| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R Hamblin, Javad Mahmoud. Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways. Brain research. 2023-09-17. PMID:37717889. |
spatial learning and memory were assessed in the lashley iii maze and hippocampus tissue samples were collected to assess oxidative stress markers and protein expression of brain-derived neurotrophic factor (bdnf), nuclear factor erythroid 2-related factor 2 (nrf2), sirtuin 1 (sirt1), and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb). |
2023-09-17 |
2023-10-07 |
mouse |
| Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R Hamblin, Javad Mahmoud. Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways. Brain research. 2023-09-17. PMID:37717889. |
our findings suggested that the protective effect of pbm against hu-induced cognitive impairment involved the activation of the sirt1/nrf2 signaling pathway, up-regulation of bdnf, and reduction of neuroinflammation and oxidative stress in the hippocampus. |
2023-09-17 |
2023-10-07 |
mouse |
| Radwa S Raafat, Mohamed Z Habib, Amany A AbdElfattah, Nouran K Olama, Sahar M Abdelraouf, Nevien Hendawy, Khaled A Kamal, Salwa A Nawishy, Sawsan Aboul-Fotou. Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3β/β-catenin signaling in Wistar rats. International immunopharmacology. vol 124. issue Pt A. 2023-09-16. PMID:37716161. |
moreover, 5-fu induced a decrease in the activity of the wnt/gsk-3β/β-catenin pathway with a decrease in brain-derived neurotrophic factor (bdnf) level in the hippocampus. |
2023-09-16 |
2023-10-07 |
human |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
this, study, then, was designed to analyze the long-term effects of early postnatal exposure to cmi on the expression of 5-ht1a, 5-ht2a, and 5-ht3 receptors, as well as bdnf and gr in the following brain regions: pfc, amygdala, hippocampus, and hypothalamus, which could be related to alterations in memory and learning, as evaluated using the novel object recognition (nor) and morris water maze (mwm). |
2023-09-15 |
2023-10-07 |
rat |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
expression of the 5-ht1a receptor increased in the hippocampus, amygdala, and hypothalamus, but decreased in the pfc, while the 5-ht2a and bdnf receptors decreased their expression in the pfc, amygdala, and hippocampus. |
2023-09-15 |
2023-10-07 |
rat |
| M Hernandez, S Ghislin, R Lalonde, C Straziell. Corticosterone effects on postnatal cerebellar development in mice. Neurochemistry international. 2023-09-13. PMID:37704081. |
the cort treatment altered the morphology of the hippocampus and down-regulated gene transcription for corticotropin-releasing hormone (crh) and its type-1 receptor (crhr1), glucocorticoid receptor (nr3c1), and brain-derived neurotrophic factor bdnf and its receptor ntrk2 (neurotrophic receptor tyrosine kinase 2). |
2023-09-13 |
2023-10-07 |
mouse |
| Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Ha. Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice. Experimental & molecular medicine. 2023-09-13. PMID:37704750. |
lpc-ev treatment restores the downregulated expression of bdnf, nt4/5, trkb, mmp-2, mmp-9, and nep; induces the upregulation of mecp2 and sirt1 in the hippocampus; alleviates aβ accumulation and neuroinflammatory responses in the brain; and mitigates cognitive decline in tg-app/ps1 mice. |
2023-09-13 |
2023-10-07 |
mouse |
| Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B Fall, Danielle M Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S Le. Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693535. |
we find that the receptor tyrosine kinase (rtk), trkb, and the g protein-coupled receptor (gpcr), metabotropic glutamate receptor 5 (mglur5), together mediate a novel form of hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (bdnf). |
2023-09-11 |
2023-10-07 |
Not clear |
| Jian Huang, Yongji Wu, Xuejun Chai, Shuai Wang, Yongkang Zhao, Yan Hou, Yue Ma, Shulin Chen, Shanting Zhao, Xiaoyan Zh. β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis. Stress biology. vol 2. issue 1. 2023-09-07. PMID:37676574. |
moreover, bhba inhibited the expression of cleaved caspase-3 by suppressing endoplasmic reticulum (er) stress, and increased the expression of brain-derived neurotrophic factor (bdnf) in the heat stress-treated hippocampus by activating the protein kinase b (akt)/camp response element binding protein (creb) and methyl-cpg binding protein 2 (mecp2) pathways. |
2023-09-07 |
2023-10-07 |
mouse |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through erk1/2-mediated bdnf synthesis in the hippocampus. |
2023-09-07 |
2023-10-07 |
mouse |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
these results demonstrate that stimulation of hippocampal microglia by intranasal lps administration can induce antidepressant effects via erk1/2-dependent synthesis of bdnf protein, providing hope for the development of new strategies for the treatment of depression. |
2023-09-07 |
2023-10-07 |
mouse |
| Grandhi Sandeep Ganesh, Prasad Konduri, Aravinda Sai Kolusu, Srihari Vandana Namburi, Bala Tejo Chandra Chunduru, Kumar V S Nemmani, Pavan Kumar Samudral. Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer's in Rats: Insights into the Underlying Mechanisms. ACS chemical neuroscience. 2023-09-05. PMID:37669120. |
additionally, biochemical parameters such as acetylcholinesterase (ache), butyrylcholinesterase (buche), nitric oxide (no), malondialdehyde (mda), reduced glutathione (gsh), superoxide dismutase (sod), brain-derived neurotrophic factor (bdnf), β-amyloid levels, and nf-κb were measured in the hippocampus. |
2023-09-05 |
2023-10-07 |
rat |
| Satoshi Deyam. [Elucidation of the Mechanisms Underlying the Rapid Antidepressant Actions of Ketamine and Search for Possible Candidates for Novel Rapid-acting Antidepressants]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 143. issue 9. 2023-09-04. PMID:37661437. |
moreover, the intranasal administration of rve1 elicits rapid antidepressant-like effects through the release of bdnf and vegf in the mpfc and hippocampal dentate gyrus (dg), as well as mtorc1 activation in the mpfc, albeit not in the dg. |
2023-09-04 |
2023-09-07 |
human |
| Jiao Liu, Jing Tao, Guiyan Cai, Jie Chen, Lei Zhao, Yajun Wang, Shurui Xu, Ruilin Chen, Li Hu, Jin Cao, Lidian Chen, Yiheng T. The altered hippocampal functional connectivity and serum brain-derived neurotrophic factor level predict cognitive decline in patients with knee osteoarthritis. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653604. |
the altered hippocampal functional connectivities were associated with serum brain-derived neurotrophic factor (bdnf) levels and spatial expression of genes enriched in synaptic plasticity. |
2023-09-01 |
2023-09-07 |
Not clear |
| Neghin Gholizadeh, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Mehryar Nader-Mohammadi, Parviz Molavi, Masoomeh Dadkhah, Soheila Molae. Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia. BMC complementary medicine and therapies. vol 23. issue 1. 2023-08-30. PMID:37649038. |
also; the brain-derived neurotrophic factor (bdnf) levels in the medial prefrontal cortex (mpfc) and hippocampus were analyzed. |
2023-08-30 |
2023-09-07 |
rat |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
binding of brain-derived neurotrophic factor (bdnf) to its receptor tyrosine kinase b (trkb) is essential for the development of the hippocampus, which regulates memory and learning. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
decreased masticatory stimulation during growth reportedly increases bdnf expression while decreasing trkb expression in the hippocampus. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
to test this hypothesis, we fed mice a powdered diet until 14 weeks of age and analyzed the bdnf and trkb mrna expression in the right hippocampus using real-time polymerase chain reaction and wnt3a and arhgap33 levels in the left hippocampus using western blotting. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
furthermore, we used staining to assess bdnf and trkb expression in the hippocampus and the number of nerve cells, the average size of each single cell and the area of intercellular spaces of the trigeminal ganglion (tg). |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
we found that decreased masticatory stimulation affected the expression of bdnf, wnt3a, arhgap33, and trkb proteins in the hippocampus, as well as memory/learning. |
2023-08-27 |
2023-09-07 |
mouse |