| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qun Wang, Yong Lin, Qiang Zhang, Si-Qing Sun, Xue-Feng Lin. [Changes of BDNF expression in hippocampus and serum of rats with artificial chronic obstructive pulmonary disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 6. 2013-02-21. PMID:22193444. |
smoking and intratracheal instillation of lps induce the increase of bdnf level in the hippocampus and serum. |
2013-02-21 |
2023-08-12 |
rat |
| Jane Evans, Yuhui Sun, Ailsa McGregor, Bronwen Conno. Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress. Neuropharmacology. vol 63. issue 8. 2013-02-20. PMID:22939998. |
this will result in increased glucocorticoid levels and reduced bdnf expression, leading to impaired hippocampal neurogenesis and the precipitation of depression/anxiety. |
2013-02-20 |
2023-08-12 |
Not clear |
| Hee Ra Park, Kyoung Hye Kong, Byung Pal Yu, Mark P Mattson, Jaewon Le. Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. The Journal of biological chemistry. vol 287. issue 51. 2013-02-14. PMID:23105098. |
resveratrol down-regulated the levels of the phosphorylated form of cyclic amp response element-binding protein (pcreb) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2013-02-14 |
2023-08-12 |
mouse |
| Hee Ra Park, Kyoung Hye Kong, Byung Pal Yu, Mark P Mattson, Jaewon Le. Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. The Journal of biological chemistry. vol 287. issue 51. 2013-02-14. PMID:23105098. |
our findings suggest that resveratrol, unlike dr, adversely affects hippocampal neurogenesis and cognitive function by a mechanism involving activation of ampk and suppression of creb and bdnf signaling. |
2013-02-14 |
2023-08-12 |
mouse |
| Annerieke S R Sierksma, Kris Rutten, Sebastian Sydlik, Somayeh Rostamian, Harry W M Steinbusch, Daniel L A van den Hove, Jos Prickaert. Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neuropharmacology. vol 64. 2013-02-11. PMID:22771768. |
based on previous research, we hypothesized that chronic pde2i treatment would improve ad-related cognitive deficits, by decreasing amyloid-β (aβ) plaque load, enhancing pcreb and bdnf levels and increasing synaptic density in the hippocampus of 8-month-old appswe/ps1de9 mice. |
2013-02-11 |
2023-08-12 |
mouse |
| Annerieke S R Sierksma, Kris Rutten, Sebastian Sydlik, Somayeh Rostamian, Harry W M Steinbusch, Daniel L A van den Hove, Jos Prickaert. Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neuropharmacology. vol 64. 2013-02-11. PMID:22771768. |
however, no treatment effects were observed on aβ plaque load, pcreb or bdnf concentrations, or presynaptic density in the hippocampus, suggesting that other signaling pathways and/or effector molecules might be responsible for its cognition-enhancing effects. |
2013-02-11 |
2023-08-12 |
mouse |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal bdnf immunocontent in middle-aged rats. |
2013-02-11 |
2023-08-12 |
rat |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
because brain-derived neurotrophic factor (bdnf) is associated with memory formation and bdnf's actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/ml drinking solution for 30 days) on short- and long term memory and on levels of hippocampal probdnf, mature bdnf, trkb and creb in young (3 month old) and middle-aged (12 month old) rats. |
2013-02-11 |
2023-08-12 |
rat |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
caffeine treatment substantially reduced i) age-related impairments in the two types of memory in an inhibitory avoidance paradigm, and ii) parallel increases in hippocampal bdnf levels. |
2013-02-11 |
2023-08-12 |
rat |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
these data provide new evidence in favor of the hypothesis that modifications in bdnf and related proteins in the hippocampus contribute to the pro-cognitive effects of caffeine on age-associated losses in memory encoding. |
2013-02-11 |
2023-08-12 |
rat |
| Catarina Rendeiro, David Vauzour, Rebecca J Kean, Laurie T Butler, Marcus Rattray, Jeremy P E Spencer, Claire M William. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology. vol 223. issue 3. 2013-02-04. PMID:22569815. |
blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal bdnf mrna expression in young rats. |
2013-02-04 |
2023-08-12 |
rat |
| Dillon Y Chen, Dhananjay Bambah-Mukku, Gabriella Pollonini, Cristina M Alberin. Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation. Nature neuroscience. vol 15. issue 12. 2013-01-29. PMID:23160045. |
hippocampal administration of bdnf, but not of other neurotrophins, selectively rescued both the amnesia and the molecular impairments produced by glucocorticoid receptor inhibition. |
2013-01-29 |
2023-08-12 |
rat |
| János Kállmán, Magdolna Pákáski, Szabina Szucs, Sára Kálmán, Orsike Fazekas, Petra Santha, Gyula Szabó, Zoltán Janka, János Kálmá. [The role of immobilization stress and sertindole on the expression of APP, MAPK-1 and beta-actin genes in rat brain]. Ideggyogyaszati szemle. vol 65. issue 11-12. 2013-01-25. PMID:23289174. |
as one of its multiple effects, elevated blood cortisol levels decrease the synthesis of the neuroprotective bdnf, thus leading to hippocampal atrophy and synapse loss, and rendering it a possible cause for the alzheimer's disease (ad) related neuropathological and cognitive changes. |
2013-01-25 |
2023-08-12 |
rat |
| Renata Suchanek, Aleksander Owczarek, Jan Kowalsk. Association study between BDNF C-281A polymorphism and paranoid schizophrenia in Polish population. Journal of molecular neuroscience : MN. vol 46. issue 1. 2013-01-24. PMID:21710362. |
polymorphism c-281a (rs28383487) in bdnf gene leads to the reduction of promoter activity in the hippocampal neurons in vitro. |
2013-01-24 |
2023-08-12 |
Not clear |
| G E Hodes, B R Brookshire, T E Hill-Smith, S L Teegarden, O Berton, I Luck. Strain differences in the effects of chronic corticosterone exposure in the hippocampus. Neuroscience. vol 222. 2013-01-24. PMID:22735575. |
chronic cort exposure also reduced protein levels of brain-derived neurotrophic factor (bdnf) in the hippocampus of c57bl/6j but not mrl/mpj mice. |
2013-01-24 |
2023-08-12 |
mouse |
| M S Costa, A P Ardais, G T Fioreze, S Mioranzza, P H S Botton, D O Souza, J B T Rocha, L O Porciúncul. The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats. Neuroscience. vol 222. 2013-01-24. PMID:22796076. |
aversive and recognition memory were assessed as well as the immunocontent of probdnf, bdnf and tyrosine kinase receptor type b (trkb) in the hippocampus. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
previous studies have shown that a 2-week treatment with 40 mg/kg corticosterone (cort) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (bdnf) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
bdnf and insulin-like growth factor (igf-1) have been suggested to mediate physical exercise-enhanced hippocampal neurogenesis and cognition. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
we examined the effects of acute (5 days) and chronic (4 weeks) treatment with cort and/or wheel running on (1) hippocampal cell proliferation, (2) spatial learning and memory and (3) plasma levels of bdnf and igf-1. |
2013-01-24 |
2023-08-12 |
rat |
| S-Y Yau, B W-M Lau, E-D Zhang, J C-D Lee, A Li, T M C Lee, Y-P Ching, A-M Xu, K-F S. Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats. Neuroscience. vol 222. 2013-01-24. PMID:22813995. |
acute cort-treated non-runners showed an increased trend in plasma bdnf levels together with a significant increase in hippocampal bdnf levels. |
2013-01-24 |
2023-08-12 |
rat |