| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariya I Zaichenko, Pavel Philenko, Viktoriya Sidorina, Grigory A Grigorya. Acute and Chronic Lipopolysaccharide-Induced Stress Changes Expression of Proinflammatory Cytokine Genes in the Rat Brain Region-Specifically and Affects Learning and Memory. Biochemistry. Biokhimiia. vol 88. issue 4. 2023-04-20. PMID:37080938. |
in total, the most pronounced molecular-biochemical changes occurred in the amygdala and hippocampus, where increase of the expression of the tnf-α and il-1β interleukins mrnas were observed in the animals under acute and chronic lps-induced stress and no changes in the bdnf mrna concentration were observed in the frontal lobe. |
2023-04-20 |
2023-08-14 |
rat |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição, Pereira, Vanessa da Silva Souza, Diego Bulcão Visco, Beatriz Souza de Silveira, Sandra Lopes de Souza, Ana Elisa Toscan. Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: A systematic review and meta-analysis of preclinical studies. Experimental neurology. 2023-04-17. PMID:37068620. |
some studies reported that regions of the hippocampus such as the dentate gyrus and cornu ammonis 1 were impaired in cp, noting an increase in oxidative stress enzymes and pro-inflammatory cytokines, associated with a reduction in bdnf and neurogenesis levels. |
2023-04-17 |
2023-08-14 |
Not clear |
| Lu Ji, Rong-Jie Jin, Lin L. Platelet-rich Plasma Improves Radiotherapy-induced Emotional Disorder and Cognitive Dysfunction, Neuroinflammation in Aged Rats by Inhibiting the Activation of NLRP3 Inflammasomes. Neurochemical research. 2023-04-12. PMID:37043084. |
besides, immunohistochemistry was used to detect the expression of microglial marker protein iba-1 in rat hippocampus; enzyme linked immunosorbent assay (elisa) to examine the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (tnf-α), interleukin (il)-1 beta (il-1β), il-18, and monocyte chemoattractant protein 1 (mcp-1) in rat hippocampus; real-time quantitative reverse transcription pcr (qrt-pcr) and western blot to measure the levels of neurotrophic factors brain-derived neurotrophic factor (bdnf), tropomyosin-related kinase b receptor (trkb), and nerve growth factor (ngf) in rat hippocampus; and western blot also to observe the protein expression levels of nod-like receptor protein 3 (nlrp3), caspase-1, apoptosis-associated speck-like protein containing a card (asc), and il-1β in rat hippocampus. |
2023-04-12 |
2023-08-14 |
rat |
| Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F Sleiman, Joseph S Stepha. Autophagy regulates the release of exercise factors and their beneficial effects on spatial memory recall. Heliyon. vol 9. issue 4. 2023-04-07. PMID:37025840. |
the positive effects of exercise are mediated by circulatory factors that predominantly increase brain derived neurotrophic factor (bdnf) signaling in the hippocampus. |
2023-04-07 |
2023-08-14 |
Not clear |
| b' Sinan Saral, Atilla Top\\xc3\\xa7u, Mehmet Alkanat, Tolga Mercantepe, Zafer \\xc5\\x9eahin, Kerimali Aky\\xc4\\xb1ld\\xc4\\xb1z, Kader Semra Karata\\xc5\\x9f, Lamiye Y\\xc4\\xb1ld\\xc4\\xb1z, Levent T\\xc3\\xbcmkaya, Zihni A\\xc3\\xa7ar Yaz\\xc4\\xb1c\\xc4\\xb. Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001681.' |
after behavioral tests, rats were euthanized and bdnf, tnf, il-1β, mda and gsh levels were measured in hippocampal homegenates by elisa. |
2023-03-31 |
2023-08-14 |
rat |
| b' Sinan Saral, Atilla Top\\xc3\\xa7u, Mehmet Alkanat, Tolga Mercantepe, Zafer \\xc5\\x9eahin, Kerimali Aky\\xc4\\xb1ld\\xc4\\xb1z, Kader Semra Karata\\xc5\\x9f, Lamiye Y\\xc4\\xb1ld\\xc4\\xb1z, Levent T\\xc3\\xbcmkaya, Zihni A\\xc3\\xa7ar Yaz\\xc4\\xb1c\\xc4\\xb. Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001681.' |
on the other hand, agomelatine treatment elevated cisplatin-suppressed hippocampal bdnf levels. |
2023-03-31 |
2023-08-14 |
rat |
| In-Seo Lee, Ga-Young Choi, Inturu Sreelatha, Ji-Won Yoon, Suk-Hee Youn, Sungho Maeng, Ji-Ho Par. Effect of Sinapic Acid on Scopolamine-Induced Learning and Memory Impairment in SD Rats. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979237. |
in addition, sinapic acid weakened the inhibition of the brain-derived neurotrophic factor (bdnf), tropomyosin receptor kinase b (trkb) and the activation of prostaglandin-endoperoxide synthase 2 (cox-2) and interleukin 1 beta (il-1β) induced by scopolamine in the hippocampus. |
2023-03-29 |
2023-08-14 |
rat |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
by using western blot and immunofluorescence, the expression of sirt1, mecp2, and bdnf in the hippocampus and hippocampal ca1 region was quantified. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
sirt1, mecp2, and bdnf expression in the hippocampus and ca1 region in the hippocampus of the alc and crc groups of mice were correlated with cognitive improvement. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
in conclusion, cr could enhance the postoperative cognitive function in aged mice, most likely by increasing the expression of sirt1, mecp2, and bdnf in the ca1 region of the hippocampus. |
2023-03-29 |
2023-08-14 |
mouse |
| Lamia M Hafez, Hebatallah Mohammed Aboudeya, Noura A Matar, Ashraf S El-Sebeay, Azhar Mohamed Nomair, Shaymaa Ali El-Hamshary, Hanan Mohamed Nomeir, Fawziya A R Ibrahi. Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats. Scientific reports. vol 13. issue 1. 2023-03-28. PMID:36977735. |
hfd feeding also reduced brain-derived neurotrophic factor (bdnf) levels and increased acetylcholinesterase (ache) activity in the hippocampus of both sexes. |
2023-03-28 |
2023-08-14 |
rat |
| Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Le. Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice. Archives of pharmacal research. 2023-03-22. PMID:36947339. |
furthermore, hippocampal bdnf levels and phosphorylated creb activity were elevated in only low-dose curcumin-treated mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
glp-1 agonist liraglutide prevents mk‑801-induced schizophrenia‑like behaviors and bdnf, creb, p-creb, trk-b expressions in the hippocampus and prefrontal cortex in balb/c mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
western blots were performed on mice' hippocampus and pfc for bdnf, trk-b, creb, and p-creb expression. |
2023-03-22 |
2023-08-14 |
mouse |
| Kennedy Kwami Edem Kukuia, Frederick Boakye Burns, Kevin Kofi Adutwum-Ofosu, Frimpong Appiah, Seth Kwabena Amponsah, Richard Begyinah, Awo Efua Koomson, Ferka Yaw Takyi, Thomas Amatey Tagoe, Patrick Amoaten. Increased BDNF and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. Neuroscience. 2023-03-22. PMID:36948482. |
increased bdnf and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Kennedy Kwami Edem Kukuia, Frederick Boakye Burns, Kevin Kofi Adutwum-Ofosu, Frimpong Appiah, Seth Kwabena Amponsah, Richard Begyinah, Awo Efua Koomson, Ferka Yaw Takyi, Thomas Amatey Tagoe, Patrick Amoaten. Increased BDNF and hippocampal dendritic spine density are associated with the rapid antidepressant-like effect of iron-citalopram and iron-imipramine combinations in mice. Neuroscience. 2023-03-22. PMID:36948482. |
iron, citalopram and imipramine or their combinations increased serum bdnf concentration, hippocampal neuronal count and dendritic spine densities. |
2023-03-22 |
2023-08-14 |
mouse |
| Sofia Elisa Alzuri, Nicolás Matías Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsov. Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. Journal of neurochemistry. 2023-03-21. PMID:36943192. |
here, we employed the paradigm of chronic restraint stress in rats and using quantitative polymerase chain reaction (qpcr) showed downregulation of expression of gpm6a and the brain-derived neurotrophic factor (bdnf) genes at mrna level as well as mir-133b, mir-124-3p, but not mir-9-5p in the hippocampus of chronically stressed rats. |
2023-03-21 |
2023-08-14 |
rat |
| Sofia Elisa Alzuri, Nicolás Matías Rosas, Natasa Hlavacova, Daniela Jezova, Beata Fuchsov. Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. Journal of neurochemistry. 2023-03-21. PMID:36943192. |
moreover, treatment of hippocampal neurons cultured in vitro with bdnf resulted in an elevation in the mir-124-3p expression, a decrease in the mir-9-5p expression but did not affect mir-133b. |
2023-03-21 |
2023-08-14 |
rat |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
concurrently, abated mir-15a expression, overexpression of its target rock-1, diminished downstream erk1/2 and camp response element-binding protein (creb) phosphorylation, and decreased hippocampal brain-derived neurotrophic factor (bdnf) levels were observed. |
2023-03-21 |
2023-08-14 |
rat |
| Qiongyu Li, Fantao Meng, Xiangxian Ma, Zhe Sun, Juanjuan Dai, Jing Liu, Dan Li, Peijia Cong, Ruixue Xu, Di Zhao, Wentao Wang, Dan Wang, Cuilan Liu, Faxiang Wang, Chen Li, Haifeng Lia. The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety. Frontiers in immunology. vol 14. 2023-03-20. PMID:36936941. |
furthermore, overexpression of il-19 in the colon also reduced the expression levels of brain-derived neurotrophic factor (bdnf), extracellular signal-regulated kinase (erk), and camp-response element binding protein (creb) signaling pathways activity in the hippocampus. |
2023-03-20 |
2023-08-14 |
mouse |