| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of ampk/akt/creb/ bdnf signaling cascades. |
2023-01-14 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Estêvão Scotti-Muzzi, Thais Chile, Homero Vallada, Maria Concepción Garcia Otaduy, Márcio Gerhardt Soeiro-de-Souz. BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects. Brain imaging and behavior. 2023-01-11. PMID:36630045. |
the single-nucleotide polymorphism in the bdnf gene (bdnf rs6265) has been associated with decreased hippocampal bdnf secretion and volume in met carriers in different populations, although the val allele has been reported to be more frequent in bd patients. |
2023-01-11 |
2023-08-14 |
human |
| Jeffrey J Moffat, Samuel A Sakhai, Zachary W Hoisington, Yann Ehinger, Dorit Ro. The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice. Psychopharmacology. 2023-01-09. PMID:36622381. |
the bdnf val68met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of bdnf in the ventral hippocampus of male mice. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
we evaluated whether sex and bdnf genotype (val66met polymorphism (met/met) versus wild-type (val/val)) influenced the ability of voluntary running to enhance cognition and hippocampal neurogenesis in mice. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
at increased neurogenesis in the ventral hippocampus of bdnf val/val mice of both sexes and increased the proportion of mature type 3 doublecortin-expressing cells in the dorsal hippocampus of female mice only. |
2023-01-09 |
2023-08-14 |
mouse |
| Dannia Islas-Preciado, Tallinn F L Splinter, Muna Ibrahim, Natasha Black, Sarah Wong, Stephanie E Lieblich, Teresa Liu-Ambrose, Cindy K Barha, Liisa A M Gale. Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice. Hormones and behavior. vol 148. 2023-01-09. PMID:36623432. |
our results indicate at improved cognitive performance in bdnf met/met mice and increased hippocampal neurogenesis in bdnf val/val mice in middle age. |
2023-01-09 |
2023-08-14 |
mouse |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
galr2 and y1r agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving bdnf actions. |
2023-01-04 |
2023-08-14 |
Not clear |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
we studied their hippocampal proliferating actions using the proliferating cell nuclear antigen (pcna) on neuroblasts or stem cells and the expression of the brain-derived neurothrophic factor (bdnf). |
2023-01-04 |
2023-08-14 |
Not clear |
| Jose Erik Alvarez-Contino, Estela Díaz-Sánchez, Marina Mirchandani-Duque, Jose Andrés Sánchez-Pérez, Miguel A Barbancho, Alexander López-Salas, Natalia García-Casares, Kjell Fuxe, Dasiel O Borroto-Escuela, Manuel Narváe. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology. 2023-01-04. PMID:36599082. |
we demonstrated that the intranasal infusion of galr2 and the y1r agonists promotes neuroblasts proliferation in the dentate gyrus of the ventral hippocampus and the induction of the neurotrophic factor bdnf. |
2023-01-04 |
2023-08-14 |
Not clear |
| Shishir Baliyan, María V Calvo, Dharna Piquera, Olimpio Montero, Francesco Visioli, César Venero, Javier Fontech. Milk fat globule membrane concentrate as a nutritional supplement prevents age-related cognitive decline in old rats: A lipidomic study of synaptosomes. Food research international (Ottawa, Ont.). vol 163. 2023-01-03. PMID:36596112. |
no significant differences between bdnf levels in the hippocampus and frontal cortex of treated rats as compared to controls were found. |
2023-01-03 |
2023-08-14 |
rat |
| Takeru Shima, Tomonori Yoshikawa, Hayate Onish. Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice. Journal of nutritional science and vitaminology. vol 68. issue 6. 2023-01-03. PMID:36596551. |
bdnf and its related signaling in mice hippocampus exhibited no change by lc-hp diets. |
2023-01-03 |
2023-08-14 |
mouse |
| Siamak Sheikhi, Leila Derafshpour, Razieh Aghazadeh, Hojat Sayyadi, Ehsan Saboory, Morteza Bagher. Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats. Molecular biology reports. 2022-12-28. PMID:36577834. |
regarding the well-known effects of choline on brain-derived neurotrophic factor (bdnf), the study examined the effects of choline on hippocampal bdnf gene expression in maternal hypothyroidism rats. |
2022-12-28 |
2023-08-14 |
rat |
| Emily J Jaehne, Jessica N Kent, Nikki Lam, Lina Schonfeld, Jereme G Spiers, Veronica Begni, Federico De Rosa, Marco A Riva, Maarten van den Buus. Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype. Developmental psychobiology. vol 65. issue 1. 2022-12-26. PMID:36567651. |
expression of bdnf and a number of stress-related genes, the glucocorticoid receptor (nr3c1), serum/glucocorticoid-regulated kinase 1 (sgk1), and fk506 binding protein 51 (fkbp5) in the hippocampus were also measured. |
2022-12-26 |
2023-08-14 |
rat |
| Emily J Jaehne, Jessica N Kent, Nikki Lam, Lina Schonfeld, Jereme G Spiers, Veronica Begni, Federico De Rosa, Marco A Riva, Maarten van den Buus. Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype. Developmental psychobiology. vol 65. issue 1. 2022-12-26. PMID:36567651. |
chronic exercise induced a significant increase in bdnf mrna and bdnf protein levels in the hippocampus with some of these effects being genotype specific. |
2022-12-26 |
2023-08-14 |
rat |
| Vicente Ruiz-Viroga, Marialuisa de Ceglia, Laura Morelli, Eduardo M Castaño, Eduardo Blanco Calvo, Juan Suárez, Fernando Rodríguez de Fonseca, Pablo Galeano, Patricia Lago. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Progress in neuro-psychopharmacology & biological psychiatry. 2022-12-24. PMID:36565982. |
moreover, mch induced a significant decrease in hippocampal mchr-1 and trkb expression with no modification in the expression of bdnf and nmda receptor subunits nr1, nr2a, and nr2b. |
2022-12-24 |
2023-08-14 |
rat |
| Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Ho-Sub Park, Jae-Min Cho, Ham Young-Ki, Jin-Hee Kim, Mi-Kyung Mun, Sungho Maeng, Ji-Ho Par. Naringin enhances long-term potentiation and recovers learning and memory deficits of amyloid-beta induced Alzheimer's disease-like behavioral rat model. Neurotoxicology. 2022-12-22. PMID:36549596. |
in the hippocampus, naringin attenuated the aβ-induced cyclooxygenase-2, bax activation and bcl-2, creb, bdnf and trkb inhibition. |
2022-12-22 |
2023-08-14 |
rat |
| Mengxin Shen, Dan Lv, Xinya Liu, Chuang Wan. ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Translational psychiatry. vol 12. issue 1. 2022-12-22. PMID:36550125. |
produced antidepressant-like actions dependent on the increase in extracellular regulated protein kinase (erk)/mammalian target of rapamycin (mtor) signaling and downstream substrates p70s6 kinase (p70s6k) and the eukaryotic initiation factor 4e-binding protein 1 (4e-bp1), which may induce the expression of vgf and bdnf in the hippocampus and prefrontal cortex of mice. |
2022-12-22 |
2023-08-14 |
mouse |
| Xinna Li, Mary Hager, Madaline McPherson, Michael Lee, Riha Hagalwadi, Mary E Skinner, David Lombard, Richard A Mille. Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice. GeroScience. 2022-12-21. PMID:36542300. |
pko mice have elevated production of hepatic gpld1 and plasma gpld1, consistent with their elevation of hippocampal bdnf and dcx, used as indices of neurogenesis. |
2022-12-21 |
2023-08-14 |
mouse |