| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| Yuka Matsuoka, Hibiki Nakasone, Rento Kasahara, Mamoru Fukuch. Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer's Disease Model Mouse. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-10. PMID:39522980. |
in this study, we investigated the temporal dynamics of bdnf expression in the hippocampus of 5xfad mice, an ad model, focusing on sex and age differences and bdnf mrna splice variants. |
2024-11-10 |
2024-11-17 |
mouse |
| Yuka Matsuoka, Hibiki Nakasone, Rento Kasahara, Mamoru Fukuch. Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer's Disease Model Mouse. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-10. PMID:39522980. |
these findings suggest that the expression of specific bdnf splice variants would be maintained at higher levels in the hippocampus of young female mice than in males but may be disrupted in ad model mice. |
2024-11-10 |
2024-11-17 |
mouse |
| Shiva Hashemizadeh, Elham Alaee, Niloofar Aghajani, Hossein Azizi, Saeed Semnania. Atorvastatin facilitates extinction and prevents reinstatement of morphine-induced conditioned place preference in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 181. 2024-11-09. PMID:39520913. |
we found that atorvastatin 1 mg/kg attenuated morphine-seeking behaviors, and this attenuation of reinstatement was partly mediated by the upregulation of brain-derived neurotrophic factor (bdnf) in the prefrontal cortex (pfc) and hippocampus (hipp). |
2024-11-09 |
2024-11-17 |
rat |
| Yan Zhang, Chu-Ke Wei, Ping Wang, Liu-Cheng Zheng, Yang Cheng, Zhen-Hua Ren, Yu-Hong Jin, Yu-You Yao, Huan-Zhong Li. S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress. Scientific reports. vol 14. issue 1. 2024-11-06. PMID:39505897. |
at the molecular level, by western blot and rt-pcr we detected that s-ketamine significantly upregulated the expression of bdnf and psd95 and activated akt and mtor in the hippocampus. |
2024-11-06 |
2024-11-09 |
mouse |
| Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Ni. Fecal microbiota transplantation and short-chain fatty acids improve learning and memory in fluorosis mice by BDNF-PI3K/AKT pathway. Chemico-biological interactions. 2024-11-04. PMID:39491142. |
moreover, the expressions of mrna in hippocampal bdnf, pdk1, akt, bcl-2, and bcl-xl were downregulated in mice exposed to fluoride, but the levels of pi3k, bax, bak, and caspase-7 mrna were upregulated. |
2024-11-04 |
2024-11-06 |
mouse |
| Xinliu Wang, Xin Zhang, Wei Xie, Yuanyuan Wang, Shuxian Zang, Ziyun Ban, Depei Li, Yugai Jia, Yonggang Ga. Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice. Brain research. 2024-11-03. PMID:39490402. |
la increased the expression levels of brain-derived neurotrophic factor (bdnf) and promoted the activation of tropomyosin receptor kinase b (trkb) and camp response element-binding (creb) in the hippocampus of cums-exposed mice or in corticosterone-injured ht22 cells. |
2024-11-03 |
2024-11-06 |
mouse |
| Mario E Lloret-Torres, Jennifer L Barreto-Estrad. LF-DBS of the Ventral Striatum Shortens Persistence for Morphine Place Preference and Modulates BDNF Expression in the Hippocampus. Behavioural brain research. 2024-11-03. PMID:39490421. |
lf-dbs of the ventral striatum shortens persistence for morphine place preference and modulates bdnf expression in the hippocampus. |
2024-11-03 |
2024-11-06 |
Not clear |
| Aiman A Yaseen, Karem H Alzoubi, Nour Al-Sawalha, Omar F Khabour, Anan Jarab, Shirin Ali, Samina Salim, Thomas Eissenber. The Impact of Electronic Cigarette Aerosol Exposure on Spatial Memory Formation: Modulation by Orally Administered Vitamin E. Neurotoxicology. 2024-11-02. PMID:39488233. |
in addition, molecular measures (bdnf, sod, gpx, gsh, and gssg), were measured in rats' hippocampal tissues. |
2024-11-02 |
2024-11-05 |
rat |
| Zhiwei Gao, Jie Peng, Yi Zhang, Zhuo Chen, Rongrong Song, Ze Song, Qijie Feng, Micona Sun, Haojie Zhu, Xu Lu, Rongrong Yang, Chao Huan. Hippocampal SENP3 mediates chronic stress-induced depression-like behaviors by impairing the CREB-BDNF signaling. Neuropharmacology. 2024-11-01. PMID:39486575. |
impaired signaling between cyclic adenosine monophosphate response element binding protein (creb) and brain-derived neurotrophic factor (bdnf) in the hippocampus is generally considered to be the cause of depression. |
2024-11-01 |
2024-11-05 |
mouse |
| Zhiwei Gao, Jie Peng, Yi Zhang, Zhuo Chen, Rongrong Song, Ze Song, Qijie Feng, Micona Sun, Haojie Zhu, Xu Lu, Rongrong Yang, Chao Huan. Hippocampal SENP3 mediates chronic stress-induced depression-like behaviors by impairing the CREB-BDNF signaling. Neuropharmacology. 2024-11-01. PMID:39486575. |
furthermore, infusion of senp3-shrna into the hippocampus failed to suppress cus-induced depression-like behaviors when mice received genetic silencing creb or bdnf in the hippocampus or inhibition of the bdnf receptor by k252a. |
2024-11-01 |
2024-11-05 |
mouse |
| YiShu Zhang, HaiChao Chen, JiaXin Cao, LiPing Gao, YuHong Jin. Maternal separation alters peripheral immune responses associated with IFN-γ and OT in mice. Peptides. 2024-11-01. PMID:39486747. |
additionally, maternal separation led to decreased levels of bdnf, igf2, and creb mrnas in the hippocampus, while levels in the prefrontal cortex (pfc) remained unaffected. |
2024-11-01 |
2024-11-05 |
mouse |
| Yuki Tomiga, Kenichi Tanaka, Joji Kusuyama, Akiko Takano, Yasuki Higaki, Keizo Anzai, Hirokazu Takahash. Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors. American journal of physiology. Gastrointestinal and liver physiology. 2024-10-29. PMID:39470596. |
in the hippocampus, ccl4-induced changes in mrna and protein levels of factors related to anxiety, including bdnf and nnos, were reversed by exercise. |
2024-10-29 |
2024-10-31 |
mouse |
| Yuki Tomiga, Kenichi Tanaka, Joji Kusuyama, Akiko Takano, Yasuki Higaki, Keizo Anzai, Hirokazu Takahash. Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors. American journal of physiology. Gastrointestinal and liver physiology. 2024-10-29. PMID:39470596. |
these results suggested that hepatic fibrosis-related anxiety-like behaviors are induced by excess hippocampal nnos, and the beneficial effects of exercise were mediated by increases in bdnf and reductions in nnos. |
2024-10-29 |
2024-10-31 |
mouse |
| Yuki Tomiga, Kenichi Tanaka, Joji Kusuyama, Akiko Takano, Yasuki Higaki, Keizo Anzai, Hirokazu Takahash. Exercise training ameliorates carbon tetrachloride-induced liver fibrosis and anxiety-like behaviors. American journal of physiology. Gastrointestinal and liver physiology. 2024-10-29. PMID:39470596. |
liver fibrosis-related anxiety-like behaviors could be alleviated through the regulation of hippocampal bdnf and nnos via exercise training. |
2024-10-29 |
2024-10-31 |
mouse |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Fernando Gabriel Altamirano, Ivanna Castro-Pascual, Ivana Tamara Ponce, Cinthia Daiana Coria-Lucero, Ethelina Cargnelutti, Mariana Lucila Ferramola, Marcela Silvia Delgado, Ana Cecilia Anzulovich, María Gabriela Lacost. Late-onset caloric restriction improves cognitive performance and restores circadian patterns of neurotrophic, clock and epigenetic factors in the hippocampus of male old rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-10-24. PMID:39447038. |
our results evidenced the existence of a highly coordinated temporal organization of bmal1, clock, bdnf, trkb, dnmts, sirt1, and pgc-1α in the hippocampus of young adult rats. |
2024-10-24 |
2024-10-28 |
rat |
| Maysam Havasi Mehr, Shahein Momenabadi, Ali Vakili, Abbas Pakdel, Abbas Ali Vafae, Abedin Vakil. Neuroprotective effects of Daphnetin on hippocampal neurons and blood-brain barrier integrity in a mouse model of cerebral ischemia. Brain research bulletin. 2024-10-24. PMID:39447767. |
the purpose of this research was to assess the impact of different doses of daphnetin (dap, a natural compound derived from coumarin) on hippocampus neuronal injury, neurobehavioral function, blood-brain barrier (bbb) integrity, expression of claudin-5, brain-derived neurotrophic factor (bdnf), superoxide dismutase (sod), and inflammatory markers in a mouse model of cerebral ischemia. |
2024-10-24 |
2024-10-28 |
mouse |
| Fardin Sehati, Saereh Hosseindoost, Mina Ranjbaran, Fatemeh Nabavizadeh, Seyed-Morteza Karimian, Soheila Adeli, Elham Zahedi, Leila Chodari, Ghorbangol Ashab. Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model. Drug development research. vol 85. issue 7. 2024-10-23. PMID:39440407. |
hippocampal phosphorylated cyclic-amp responsive element binding protein (p-creb), c-fos, brain-derived neurotrophic factor (bdnf), and h3k9me2, were detected by western blot analysis technique. |
2024-10-23 |
2024-10-25 |
Not clear |
| Ludmila S Inozemtseva, Ksenia A Yatsenko, Natalya Yu Glazova, Andrey A Kamensky, Nikolai F Myasoedov, Natalia G Levitskaya, Igor A Grivennikov, Oleg V Doloto. Antidepressant-Like and Antistress Effects of the ACTH(4-10) Synthetic Analogs Semax and Melanotan II on Male Rats in a Model of Chronic Unpredictable Stress. European journal of pharmacology. 2024-10-23. PMID:39442746. |
we found that chronic treatment with semax and mtii reversed or substantially attenuated cus-induced anhedonia, bw gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of bdnf. |
2024-10-23 |
2024-10-26 |
rat |