| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengdie Wang, Namin Feng, Jia Qin, Shengqiang Wang, Jiabao Chen, Shaojie Qian, Yulin Liu, Foquan Lu. Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats. Neurotoxicology. 2024-02-12. PMID:38346645. |
accordingly, the activity of histone deacetylases increased, the protein levels of nedd9, bdnf, p-trkb, syn and psd-95 decreased, and the density of dendritic spines reduced in the hippocampus of the offspring of the surgery group, and such effects were not seen in the offspring of the ketamine group, neither in the offspring of control group. |
2024-02-12 |
2024-02-15 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
potential effect of physical exercise on the downregulation of bdnf mrna expression in rat hippocampus following intracerebral hemorrhage. |
2024-02-11 |
2024-02-14 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
physical exercise is known to induce expression of the neuroprotective brain derived neurotrophic factor (bdnf) in the hippocampus. |
2024-02-11 |
2024-02-14 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
this study examined the effects of physical exercise on hippocampal bdnf expression and the potential benefits for preventing remote secondary hippocampal damage and neurological impairment following intracerebral hemorrhage (ich). |
2024-02-11 |
2024-02-14 |
rat |
| Rémi Chaney, Clémence Leger, Julien Wirtz, Estelle Fontanier, Alexandre Méloux, Aurore Quirié, Alain Martin, Anne Prigent-Tessier, Philippe Garnie. Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339161. |
in parallel, our results from the animal studies revealed an elevation in brain-derived neurotrophic factor (bdnf), specifically in the hippocampus. |
2024-02-10 |
2024-02-12 |
human |
| Yunting Li, Anfei Liu, Kaiju Chen, Lifan Li, Xiaoshun Zhang, Fei Zou, Xingmei Zhang, Xiaojing Men. Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway. Environment international. vol 184. 2024-02-10. PMID:38340407. |
butyrate also promoted the expression of acetyl-coa synthetase acss2 in hippocampal neurons, thereby increasing the content of acetyl-coa and restoring the expression of both histone h3k9ac and the downstream bdnf. |
2024-02-10 |
2024-02-14 |
mouse |
| Jie Wan, Linhui Ma, Xinhao Jiao, Wei Dong, Jiatao Lin, Yongkang Qiu, Weifeng Wu, Qiang Liu, Chen Chen, He Huang, Shuai Li, Hui Zheng, Yuqing W. Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine. CNS neuroscience & therapeutics. vol 30. issue 2. 2024-02-09. PMID:38332635. |
impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by bdnf downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine. |
2024-02-09 |
2024-02-11 |
mouse |
| Liang Zhang, Jing Zheng, Shi-Yan Liu, Li-Li Hou, Bo Zhang, Shao-Wen Tia. Acute Administration of Lactate Exerts Antidepressant-like Effect Through cAMP-dependent Protein Synthesis. Neuroscience. 2024-02-09. PMID:38336096. |
furthermore, lactate rapidly promoted dephosphorylation of eukaryotic elongation factor 2 (eef2) and increased brain-derived neurotrophic factor (bdnf) protein synthesis in the hippocampus in a cyclic adenosine monophosphate (camp)-dependent manner. |
2024-02-09 |
2024-02-12 |
human |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus. Neurobiology of learning and memory. 2024-02-09. PMID:38336097. |
in addition, immunohistochemistry targetingΔfosb (neuronal activity),brain-derived neurotrophic factor (bdnf) and thedna oxidative damage (8ohdg) in hippocampal subfields ca1, ca2, ca3, and dentate gyrus (dg), and in basolateral amygdala and striatum were performed. |
2024-02-09 |
2024-02-12 |
mouse |
| Flores-Ramos Mónica, Ramírez-Rodríguez Gerardo Bernabé, Guiza Zayas Rodrigo, Solares-Bravo Melissa, Rodríguez-Bores Loren. Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response. Journal of psychiatric research. vol 171. 2024-02-08. PMID:38330627. |
response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as brain derived neurotrophic factor (bdnf). |
2024-02-08 |
2024-02-11 |
human |
| Judit Català-Solsona, Stefano Lutzu, Pablo J Lituma, Cristina Fábregas-Ordoñez, Dolores Siedlecki, Lydia Giménez-Llort, Alfredo J Miñano-Molina, Carlos A Saura, Pablo E Castillo, José Rodriguez-Álvare. Nr4a2 blocks oAβ-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APP bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328087. |
recently, it has been reported that nr4a2, a member of the nr4a family of orphan nuclear receptors, plays a role in hippocampal synaptic plasticity by regulating bdnf and synaptic ampa receptors. |
2024-02-08 |
2024-02-10 |
mouse |
| Masatake Fujimura, Takamitsu Unok. BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance. Environmental toxicology. 2024-02-07. PMID:38323385. |
bdnf specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance. |
2024-02-07 |
2024-02-09 |
rat |
| Ghida Hassan, Sherif A Kamar, Hagar Yousry Rady, Dina Sayed Abdelrahim, Nesma Hussein Abdel Hay Ibrahim, Noha N Lashee. A study of roflumilast treatment on functional and structural changes in hippocampus in depressed Adult male Wistar rats. PloS one. vol 19. issue 2. 2024-02-06. PMID:38315652. |
the depressed group showed significant increase in immobility time with significant decrease in swimming and struggling times, significant decrease in hippocampal pka, cerb, bdnf, dopamine, cortisone, and superoxide dismutase while hippocampal phosphodiesterase-e4, interleukin-6, and malondialdhyde levels were significantly elevated. |
2024-02-06 |
2024-02-09 |
rat |
| Rosa López-Hidalgo, Raúl Ballestín, Lorena Lorenzo, Sandra Sánchez, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher, Emilio Vare. Early chronic fasudil treatment rescues hippocampal alterations in the Ts65Dn model for down syndrome. Neurochemistry international. 2024-02-03. PMID:38309665. |
we observed that treating ts65dn mice with fasudil induced an increase in neural plasticity in the hippocampus: there was an increment in the expression of psa-ncam and bdnf, in the dendritic branching and spine density of granule neurons, as well as in cell proliferation and neurogenesis in the subgranular zone. |
2024-02-03 |
2024-02-06 |
mouse |
| Navneet Dhaliwal, Jatinder Dhaliwal, Kanwaljit Chopr. 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia. Neurochemical research. 2024-02-01. PMID:38300457. |
p-akt, p-creb, bdnf, and neurotransmitter (nt) (glu, gaba, and ach) levels were also analyzed in the hippocampus of 2-vo rats. our results show that 7,8-dhf effectively improved memory performance and cholinergic dysfunction in 2-vo model rats. |
2024-02-01 |
2024-02-03 |
rat |
| Micaela Gliozzi, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Stefano Ruga, Federica Scarano, Francesca Bosco, Lorenza Guarnieri, Roberta Macrì, Rocco Mollace, Catherine Belzung, Vincenzo Mollac. The dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: role of kynurenine catabolism. Pharmacological research. 2024-02-01. PMID:38301816. |
we demonstrated that the coexistence of hyperglycaemia and chronic stress worsened hippocampal damage through alternative mechanisms, such as glut-4 and bdnf down-expression, denoting mitochondrial dysfunction and apoptosis on one hand and evoking the compromission of neurogenesis on the other. |
2024-02-01 |
2024-02-04 |
mouse |
| Clémence Leger, Aurore Quirié, Alexandre Méloux, Estelle Fontanier, Rémi Chaney, Christelle Basset, Stéphanie Lemaire, Philippe Garnier, Anne Prigent-Tessie. Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279218. |
soleus (sol) versus gastrocnemius (gas) fndc5 and hippocampal bdnf expressions were evaluated by western blotting. |
2024-01-27 |
2024-01-29 |
rat |
| Clémence Leger, Aurore Quirié, Alexandre Méloux, Estelle Fontanier, Rémi Chaney, Christelle Basset, Stéphanie Lemaire, Philippe Garnier, Anne Prigent-Tessie. Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279218. |
our findings revealed that (1) serum irisin and hippocampal bdnf levels vary with ex intensity, showing a threshold intensity at 50% of mas; (2) hippocampal bdnf levels positively correlate with serum irisin but not with hippocampal fndc5/irisin; and (3) gas, in response to ex intensity, overexpresses fndc5/irisin in type ii muscle fibers. |
2024-01-27 |
2024-01-29 |
rat |
| Clémence Leger, Aurore Quirié, Alexandre Méloux, Estelle Fontanier, Rémi Chaney, Christelle Basset, Stéphanie Lemaire, Philippe Garnier, Anne Prigent-Tessie. Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279218. |
altogether, peripheral fndc5/irisin levels likely explain ex-dependent hippocampal bdnf expression. |
2024-01-27 |
2024-01-29 |
rat |
| Ling-Sha Ju, Jiepei Zhu, Timothy Morey, Nikolaus Gravenstein, Christoph Seubert, Barry Setlow, Anatoly Martynyu. Neurobehavioral abnormalities in offspring of young adult male rats with a history of traumatic brain injury. Journal of neurotrauma. 2024-01-27. PMID:38279844. |
these abnormalities were underpinned by reduced mrna levels of hypothalamic and hippocampal mineralocorticoid receptors (nr3c2), hippocampal nr3c1, and hypothalamic brain-derived neurotrophic factor (bdnf), as well as elevated serum levels of il-1β, and biomarkers of activated hippocampal microglia and astrocytes. |
2024-01-27 |
2024-01-30 |
rat |