| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauricio G Martin, Simona Perga, Laura Trovò, Andrea Rasola, Pontus Holm, Tomi Rantamäki, Tibor Harkany, Eero Castrén, Federica Chiara, Carlos G Dott. Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Molecular biology of the cell. vol 19. issue 5. 2008-11-12. PMID:18287532. |
moreover, robust trkb activity is evident in old but not young hippocampal neurons differentiating in vitro in the absence of any exogenous neurotrophin and also in neurons from bdnf -/- embryos. |
2008-11-12 |
2023-08-12 |
mouse |
| Ozlem Bozdagi, Erin Rich, Sophie Tronel, Masato Sadahiro, Kamara Patterson, Matthew L Shapiro, Cristina M Alberini, George W Huntley, Stephen R J Salto. The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815270. |
vgf synthesis is stimulated by bdnf, a critical regulator of hippocampal development and function, and two vgf c-terminal peptides increase synaptic activity in cultured hippocampal neurons. |
2008-11-12 |
2023-08-12 |
mouse |
| Ozlem Bozdagi, Erin Rich, Sophie Tronel, Masato Sadahiro, Kamara Patterson, Matthew L Shapiro, Cristina M Alberini, George W Huntley, Stephen R J Salto. The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815270. |
treatment of rat hippocampal slices with the vgf-derived peptide tlqp62 resulted in transient potentiation through a mechanism that was selectively blocked by the bdnf scavenger trkb-fc, the trk tyrosine kinase inhibitor k252a (100 nm), and tpa stop, an inhibitor of tissue plasminogen activator (tpa), an enzyme involved in pro-bdnf cleavage to bdnf, but was not blocked by the nmda receptor antagonist apv, anti-p75(ntr) function-blocking antiserum, or previous tetanic stimulation. |
2008-11-12 |
2023-08-12 |
mouse |
| Marcelo S Costa, Paulo H Botton, Sabrina Mioranzza, Ana Paula Ardais, Julia D Moreira, Diogo O Souza, Lisiane O Porciúncul. Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18620014. |
caffeine improves adult mice performance in the object recognition task and increases bdnf and trkb independent on phospho-creb immunocontent in the hippocampus. |
2008-11-06 |
2023-08-12 |
mouse |
| Marcelo S Costa, Paulo H Botton, Sabrina Mioranzza, Ana Paula Ardais, Julia D Moreira, Diogo O Souza, Lisiane O Porciúncul. Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18620014. |
western blotting analysis of hippocampus from caffeine-treated mice revealed an increase in bdnf and trkb immunocontent, compared to their saline-matched controls. |
2008-11-06 |
2023-08-12 |
mouse |
| Marcelo S Costa, Paulo H Botton, Sabrina Mioranzza, Ana Paula Ardais, Julia D Moreira, Diogo O Souza, Lisiane O Porciúncul. Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18620014. |
our results suggest that acute treatment with caffeine improves recognition memory, and this effect may be related to an increase of the bdnf and trkb immunocontent in the hippocampus. |
2008-11-06 |
2023-08-12 |
mouse |
| Daniela D Pollak, Francisco J Monje, Lee Zuckerman, Christine A Denny, Michael R Drew, Eric R Kande. An animal model of a behavioral intervention for depression. Neuron. vol 60. issue 1. 2008-11-06. PMID:18940595. |
learned safety also increases the expression of bdnf in the hippocampus and leads to downregulation of genes involved in the dopaminergic and neuropeptidergic but not the serotonergic system in the basolateral amygdala. |
2008-11-06 |
2023-08-12 |
mouse |
| Tsutomu Takahashi, Michio Suzuki, Masahiko Tsunoda, Yukiko Kawamura, Nagahide Takahashi, Nobuhisa Maeno, Yasuhiro Kawasaki, Shi-Yu Zhou, Hirofumi Hagino, Lisha Niu, Hiroshi Tsuneki, Soushi Kobayashi, Toshiyasu Sasaoka, Hikaru Seto, Masayoshi Kurachi, Norio Ozak. The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18472202. |
this magnetic resonance imaging study investigated the effect of the genotypic combination of the dopamine d3 receptor (drd3) ser9gly and brain-derived neurotrophic factor (bdnf) val66met polymorphisms on the ai length and volumetric measures of the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) in 33 schizophrenia patients and 29 healthy controls. |
2008-11-05 |
2023-08-12 |
human |
| Fatma Simsek-Duran, György Lonar. The role of RIM1alpha in BDNF-enhanced glutamate release. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18499195. |
here we demonstrate that bdnf enhances depolarization-evoked efflux of [(3)h]-glutamate from nerve terminals isolated from the ca1 region of the hippocampus. |
2008-11-05 |
2023-08-12 |
mouse |
| Anne-Marie T McGauran, J Bernadette Moore, Declan Madsen, Daniel Barry, Shirley O'Dea, Bernard P Mahon, Sean Commin. A possible role for protein synthesis, extracellular signal-regulated kinase, and brain-derived neurotrophic factor in long-term spatial memory retention in the water maze. Behavioral neuroscience. vol 122. issue 4. 2008-11-05. PMID:18729634. |
a second experiment was designed to investigate the effect of psi on the formation of cue-platform associations in the watermaze, and on bdnf and erk expression in the hippocampus. |
2008-11-05 |
2023-08-12 |
Not clear |
| Gil M Lewitus, Hagit Cohen, Michal Schwart. Reducing post-traumatic anxiety by immunization. Brain, behavior, and immunity. vol 22. issue 7. 2008-11-03. PMID:18562161. |
furthermore, we found that the ability to cope with this stress is interrelated with t-cell trafficking and with the brain and hippocampal bdnf levels. |
2008-11-03 |
2023-08-12 |
mouse |
| Ritsuko Katoh-Semba, Masako Tsuzuki, Noriko Miyazaki, Motoko Matsuda, Chiaki Nakagawa, Satoshi Ichisaka, Kaori Sudo, Satoko Kitajima, Michiko Hamatake, Yoshio Hata, Koh-ichi Nagat. A phase advance of the light-dark cycle stimulates production of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex: association with the activation of CREB. Journal of neurochemistry. vol 106. issue 5. 2008-11-03. PMID:18636983. |
the cerebellum, hippocampus and cerebral cortex containing visual cortex (vcx) showed diurnal variation in bdnf protein levels and the vcx also in nt-3 levels. |
2008-11-03 |
2023-08-12 |
rat |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
daily running activity, body weight (bw), ratio of cerebral weight to bw (cw/bw) and expression levels of bdnf and bcl-2 mrna in the hippocampus were determined. |
2008-10-31 |
2023-08-12 |
mouse |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
bdnf and bcl-2 mrna expression levels in the hippocampus were suppressed in the cfs model and tj-41 treated mice, while no significant difference was found between them. |
2008-10-31 |
2023-08-12 |
mouse |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
in this model, reduced daily activity might have been associated with decreased hippocampal bdnf mrna expression, hippocampal apoptosis and brain atrophy. |
2008-10-31 |
2023-08-12 |
mouse |
| Alejandro Hernández, Héctor Burgos, Mauricio Mondaca, Rafael Barra, Héctor Núñez, Hernán Pérez, Rubén Soto-Moyano, Walter Sierralta, Victor Fernández, Ricardo Olivares, Luis Valladare. Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization. Neural plasticity. vol 2008. 2008-10-30. PMID:18604298. |
effect of prenatal protein malnutrition on long-term potentiation and bdnf protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization. |
2008-10-30 |
2023-08-12 |
rat |
| Joshua J Park, Niamh X Cawley, Y Peng Lo. A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Molecular and cellular neurosciences. vol 39. issue 1. 2008-10-29. PMID:18573344. |
a bi-directional carboxypeptidase e-driven transport mechanism controls bdnf vesicle homeostasis in hippocampal neurons. |
2008-10-29 |
2023-08-12 |
Not clear |
| Joshua J Park, Niamh X Cawley, Y Peng Lo. A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Molecular and cellular neurosciences. vol 39. issue 1. 2008-10-29. PMID:18573344. |
in our study, overexpression of the cytoplasmic tail of the carboxypeptidase e (cpe) found in bdnf vesicles significantly reduced localization of bdnf in neurites of hippocampal neurons. |
2008-10-29 |
2023-08-12 |
Not clear |
| Joshua J Park, Niamh X Cawley, Y Peng Lo. A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Molecular and cellular neurosciences. vol 39. issue 1. 2008-10-29. PMID:18573344. |
thus, the cpe cytoplasmic tail binds dynactin that recruits kinesins or dynein for driving bi-directional transport of bdnf vesicle to maintain vesicle homeostasis and secretion in hippocampal neurons. |
2008-10-29 |
2023-08-12 |
Not clear |
| Farah D Lubin, Tania L Roth, J David Sweat. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 42. 2008-10-29. PMID:18923034. |
here, we determined the contribution of chromatin remodeling to learning-induced changes in brain-derived neurotrophic factor (bdnf) gene expression in the adult hippocampus. |
2008-10-29 |
2023-08-12 |
Not clear |