| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinlan Li, Min Jia, Guiqin Chen, Shuke Nie, Cong Zheng, Weiqi Zeng, Yan Xu, Congping Wang, Xuebing Cao, Qunhui Li. Involvement of p38 mitogen-activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes. Basic & clinical pharmacology & toxicology. vol 125. issue 4. 2020-02-14. PMID:31063681. |
compared with the control injected intraperitoneally with equal volume of air, the dry weight/wet weight (dw/ww) ratio of brain water content, levels of aqp1, aqp4, phosph-p38 mitogen-activated protein kinase (p-p38 mapk) and astrocyte marker, glial fibrillary acidic protein (gfap) in the frontal cortex and hippocampal ca1 of acute co poisoning group significantly increased at 6, 12, 24 hours after co injection. |
2020-02-14 |
2023-08-13 |
rat |
| Aasef G Shaikh, Mario Mant. Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. Cerebellum (London, England). vol 18. issue 4. 2020-01-13. PMID:31028519. |
aqp4 is particularly expressed in ependymal/subependymal astrocytes and glia limitans astrocyte processes, including around the fourth ventricle. |
2020-01-13 |
2023-08-13 |
Not clear |
| George W Farr, Christopher H Hall, Susan M Farr, Ramon Wade, Joshua M Detzel, Amielia G Adams, Jasen M Buch, Derek L Beahm, Christopher A Flask, Kui Xu, Joseph C LaManna, Paul R McGuirk, Walter F Boron, Marc F Pelletie. Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury. Neuroscience. vol 404. 2019-12-24. PMID:30738082. |
during the development of cytotoxic and subsequent ionic cerebral edema water enters the brain by moving across an intact blood brain barrier and through aquaporin-4 (aqp4) at astrocyte endfeet. |
2019-12-24 |
2023-08-13 |
Not clear |
| Raphaël Bernard-Valnet, Alvaro Cobo-Calvo, Aurore Siegfried, Raluca Marasescu, Mickael Bonnan, Guillaume Ballan, Emmanuel Ellie, Jan Bauer, Emmanuelle Uro-Coste, Romain Marignier, David Brassa. Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series. Multiple sclerosis and related disorders. vol 31. 2019-12-23. PMID:30954932. |
neuromyelitis optica spectrum disorder (nmosd) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (aqp4) expressed on astrocyte end-feet. |
2019-12-23 |
2023-08-13 |
Not clear |
| Laura Maria Azzurra Camassa, Lisa K Lunde, Eystein H Hoddevik, Maria Stensland, Henning B Boldt, Gustavo A De Souza, Ole P Ottersen, Mahmood Amiry-Moghadda. Mechanisms underlying AQP4 accumulation in astrocyte endfeet. Glia. vol 63. issue 11. 2019-11-20. PMID:26119521. |
mechanisms underlying aqp4 accumulation in astrocyte endfeet. |
2019-11-20 |
2023-08-13 |
Not clear |
| Fumitaka Shimizu, Hideaki Nishihara, Takashi Kand. Blood-brain barrier dysfunction in immuno-mediated neurological diseases. Immunological medicine. vol 41. issue 3. 2019-11-20. PMID:30938273. |
in the development of nmo, circulating aqp4 autoantibodies need to pass through the bbb in order to reach aqp4 on the astrocyte endfeet. |
2019-11-20 |
2023-08-13 |
Not clear |
| Junya Sato, Sayo Horibe, Shoji Kawauchi, Naoto Sasaki, Ken-Ichi Hirata, Yoshiyuki Rikitak. Involvement of aquaporin-4 in laminin-enhanced process formation of mouse astrocytes in 2D culture: Roles of dystroglycan and α-syntrophin in aquaporin-4 expression. Journal of neurochemistry. vol 147. issue 4. 2019-10-07. PMID:29981530. |
knockdown of dystroglycan or α-syntrophin, constituent proteins of the dystrophin-glycoprotein complex that provides a link between laminin and the cytoskeleton, using small interference rnas inhibited astrocyte process formation and branching, and down-regulated expression of the water channel aquaporin-4 (aqp4). |
2019-10-07 |
2023-08-13 |
mouse |
| Junya Sato, Sayo Horibe, Shoji Kawauchi, Naoto Sasaki, Ken-Ichi Hirata, Yoshiyuki Rikitak. Involvement of aquaporin-4 in laminin-enhanced process formation of mouse astrocytes in 2D culture: Roles of dystroglycan and α-syntrophin in aquaporin-4 expression. Journal of neurochemistry. vol 147. issue 4. 2019-10-07. PMID:29981530. |
direct knockdown and a specific inhibitor of aqp4 also inhibited, whereas over-expression of aqp4 enhanced astrocyte process formation and branching. |
2019-10-07 |
2023-08-13 |
mouse |
| Amandine Jullienne, Andrew M Fukuda, Aleksandra Ichkova, Nina Nishiyama, Justine Aussudre, André Obenaus, Jérôme Badau. Modulating the water channel AQP4 alters miRNA expression, astrocyte connectivity and water diffusion in the rodent brain. Scientific reports. vol 8. issue 1. 2019-09-18. PMID:29520011. |
modulating the water channel aqp4 alters mirna expression, astrocyte connectivity and water diffusion in the rodent brain. |
2019-09-18 |
2023-08-13 |
rat |
| Hiroshi Kuroda, Kazuo Fujihar. [Current Status and Prospects of Complement-Targeting Therapy for Neuromyelitis Optica]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 6. 2019-08-07. PMID:31171754. |
however, several studies on the pathogehesis of the disease in human pathology, cultured cells, and animal models have revealed that astrocyte injury in nmo is mainly caused by the complement-dependent cytotoxicity following aqp4-igg binding to aqp4. |
2019-08-07 |
2023-08-13 |
human |
| Nasrin Asgari, Sven Jarius, Helle Laustrup, Hanne Pb Skejoe, Soeren T Lillevang, Brian G Weinshenker, Anne Vos. Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A predominantly population-based study. Multiple sclerosis (Houndmills, Basingstoke, England). vol 24. issue 3. 2019-07-26. PMID:28326889. |
serum immunoglobulin g targeting the astrocyte water channel aquaporin-4 (aqp4) in the central nervous system (cns) is a biomarker for neuromyelitis optica spectrum disease (nmosd). |
2019-07-26 |
2023-08-13 |
Not clear |
| Stefania Rosito, Grazia Paola Nicchia, Claudia Palazzo, Anna Lia, Cinzia Buccoliero, Francesco Pisani, Maria Svelto, Maria Trojano, Antonio Friger. Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica. Journal of cellular and molecular medicine. vol 22. issue 2. 2019-04-29. PMID:29055082. |
super-resolution microscopy analysis with g-sted revealed different aqp4 organization in native tissues, while in the brain perivascular astrocyte endfoot membrane aqp4 was mainly organized in large interconnected and raft-like clusters, in the sarcolemma of fast-twitch fibres aqp4 aggregates often appeared as small, relatively isolated linear entities. |
2019-04-29 |
2023-08-13 |
human |
| Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao, Shao L. Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease. Current pharmaceutical design. vol 23. issue 33. 2019-04-25. PMID:28714415. |
in this paper, we review how aqp4 and altered astrocyte functions interact in ad, and provide experimental evidence highlighting the importance of this topic for the future investigations. |
2019-04-25 |
2023-08-13 |
Not clear |
| Yueying Zheng, Caifei Pan, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zh. miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncology reports. vol 41. issue 3. 2019-03-11. PMID:30628716. |
aqp4 was the target of mir‑29a, which suppressed aqp4 expression, and knockdown of aqp4 mitigated ogd‑induced astrocyte injury. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yueying Zheng, Caifei Pan, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zh. miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncology reports. vol 41. issue 3. 2019-03-11. PMID:30628716. |
aqp4 exacerbated astrocyte injury following ischemic stroke, and knockdown of aqp4 protected ogd/rx‑induced primary cultured astrocytes against injury. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yueying Zheng, Caifei Pan, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zh. miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncology reports. vol 41. issue 3. 2019-03-11. PMID:30628716. |
these findings indicated that mir‑29a prevented astrocyte injury in vitro by inhibiting aqp4. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yuxin Zhang, Yiqin Bao, Wei Qiu, Lisheng Peng, Ling Fang, Ying Xu, Hui Yan. Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis. Experimental eye research. vol 175. 2019-02-11. PMID:29913164. |
neuromyelitis optica spectrum disorders (nmosd) are a group of autoimmune astrocytopathies in the central nervous system, which are mainly caused by immunoglobulin g (igg) against astrocyte water channel aquaporin-4 (aqp4). |
2019-02-11 |
2023-08-13 |
rat |
| Yuxin Zhang, Yiqin Bao, Wei Qiu, Lisheng Peng, Ling Fang, Ying Xu, Hui Yan. Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis. Experimental eye research. vol 175. 2019-02-11. PMID:29913164. |
at the end of 3 weeks, there was a loss of retinal ganglion cells and the optic nerves showed characteristic nmosd-like pathologic changes, including deposition of aqp4 igg, local astrocyte damage, demyelination, microglia activation, macrophage infiltration and axonal injury. |
2019-02-11 |
2023-08-13 |
rat |
| Tianjiao Duan, Alex J Smith, Alan S Verkma. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. Journal of neuroinflammation. vol 15. issue 1. 2018-12-18. PMID:30348195. |
aquaporin-4-immunoglobulin g (aqp4-igg) seropositive neuromyelitis optica spectrum disorder (herein called nmo) is an autoimmune disease of the central nervous system in which aqp4-igg binding to aqp4 on astrocytes results in complement-dependent astrocyte injury and secondary inflammation, demyelination, and neuron loss. |
2018-12-18 |
2023-08-13 |
Not clear |
| Ge Li, Xiaofei He, Hang Li, Yu'e Wu, Yalun Guan, Shuhua Liu, Huanhuan Jia, Yunfeng Li, Lijing Wang, Ren Huang, Zhong Pei, Yue Lan, Yu Zhan. Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain. International journal of molecular medicine. vol 42. issue 4. 2018-11-19. PMID:30085336. |
it was found that the overexpression of slit2 improved the clearance of the paravascular pathway by inhibiting astrocyte activation and maintaining aqp4 polarity on the astrocytic endfeet in slit2‑tg mice. |
2018-11-19 |
2023-08-13 |
mouse |