| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yusufhan Yazir, Tijen Utkan, Feyza Ariciogl. Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress. Basic & clinical pharmacology & toxicology. vol 111. issue 3. 2012-12-21. PMID:22385503. |
cums also significantly decreased bdnf protein levels in the ca1 and ca3 regions of the hippocampus, which was reversed by 3-br-7-ni and odq administration. |
2012-12-21 |
2023-08-12 |
rat |
| Satoshi Okuyama, Naoko Shimada, Miki Kaji, Mayu Morita, Kazuhiro Miyoshi, Sona Minami, Yoshiaki Amakura, Morio Yoshimura, Takashi Yoshida, Sono Watanabe, Mitsunari Nakajima, Yoshiko Furukaw. Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22985518. |
in the present study using a transient global ischemia mouse model, we showed that (1) a citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (hmf) induced the phosphorylation of extracellular signal-regulated kinases 1/2 (erk1/2) and camp response element-binding protein (creb) in the hippocampus after ischemia; (2) hmf increased the expression of brain-derived neurotrophic factor (bdnf), a representative neurotrophic factor in the central nervous system, in the hippocampal dentate gyrus, and most bdnf-positive cells were also stained with anti-glial fibrillary acidic protein (one of the major intermediate filament proteins of mature astrocytes) and (3) hmf increased doublecortin positive neuronal precursor cells in the dentate gyrus subventricular zone or subgranular zone. |
2012-12-20 |
2023-08-12 |
mouse |
| Yoko Furukawa-Hibi, Atsumi Nitta, Hidefumi Fukumitsu, Hitomi Somiya, Kazuya Toriumi, Shoei Furukawa, Toshitaka Nabeshima, Kiyofumi Yamad. Absence of SHATI/Nat8l reduces social interaction in mice. Neuroscience letters. vol 526. issue 2. 2012-12-19. PMID:22940080. |
lack of the shati gene increased brain-derived neurotrophic factor (bdnf) mrna in the prefrontal cortex and hippocampus, and decreased glial cell line-derived neurotrophic factor (gdnf) mrna in the striatum and hippocampus, and lipopolysaccharides-induced tnf-α factor (litaf) mrna in the striatum. |
2012-12-19 |
2023-08-12 |
mouse |
| Wenjun Xie, Kai Zhang, Bianxiao Cu. Functional characterization and axonal transport of quantum dot labeled BDNF. Integrative biology : quantitative biosciences from nano to macro. vol 4. issue 8. 2012-12-18. PMID:22772872. |
here we labeled bdnf with bright, photostable quantum dots (qd-bdnf) and followed the axonal transport of qd-bdnf in real time in hippocampal neurons. |
2012-12-18 |
2023-08-12 |
Not clear |
| S Chourbaji, H Hörtnagl, R Molteni, M A Riva, P Gass, R Hellwe. The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience. vol 220. 2012-12-14. PMID:22710068. |
to investigate the basis of this behavioral "rescue" effect, we analyzed neurochemical changes (bdnf expression, serotonergic changes, and corticosterone) in the hippocampus, frontal cortex and hypothalamus of animals housed under respective conditions. |
2012-12-14 |
2023-08-12 |
mouse |
| S Chourbaji, H Hörtnagl, R Molteni, M A Riva, P Gass, R Hellwe. The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience. vol 220. 2012-12-14. PMID:22710068. |
in male mice, enrichment induced an increase of bdnf expression in the hippocampus of both bdnf heterozygous (bdnf(+/-)) and wild-types. |
2012-12-14 |
2023-08-12 |
mouse |
| S Chourbaji, H Hörtnagl, R Molteni, M A Riva, P Gass, R Hellwe. The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience. vol 220. 2012-12-14. PMID:22710068. |
in female mice, environmental enrichment did not affect bdnf expression in the hippocampus and hypothalamus. |
2012-12-14 |
2023-08-12 |
mouse |
| S Chourbaji, H Hörtnagl, R Molteni, M A Riva, P Gass, R Hellwe. The impact of environmental enrichment on sex-specific neurochemical circuitries - effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience. vol 220. 2012-12-14. PMID:22710068. |
only in male bdnf(+/-) mice the rescue is related to an increase in hippocampal bdnf expression suggesting that enrichment triggers different neuronal systems in a gender-specific manner. |
2012-12-14 |
2023-08-12 |
mouse |
| Juan Gibert Rahol. Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression? Current neuropharmacology. vol 10. issue 2. 2012-12-12. PMID:23204984. |
although scientists are still a long way from understanding its true aetiology, the neurobiological concept of depression has evolved from receptor regulation disorder, to a neurodegenerative disorder with a hippocampal volume decrease with the controversial reduction in neurotrophins such as bdnf, to current hypotheses that consider depression to be an inflammatory and neuroprogressive process. |
2012-12-12 |
2023-08-12 |
Not clear |
| H Stuke, R Hellweg, F Bermpoh. [The development of depression: the role of brain-derived neurotrophic factor]. Der Nervenarzt. vol 83. issue 7. 2012-12-10. PMID:21947218. |
as a possible mechanism of bdnf action, a reactivation of neuroplasticity is being discussed, especially in hippocampal and cortical networks. |
2012-12-10 |
2023-08-12 |
Not clear |
| Daria Peleg-Raibstein, Edlira Luca, Christian Wolfru. Maternal high-fat diet in mice programs emotional behavior in adulthood. Behavioural brain research. vol 233. issue 2. 2012-12-10. PMID:22633920. |
in addition, brain-derived neurotrophic factor (bdnf) was significantly increased in the dorsal hippocampus, while gaba(a) alpha2 receptor subunit and 5-hydroxytryptamine 1a (5-ht1a) receptor showed increased levels in the ventral hippocampus. |
2012-12-10 |
2023-08-12 |
mouse |
| Franciela P Della, Helena M Abelaira, Gislaine Z Réus, Karine F Ribeiro, Altamir R Antunes, Giselli Scaini, Isabela C Jeremias, Lis Mairá M dos Santos, Gabriela C Jeremias, Emilio L Streck, João Queved. Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats. Behavioural brain research. vol 233. issue 2. 2012-12-10. PMID:22659397. |
the bdnf levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, bdnf levels were increased in the prefrontal and hippocampus with tianeptine. |
2012-12-10 |
2023-08-12 |
rat |
| Gislaine Z Réus, Helena M Abelaira, Fabiano R Agostinho, Karine F Ribeiro, Marcelo F Vitto, Thais F Luciano, Claúdio T de Souza, João Queved. The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. Journal of psychiatric research. vol 46. issue 8. 2012-12-04. PMID:22575330. |
adult wistar rats received an acute injection of olz (3 or 6 mg/kg) and/or flx (12.5 or 25 mg/kg), and were evaluated for akt, bdnf, creb, bcl-2 and bad protein levels in the prefrontal cortex, hippocampus and striatum. |
2012-12-04 |
2023-08-12 |
rat |
| Gislaine Z Réus, Helena M Abelaira, Fabiano R Agostinho, Karine F Ribeiro, Marcelo F Vitto, Thais F Luciano, Claúdio T de Souza, João Queved. The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. Journal of psychiatric research. vol 46. issue 8. 2012-12-04. PMID:22575330. |
our results showed that treatment with flx and olz alone or in combination increased the akt, creb, bdnf, bcl-2 and bad levels in the prefrontal cortex, hippocampus and striatum. |
2012-12-04 |
2023-08-12 |
rat |
| G Paslakis, W F Blum, M Deuschl. Intranasal insulin-like growth factor I (IGF-I) as a plausible future treatment of depression. Medical hypotheses. vol 79. issue 2. 2012-11-30. PMID:22626951. |
data have shown that bdnf plus igf-i are more effective than either neurotrophin alone in activating neurotrophic cascades and promoting survival of hippocampal neurons. |
2012-11-30 |
2023-08-12 |
human |
| G Paslakis, W F Blum, M Deuschl. Intranasal insulin-like growth factor I (IGF-I) as a plausible future treatment of depression. Medical hypotheses. vol 79. issue 2. 2012-11-30. PMID:22626951. |
in fact, it has been suggested that the increase in hippocampal bdnf following antidepressant treatment or physical exercise in animal models is igf-i-dependent and that antidepressant treatment increases igf-i in human cerebrospinal fluid (csf). |
2012-11-30 |
2023-08-12 |
human |
| G Martinotti, G Di Iorio, S Marini, V Ricci, D De Berardis, M Di Giannantoni. Nerve growth factor and brain-derived neurotrophic factor concentrations in schizophrenia: a review. Journal of biological regulators and homeostatic agents. vol 26. issue 3. 2012-11-30. PMID:23034254. |
low serum bdnf levels were associated with reduction in hippocampal volume (hv) at the onset of schizophrenia. |
2012-11-30 |
2023-08-12 |
Not clear |
| Karin Wibrand, Balagopal Pai, Taweeporn Siripornmongcolchai, Margarethe Bittins, Birgitte Berentsen, May Lillian Ofte, Arwed Weigel, Kai Ove Skaftnesmo, Clive R Bramha. MicroRNA regulation of the synaptic plasticity-related gene Arc. PloS one. vol 7. issue 7. 2012-11-28. PMID:22844515. |
in primary rat hippocampal neuronal cultures, ectopic expression of mir-34a, mir-193a, or mir-326, downregulated endogenous arc protein expression in response to bdnf treatment. |
2012-11-28 |
2023-08-12 |
human |
| Alexander V Kulikov, Maria A Tikhonova, Elizabeth A Kulikova, Konstantin P Volcho, Tatyana M Khomenko, Nariman F Salakhutdinov, Nina K Popov. A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice. Psychopharmacology. vol 221. issue 3. 2012-11-26. PMID:22127556. |
a new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (tc-2153), decreased hereditary catalepsy and increased the bdnf gene expression in the hippocampus in mice. |
2012-11-26 |
2023-08-12 |
mouse |
| Nataly Ladurelle, Cecilia Gabriel, Adela Viggiano, Elisabeth Mocaër, Etienne E Baulieu, Massimiliano Bianch. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology. vol 221. issue 3. 2012-11-26. PMID:22160164. |
agomelatine (s20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and bdnf in the rat hippocampus, amygdala and pfc. |
2012-11-26 |
2023-08-12 |
rat |