| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Le. Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice. Archives of pharmacal research. 2023-03-22. PMID:36947339. |
furthermore, hippocampal bdnf levels and phosphorylated creb activity were elevated in only low-dose curcumin-treated mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
glp-1 agonist liraglutide prevents mk‑801-induced schizophrenia‑like behaviors and bdnf, creb, p-creb, trk-b expressions in the hippocampus and prefrontal cortex in balb/c mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
western blots were performed on mice' hippocampus and pfc for bdnf, trk-b, creb, and p-creb expression. |
2023-03-22 |
2023-08-14 |
mouse |
| Kennedy Kwami Edem Kukuia, Frederick Boakye Burns, Kevin Kofi Adutwum-Ofosu, Frimpong Appiah, Seth Kwabena Amponsah, Richard Begyinah, Awo Efua Koomson, Ferka Yaw Takyi, Thomas Amatey Tagoe, Patrick Amoaten. Increased BDNF and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. Neuroscience. 2023-03-22. PMID:36948482. |
increased bdnf and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Kennedy Kwami Edem Kukuia, Frederick Boakye Burns, Kevin Kofi Adutwum-Ofosu, Frimpong Appiah, Seth Kwabena Amponsah, Richard Begyinah, Awo Efua Koomson, Ferka Yaw Takyi, Thomas Amatey Tagoe, Patrick Amoaten. Increased BDNF and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. Neuroscience. 2023-03-22. PMID:36948482. |
iron, citalopram and imipramine or their combinations increased serum bdnf concentration, hippocampal neuronal count and dendritic spine densities. |
2023-03-22 |
2023-08-14 |
mouse |
| Sofia Elisa Alzuri, Nicolás Matías Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsov. Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. Journal of neurochemistry. 2023-03-21. PMID:36943192. |
here, we employed the paradigm of chronic restraint stress in rats and using quantitative polymerase chain reaction (qpcr) showed downregulation of expression of gpm6a and the brain-derived neurotrophic factor (bdnf) genes at mrna level as well as mir-133b, mir-124-3p, but not mir-9-5p in the hippocampus of chronically stressed rats. |
2023-03-21 |
2023-08-14 |
rat |
| Sofia Elisa Alzuri, Nicolás Matías Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsov. Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. Journal of neurochemistry. 2023-03-21. PMID:36943192. |
moreover, treatment of hippocampal neurons cultured in vitro with bdnf resulted in an elevation in the mir-124-3p expression, a decrease in the mir-9-5p expression but did not affect mir-133b. |
2023-03-21 |
2023-08-14 |
rat |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
concurrently, abated mir-15a expression, overexpression of its target rock-1, diminished downstream erk1/2 and camp response element-binding protein (creb) phosphorylation, and decreased hippocampal brain-derived neurotrophic factor (bdnf) levels were observed. |
2023-03-21 |
2023-08-14 |
rat |
| Qiongyu Li, Fantao Meng, Xiangxian Ma, Zhe Sun, Juanjuan Dai, Jing Liu, Dan Li, Peijia Cong, Ruixue Xu, Di Zhao, Wentao Wang, Dan Wang, Cuilan Liu, Faxiang Wang, Chen Li, Haifeng Lia. The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety. Frontiers in immunology. vol 14. 2023-03-20. PMID:36936941. |
furthermore, overexpression of il-19 in the colon also reduced the expression levels of brain-derived neurotrophic factor (bdnf), extracellular signal-regulated kinase (erk), and camp-response element binding protein (creb) signaling pathways activity in the hippocampus. |
2023-03-20 |
2023-08-14 |
mouse |
| Medha Kaushik, Pooja Kaushik, Siddharth Panwar, Shiv Dutt Joshi, Suhel Parve. Environment Enrichment Facilitates Long-Term Memory Consolidation Through Behavioral Tagging. eNeuro. 2023-03-20. PMID:36941060. |
further, our results did not find alterations in bdnf expression after ee and of exposure in the hippocampus. |
2023-03-20 |
2023-08-14 |
rat |
| Irena Smaga, Kinga Gawlińska, Dawid Gawliński, Paulina Surówka, Małgorzata Fili. A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring. Behavioural brain research. 2023-03-19. PMID:36934986. |
the latter change is likely related to the dysregulation of hippocampal levels of glun2b subunit of nmda receptors and of reduced levels of bdnf. |
2023-03-19 |
2023-08-14 |
rat |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
prenatal vpa induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated camp response element-binding protein (p-creb), brain-derived neurotrophic factor (bdnf), and gene expression of glutamate transporter-1 (glt-1) with a decline in gaba/glutamate ratio (both measured by hplc). |
2023-03-15 |
2023-08-14 |
human |
| Jacqueline M Anderson, Amber A Boardman, Rhiannon Bates, Xunchang Zou, Wei Huang, Lei Ca. Hypothalamic TrkB.FL overexpression improves metabolic outcomes in the BTBR mouse model of autism. PloS one. vol 18. issue 3. 2023-03-09. PMID:36893171. |
brain-derived neurotrophic factor (bdnf) and its receptor tropomyosin kinase receptor b (ntrk2) were upregulated in the hypothalamus, hippocampus, and amygdala by implementing ee in btbr mice, suggesting that bdnf-trkb signaling plays a role in the ee-btbr phenotype. |
2023-03-09 |
2023-08-14 |
mouse |
| Xiao-Qian Ren, Xin Huang, Shu-Yun Xing, Yan Long, Dan-Hua Yuan, Hao Hong, Su-Su Tan. Neuroprotective effects of novel compound FMDB on cognition, neurogenesis and apoptosis in APP/PS1 transgenic mouse model of Alzheimer's disease. Neurochemistry international. 2023-03-09. PMID:36893915. |
importantly, fmdb activated nuclear erβ mediated cbp/p300, creb and brain-derived neurotrophic factor (bdnf) signaling, and membrane erβ mediated pi3k/akt, creb and bdnf signaling in the hippocampus. |
2023-03-09 |
2023-08-14 |
mouse |
| Guanlan Liu, Israr Khan, Yuxi Li, Yun Yang, Xuerui Lu, Yafei Wang, Junxiang Li, Chunjiang Zhan. Overcoming Anxiety Disorder by Probiotic Foods (Basel, Switzerland). vol 11. issue 22. 2023-03-08. PMID:36429192. |
lzu-j-tsl6 was able to effectively increase the gaba content in the mice hippocampus (p < 0.0001) and restore some markers related to anxiety such as brain-derived neurotrophic factor (bdnf), glial fibrillary acidic protein (gfap), and 5-hydroxytryptamine (5-ht). |
2023-03-08 |
2023-08-16 |
mouse |
| Wanxu Guo, Xiaoxiao Yao, Ranji Cui, Wei Yang, Lei Wan. Mechanisms of paeoniaceae action as an antidepressant. Frontiers in pharmacology. vol 13. 2023-02-27. PMID:36844911. |
therefore, in this review the antidepressant effect of pf and its mechanism of action are outlined with particular focus on the following aspects: increasing the levels of monoamine neurotransmitters, inhibiting the hpa axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of brain-derived neurotrophic factor (bdnf). |
2023-02-27 |
2023-08-14 |
mouse |
| Douglas A Formolo, Thomas H Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S Kranz, Suk-Yu Ya. Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830788. |
adiporon treatment reduced hippocampal brain-derived neurotrophic factor (bdnf) levels, neuronal activation in the ventral dentate gyrus, and long-term potentiation of the perforant path. |
2023-02-25 |
2023-08-14 |
mouse |
| Aleksandra Gliwińska, Justyna Czubilińska-Łada, Gniewko Więckiewicz, Elżbieta Świętochowska, Andrzej Badeński, Marta Dworak, Maria Szczepańsk. The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer's Disease as Highly Drug-Resistant Diseases: A Narrative Review. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831706. |
bdnf is the most widely distributed neurotrophin in the central nervous system (cns) and is highly expressed in the prefrontal cortex (pfc) and hippocampus. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
in the adult hippocampus, bdnf is critical for maintaining adult neurogenesis. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yoko Amagase, Ryuichi Kambayashi, Atsushi Sugiyama, Yoshinori Take. Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834953. |
therefore, elucidating the mechanisms that maintain hippocampal bdnf levels is biologically and clinically important. |
2023-02-25 |
2023-08-14 |
Not clear |