| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through erk1/2-mediated bdnf synthesis in the hippocampus. |
2023-09-07 |
2023-10-07 |
mouse |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
these results demonstrate that stimulation of hippocampal microglia by intranasal lps administration can induce antidepressant effects via erk1/2-dependent synthesis of bdnf protein, providing hope for the development of new strategies for the treatment of depression. |
2023-09-07 |
2023-10-07 |
mouse |
| Grandhi Sandeep Ganesh, Prasad Konduri, Aravinda Sai Kolusu, Srihari Vandana Namburi, Bala Tejo Chandra Chunduru, Kumar V S Nemmani, Pavan Kumar Samudral. Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer's in Rats: Insights into the Underlying Mechanisms. ACS chemical neuroscience. 2023-09-05. PMID:37669120. |
additionally, biochemical parameters such as acetylcholinesterase (ache), butyrylcholinesterase (buche), nitric oxide (no), malondialdehyde (mda), reduced glutathione (gsh), superoxide dismutase (sod), brain-derived neurotrophic factor (bdnf), β-amyloid levels, and nf-κb were measured in the hippocampus. |
2023-09-05 |
2023-10-07 |
rat |
| Satoshi Deyam. [Elucidation of the Mechanisms Underlying the Rapid Antidepressant Actions of Ketamine and Search for Possible Candidates for Novel Rapid-acting Antidepressants]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 143. issue 9. 2023-09-04. PMID:37661437. |
moreover, the intranasal administration of rve1 elicits rapid antidepressant-like effects through the release of bdnf and vegf in the mpfc and hippocampal dentate gyrus (dg), as well as mtorc1 activation in the mpfc, albeit not in the dg. |
2023-09-04 |
2023-09-07 |
human |
| Jiao Liu, Jing Tao, Guiyan Cai, Jie Chen, Lei Zhao, Yajun Wang, Shurui Xu, Ruilin Chen, Li Hu, Jin Cao, Lidian Chen, Yiheng T. The altered hippocampal functional connectivity and serum brain-derived neurotrophic factor level predict cognitive decline in patients with knee osteoarthritis. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653604. |
the altered hippocampal functional connectivities were associated with serum brain-derived neurotrophic factor (bdnf) levels and spatial expression of genes enriched in synaptic plasticity. |
2023-09-01 |
2023-09-07 |
Not clear |
| Neghin Gholizadeh, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Mehryar Nader-Mohammadi, Parviz Molavi, Masoomeh Dadkhah, Soheila Molae. Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia. BMC complementary medicine and therapies. vol 23. issue 1. 2023-08-30. PMID:37649038. |
also; the brain-derived neurotrophic factor (bdnf) levels in the medial prefrontal cortex (mpfc) and hippocampus were analyzed. |
2023-08-30 |
2023-09-07 |
rat |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
binding of brain-derived neurotrophic factor (bdnf) to its receptor tyrosine kinase b (trkb) is essential for the development of the hippocampus, which regulates memory and learning. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
decreased masticatory stimulation during growth reportedly increases bdnf expression while decreasing trkb expression in the hippocampus. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
to test this hypothesis, we fed mice a powdered diet until 14 weeks of age and analyzed the bdnf and trkb mrna expression in the right hippocampus using real-time polymerase chain reaction and wnt3a and arhgap33 levels in the left hippocampus using western blotting. |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
furthermore, we used staining to assess bdnf and trkb expression in the hippocampus and the number of nerve cells, the average size of each single cell and the area of intercellular spaces of the trigeminal ganglion (tg). |
2023-08-27 |
2023-09-07 |
mouse |
| Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi On. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. vol 102. 2023-08-27. PMID:37634443. |
we found that decreased masticatory stimulation affected the expression of bdnf, wnt3a, arhgap33, and trkb proteins in the hippocampus, as well as memory/learning. |
2023-08-27 |
2023-09-07 |
mouse |
| Samira S Valvassori, Richard T da Rosa, Gustavo C Dal-Pont, Roger B Varela, Gustavo A Mastella, Thiani Daminelli, Gabriel R Fries, João Quevedo, Alexandra I Zugn. Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamine. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-08-27. PMID:37635268. |
the activity of dna methyltransferase (dnmt), histone deacetylase (hdac), and histone acetyltransferase and levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), neurotrophin-3 (nt-3), and glial-derived neurotrophic factor (gdnf) were evaluated in the frontal cortex, hippocampus, and striatum. |
2023-08-27 |
2023-09-07 |
rat |
| Akanksha Kushwaha, Mahendra Kumar Thaku. Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model. Molecular neurobiology. 2023-08-25. PMID:37626270. |
suv39h1 silencing in amnesic mice reduced h3k9me3 levels at the neuronal iegs (arc and bdnf) promoter, increased the expression of arc and bdnf in the hippocampus, and improved recognition memory. |
2023-08-25 |
2023-09-07 |
mouse |
| Yujuan Zhao, You Kang, Zijian Zhao, Ge Yang, Yansong Gao, Lei Gao, Chao Wang, Shengyu L. Lacticaseibacillus rhamnosus TF318 prevents depressive behavior in rats by inhibiting HPA-axis hyperactivity and upregulating BDNF expression. Neuroscience letters. 2023-08-24. PMID:37619699. |
a marked increase was observed in the hippocampal concentration of brain-derived neurotrophic factor (bdnf), a change that may have involved the cyclic adenosine monophosphate (camp)/camp response element-binding/bdnf signaling pathway. |
2023-08-24 |
2023-09-07 |
rat |
| Aanchal Aggarwal, Binduma Yadav, Nishtha Sharma, Raminder Kaur, Vikas Rish. Disruption of histone acetylation homeostasis triggers cognitive dysfunction in experimental diabetes. Neurochemistry international. 2023-08-20. PMID:37598859. |
reduced h3k9/14 and h4k12 acetylation paralleled transcriptional repression of memory-related markers bdnf, syp, and psd-95 in the cortex and hippocampus of t1d and t2d. |
2023-08-20 |
2023-09-07 |
mouse |
| Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfa. Repeated Pre-exposure to Morphine Inhibited the Amnesic Effect of Ethanol on Spatial Memory: Involvement of CaMKII and BDNF. Alcohol (Fayetteville, N.Y.). 2023-08-19. PMID:37597575. |
also, we assessed how these drug-exposures influence the expression level of camkii and bdnf in the hippocampus and amygdala. |
2023-08-19 |
2023-09-07 |
rat |
| Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfa. Repeated Pre-exposure to Morphine Inhibited the Amnesic Effect of Ethanol on Spatial Memory: Involvement of CaMKII and BDNF. Alcohol (Fayetteville, N.Y.). 2023-08-19. PMID:37597575. |
our findings suggest that sub-chronic morphine treatment reverses ethanol-induced spatial memory impairment which could be explained by modulating camkii and bdnf mrna expressions in the hippocampus and amygdala. |
2023-08-19 |
2023-09-07 |
rat |
| Shubha M Basavaraju, Seema Mudhol, Muthukumar Serva Peddha, Shahid Ud Din Wani, Kamsagara L Krishna, Seema Mehdi, Nabeel Kinattinga. Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour in mice. Neuroscience letters. 2023-08-17. PMID:37591360. |
within the same period, nanopiperine improved hippocampal progenitor cell proliferation and increased brain-derived neurotrophic factor (bdnf) levels in the hippocampus of mice subjected to lps-induced stress. |
2023-08-17 |
2023-09-07 |
mouse |
| Shubha M Basavaraju, Seema Mudhol, Muthukumar Serva Peddha, Shahid Ud Din Wani, Kamsagara L Krishna, Seema Mehdi, Nabeel Kinattinga. Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour in mice. Neuroscience letters. 2023-08-17. PMID:37591360. |
in summary, the nanopiperine showed potent neuroprotective and antidepressant activity, and stability relating to the elevated level of hippocampal bdnf level and as compared to pure piperine, the nanopiperine showed better oral bioavailability and stability. |
2023-08-17 |
2023-09-07 |
mouse |
| Chiara Musillo, Letizia Giona, Michael Ristow, Kim Zarse, Karsten Siems, Alessia Di Francesco, Barbara Collacchi, Carla Raggi, Francesca Cirulli, Alessandra Berr. Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion. Nutrients. vol 15. issue 15. 2023-08-12. PMID:37571303. |
brain-derived neurotrophic factor (bdnf) protein levels were evaluated in the hippocampus. |
2023-08-12 |
2023-08-16 |
mouse |