| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamileh Gholami, Sajad Sahab Negah, Arezoo Rajabian, Ehsan Saburi, Vahid Hajal. The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model. Biochemistry and biophysics reports. vol 32. 2022-11-28. PMID:36438603. |
this additive protective effect may be in part due to the augmented influence of this combination on bdnf levels and cholinergic neuronal system within the hippocampus. |
2022-11-28 |
2023-08-14 |
rat |
| Mengyu Cai, Yicui Qu, Zifu Ren, Xin Xu, Chuyang Ye, Hongtao Lu, Yinyin Zhang, Wenlan Pan, Hui Shen, Hongxia L. Nutritional supplements formulated to prevent cognitive impairment in animals. Current research in food science. vol 5. 2022-11-28. PMID:36439642. |
likewise, western blot results showed that the formula could activate the camp pathway and increase the expression of phosphorylated pka and bdnf in hippocampal cells. |
2022-11-28 |
2023-08-14 |
Not clear |
| Dawei Dong, Aihui Ren, Ying Yang, Jiayi Su, Libin Liu, Wenyan Zhuo, Yubin Lian. VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats. Journal of molecular neuroscience : MN. 2022-11-28. PMID:36441377. |
in addition, vx-765 treatment increased bdnf levels and normalized synaptophysin protein levels in the hippocampus after cortical infarction. |
2022-11-28 |
2023-08-14 |
rat |
| Muhammad Zahid Khan, Yong-Bo Zheng, Kai Yuan, Ying Han, Lin L. Extracellular zinc regulates contextual fear memory formation in male rats through MMP-BDNF-TrkB pathway in dorsal hippocampus and basolateral amygdala. Behavioural brain research. 2022-11-28. PMID:36442645. |
extracellular zinc chelator caedta, bdnf scavenger trkb-fc, exogenous 7,8-dhf and matrix metalloproteinases (mmp) inhibitor were infused into the ca1 and ca3 regions of hippocampus and bla after cfc. |
2022-11-28 |
2023-08-14 |
rat |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430520. |
bdnf levels were significantly increased in pfcx and hippocampus by trazodone and in the nac and hypothalamus by citalopram. |
2022-11-26 |
2023-08-14 |
rat |
| Verona E Mulgrave, Abdulrahman A Alsayegh, Aida Jaldi, DianneMarie T Omire-Mayor, Niaya James, Oyonumo Ntekim, Eric Walters, Emanuel O Akala, Joanne S Allar. Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice. Neuropeptides. vol 97. 2022-11-26. PMID:36434832. |
hippocampal bdnf protein were similar between genotypes and was not significantly modulated by treadmill running. |
2022-11-26 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in this preclinical experimental study, we investigated in the offspring of c57bl/6 female mice submitted to mia with lipopolysaccharide (lps), typically altered behaviors in asd, such as social interaction and stereotyped self-grooming movement, as well as the levels of the brain-derived neurotrophic factor (bdnf) and interleukin 17a (il-17a) in the hippocampus and cortex, at 28 and 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in the hippocampus of the offspring of females submitted to mia, a decrease in bdnf levels was found at 28 days and 60 days of life, and a decrease in il-17a levels only at 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Matheus Luchini Dutra, Paula Dias, Viviane Freiberger, Leticia Ventura, Clarissa Martinelli Comim, Daniel Fernandes Martins, Franciane Bobinsk. Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice. Neuroscience letters. 2022-11-22. PMID:36414133. |
in the neurochemical issues of the hippocampal region, impairment of bdnf levels has already been demonstrated, which may be an important factor for the observation of asd-like behaviors in adult mice at 60 days. |
2022-11-22 |
2023-08-14 |
mouse |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
the neurotrophic hypothesis of depression proposes that reduced levels of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) contribute to neuronal atrophy or loss in the prefrontal cortex (pfc) and hippocampus and impaired hippocampal adult neurogenesis, which are associated with depressive symptoms. |
2022-11-20 |
2023-08-14 |
mouse |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
rodent studies have revealed that ketamine rapidly increases bdnf and vegf release and/or expression in the pfc and hippocampus, which in turn increases the number and function of spine synapses in the pfc and hippocampal neurogenesis. |
2022-11-20 |
2023-08-14 |
mouse |
| Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Y. CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice. ACS chemical neuroscience. 2022-11-18. PMID:36399525. |
moreover, cy-09 increased the brain-derived neurotrophic factor (bdnf) only in microglia but not in the whole hippocampus. |
2022-11-18 |
2023-08-14 |
mouse |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
after 3 months, we evaluated zoometry, a serum bioclinical profile, and in the hippocampus and frontal cortex, we performed biochemical assays (concentration of lactate, glutamate, fatty acids, and asat, alat, and ldh activity), immunoreactivity tests (gfap, cox2, cd36, and bdnf), and immunoassays (tnf-α, il-1β, il-6, and pge2). |
2022-11-14 |
2023-08-14 |
rat |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
at the brain level, it is noteworthy that the hcd group had an increase in lactate and glutamate concentration, reactive astrogliosis, immunoreactive cox2 neurons in the ca1 subfield hippocampus and frontal cortex, and high levels of pge2, tnf-α, il-1β, and il-6, and low bdnf immunoreactivity. |
2022-11-14 |
2023-08-14 |
rat |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
meanwhile, the hfd is highlighted by increased fatty acid levels and cd36 expression in the hippocampus and frontal cortex, strong reactive astrogliosis and cox2 immunoreactivity, and the greatest inflammation with the lowest bdnf immunoreactivity. |
2022-11-14 |
2023-08-14 |
rat |
| Benneth Ben-Azu, Christian I Uruaka, Abayomi M Ajayi, Thiophilus Aghogho Jarikre, Kingsley E Nwangwa, Kingsley C Chilaka, Bienose S Chijioke, Marymagdalene G Omonyeme, Chineye B Ozege, Emmanuella C Ofili, Ebidenara B Warekoromor, Nwanneka L Edigbue, Ufoma V Esiekpe, Dabrechi E Akaenyi, Gladys O Ag. Reversal and Preventive Pleiotropic Mechanisms Involved in the Antipsychotic-Like Effect of Taurine, an Essential β-Amino Acid in Ketamine-Induced Experimental Schizophrenia in Mice. Neurochemical research. 2022-11-09. PMID:36350433. |
taurine reduced ketamine-induced dopamine and 5-hydroxytryptamine changes, and increased gad and bdnf levels in the striatum, prefrontal-cortex and hippocampus, suggesting increased gabaergic and neurotrophic transmissions. |
2022-11-09 |
2023-08-14 |
mouse |
| Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park, Pann-Ghill Suh, C Justin Le. Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus. Experimental neurobiology. vol 31. issue 5. 2022-11-09. PMID:36351843. |
because ca2 hippocampus has been reported as a critical brain region for social memory, we develop ca2-specific blockade of memory formation through deletion of phospholipase c gamma 1 (plcγ1), which is a key molecule in the brain-derived neurotrophic factor (bdnf) signaling pathway. |
2022-11-09 |
2023-08-14 |
mouse |
| Feng Gao, Juan Wang, Shaojie Yang, Manman Ji, Guoqi Zh. Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice. Neuropharmacology. vol 222. 2022-11-07. PMID:36341808. |
moreover, systemic application of rol before re-exposure improved hippocampal brain-derived neurotrophic factor (bdnf)/tyrosine kinase receptor b (trkb) signaling and calpain1/akt/mtor signaling. |
2022-11-07 |
2023-08-14 |
mouse |
| Wei Liu, Jiaxi Liu, Jie Gao, Xiaoxu Duan, Lifeng Zhan. Effects of Subchronic Aluminum Exposure on Learning, Memory, and Neurotrophic Factors in Rats. Neurotoxicity research. 2022-11-07. PMID:36342585. |
with hematoxylin and eosin staining, western blot, immunofluorescence, and rt-pcr, the morphology of nerve cells in the hippocampus of rat brain were observed, and the levels of activator protein-1 (ap-1) gene and protein, nerve growth factor (ngf), neurotrophin-3 (nt3), glial cell line-derived neurotrophic factor (gdnf), and brain-derived neurotrophic factor (bdnf) gene and protein level, etc. |
2022-11-07 |
2023-08-14 |
human |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal bdnf level following postnatal serotonin depletion in male rats. |
2022-11-07 |
2023-08-14 |
rat |