| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
we demonstrated that 500 ng of ifn-γ injection results in significant decrease in social index and social novelty recognition index, and induces microglial priming in hippocampus, characterized by enlarged cell bodies, shortened branches, increased expression of cd68, cd86, cd74, cd11b, cd11c, cd47, il-33, il-1β, il-6 and inos, and decreased expression of mcr1, arg-1, igf-1 and bdnf. |
2024-05-17 |
2024-05-27 |
mouse |
| Yongbiao Li, Zhen Nie, Yang Du, Lei Chen, Qingshan Liu, Xiaoling Wu, Yong Chen. "RNSP (Rannasangpei)" Rescued MK-801-induced Schizophrenia-like Behaviors in Mice via Oxidative Stress and BDNF-TrkB/Akt Pathway. Molecular neurobiology. 2024-05-16. PMID:38753130. |
in our study, rnsp treatment restored the expression of brain-derived neurotrophic factor (bdnf), dopamine d2 receptor, p-trkb, akt/p-akt, and doublecortin and inhibited the expression of iba1 and bax in the hippocampus of scz model mice. |
2024-05-16 |
2024-05-27 |
mouse |
| Goran Papenberg, Nina Karalija, Jarkko Johansson, Micael Andersson, Jan Axelsson, Katrine Riklund, Ulman Lindenberger, Lars Nyberg, Lars Bäckma. The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms. Cortex; a journal devoted to the study of the nervous system and behavior. vol 176. 2024-05-15. PMID:38749085. |
the influence of hippocampal dopamine d2 receptor losses on episodic-memory decline across 5 years is moderated by bdnf and kibra polymorphisms. |
2024-05-15 |
2024-05-27 |
Not clear |
| Goran Papenberg, Nina Karalija, Jarkko Johansson, Micael Andersson, Jan Axelsson, Katrine Riklund, Ulman Lindenberger, Lars Nyberg, Lars Bäckma. The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms. Cortex; a journal devoted to the study of the nervous system and behavior. vol 176. 2024-05-15. PMID:38749085. |
previously, we reported that higher da d2 receptor (d2dr) availability in hippocampus is beneficial for episodic memory only in older carriers of more advantageous genotypes of well-established plasticity-related genetic variations, the brain-derived neurotrophic factor (bdnf, rs6265) and the kidney and brain expressed protein (kibra, rs17070145) polymorphisms. |
2024-05-15 |
2024-05-27 |
Not clear |
| Goran Papenberg, Nina Karalija, Jarkko Johansson, Micael Andersson, Jan Axelsson, Katrine Riklund, Ulman Lindenberger, Lars Nyberg, Lars Bäckma. The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms. Cortex; a journal devoted to the study of the nervous system and behavior. vol 176. 2024-05-15. PMID:38749085. |
extending our observations to the longitudinal level, the current data show that individuals with one or no beneficial bdnf and kibra genotype (n = 80) decline more in episodic memory across five years, without any contribution of losses in hippocampal d2dr availability to memory decline. |
2024-05-15 |
2024-05-27 |
Not clear |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
further, hippocampal neuroplasticity (bdnf, pcreb, and perk/erk), tau pathogenesis (pgsk3β/gsk3β, cdk5, and ptau), inflammatory, and apoptotic markers were evaluated. |
2024-05-11 |
2024-05-27 |
rat |
| Nestor I Martínez-Torres, Jhonathan Cárdenas-Bedoya, Blanca Miriam Torres-Mendoz. Acute combined cerebrolysin and nicotinamide administration promote cognitive recovery through neuronal changes in the hippocampus of rats with permanent middle cerebral artery occlusion. Neuroscience. 2024-05-11. PMID:38734304. |
the rats were evaluated in the novel object recognition test; hippocampal infarct area measurement; reconstruction of neurons from ca1 for sholl analysis; and, measurement of brain-derived neurotrophic factor (bdnf) levels near the infarct zone. |
2024-05-11 |
2024-05-27 |
rat |
| Ayfer Yalcin, Ezgi Turunc, Mehmet Mahsum Kaplan, Yigit Uyanikgil, Yalcin Erzurumlu, Elisabetta Gavini, Lutfiye Kani. Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus. Drug and chemical toxicology. 2024-05-10. PMID:38726980. |
the gene expressions of cav-1, mglur5, pkcβ1, pkcβ2, erk1/2, creb, bdnf, and ngf in hippocampus tissue were evaluated using reverse transcription pcr after real-time pcr analysis. |
2024-05-10 |
2024-05-27 |
rat |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
in this study, we investigated the effect of olanzapine on locomotor activity (using open field test), pain threshold (using hot plate), depressive-like behavior (using forced swim test), spatial learning and memory (using morris water maze), and bdnf and synaptophysin hippocampal expression (using real-time pcr) in both male and female cums rats. |
2024-05-09 |
2024-05-27 |
rat |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
our data showed that olanzapine can reverse the effects of cums on behavioral functions and bdnf and synaptophysin expression levels in the hippocampus of both males and females. |
2024-05-09 |
2024-05-27 |
rat |
| Hamed Fanaei, Behrad Tabatabaei Shoorijeh, Hamid Hafezinori, Ilia Mirzaei, Abolfazl Parsi-Mou. Impact of social isolation on corticosterone release and recovery after stroke in aged rats: A behavioral and biochemical analysis. Experimental gerontology. 2024-05-09. PMID:38723916. |
in the hippocampus of co/ph group, bdnf and tac levels were significantly higher than co/si group. |
2024-05-09 |
2024-05-27 |
rat |
| Hamed Fanaei, Behrad Tabatabaei Shoorijeh, Hamid Hafezinori, Ilia Mirzaei, Abolfazl Parsi-Mou. Impact of social isolation on corticosterone release and recovery after stroke in aged rats: A behavioral and biochemical analysis. Experimental gerontology. 2024-05-09. PMID:38723916. |
bdnf and tac levels in the hippocampus, striatum and cerebral cortex of st/ph group were significantly higher and mda level was significantly lower as compared with st/si group. |
2024-05-09 |
2024-05-27 |
rat |
| Xin Shi, Xiao-Zhong Zhou, Gang Chen, Wei-Feng Luo, Chengyu Zhou, Tian-Ju He, Mandar T Naik, Qin Jiang, John Marshall, Cong Ca. Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice. Science signaling. vol 17. issue 834. 2024-04-30. PMID:38687826. |
we found that peptidomimetic compounds that bind to psd-95 promoted signaling by the bdnf receptor trkb in the hippocampus and reduced depression-like behaviors in mice. |
2024-04-30 |
2024-05-03 |
mouse |
| Jiena Hong, Jiemei Chen, Chao Li, Fei Zhao, Jiantao Zhang, Yilong Shan, Hongmei We. High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia. Behavioural brain research. vol 467. 2024-04-28. PMID:38678971. |
the underlying mechanism might be modulating the synaptic plasticity and up-regulating the expression psd95, syn, and bdnf in the hippocampus. |
2024-04-28 |
2024-05-01 |
rat |
| Erratum to: Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669561. |
erratum to: loss in pkc epsilon causes downregulation of mnsod and bdnf expression in neurons of alzheimer's disease hippocampus. |
2024-04-26 |
2024-04-29 |
Not clear |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
our findings reveal that co-exposure to mn and pb leads to severe learning and memory impairment in mice, which correlates with the accumulation of metals in the hippocampus and synergistic suppression of bdnf. |
2024-04-24 |
2024-04-28 |
mouse |
| Maysam Fadaei-Kenarsary, Khadijeh Esmaeilpour, Mohammad Shabani, Vahid Sheiban. Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments. Addiction & health. vol 16. issue 1. 2024-04-23. PMID:38651025. |
after early-life adversity, histone acetylation in the hippocampus may be linked to brain-derived neurotrophic factor (bdnf) gene epigenetics and glucocorticoid receptors (grs). |
2024-04-23 |
2024-04-26 |
Not clear |
| Scheila Iria Kraus, Jeane Bachi Ferreira, Angela Patricia França, Vinícius Alexandre Wippel, Rodrigo Bainy Leal, Raquel Oppermann, Michele Debiasi Alberton, Morgana Duarte da Silv. Pharmacological Evidence of Eugenia Brasiliensis Leaves in a Reserpine-Induced Fibromyalgia Model: Antinociceptive, Emotional, Anti-Inflammatory, and Neurotrophic Effects. Molecular neurobiology. 2024-04-19. PMID:38639862. |
finally, we observed a reduction in inflammatory cytokines in the hippocampus of animals treated with heeb, while an increase in bdnf was observed in the prefrontal cortex (pfc). |
2024-04-19 |
2024-04-21 |
mouse |
| Yuhai Xu, Xin Xin, Tianzhu Ta. Decoding the Neurotoxic Effects of Propofol: Insights into the RARα-Snhg1-Bdnf Regulatory Cascade. American journal of physiology. Cell physiology. 2024-04-15. PMID:38618701. |
the findings draw a clear link between propofol-induced neurotoxicity and the amplification of rar signaling pathways, impacting hippocampal development and apoptosis and leading to increased rarα and snhg1 and decreased bdnf. |
2024-04-15 |
2024-04-17 |
Not clear |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
tan iia can significantly increase the expression of creb, bdnf, trkb in the hippocampal tissue of stz-injured rats (p < 0.05). |
2024-04-14 |
2024-04-17 |
rat |