| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
myrtenol inhalation increased the bdnf level and decreased the il1β level and nfκb expression in the hippocampus of the asthmatic rats. |
2023-12-26 |
2023-12-29 |
rat |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
we believe that these ameliorating effects of myrtenol can be attributed to inflammation suppression and increased bdnf in the hippocampus. |
2023-12-26 |
2023-12-29 |
rat |
| Nan Yan, Zhengdong Wang, Zhou Li, Yang Zheng, Nan Chang, Kangjie Xu, Qian Wang, Xiaoxu Dua. Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice. Biological trace element research. 2023-12-26. PMID:38148432. |
the mrna levels of corticocerebral and hippocampal brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) were decreased in the 50 mg/l arsenic-treated group (p < 0.05). |
2023-12-26 |
2023-12-29 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
our results showed that a single injection of β-glucan one day before stress exposure dose-dependently prevented the depression-like behaviors triggered by chronic unpredictable stress (cus), which peaked at 20 mg/kg and prevented the impairment of hippocampal brain-derived neurotrophic factor (bdnf) signaling, a pathological process critical for the progression of depression-like phenotypes. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
inhibition of bdnf signaling by infusion of an anti-bdnf antibody into the hippocampus, knock-in of the mutant bdnf val68met allele, or blockade of the bdnf receptor in the hippocampus abolished the preventive effect of β-glucan on cus-induced depression-like behaviors. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
further analysis showed that camp-response element binding protein (creb)-mediated increase of bdnf expression in the hippocampus was essential for the prevention of depression-like phenotypes by β-glucan. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
these results suggest that an increase in hippocampal bdnf following creb activation triggered by β-glucan-induced microglia stimulation and subsequent trkb signaling mediates the preventive effect of β-glucan on depression. |
2023-12-24 |
2023-12-27 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
morris water maze tests were carried out to evaluate the cognitive impairment, while mrna levels of neurotrophic factors (bdnf, ng) and neurodegenerative biomarker (vilip-1) in hippocampus were tested by q-pcr. |
2023-12-23 |
2023-12-25 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
postoperative pain induced cognitive impairment, promoted axon demyelination, decreased bdnf, ng and increased vilip-1 expressions in hippocampus. |
2023-12-23 |
2023-12-25 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
the cognitive impairment, axon demyelination, decreased bdnf, ng and increased vilip-1 expressions in hippocampus were all alleviated by exogenous exosome mir-124-3p. |
2023-12-23 |
2023-12-25 |
mouse |
| Xiao-Qin Zhu, Dong Ga. Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury through up-regulating hippocampal BDNF-TrkB signaling: involving suppression in neuroinflammation and oxidative stress. Neuroreport. 2023-12-23. PMID:38141009. |
moreover, nar inhibited oxidative stress (reduced levels of malondialdehyde and 4-hydroxynonenal, increased activities of superoxide dismutase and glutathione peroxidase) and inflammatory cytokines (reduced levels of tumor necrosis factor-α, interleukin-1β and interleukin-6), up-regulated the expressions of bdnf and p-trkb in hippocampus of mcao-induced ci/r rats. |
2023-12-23 |
2023-12-25 |
rat |
| b' Alba Toll, Laura Blanco-Hinojo, Daniel Berge, Ana Manzano, Khadija El Abidi, V\\xc3\\xadctor Perez-Sol\\xc3\\xa0, Anna Man\\xc3\\xa. Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-na\\xc3\\xafve first-episode psychosis patients. Frontiers in psychiatry. vol 14. 2023-12-22. PMID:38130289.' |
it has been hypothesized that thyroid hormones could cause morphological modifications in the hippocampal structure through the upregulation of brain-derived neurotrophic factor (bdnf). |
2023-12-22 |
2023-12-24 |
Not clear |
| b' Alba Toll, Laura Blanco-Hinojo, Daniel Berge, Ana Manzano, Khadija El Abidi, V\\xc3\\xadctor Perez-Sol\\xc3\\xa0, Anna Man\\xc3\\xa. Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-na\\xc3\\xafve first-episode psychosis patients. Frontiers in psychiatry. vol 14. 2023-12-22. PMID:38130289.' |
in this study, we primarily aimed to determine the relationship between thyroid-stimulating hormone (tsh) levels, peripheral bdnf levels, and hippocampal volume in antipsychotic-naïve fep patients. |
2023-12-22 |
2023-12-24 |
Not clear |
| b' Alba Toll, Laura Blanco-Hinojo, Daniel Berge, Ana Manzano, Khadija El Abidi, V\\xc3\\xadctor Perez-Sol\\xc3\\xa0, Anna Man\\xc3\\xa. Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-na\\xc3\\xafve first-episode psychosis patients. Frontiers in psychiatry. vol 14. 2023-12-22. PMID:38130289.' |
relationship between thyroid-stimulating hormone, bdnf levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients. |
2023-12-22 |
2023-12-24 |
Not clear |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
when l1 (weakest in vitro), l3, and l6 were orally administered in mice with pcm-induced depression, l6 most potently suppressed depression-like behaviors and hippocampal tnf-α and il-6 expression and increased hippocampal serotonin, bdnf, 5ht7, gabaarα1, and gababr1b expression, followed by l3 and l1. |
2023-12-21 |
2023-12-23 |
mouse |
| Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B Fall, Danielle M Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S Le. Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell reports. vol 43. issue 1. 2023-12-20. PMID:38117654. |
we find that the receptor tyrosine kinase (rtk) trkb and the g-protein-coupled receptor (gpcr) metabotropic glutamate receptor 5 (mglur5) together mediate hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (bdnf). |
2023-12-20 |
2023-12-23 |
Not clear |
| Odair José Farias de Lima, Juliana da Silva Ribeiro, Jefferson Diego Costa Vasconcelos, Marília Freire Isidro Ferraz, Caroline Emiliane de Melo Tavares da Rosa E Silva, Waleska Maria Almeida Barros, Gilberto Ramos Vieira, Mírian Celly Medeiros Miranda David, Rhowena Jane Barbosa de Mato. Environmental enrichment changes the effects of prenatal and postnatal undernutrition on memory, anxiety traits, Bdnf and TrkB expression in the hippocampus of male adult rats. Behavioural brain research. 2023-12-20. PMID:38122904. |
environmental enrichment changes the effects of prenatal and postnatal undernutrition on memory, anxiety traits, bdnf and trkb expression in the hippocampus of male adult rats. |
2023-12-20 |
2023-12-23 |
rat |
| Heaji Lee, Sun Yeou Kim, Yunsook Li. Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice. The Journal of nutritional biochemistry. vol 124. 2023-12-19. PMID:38030047. |
accordingly, sme activated hippocampal neurotrophic factors including bdnf (1.0%, 1.2%) and its associated pgc1α/irisin pathway (pgc1α :1.1%, 1.1%; irisin:1.1%, 0.9%) significantly. |
2023-12-19 |
2023-12-23 |
mouse |
| Chiara Musillo, Kerstin C Creutzberg, Barbara Collacchi, Maria Antonietta Ajmone-Cat, Roberta De Simone, Marcello Lepre, Irmgard Amrein, Marco A Riva, Alessandra Berry, Francesca Cirull. Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity. Translational psychiatry. vol 13. issue 1. 2023-12-19. PMID:38105264. |
our findings show that these two stressors produce overlapping effects, reducing brain anti-oxidant defenses (nrf-2) and leading to sex-dependent impairments of hippocampal bdnf expression and alterations of the emotional behavior and hpa axis functionality. |
2023-12-19 |
2023-12-21 |
mouse |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
western blot was used to measure the expression levels of cx3cl1, cx3cr1, a2a adenosine receptor(a2ar), glutamate receptor 2a(nr2a), glutamate receptor 2b(nr2b), and brain-derived neurotrophic factor(bdnf) in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |