| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
conversely, chronic cort treatment in non-runners significantly impaired spatial learning and suppressed cell proliferation in association with a decreased trend in plasma bdnf level and a significant increase in hippocampal bdnf levels. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
running counteracted cognitive deficit and restored hippocampal cell proliferation following chronic cort treatment; but without corresponding changes in plasma bdnf and igf-1 levels. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
the results suggest that the beneficial effects of acute stress on cognitive improvement may be mediated by bdnf-enhanced synaptic plasticity that is hippocampal cell proliferation-independent, whereas chronic stress may impair cognition by decreasing hippocampal cell proliferation and bdnf levels. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
furthermore, the results indicate a trend in changes of plasma bdnf levels associated with a significant alteration in hippocampal levels, suggesting that treatment with running/cort for 4 weeks may induce a change in central levels of hippocampal bdnf level, which may not lead to a significant change in peripheral levels. |
2013-01-24 |
2023-08-12 |
rat |
| R Hanaya, H Hosoyama, S Sugata, M Tokudome, H Hirano, H Tokimura, K Kurisu, T Serikawa, M Sasa, K Arit. Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure. Neuroscience. vol 221. 2013-01-23. PMID:22766234. |
the spontaneously epileptic rat (ser) is a double mutant (zi/zi, tm/tm) which begins to exhibit tonic convulsions and absence seizures after 6 weeks of age, and repetitive tonic seizures over time induce sclerosis-like changes in ser hippocampus with high brain-derived neurotrophic factor (bdnf) expression. |
2013-01-23 |
2023-08-12 |
rat |
| R Hanaya, H Hosoyama, S Sugata, M Tokudome, H Hirano, H Tokimura, K Kurisu, T Serikawa, M Sasa, K Arit. Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure. Neuroscience. vol 221. 2013-01-23. PMID:22766234. |
bdnf distributions portrayed higher values in the entorhinal and piriform cortices which would relate with hippocampal sclerosis-like changes. |
2013-01-23 |
2023-08-12 |
rat |
| Bo Xing, Juan Guo, Xia Meng, Shu-guang Wei, Sheng-bin L. The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22776159. |
bdnf protein was significantly decreased in prefrontal cortex, though not in hippocampus, of the d1 receptor knockout mice, whereas no changes were found in both prefrontal cortex and hippocampus of d3 receptor knockout mice. |
2013-01-23 |
2023-08-12 |
mouse |
| Sanghyeon Kim, Katerina Zavitsanou, George Gurguis, Maree J Webste. Neuropathology markers and pathways associated with molecular targets for antipsychotic drugs in postmortem brain tissues: exploration of drug targets through the Stanley Neuropathology Integrative Database. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 10. 2013-01-18. PMID:22356822. |
the neo analysis revealed that htr2a and grm2 are likely to regulate bdnf levels in the hippocampus and frontal cortex, respectively, whereas drd2 and adra2a activity are likely to be regulated by bdnf in the frontal cortex. |
2013-01-18 |
2023-08-12 |
Not clear |
| Amine Bahi, Jean-Luc Dreye. Hippocampus-specific deletion of tissue plasminogen activator "tPA" in adult mice impairs depression- and anxiety-like behaviors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 9. 2013-01-17. PMID:22377193. |
we also found that bdnf protein levels were elevated in the hippocampus of mice receiving tpa-expressing vectors. |
2013-01-17 |
2023-08-12 |
mouse |
| Gaston Calfa, Christopher A Chapleau, Susan Campbell, Takafumi Inoue, Sarah J Morse, Farah D Lubin, Lucas Pozzo-Mille. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus. vol 22. issue 7. 2013-01-15. PMID:22161912. |
by using two different inhibitors of histone deacetylases (hdacs), we describe here that their activity is required for bdnf to increase dendritic spine density and excitatory quantal transmitter release onto ca1 pyramidal neurons in hippocampal slice cultures. |
2013-01-15 |
2023-08-12 |
human |
| Gaston Calfa, Christopher A Chapleau, Susan Campbell, Takafumi Inoue, Sarah J Morse, Farah D Lubin, Lucas Pozzo-Mille. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus. vol 22. issue 7. 2013-01-15. PMID:22161912. |
these results suggest that histone acetylation/deacetylation is a critical step in the modulation of hippocampal synapses by bdnf. |
2013-01-15 |
2023-08-12 |
human |
| Aaron Y Lai, Kamaldeep S Dhami, Comfort D Dibal, Kathryn G Tod. Neonatal rat microglia derived from different brain regions have distinct activation responses. Neuron glia biology. vol 7. issue 1. 2013-01-14. PMID:22857737. |
primary microglial cultures were prepared from brainstem (brs), cortex (ctx), hippocampus (hip), striatum (str) and thalamus (thl) of 1-day-old rats and were shown to upregulate the release of nitric oxide (no) and brain-derived neurotrophic factor (bdnf) in a region- and activator-specific manner. |
2013-01-14 |
2023-08-12 |
rat |
| Jos Prickaerts, Jochen De Vry, Janneke Boere, Gunter Kenis, Maria S Quinton, Sharon Engel, Larry Melnick, Rudy Schreibe. Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. Journal of molecular neuroscience : MN. vol 48. issue 1. 2013-01-09. PMID:22581450. |
differential bdnf responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. |
2013-01-09 |
2023-08-12 |
rat |
| Jos Prickaerts, Jochen De Vry, Janneke Boere, Gunter Kenis, Maria S Quinton, Sharon Engel, Larry Melnick, Rudy Schreibe. Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. Journal of molecular neuroscience : MN. vol 48. issue 1. 2013-01-09. PMID:22581450. |
twenty-one days of oral treatment (30 mg/kg) with the dual serotonin/noradrenaline reuptake inhibitor duloxetine or the triple serotonin/noradrenaline/dopamine reuptake inhibitor dov 216,303 restored bdnf protein levels in the rat hippocampus, which were initially decreased due to injection stress. |
2013-01-09 |
2023-08-12 |
rat |
| Emily G Waterhouse, Juan Ji An, Lauren L Orefice, Maryna Baydyuk, Guey-Ying Liao, Kang Zheng, Bai Lu, Baoji X. BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 41. 2013-01-03. PMID:23055503. |
kcl-induced membrane depolarization stimulated release of dendritic bdnf translated from long 3' utr bdnf mrna in cultured hippocampal neurons, but not from short 3' utr bdnf mrna. |
2013-01-03 |
2023-08-12 |
mouse |
| Wei Li, Gaston Calfa, Jennifer Larimore, Lucas Pozzo-Mille. Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 42. 2012-12-31. PMID:23027959. |
activity-dependent bdnf release and trpc signaling is impaired in hippocampal neurons of mecp2 mutant mice. |
2012-12-31 |
2023-08-12 |
mouse |
| Wei Li, Gaston Calfa, Jennifer Larimore, Lucas Pozzo-Mille. Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 42. 2012-12-31. PMID:23027959. |
bdnf mrna and protein levels are also lower in mecp2 mutant hippocampus and dentate gyrus granule cells, which is reflected in impaired activity-dependent release of endogenous bdnf estimated from trpc currents and dendritic ca(2+) signals in ca3 pyramidal neurons. |
2012-12-31 |
2023-08-12 |
mouse |
| Ammar Kutiyanawalla, Wanwisa Promsote, Alvin Terry, Anilkumar Pilla. Cysteamine treatment ameliorates alterations in GAD67 expression and spatial memory in heterozygous reeler mice. The international journal of neuropsychopharmacology. vol 15. issue 8. 2012-12-28. PMID:21777509. |
we found that cysteamine administration (150 mg/kg.d, through drinking water) for 30 d significantly ameliorated the decreases in gad67, mature bdnf and full-length trkb protein levels found in frontal cortex and hippocampus of hrm. |
2012-12-28 |
2023-08-12 |
mouse |
| Ammar Kutiyanawalla, Wanwisa Promsote, Alvin Terry, Anilkumar Pilla. Cysteamine treatment ameliorates alterations in GAD67 expression and spatial memory in heterozygous reeler mice. The international journal of neuropsychopharmacology. vol 15. issue 8. 2012-12-28. PMID:21777509. |
a significant attenuation of the increased levels of truncated bdnf in frontal cortex and hippocampus, as well as truncated trkb in frontal cortex of hrm was also observed following cysteamine treatment. |
2012-12-28 |
2023-08-12 |
mouse |
| Bombi Lee, Bongjun Sur, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 16. issue 6. 2012-12-28. PMID:23269899. |
ber administration also significantly blocked the increase in hypothalamic crf expression and th expression in the locus coeruleus (lc) and the decrease in hippocampal brain-derived neurotrophic factor (bdnf) mrna expression. |
2012-12-28 |
2023-08-12 |
rat |