density protein 95 (psd95), and synaptophysin (syn) in the hippocampus and cultured hippocampal neurons. |
2023-02-21 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
polydatin increased the number and length of dendrites of cultured hippocampal neurons from mice exposed to cums and alleviated cums-induced synaptic deficits by restoring bdnf, psd95, and syn levels in vivo and in vitro. |
2023-02-21 |
2023-08-14 |
mouse |
| Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu W. Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. Theranostics. vol 13. issue 3. 2023-02-16. PMID:36793868. |
hyperactive neuronal autophagy depletes bdnf and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. |
2023-02-16 |
2023-08-14 |
mouse |
| Min-Kyung Joo, Xiaoyang Ma, Jong-Wook Yoo, Yoon-Jung Shin, Hyo-Jong Kim, Dong-Hyun Ki. Patient-derived Enterococcus mundtii and its capsular polysaccharides cause depression through the downregulation of NF-κB-involved serotonin and BDNF expression. Microbes and infection. 2023-02-09. PMID:36758891. |
nk1516 also caused the most potent depression-like behaviors in the absence of sickness behaviors, neuroinflammation, downregulated brain-derived neurotrophic factor (bdnf), and serotonin (5-ht) levels in the hippocampus of mice. |
2023-02-09 |
2023-08-14 |
mouse |
| Min-Kyung Joo, Xiaoyang Ma, Jong-Wook Yoo, Yoon-Jung Shin, Hyo-Jong Kim, Dong-Hyun Ki. Patient-derived Enterococcus mundtii and its capsular polysaccharides cause depression through the downregulation of NF-κB-involved serotonin and BDNF expression. Microbes and infection. 2023-02-09. PMID:36758891. |
its capsular polysaccharide (cp), but not cytoplasmic components, also caused depression-like behaviors and reduced bdnf and serotonin levels in the hippocampus. |
2023-02-09 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Józefa Macała, Agnieszka Zabłock. Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. Molecular neurobiology. 2023-02-03. PMID:36735179. |
the goal of the present study was to examine what molecular mechanism regulating brain-derived neurotrophic factor (bdnf) expression is activated by the yolkin complex, using in vitro models of pc12 cell line and fetal rat hippocampal cell line h19-7. |
2023-02-03 |
2023-08-14 |
rat |
| Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Józefa Macała, Agnieszka Zabłock. Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. Molecular neurobiology. 2023-02-03. PMID:36735179. |
it was shown that yolkin increased the proliferative activity of rat hippocampal precursor cells h19-7 cells and upregulated the expression/production of bdnf in a cyclic adenosine monophosphate (camp)-response element-binding protein (creb)-dependent manner. |
2023-02-03 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
subsequently, an elisa was applied to detect amyloid-β (aβ) 1-40 and aβ1-42 levels in rat hippocampal tissues, quantitative reverse transcription pcr assays were used to detect the mrna expression levels of brain-derived neurotrophic factor (bdnf) and trk b, and western blots were used to detect the protein expression levels of bace1, tau, p-tau, and protein kinase b (akt)/glycogen synthase kinase 3β (gsk3β) pathway-related proteins. |
2023-01-31 |
2023-08-14 |
rat |