| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria A Tikhonova, Anna A Shvaikovskaya, Svetlana Y Zhanaeva, Galina I Moysak, Anna A Akopyan, Jamil A Rzaev, Konstantin V Danilenko, Lyubomir I Aftana. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203674. |
bdnf levels in pbmcs were associated with seizure frequency and hippocampal sclerosis. |
2024-01-11 |
2024-01-13 |
human |
| Navid Fatahi, Majid Jafari-Sabet, Gelareh Vahabzadeh, Alireza Komak. Role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of CREB- BDNF signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-08. PMID:38189934. |
role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of creb- bdnf signaling pathways. |
2024-01-08 |
2024-01-10 |
rat |
| Navid Fatahi, Majid Jafari-Sabet, Gelareh Vahabzadeh, Alireza Komak. Role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of CREB- BDNF signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-08. PMID:38189934. |
this study examined the effects of co-administration of cbd and valproate on memory consolidation, cholinergic transmission, and cyclic amp response element-binding protein (creb)-brain-derived neurotrophic factor (bdnf) signaling pathway in the prefrontal cortex (pfc) and hippocampus (hpc). |
2024-01-08 |
2024-01-10 |
rat |
| b' B \\xc4\\x8cechov\\xc3\\xa1, L Mihal\\xc4\\x8d\\xc3\\xadkov\\xc3\\xa1, \\xc5\\xa0 Vaculin, \\xc5\\xa0 \\xc5\\xa0andera, R \\xc5\\xa0lamberov\\xc3\\xa. Levels of BDNF and NGF in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations. Physiological research. vol 72. issue S5. 2024-01-04. PMID:38165760.' |
levels of bdnf and ngf in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations. |
2024-01-04 |
2024-01-06 |
rat |
| Aaron W Fleischer, Laura C Fox, Daniel R Davies, Nathan J Vinzant, Jamie L Scholl, Gina L Forste. Sub-region expression of brain-derived neurotrophic factor in the dorsal hippocampus and amygdala is Affected by mild traumatic brain injury and stress in male rats. Heliyon. vol 10. issue 1. 2024-01-03. PMID:38169784. |
these findings suggest bdnf plays a role in the mechanism underlying neuronal changes following mtbi in amygdalar and hippocampal subregions, and may participate in stress elicited changes to neural plasticity in these regions. |
2024-01-03 |
2024-01-06 |
rat |
| Chiara Criscuolo, Elissavet Chartampila, Stephen D Ginsberg, Helen E Scharfma. Dentate gyrus granule cells show stability of BDNF protein expression in mossy fiber axons with age and resistance to Alzheimer's disease neuropathology in a mouse model. eNeuro. 2024-01-02. PMID:38164567. |
hippocampal bdnf has been implicated in alzheimer's disease (ad) because hippocampal levels in ad patients and ad animal models are often downregulated, suggesting that reduced bdnf contributes to ad. |
2024-01-02 |
2024-01-05 |
mouse |
| Chiara Criscuolo, Elissavet Chartampila, Stephen D Ginsberg, Helen E Scharfma. Dentate gyrus granule cells show stability of BDNF protein expression in mossy fiber axons with age and resistance to Alzheimer's disease neuropathology in a mouse model. eNeuro. 2024-01-02. PMID:38164567. |
however, the location where hippocampal bdnf protein is most highly expressed, the mossy fiber (mf) axons of dentate gyrus granule cells (gcs), has been understudied, and never in controlled conditions. |
2024-01-02 |
2024-01-05 |
mouse |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
moreover, rtms ameliorated the reduction in gfap and glt-1 expression, alleviated the decrease in bdnf, psd95 and synapsin-1 expression, also reversed the expression levels of bax and bcl2 in the hippocampus of cums-induced rats. |
2023-12-30 |
2024-01-05 |
rat |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
myrtenol (8 mg/kg) or budesonide (160 μg/kg) was administered through inhalation once a day for 1 week, and at the end of the inhalation period, behavioral tests (mwm and open field), field potential recording, hippocampal brain-derived neurotrophic factor (bdnf), il1β (elisa), and nfκb measurement (western blot) were performed to evaluate cognitive performance. |
2023-12-26 |
2023-12-29 |
rat |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
myrtenol inhalation increased the bdnf level and decreased the il1β level and nfκb expression in the hippocampus of the asthmatic rats. |
2023-12-26 |
2023-12-29 |
rat |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
we believe that these ameliorating effects of myrtenol can be attributed to inflammation suppression and increased bdnf in the hippocampus. |
2023-12-26 |
2023-12-29 |
rat |
| Nan Yan, Zhengdong Wang, Zhou Li, Yang Zheng, Nan Chang, Kangjie Xu, Qian Wang, Xiaoxu Dua. Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice. Biological trace element research. 2023-12-26. PMID:38148432. |
the mrna levels of corticocerebral and hippocampal brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) were decreased in the 50 mg/l arsenic-treated group (p < 0.05). |
2023-12-26 |
2023-12-29 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
our results showed that a single injection of β-glucan one day before stress exposure dose-dependently prevented the depression-like behaviors triggered by chronic unpredictable stress (cus), which peaked at 20 mg/kg and prevented the impairment of hippocampal brain-derived neurotrophic factor (bdnf) signaling, a pathological process critical for the progression of depression-like phenotypes. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
inhibition of bdnf signaling by infusion of an anti-bdnf antibody into the hippocampus, knock-in of the mutant bdnf val68met allele, or blockade of the bdnf receptor in the hippocampus abolished the preventive effect of β-glucan on cus-induced depression-like behaviors. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
further analysis showed that camp-response element binding protein (creb)-mediated increase of bdnf expression in the hippocampus was essential for the prevention of depression-like phenotypes by β-glucan. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
these results suggest that an increase in hippocampal bdnf following creb activation triggered by β-glucan-induced microglia stimulation and subsequent trkb signaling mediates the preventive effect of β-glucan on depression. |
2023-12-24 |
2023-12-27 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
morris water maze tests were carried out to evaluate the cognitive impairment, while mrna levels of neurotrophic factors (bdnf, ng) and neurodegenerative biomarker (vilip-1) in hippocampus were tested by q-pcr. |
2023-12-23 |
2023-12-25 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
postoperative pain induced cognitive impairment, promoted axon demyelination, decreased bdnf, ng and increased vilip-1 expressions in hippocampus. |
2023-12-23 |
2023-12-25 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
the cognitive impairment, axon demyelination, decreased bdnf, ng and increased vilip-1 expressions in hippocampus were all alleviated by exogenous exosome mir-124-3p. |
2023-12-23 |
2023-12-25 |
mouse |
| Xiao-Qin Zhu, Dong Ga. Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury through up-regulating hippocampal BDNF-TrkB signaling: involving suppression in neuroinflammation and oxidative stress. Neuroreport. 2023-12-23. PMID:38141009. |
moreover, nar inhibited oxidative stress (reduced levels of malondialdehyde and 4-hydroxynonenal, increased activities of superoxide dismutase and glutathione peroxidase) and inflammatory cytokines (reduced levels of tumor necrosis factor-α, interleukin-1β and interleukin-6), up-regulated the expressions of bdnf and p-trkb in hippocampus of mcao-induced ci/r rats. |
2023-12-23 |
2023-12-25 |
rat |