| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
lps treatment decreased bdnf expression in all the brain regions examined in ee mice, except for the ca3 region of the hippocampus, where ee housing successfully mitigated the pubertal lps-induced decrease in bdnf expression. |
2023-02-21 |
2023-08-14 |
mouse |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
interestingly, lps-treated mice housed in deprived conditions displayed unexpected increases in bdnf and psd-95 expressions throughout the medial prefrontal cortex and hippocampus. |
2023-02-21 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
synaptic function was determined by the levels of brain-derived neurotrophic factor (bdnf), postsynaptic density protein 95 (psd95), and synaptophysin (syn) in the hippocampus and cultured hippocampal neurons. |
2023-02-21 |
2023-08-14 |
mouse |
| Jianping Wang, Yujiao Men, Zeyu Wan. Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model. ACS chemical neuroscience. 2023-02-21. PMID:36802487. |
polydatin increased the number and length of dendrites of cultured hippocampal neurons from mice exposed to cums and alleviated cums-induced synaptic deficits by restoring bdnf, psd95, and syn levels in vivo and in vitro. |
2023-02-21 |
2023-08-14 |
mouse |
| Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu W. Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. Theranostics. vol 13. issue 3. 2023-02-16. PMID:36793868. |
hyperactive neuronal autophagy depletes bdnf and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression. |
2023-02-16 |
2023-08-14 |
mouse |
| Min-Kyung Joo, Xiaoyang Ma, Jong-Wook Yoo, Yoon-Jung Shin, Hyo-Jong Kim, Dong-Hyun Ki. Patient-derived Enterococcus mundtii and its capsular polysaccharides cause depression through the downregulation of NF-κB-involved serotonin and BDNF expression. Microbes and infection. 2023-02-09. PMID:36758891. |
nk1516 also caused the most potent depression-like behaviors in the absence of sickness behaviors, neuroinflammation, downregulated brain-derived neurotrophic factor (bdnf), and serotonin (5-ht) levels in the hippocampus of mice. |
2023-02-09 |
2023-08-14 |
mouse |
| Min-Kyung Joo, Xiaoyang Ma, Jong-Wook Yoo, Yoon-Jung Shin, Hyo-Jong Kim, Dong-Hyun Ki. Patient-derived Enterococcus mundtii and its capsular polysaccharides cause depression through the downregulation of NF-κB-involved serotonin and BDNF expression. Microbes and infection. 2023-02-09. PMID:36758891. |
its capsular polysaccharide (cp), but not cytoplasmic components, also caused depression-like behaviors and reduced bdnf and serotonin levels in the hippocampus. |
2023-02-09 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Józefa Macała, Agnieszka Zabłock. Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. Molecular neurobiology. 2023-02-03. PMID:36735179. |
the goal of the present study was to examine what molecular mechanism regulating brain-derived neurotrophic factor (bdnf) expression is activated by the yolkin complex, using in vitro models of pc12 cell line and fetal rat hippocampal cell line h19-7. |
2023-02-03 |
2023-08-14 |
rat |
| Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Józefa Macała, Agnieszka Zabłock. Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. Molecular neurobiology. 2023-02-03. PMID:36735179. |
it was shown that yolkin increased the proliferative activity of rat hippocampal precursor cells h19-7 cells and upregulated the expression/production of bdnf in a cyclic adenosine monophosphate (camp)-response element-binding protein (creb)-dependent manner. |
2023-02-03 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
subsequently, an elisa was applied to detect amyloid-β (aβ) 1-40 and aβ1-42 levels in rat hippocampal tissues, quantitative reverse transcription pcr assays were used to detect the mrna expression levels of brain-derived neurotrophic factor (bdnf) and trk b, and western blots were used to detect the protein expression levels of bace1, tau, p-tau, and protein kinase b (akt)/glycogen synthase kinase 3β (gsk3β) pathway-related proteins. |
2023-01-31 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp treatment greatly ameliorated the cognitive disability, reduced aβ1-40 and aβ1-42 levels and tau phosphorylation, and upregulated bace1, trk b, and bdnf expression in the hippocampus of 2vo rats. |
2023-01-31 |
2023-08-14 |
rat |
| Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Li. Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice. European journal of pharmacology. 2023-01-28. PMID:36708979. |
although ana-12 treatment had no significant effect on the expression of enk/δor, it blocked the promoting effects of brain-derived neurotrophic factor (bdnf)/tyrosine kinase b(trkb) signaling by snc80 in the hippocampus and amygdala. |
2023-01-28 |
2023-08-14 |
mouse |
| Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu, Bo Jian. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023-01-26. PMID:36702294. |
we have previously demonstrated that hippocampal salt-inducible kinase 2 (sik2) plays a role in the pathogenesis of depression via regulating the downstream creb-regulated transcription coactivator 1 (crtc1)-camp response element-binding protein (creb)-brain derived neurotrophic factor (bdnf) pathway. |
2023-01-26 |
2023-08-14 |
mouse |
| Jie Huang, Hua Fan, Yan-Mei Chen, Cheng-Niu Wang, Wei Guan, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Jian-Feng Liu, Bo Jian. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023-01-26. PMID:36702294. |
hg-9-91-01 treatment also reversed the decreasing effects of cums on the bdnf signaling cascade and adult neurogenesis in the hippocampus. |
2023-01-26 |
2023-08-14 |
mouse |
| Renrui Lu, Li Zhang, Huihui Wang, Meng Li, Weisheng Feng, Xiaoke Zhen. Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation Frontiers in pharmacology. vol 13. 2023-01-23. PMID:36686689. |
moreover, echinacoside significantly increased p-creb/creb ratio and bdnf level in hippocampus. |
2023-01-23 |
2023-08-14 |
mouse |
| Juliano Viana Borges, Vivian Naziaseno Pires, Betânia Souza de Freitas, Gabriel Rübensam, Vitória Corrêa Vieira, Cristophod de Souza Dos Santos, Nadja Schröder, Elke Bromber. Behavior, BDNF and epigenetic mechanisms in response to social isolation and social support in middle aged rats exposed to chronic stress. Behavioural brain research. 2023-01-19. PMID:36657665. |
more specifically, we investigated the behavioral responses, corticosterone levels, bdnf gene expression, and markers of hippocampal epigenetic alterations (levels of h3k9 acetylation and methylation, h3k27 methylation, hdac5, dnmt1, and dnmt3a gene expressions) in middle-aged adult rats maintained in different housing conditions (isolation or accompanied housing) and exposed to the chronic unpredictable stress protocol (cus). |
2023-01-19 |
2023-08-14 |
rat |
| Pan Meng, Xi Zhang, Dandan Li, Hui Yang, Xiaoyuan Lin, Hongqing Zhao, Ping Li, Yuhong Wang, Xiaoye Wang, Jinwen G. Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis. Neural plasticity. vol 2023. 2023-01-17. PMID:36647544. |
western blot was utilized to measure the expression of bdnf and 5-ht in the hippocampus. |
2023-01-17 |
2023-08-14 |
rat |
| Shuichi Chiba, Hikaru Asano, Shogo Moriya, Taichi Hatakeyama, Shohei Kobayashi, Ryo Ohta, Maiko Kawaguch. Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels. Neuropsychopharmacology reports. 2023-01-17. PMID:36649932. |
bidirectional effects of voluntary exercise on the expression of bdnf isoforms in the hippocampus of hatano rat strains displaying different activity levels. |
2023-01-17 |
2023-08-14 |
human |
| Shuichi Chiba, Hikaru Asano, Shogo Moriya, Taichi Hatakeyama, Shohei Kobayashi, Ryo Ohta, Maiko Kawaguch. Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels. Neuropsychopharmacology reports. 2023-01-17. PMID:36649932. |
the expression levels of bdnf isoforms and the corresponding coding sequences (cds) were measured in the hippocampus using real-time polymerase chain reaction (pcr). |
2023-01-17 |
2023-08-14 |
human |