| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Medha Kaushik, Pooja Kaushik, Siddharth Panwar, Shiv Dutt Joshi, Suhel Parve. Environment Enrichment Facilitates Long-Term Memory Consolidation Through Behavioral Tagging. eNeuro. 2023-03-20. PMID:36941060. |
further, our results did not find alterations in bdnf expression after ee and of exposure in the hippocampus. |
2023-03-20 |
2023-08-14 |
rat |
| Irena Smaga, Kinga Gawlińska, Dawid Gawliński, Paulina Surówka, Małgorzata Fili. A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring. Behavioural brain research. 2023-03-19. PMID:36934986. |
the latter change is likely related to the dysregulation of hippocampal levels of glun2b subunit of nmda receptors and of reduced levels of bdnf. |
2023-03-19 |
2023-08-14 |
rat |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
prenatal vpa induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated camp response element-binding protein (p-creb), brain-derived neurotrophic factor (bdnf), and gene expression of glutamate transporter-1 (glt-1) with a decline in gaba/glutamate ratio (both measured by hplc). |
2023-03-15 |
2023-08-14 |
human |
| Jacqueline M Anderson, Amber A Boardman, Rhiannon Bates, Xunchang Zou, Wei Huang, Lei Ca. Hypothalamic TrkB.FL overexpression improves metabolic outcomes in the BTBR mouse model of autism. PloS one. vol 18. issue 3. 2023-03-09. PMID:36893171. |
brain-derived neurotrophic factor (bdnf) and its receptor tropomyosin kinase receptor b (ntrk2) were upregulated in the hypothalamus, hippocampus, and amygdala by implementing ee in btbr mice, suggesting that bdnf-trkb signaling plays a role in the ee-btbr phenotype. |
2023-03-09 |
2023-08-14 |
mouse |
| Xiao-Qian Ren, Xin Huang, Shu-Yun Xing, Yan Long, Dan-Hua Yuan, Hao Hong, Su-Su Tan. Neuroprotective effects of novel compound FMDB on cognition, neurogenesis and apoptosis in APP/PS1 transgenic mouse model of Alzheimer's disease. Neurochemistry international. 2023-03-09. PMID:36893915. |
importantly, fmdb activated nuclear erβ mediated cbp/p300, creb and brain-derived neurotrophic factor (bdnf) signaling, and membrane erβ mediated pi3k/akt, creb and bdnf signaling in the hippocampus. |
2023-03-09 |
2023-08-14 |
mouse |
| Guanlan Liu, Israr Khan, Yuxi Li, Yun Yang, Xuerui Lu, Yafei Wang, Junxiang Li, Chunjiang Zhan. Overcoming Anxiety Disorder by Probiotic Foods (Basel, Switzerland). vol 11. issue 22. 2023-03-08. PMID:36429192. |
lzu-j-tsl6 was able to effectively increase the gaba content in the mice hippocampus (p < 0.0001) and restore some markers related to anxiety such as brain-derived neurotrophic factor (bdnf), glial fibrillary acidic protein (gfap), and 5-hydroxytryptamine (5-ht). |
2023-03-08 |
2023-08-16 |
mouse |
| Wanxu Guo, Xiaoxiao Yao, Ranji Cui, Wei Yang, Lei Wan. Mechanisms of paeoniaceae action as an antidepressant. Frontiers in pharmacology. vol 13. 2023-02-27. PMID:36844911. |
therefore, in this review the antidepressant effect of pf and its mechanism of action are outlined with particular focus on the following aspects: increasing the levels of monoamine neurotransmitters, inhibiting the hpa axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of brain-derived neurotrophic factor (bdnf). |
2023-02-27 |
2023-08-14 |
mouse |
| Douglas A Formolo, Thomas H Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S Kranz, Suk-Yu Ya. Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830788. |
adiporon treatment reduced hippocampal brain-derived neurotrophic factor (bdnf) levels, neuronal activation in the ventral dentate gyrus, and long-term potentiation of the perforant path. |
2023-02-25 |
2023-08-14 |
mouse |
| Aleksandra Gliwińska, Justyna Czubilińska-Łada, Gniewko Więckiewicz, Elżbieta Świętochowska, Andrzej Badeński, Marta Dworak, Maria Szczepańsk. The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer's Disease as Highly Drug-Resistant Diseases: A Narrative Review. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831706. |
bdnf is the most widely distributed neurotrophin in the central nervous system (cns) and is highly expressed in the prefrontal cortex (pfc) and hippocampus. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
in the adult hippocampus, bdnf is critical for maintaining adult neurogenesis. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
therefore, elucidating the mechanisms that maintain hippocampal bdnf levels is biologically and clinically important. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
in this review, we give an overview of the current status in the regulation of central bdnf expression by peripheral signalling, with a special interest in the regulation of hippocampal bdnf levels by signals via the vagus nerve. |
2023-02-25 |
2023-08-14 |
Not clear |
| Łukasz Zapała, Grzegorz Niemczyk, Piotr Zapała, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wróbe. The Cannabinoid Ligand Arachidonyl-2'-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835228. |
acea restored the cort-induced changes in the biomarkers in urine (bdnf, ngf), bladder detrusor (vacht, rho kinase), bladder urothelium (cgrp, atp, crf, oct-3, trpv1), and hippocampus (tnf-α, il-1β and il-6, crf, il-10, bdnf, ngf). |
2023-02-25 |
2023-08-14 |
rat |
| Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. |
serum levels of brain-derived neurotrophic factor (bdnf), numerous endocannabinoids and hippocampal fatty acid amide hydrolase (faah) levels were assessed. |
2023-02-25 |
2023-08-14 |
human |
| Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. |
the effect of cbda-me in females was accompanied by elevated serum bdnf and some endocannabinoids and low hippocampal expression of faah. |
2023-02-25 |
2023-08-14 |
human |
| Ying Zhang, Qian Zhou, Lu Lu, Yu Su, Wei Shi, Hu Zhang, Ran Liu, Yuepu Pu, Lihong Yi. Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling. Nutrients. vol 15. issue 4. 2023-02-25. PMID:36839332. |
cu also suppresses phosphorylation levels in creb and decreases the expression of bdnf and trkb in the mouse hippocampus. |
2023-02-25 |
2023-08-14 |
mouse |
| Hailing Zhao, Xiuxiu Zhao, Yue Sun, Xiaomei Yao, Wanqi Zhan. Iodide intake during pregnancy and lactation stimulates KLF9, BDNF expression in offspring brain with elevated DHA, EPA metabolites. Heliyon. vol 9. issue 2. 2023-02-23. PMID:36816261. |
in both male and female offspring rats, serum ft3, ft4 levels and the expression of klf9, thyroid hormone receptors (tr)α, trβ and bdnf in the hippocampal region and cerebellum were significantly increased in 5 times higher-than-normal pregnant iodide intake (5 hi) and 10 times higher-than-normal pregnant iodide intake (10 hi) group. |
2023-02-23 |
2023-08-14 |
rat |
| Yahui Wang, Zehuai Liang, Wenyue Song, Yu Qin, Noah Todd, Mingqi Ga. Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway. Oxidative medicine and cellular longevity. vol 2023. 2023-02-23. PMID:36819781. |
compared with the control group, cums treatment increased immobility time; decreased sucrose preference; reduced expression of bdnf, p-erk1/2, and p-creb; and increased expression of akt, foxo, and bim in the hippocampus. |
2023-02-23 |
2023-08-14 |
mouse |
| P Stepanova, D Kumar, K Cavonius, J Korpikoski, J Sirjala, D Lindholm, M H Voutilaine. Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington's disease. Scientific reports. vol 13. issue 1. 2023-02-22. PMID:36807563. |
furthermore, cdnf increased bdnf mrna level in hippocampus in vivo in the n171-82q model and bdnf protein level in cultured striatal neurons. |
2023-02-22 |
2023-08-14 |
mouse |
| Michael Murack, Kevin B Smith, Olivia H Traynor, Atiqa F Pirwani, Sarah K Gostlin, Taha Mohamed, Despina A Tata, Claude Messier, Nafissa Ismai. Environmental Enrichment Alters LPS-induced changes in BDNF and PSD-95 Expressions During Puberty. Brain research. 2023-02-21. PMID:36801452. |
male and female ee mice displayed greater bdnf and psd-95 expressions in the medial prefrontal cortex and hippocampus compared to socially housed and deprived housed mice. |
2023-02-21 |
2023-08-14 |
mouse |