| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farah D Lubin, Tania L Roth, J David Sweat. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 42. 2008-10-29. PMID:18923034. |
infusions of zebularine (a dna methyltransferase inhibitor) significantly altered bdnf dna methylation and triggered changes in exon-specific bdnf mrna levels, indicating that altered dna methylation is sufficient to drive differential bdnf transcript regulation in the hippocampus. |
2008-10-29 |
2023-08-12 |
Not clear |
| Farah D Lubin, Tania L Roth, J David Sweat. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 42. 2008-10-29. PMID:18923034. |
in addition, nmda receptor blockade prevented memory-associated alterations in bdnf dna methylation, resulting in a block of altered bdnf gene expression in hippocampus and a deficit in memory formation. |
2008-10-29 |
2023-08-12 |
Not clear |
| Sarah Mustafa, Alex Walker, Geoffrey Bennett, Peter M Wigmor. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702703. |
proliferating cells within the adult dentate gyrus of the hippocampus give rise to new neurons involved in memory and learning and require neurotrophic factors such as brain-derived neurotrophic factor (bdnf) to nurture this process of adult neurogenesis. |
2008-10-23 |
2023-08-12 |
rat |
| Sarah Mustafa, Alex Walker, Geoffrey Bennett, Peter M Wigmor. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702703. |
we propose that systemically administered 5-fu chemotherapy will cause deficits in hippocampal memory that are associated with altered bdnf levels and proliferating cells (particularly vascular-associated cells) in the dentate gyrus. |
2008-10-23 |
2023-08-12 |
rat |
| Sarah Mustafa, Alex Walker, Geoffrey Bennett, Peter M Wigmor. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702703. |
5-fu-induced changes in hippocampal bdnf and doublecortin (dcx) protein levels were quantified using western immunoblotting. |
2008-10-23 |
2023-08-12 |
rat |
| Sarah Mustafa, Alex Walker, Geoffrey Bennett, Peter M Wigmor. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702703. |
in contrast, 5-fu significantly reduced bdnf and dcx levels in the hippocampus, indicating alterations in neurotrophin levels and neurogenesis. |
2008-10-23 |
2023-08-12 |
rat |
| Lei An, You-Zhi Zhang, Neng-Jiang Yu, Xin-Min Liu, Nan Zhao, Li Yuan, Hong-Xia Chen, Yun-Feng L. The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18547700. |
furthermore, xbxt-2 treatment reserved stress-induced decrease of hippocampal bdnf and pcreb (ser133) expression, two important factors which were closely related to hippocampal neurogenesis. |
2008-10-22 |
2023-08-12 |
rat |
| Lei An, You-Zhi Zhang, Neng-Jiang Yu, Xin-Min Liu, Nan Zhao, Li Yuan, Hong-Xia Chen, Yun-Feng L. The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18547700. |
in conclusion, the increase of neurogenesis, as well as expression of bdnf and pcreb in hippocampus may be one of the molecular and cellular mechanisms underlying the antidepressant action of xbxt-2. |
2008-10-22 |
2023-08-12 |
rat |
| Chu-Hsin Shieh, Chen-Jee Hong, Yn-Ho Huang, Shih-Jen Tsa. Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18582526. |
potential antidepressant properties of cysteamine on hippocampal bdnf levels and behavioral despair in mice. |
2008-10-22 |
2023-08-12 |
mouse |
| Chu-Hsin Shieh, Chen-Jee Hong, Yn-Ho Huang, Shih-Jen Tsa. Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18582526. |
other groups of mice treated with the same drugs and doses, without behavioral tests, were sacrificed for hippocampal bdnf measurements. |
2008-10-22 |
2023-08-12 |
mouse |
| Chu-Hsin Shieh, Chen-Jee Hong, Yn-Ho Huang, Shih-Jen Tsa. Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18582526. |
a significant increase in hippocampal bdnf levels was found in the cysteamine 200-mg/kg group (p<0.05). |
2008-10-22 |
2023-08-12 |
mouse |
| Stephen Michael Taylo. Electroconvulsive therapy, brain-derived neurotrophic factor, and possible neurorestorative benefit of the clinical application of electroconvulsive therapy. The journal of ECT. vol 24. issue 2. 2008-10-21. PMID:18580563. |
hippocampal volumes are correlated with decreased expression of neurotrophic factors (most notably, brain-derived neurotrophic factor [bdnf]), and decreased expression of bdnf correlates with the presence of depression. |
2008-10-21 |
2023-08-12 |
Not clear |
| Stephen Michael Taylo. Electroconvulsive therapy, brain-derived neurotrophic factor, and possible neurorestorative benefit of the clinical application of electroconvulsive therapy. The journal of ECT. vol 24. issue 2. 2008-10-21. PMID:18580563. |
increased expression of bdnf has a strong association with increased volumes in the hippocampus. |
2008-10-21 |
2023-08-12 |
Not clear |
| Jia-Xu Chen, Wei Li, Xin Zhao, Jian-Xing Yan. Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats. Cellular and molecular neurobiology. vol 28. issue 5. 2008-10-14. PMID:17647101. |
in rats with chronic immobilization stress (cis), we examined the effects of the xys decoction on tail suspension behavior and the levels of brain-derived neurotrophic factor (bdnf), tyroxine hydroxylase (trkb), and neurotrophin 3 (nt-3) in the frontal cortex and hippocampus. |
2008-10-14 |
2023-08-12 |
rat |
| Jia-Xu Chen, Wei Li, Xin Zhao, Jian-Xing Yan. Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats. Cellular and molecular neurobiology. vol 28. issue 5. 2008-10-14. PMID:17647101. |
biochemically, the xys decoction also reversed cis-induced decreases in bdnf and increases in trkb and nt-3 in the frontal cortex and the hippocampal ca(1) subregion. |
2008-10-14 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. Neurobiology of disease. vol 30. issue 2. 2008-10-13. PMID:18353663. |
sup also enhanced pre-seizure hippocampal levels of bdnf, ngf, and igf-1, which may confer a neuroprotective hippocampal microenvironment that dampens the neuropathological response to and/or helps facilitate recovery from se to protect cognitive function. |
2008-10-13 |
2023-08-12 |
rat |
| T Iu Agapova, Ia V Agniullin, D N Silachev, M I Shadrina, P A Slominskiĭ, S I Shram, S A Limborskaia, N F Miasoedo. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Molekuliarnaia genetika, mikrobiologiia i virusologiia. issue 3. 2008-10-10. PMID:18756821. |
temporary dynamics of bdnf and ngf ex- pression in rat hippocampus and frontal cortex under semax action (50 mg/kg, single intranasal administration) was studied in this work. |
2008-10-10 |
2023-08-12 |
rat |
| M S Costa, P H Botton, S Mioranzza, D O Souza, L O Porciúncul. Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice. Neuroscience. vol 153. issue 4. 2008-10-08. PMID:18436387. |
this preventive effect may involve a decrease in the hippocampal bdnf and trkb immunocontent. |
2008-10-08 |
2023-08-12 |
mouse |
| Sandra H Vaz, Sofia Cristóvão-Ferreira, Joaquim A Ribeiro, Ana M Sebastiã. Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals. Brain research. vol 1219. 2008-10-08. PMID:18539266. |
bdnf (10-200 ng/ml) decreased gat-1-mediated gaba uptake by isolated hippocampal rat nerve terminals (synaptosomes), an effect that occurred within 1 min of incubation with bdnf and blocked by the tyrosine kinase inhibitor k252a (100 nm) as well as by the plc inhibitor, u73122 (3 microm). |
2008-10-08 |
2023-08-12 |
rat |
| Carmela Matrone, Maria Teresa Ciotti, Delio Mercanti, Roberta Marolda, Pietro Calissan. NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18728191. |
ngf and bdnf signaling control amyloidogenic route and abeta production in hippocampal neurons. |
2008-10-06 |
2023-08-12 |
Not clear |