| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sri-Arun Iamjan, Siriluk Veerasakul, Gavin P Reynolds, Samur Thanoi, Sutisa Nudmamud-Thano. Regional-specific changes in rat brain BDNF in a model of methamphetamine abuse. Neuroscience letters. 2024-06-17. PMID:38885757. |
the results showed that hippocampal ca1 bdnf protein was significantly increased by 72 % above control values in the ed-binge rats, while other hippocampal regions and frontal cortex were not significantly affected. |
2024-06-17 |
2024-06-21 |
rat |
| Sri-Arun Iamjan, Siriluk Veerasakul, Gavin P Reynolds, Samur Thanoi, Sutisa Nudmamud-Thano. Regional-specific changes in rat brain BDNF in a model of methamphetamine abuse. Neuroscience letters. 2024-06-17. PMID:38885757. |
the hippocampal bdnf increase may reflect an initial increase in a protective factor produced in response to elevated glutamate release resulting in neurodegenerative excitotoxicity. |
2024-06-17 |
2024-06-21 |
rat |
| Shiyan Zhang, Boya Gu, Kai Zhen, Liwen Du, Yuanyuan Lv, Laikang Y. Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis. Archives of gerontology and geriatrics. vol 126. 2024-06-15. PMID:38878598. |
in addition, exercise significantly increased bdnf levels in the hippocampus (smd = 0.92, p< 0.00001) and cortex (smd = 1.56, p= 0.02) of ad models. |
2024-06-15 |
2024-06-18 |
Not clear |
| Shiyan Zhang, Boya Gu, Kai Zhen, Liwen Du, Yuanyuan Lv, Laikang Y. Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis. Archives of gerontology and geriatrics. vol 126. 2024-06-15. PMID:38878598. |
exercise, especially treadmill exercise, swimming, and voluntary wheel running, significantly increased bdnf levels in hippocampus and cortex of ad models, with swimming being the most effective intervention type. |
2024-06-15 |
2024-06-18 |
Not clear |
| Caíque Olegário Diniz E Magalhães, Ricardo Augusto Leoni De Sousa, Bruno Ferreira Mendes, Isabela Rocha Dias, Ramona Ramalho Souza Pereira, Gabriela Cruz Pereira, Kil Sun Lee, Marco Fabricio Dias Peixoto, Ricardo Cardoso Cassilha. Accumulated HIIT inhibits anxiety and depression, improves cognitive function, and memory-related proteins in the hippocampus of aged rats. Experimental brain research. 2024-06-12. PMID:38864869. |
rats were euthanized, and the hippocampus was harvested for western blot analyses (camkii and bdnf). |
2024-06-12 |
2024-06-14 |
rat |
| Ashrakt H Abdelhamid, Eman M Mantawy, Riham S Said, Ebtehal El-Demerdas. Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway. Toxicology and applied pharmacology. 2024-06-10. PMID:38857790. |
furthermore, saxa boosted hippocampal neurogenesis by upregulating brain-derived neurotrophic factor (bdnf) expression. |
2024-06-10 |
2024-06-14 |
rat |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Hiroyoshi Harada, Masayoshi Mori, Yusuke Murata, Yuri Kohno, Kazuki Terada, Kenji Ohe, Munechika Enjoj. Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus. Neuroscience letters. 2024-06-05. PMID:38838971. |
conversely, is resulted in increased anxiety-like behavior and behavioral despair alongside decreased levels of phosphorylated creb and bdnf, particularly in the dorsal hippocampus. |
2024-06-05 |
2024-06-08 |
rat |
| Hiroyoshi Harada, Masayoshi Mori, Yusuke Murata, Yuri Kohno, Kazuki Terada, Kenji Ohe, Munechika Enjoj. Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus. Neuroscience letters. 2024-06-05. PMID:38838971. |
divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: impact on phosphorylated creb and bdnf protein levels in the rat hippocampus. |
2024-06-05 |
2024-06-08 |
rat |
| Hiroyoshi Harada, Masayoshi Mori, Yusuke Murata, Yuri Kohno, Kazuki Terada, Kenji Ohe, Munechika Enjoj. Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus. Neuroscience letters. 2024-06-05. PMID:38838971. |
however, whether stress episodes divergently could affect hippocampal cyclic amp response element-binding protein (creb)-brain-derived neurotrophic factor (bdnf) signaling remains unclear, a key regulator of psychiatric symptoms. |
2024-06-05 |
2024-06-08 |
rat |
| Mikhail Yu Stepanichev, Diana I Mamedova, Natalia V Gulyaev. Hippocampus under Pressure: Molecular Mechanisms of Development of Cognitive Impairments in SHR Rats. Biochemistry. Biokhimiia. vol 89. issue 4. 2024-06-04. PMID:38831507. |
changes in multiple biochemical glucocorticoid-dependent processes in the hippocampus, including dysfunction of steroid hormones receptors, impairments of neurotransmitter systems, bdnf deficiency, oxidative stress, and neuroinflammation are accompanied by the structural alterations, such as cellular signs of neuroinflammation micro- and astrogliosis, impairments of neurogenesis in the subgranular neurogenic zone, and neurodegenerative processes at the level of synapses, axons, and dendrites up to the death of neurons. |
2024-06-04 |
2024-06-06 |
rat |
| Youjin Wang, Dong Peng, Xiang Zhang, Jiayan Chen, Jianfeng Feng, Runze Zhang, Wanwen Mai, Hongxia Chen, Yan Yang, Yadong Huang, Qihao Zhan. PLCβ4 driven by cadmium-exposure during gestation and lactation contributes to cognitive deficits by suppressing PIP2/PLCγ1/CREB/BDNF signaling pathway in male offspring. Journal of hazardous materials. vol 474. 2024-05-31. PMID:38820747. |
the decreased activation of plcγ1 inhibited the phosphorylation of creb to reduce bdnf transcription, which consequently resulted in the damage of hippocampal neurons and cognitive deficiency. |
2024-05-31 |
2024-06-02 |
rat |
| Youjin Wang, Dong Peng, Xiang Zhang, Jiayan Chen, Jianfeng Feng, Runze Zhang, Wanwen Mai, Hongxia Chen, Yan Yang, Yadong Huang, Qihao Zhan. PLCβ4 driven by cadmium-exposure during gestation and lactation contributes to cognitive deficits by suppressing PIP2/PLCγ1/CREB/BDNF signaling pathway in male offspring. Journal of hazardous materials. vol 474. 2024-05-31. PMID:38820747. |
moreover, the low level of bdnf promoted aep activation to induce aβ deposition in the hippocampus. |
2024-05-31 |
2024-06-02 |
rat |
| Hyo-Sun Choi, Joonki Kim, Sang-Bin Lee, Lijun Zhang, Dowan Kwon, Huynh Nguyen Khanh Tran, Siqi Zhang, Tianqi Huang, Jae Sik Yu, Gakyung Lee, Hyun Ok Yan. Euonymus hamiltonianus Extract Improves Amnesia in APPswe/Tau Transgenic and Scopolamine-Induced Dementia Models. Molecular neurobiology. 2024-05-27. PMID:38801629. |
kgc07eh also improved scopolamine-induced learning and memory impairment in scopolamine-injected mice, and in their cerebral cortex and hippocampus, the expression levels of p-erk, p-creb, p-akt, and bdnf were attenuated. |
2024-05-27 |
2024-05-31 |
mouse |
| Yuan Meng, Lifei Xiao, Ruyun Liu, Juan Du, Ning Liu, Jianqiang Yu, Yanqin Li, Guangyuan L. Antidepressant effect and mechanism of TMP269 on stress-induced depressive-like behavior in mice. Biochemical pharmacology. 2024-05-27. PMID:38801927. |
pharmacological, immunofluorescence and biochemical experiments showed that tmp269 could produce antidepressant effects by inhibiting mouse hippocampal hdac5 and thus modulating its downstream bdnf. |
2024-05-27 |
2024-06-01 |
mouse |
| Annela Avarlaid, Kaisa Falkenberg, Karin Lehe, Giuseppa Mudò, Natale Belluardo, Valentina Di Liberto, Monica Frinchi, Jürgen Tuvikene, Tõnis Timmus. An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons. The Journal of biological chemistry. 2024-05-25. PMID:38796067. |
an upstream enhancer and mef2 transcription factors fine-tune the regulation of the bdnf gene in cortical and hippocampal neurons. |
2024-05-25 |
2024-05-31 |
rat |
| Annela Avarlaid, Kaisa Falkenberg, Karin Lehe, Giuseppa Mudò, Natale Belluardo, Valentina Di Liberto, Monica Frinchi, Jürgen Tuvikene, Tõnis Timmus. An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons. The Journal of biological chemistry. 2024-05-25. PMID:38796067. |
here, we aimed to deepen the knowledge of mef2 transcription factors and their role in the regulation of bdnf comparatively in rat cortical and hippocampal neurons. |
2024-05-25 |
2024-05-31 |
rat |
| Annela Avarlaid, Kaisa Falkenberg, Karin Lehe, Giuseppa Mudò, Natale Belluardo, Valentina Di Liberto, Monica Frinchi, Jürgen Tuvikene, Tõnis Timmus. An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons. The Journal of biological chemistry. 2024-05-25. PMID:38796067. |
as a result, we demonstrate that the mef2 transcription factor-dependent enhancer located at -4.8 kb from the bdnf gene regulates the endogenous expression of bdnf in hippocampal neurons. |
2024-05-25 |
2024-05-31 |
rat |
| Benedikt Grünewald, Jonathan Wickel, Nina Hahn, Vahid Rahmati, Hanna Rupp, Ha-Yeun Chung, Holger Haselmann, Anja S Strauss, Lars Schmidl, Nina Hempel, Lena Grünewald, Anja Urbach, Michael Bauer, Klaus V Toyka, Markus Blaess, Ralf A Claus, Rainer König, Christian Gei. Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-05-24. PMID:38788710. |
the beneficial effects of an enriched environment were accompanied by an increase in brain-derived neurotrophic factor (bdnf) and arc expression in the hippocampus, suggesting that activation of the bdnf-trkb pathway leads to restoration of the pci-induced reduction of arc. |
2024-05-24 |
2024-05-27 |
Not clear |
| Emma E Waddington, David J Allison, Emilie M Calabrese, Cara Pekos, Adrienne Lee, Jeremy J Walsh, Jennifer J Heis. Orienteering combines vigorous-intensity exercise with navigation to improve human cognition and increase brain-derived neurotrophic factor. PloS one. vol 19. issue 5. 2024-05-22. PMID:38776348. |
recent animal research suggests that vigorous exercise, which releases greater amounts of lactate, activates more brain-derived neurotrophic factor (bdnf) in the hippocampus and, thus, may be optimal for supporting cognitive function. |
2024-05-22 |
2024-05-27 |
human |