| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Svitlana V Bach, Allison J Bauman, Darya Hosein, Jennifer J Tuscher, Lara Ianov, Kelsey M Greathouse, Benjamin W Henderson, Jeremy H Herskowitz, Keri Martinowich, Jeremy J Da. Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons. Hippocampus. 2024-02-16. PMID:38362938. |
in contrast, upregulation of bdnf iv, but not bdnf i, in the rat hippocampus attenuated contextual fear expression. |
2024-02-16 |
2024-02-18 |
rat |
| Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang L. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364739. |
radix bupleuri aqueous extract significantly improved the aberrant behaviors and neuronal damage in scz mice, upregulated syp and psd-95 expression and bdnf levels in hippocampal homogenates, down-regulated da and 5-ht levels, and suppressed microglial activation in scz mice. |
2024-02-16 |
2024-02-19 |
mouse |
| Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang L. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364739. |
lactobacillus abundance was decreased in scz mice and reversed by radix bupleuri aqueous extract administration which exhibited a significant negative correlation with il-6, il-1β, da, and 5-ht, and a significant positive correlation with bdnf levels in hippocampal tissues. |
2024-02-16 |
2024-02-19 |
mouse |
| Rong Wu, Ying Xiong, Yun Gu, Li-Yue Cao, Shu-Ying Zhang, Zhi-Xiu Song, Pu Fan, Lin Li. Traditional pediatric massage enhanced hippocampal GR, BDNF and IGF-1 expressions and exerted an anti-depressant effect in an adolescent rat model of CUMS-induced depression. Neuroscience. 2024-02-16. PMID:38364964. |
traditional pediatric massage enhanced hippocampal gr, bdnf and igf-1 expressions and exerted an anti-depressant effect in an adolescent rat model of cums-induced depression. |
2024-02-16 |
2024-02-19 |
rat |
| Rong Wu, Ying Xiong, Yun Gu, Li-Yue Cao, Shu-Ying Zhang, Zhi-Xiu Song, Pu Fan, Lin Li. Traditional pediatric massage enhanced hippocampal GR, BDNF and IGF-1 expressions and exerted an anti-depressant effect in an adolescent rat model of CUMS-induced depression. Neuroscience. 2024-02-16. PMID:38364964. |
the results showed that cums induced depression-related behaviors in the adolescent rats, along with decreased weight gain and reduced hippocampal expressions of gr, igf-1and bdnf. |
2024-02-16 |
2024-02-19 |
rat |
| Rong Wu, Ying Xiong, Yun Gu, Li-Yue Cao, Shu-Ying Zhang, Zhi-Xiu Song, Pu Fan, Lin Li. Traditional pediatric massage enhanced hippocampal GR, BDNF and IGF-1 expressions and exerted an anti-depressant effect in an adolescent rat model of CUMS-induced depression. Neuroscience. 2024-02-16. PMID:38364964. |
tpm also decreased cort level in plasma, together with enhancing expressions of gr, igf-1 and bdnf in the hippocampus. |
2024-02-16 |
2024-02-19 |
rat |
| Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hs. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis. Environmental toxicology. 2024-02-14. PMID:38351887. |
overall, our results revealed that n. nucifera leaf extracts and q3g promoted adult hippocampus neurogenesis and prevented apoptosis to mitigate scopolamine-induced cognition dysfunction through the regulation of bdnf signaling pathway. |
2024-02-14 |
2024-02-16 |
mouse |
| Ruchika Kumari, Vivek Verma, Muniyandi Singarave. Simulated chronic jet lag affects the structural and functional complexity of hippocampal neurons in mice. Neuroscience. 2024-02-14. PMID:38354900. |
moreover, cjl-exposed mice exhibited a reduction in structural complexity of hippocampal ca1 neurons along with decreased expression of neurotrophic growth factors, bdnf and ngf in the hippocampus compared to ld control. |
2024-02-14 |
2024-02-17 |
mouse |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. |
2024-02-13 |
2024-02-15 |
rat |
| Mengdie Wang, Namin Feng, Jia Qin, Shengqiang Wang, Jiabao Chen, Shaojie Qian, Yulin Liu, Foquan Lu. Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats. Neurotoxicology. 2024-02-12. PMID:38346645. |
accordingly, the activity of histone deacetylases increased, the protein levels of nedd9, bdnf, p-trkb, syn and psd-95 decreased, and the density of dendritic spines reduced in the hippocampus of the offspring of the surgery group, and such effects were not seen in the offspring of the ketamine group, neither in the offspring of control group. |
2024-02-12 |
2024-02-15 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
potential effect of physical exercise on the downregulation of bdnf mrna expression in rat hippocampus following intracerebral hemorrhage. |
2024-02-11 |
2024-02-14 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
physical exercise is known to induce expression of the neuroprotective brain derived neurotrophic factor (bdnf) in the hippocampus. |
2024-02-11 |
2024-02-14 |
rat |
| Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejim. Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage. Neuroscience letters. 2024-02-11. PMID:38342427. |
this study examined the effects of physical exercise on hippocampal bdnf expression and the potential benefits for preventing remote secondary hippocampal damage and neurological impairment following intracerebral hemorrhage (ich). |
2024-02-11 |
2024-02-14 |
rat |
| Rémi Chaney, Clémence Leger, Julien Wirtz, Estelle Fontanier, Alexandre Méloux, Aurore Quirié, Alain Martin, Anne Prigent-Tessier, Philippe Garnie. Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339161. |
in parallel, our results from the animal studies revealed an elevation in brain-derived neurotrophic factor (bdnf), specifically in the hippocampus. |
2024-02-10 |
2024-02-12 |
human |
| Yunting Li, Anfei Liu, Kaiju Chen, Lifan Li, Xiaoshun Zhang, Fei Zou, Xingmei Zhang, Xiaojing Men. Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway. Environment international. vol 184. 2024-02-10. PMID:38340407. |
butyrate also promoted the expression of acetyl-coa synthetase acss2 in hippocampal neurons, thereby increasing the content of acetyl-coa and restoring the expression of both histone h3k9ac and the downstream bdnf. |
2024-02-10 |
2024-02-14 |
mouse |
| Jie Wan, Linhui Ma, Xinhao Jiao, Wei Dong, Jiatao Lin, Yongkang Qiu, Weifeng Wu, Qiang Liu, Chen Chen, He Huang, Shuai Li, Hui Zheng, Yuqing W. Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine. CNS neuroscience & therapeutics. vol 30. issue 2. 2024-02-09. PMID:38332635. |
impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by bdnf downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine. |
2024-02-09 |
2024-02-11 |
mouse |
| Liang Zhang, Jing Zheng, Shi-Yan Liu, Li-Li Hou, Bo Zhang, Shao-Wen Tia. Acute Administration of Lactate Exerts Antidepressant-like Effect Through cAMP-dependent Protein Synthesis. Neuroscience. 2024-02-09. PMID:38336096. |
furthermore, lactate rapidly promoted dephosphorylation of eukaryotic elongation factor 2 (eef2) and increased brain-derived neurotrophic factor (bdnf) protein synthesis in the hippocampus in a cyclic adenosine monophosphate (camp)-dependent manner. |
2024-02-09 |
2024-02-12 |
human |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus. Neurobiology of learning and memory. 2024-02-09. PMID:38336097. |
in addition, immunohistochemistry targetingΔfosb (neuronal activity),brain-derived neurotrophic factor (bdnf) and thedna oxidative damage (8ohdg) in hippocampal subfields ca1, ca2, ca3, and dentate gyrus (dg), and in basolateral amygdala and striatum were performed. |
2024-02-09 |
2024-02-12 |
mouse |
| Flores-Ramos Mónica, Ramírez-Rodríguez Gerardo Bernabé, Guiza Zayas Rodrigo, Solares-Bravo Melissa, Rodríguez-Bores Loren. Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response. Journal of psychiatric research. vol 171. 2024-02-08. PMID:38330627. |
response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as brain derived neurotrophic factor (bdnf). |
2024-02-08 |
2024-02-11 |
human |
| Judit Català-Solsona, Stefano Lutzu, Pablo J Lituma, Cristina Fábregas-Ordoñez, Dolores Siedlecki, Lydia Giménez-Llort, Alfredo J Miñano-Molina, Carlos A Saura, Pablo E Castillo, José Rodriguez-Álvare. Nr4a2 blocks oAβ-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APP bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328087. |
recently, it has been reported that nr4a2, a member of the nr4a family of orphan nuclear receptors, plays a role in hippocampal synaptic plasticity by regulating bdnf and synaptic ampa receptors. |
2024-02-08 |
2024-02-10 |
mouse |