| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
these results suggest that zgjtjy may exert its neuroprotective effect by inhibiting the cx3cl1-cx3cr1 axis and activation of hippocampal microglia, thereby improving neuroinflammation and abnormal activation of n-methyl-d-aspartate receptor(nmdar) subunits, and ultimately enhancing the expression of synaptic-related proteins psd95, syn1, and bdnf in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |
| Kate M O'Neill, Erin D Anderson, Shoutik Mukherjee, Srinivasa Gandu, Sara A McEwan, Anton Omelchenko, Ana R Rodriguez, Wolfgang Losert, David F Meaney, Behtash Babadi, Bonnie L Firestei. Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry. Communications biology. vol 6. issue 1. 2023-12-19. PMID:38110605. |
here we report that bdnf treatment affects rodent hippocampal network dynamics during development and recovery from glutamate-induced excitotoxicity in culture. |
2023-12-19 |
2023-12-21 |
Not clear |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
collectively, our findings suggest that es inhibits inflammation, regulates microglial bdnf, and causes remodeling of hippocampal function in mice to counteract obesity-like induced cognitive impairment. |
2023-12-17 |
2023-12-21 |
mouse |
| Setare Farokhi Larijani, Gholamreza Hassanzadeh, Maryam Zahmatkesh, Forough Radfar, Maryam Farahmandfa. Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptor. Behavioural brain research. 2023-12-17. PMID:38104636. |
the level of hippocampal brain-derived neurotrophic factor (bdnf) and tropomyosin-related kinase b (trkb) were analyzed to understand the involvement of bdnf-trkb pathway in this modulation. |
2023-12-17 |
2023-12-21 |
rat |
| Setare Farokhi Larijani, Gholamreza Hassanzadeh, Maryam Zahmatkesh, Forough Radfar, Maryam Farahmandfa. Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptor. Behavioural brain research. 2023-12-17. PMID:38104636. |
results showed that animals received aβ had impaired working memory, increased anxiety which were accompanied by lower protein levels of bdnf and trkb in the hippocampus. |
2023-12-17 |
2023-12-21 |
rat |
| Setare Farokhi Larijani, Gholamreza Hassanzadeh, Maryam Zahmatkesh, Forough Radfar, Maryam Farahmandfa. Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptor. Behavioural brain research. 2023-12-17. PMID:38104636. |
the exercise training and intranasal insulin improved working memory deficits, decreased anxiety, and increased bdnf, and trkb levels in the hippocampus of animals received aβ. |
2023-12-17 |
2023-12-21 |
rat |
| Sudipta Jana, Bhaskarjyoti Giri, Sagarika Das, Anirban Manna, Subhash C Mandal, Nihar Ranjan Jan. Azadiradione up-regulates the expression of parvalbumin and BDNF via Ube3a. Gene. 2023-12-15. PMID:38101713. |
treatment of azadiradione to ht22 hippocampal cell line and in adult mice induced the expression of ube3a as well as two important synaptic function and plasticity regulating proteins, parvalbumin and brain-derived neurotropic factor (bdnf). |
2023-12-15 |
2023-12-18 |
mouse |
| Handan Deng, Yongjun Yu, Qi Sha, Weiyi Sun, Lundan Liang, Feier Ren, Hua Ji, Xiangdi Shen, Xingli Fa. Construction of antibiotic-induced depression mice model and the function of intestinal microbiota. Frontiers in microbiology. vol 14. 2023-12-13. PMID:38088959. |
by using these antibiotics, the concentrations of norepinephrine (ne), 5-hydroxytryptamine (5-ht), and brain-derived neurotrophic factor (bdnf) in mice hippocampus and prefrontal cortex tissues were significantly decreased. |
2023-12-13 |
2023-12-17 |
mouse |
| Andressa Radiske, Carla Miranda de Castro, Janine I Rossato, Maria Carolina Gonzalez, Martín Cammarot. Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse. Scientific reports. vol 13. issue 1. 2023-12-08. PMID:38066022. |
hippocampal glun2b subunit-containing nmdar (glun2b-nmdar) activation during recall destabilizes fear extinction memory, which must undergo brain-derived neurotrophic factor (bdnf)-dependent reconsolidation to persist. |
2023-12-08 |
2023-12-17 |
rat |
| Hou Liu, Guicheng Wang, Jin Zhang, Bingjie Lu, Dan Li, Jianmin Che. Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism. Environment international. vol 183. 2023-12-06. PMID:38056096. |
exposure to depm disrupted motor behavior generation related cerebellar purkinje cells, induced widespread reduction of neurotransmitters in the frontal cortex, and downregulated expression of genes encoding brain-derived neurotrophic factor (bdnf) and involved in the brain-blood-barrier (bbb) in the hippocampus. |
2023-12-06 |
2023-12-10 |
mouse |
| Yue Teng, JiaYao Niu, Yang Liu, Han Wang, JinHong Chen, YuJia Kong, Ling Wang, Bo Lian, WeiWeng Wang, HongWei Sun, KuiTao Yu. Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala. Behavioural brain research. 2023-12-04. PMID:38048914. |
ketamine alleviates fear memory and spatial cognition deficits in a ptsd rat model via the bdnf signaling pathway of the hippocampus and amygdala. |
2023-12-04 |
2023-12-10 |
rat |
| Heliana de Barros Fernandes, Bruna da Silva Oliveira, Caroline Amaral Machado, Brener Cunha Carvalho, Eliana Cristina de Brito Toscano, Maria Carolina M da Silva, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Antônio Lúcio Teixeira, Aline Silva de Miranda, Aristóbolo Mendes da Silv. Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice. Progress in neuro-psychopharmacology & biological psychiatry. 2023-12-04. PMID:38048936. |
in addition, morphological alterations were observed in rasgef1b deficient microglia along with decreased levels of hippocampal bdnf. |
2023-12-04 |
2023-12-10 |
mouse |
| Paromita Deb, Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Arunoday Bhan, Blake Brady, Linda I Perrotti, Subhrangsu S Manda. Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR. Gene. 2023-12-03. PMID:38043834. |
our results demonstrated that bdnf expression is induced by e2 in vitro in ht22 cells (hippocampal neuronal cells) and in vivo (in ovariectomized mouse brain under e2-treatment). |
2023-12-03 |
2023-12-10 |
mouse |
| Qingyang Zhan, Fanyi Kong, Shuai Shao, Bo Zhang, Shuming Huan. Pathogenesis of Depression in Alzheimer's Disease. Neurochemical research. 2023-11-28. PMID:38015411. |
these alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (hpa) axis, diminished levels of brain-derived neurotrophic factor (bdnf), and hippocampal atrophy. |
2023-11-28 |
2023-11-29 |
Not clear |
| Marco Paolini, Lidia Fortaner-Uyà, Cristina Lorenzi, Sara Spadini, Melania Maccario, Raffaella Zanardi, Cristina Colombo, Sara Poletti, Francesco Benedett. Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder. Genes. vol 14. issue 11. 2023-11-25. PMID:38002980. |
brain-derived neurotrophic factor (bdnf)-tyrosine receptor kinase b (trkb) signaling is thought to influence antidepressant efficacy and hippocampal volumes, robust predictors of treatment resistance. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Sh. Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway. Physiology & behavior. 2023-11-24. PMID:38000530. |
the levels of pka, phosphorylated creb (pcreb) and bdnf were significantly lowered in the hippocampus of crs mice, suggesting disruption of the pka-creb-bdnf signaling pathway signaling pathway; p-ca treatment restored the signaling pathway. |
2023-11-24 |
2023-11-28 |
mouse |
| Zsolt Kristóf Bali, Lili Veronika Nagy, Nóra Bruszt, Kornélia Bodó, Péter Engelmann, Zsófia Hernádi, Kitti Göntér, Sai Ambika Tadepalli, István Hernád. Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment. GeroScience. 2023-11-23. PMID:37994990. |
at the end of the behavioral experiments, mrna and protein expression of alpha7 nachrs, cytokines, and brain-derived neurotrophic factor (bdnf) were quantitatively measured in the hippocampus, frontal cortex, striatum, and cerebellum. |
2023-11-23 |
2023-11-29 |
human |
| Zsolt Kristóf Bali, Lili Veronika Nagy, Nóra Bruszt, Kornélia Bodó, Péter Engelmann, Zsófia Hernádi, Kitti Göntér, Sai Ambika Tadepalli, István Hernád. Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment. GeroScience. 2023-11-23. PMID:37994990. |
the deficit was accompanied by increased il-1beta and tnfalpha mrna expression and decreased bdnf protein expression in the hippocampus. |
2023-11-23 |
2023-11-29 |
human |
| Jeferson Machado Batista Sohn, Nathalie Carla Cardoso, Ana Maria Raymundi, Jos Prickaerts, Cristina Aparecida Jark Ster. Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation. Scientific reports. vol 13. issue 1. 2023-11-22. PMID:37990053. |
phosphodiesterase 4 (pde4), an enzyme expressed in the dorsal hippocampus (dh), hydrolyzes the camp, limiting the pka-induced creb phosphorylation (pcreb) and bdnf expression. |
2023-11-22 |
2023-11-29 |
rat |
| Destynie Medeiros, Karen Ayala-Baylon, Hailey Egido-Betancourt, Eric Miller, Christopher A Chapleau, Holly A Robinson, Mary L Phillips, Tao Yang, Frank Longo, Wei Li, Lucas Pozzo-Mille. A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice. bioRxiv : the preprint server for biology. 2023-11-21. PMID:37986936. |
applied in vitro, lm22a-4 increased dendritic spine density in pyramidal neurons in cultured hippocampal slices from postnatal day (p) 7 male mecp2 knockout (ko) mice as much as recombinant bdnf, and both effects were prevented by the trkb receptor inhibitors k-252a and ana-12. |
2023-11-21 |
2023-11-29 |
mouse |