| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
aquaporin 4 (aqp4), the predominant water channel in the brain, is expressed in astrocyte endfeet and plays an important role in brain edema following ischemia. |
2020-10-01 |
2023-08-13 |
rat |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
furthermore, rnai technology revealed that aqp4 gene silencing inhibited glutamate-induced astrocyte swelling. |
2020-10-01 |
2023-08-13 |
rat |
| Zhongfang Shi, Wei Zhang, Yang Lu, Yi Lu, Lixin Xu, Qing Fang, Min Wu, Mei Jia, Yujiao Wang, Liping Dong, Xu Yan, Shaohua Yang, Fang Yua. Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28503134. |
finally, experiments in a rat model of transient middle cerebral artery occlusion (tmcao) revealed that co-expression of mglur5 and aqp4 was increased in astrocyte endfeet around capillaries in the penumbra, and this was accompanied by brain edema. |
2020-10-01 |
2023-08-13 |
rat |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
hippocampal atrophy following subarachnoid hemorrhage correlates with disruption of astrocyte morphology and capillary coverage by aqp4. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
glial fibrillary acid protein (gfap) immunostained hippocampal sections were examined by stereological techniques to detect differences in astrocyte morphology, and global spatial sampling method was used to quantify the length density of aquaporin-4 (aqp4) positive capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
sah induced retraction of gfap positive astrocyte processes, accompanied by a significant reduction in the length density of aqp4 positive capillaries as well as narrowing of hippocampal capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Tinglin Pu, Wenyan Zou, Weixi Feng, Yanli Zhang, Linmei Wang, Hongxing Wang, Ming Xia. Persistent Malfunction of Glymphatic and Meningeal Lymphatic Drainage in a Mouse Model of Subarachnoid Hemorrhage. Experimental neurobiology. vol 28. issue 1. 2020-10-01. PMID:30853828. |
moreover, sah impaired polarization of astrocyte aquaporin-4 (aqp4) that is a functional marker of glymphatic clearance and resulted in accumulations of tau proteins as well as cd3 |
2020-10-01 |
2023-08-13 |
mouse |
| Nancy K Glober, Shane Sprague, Sadiya Ahmad, Katherine G Mayfield, Lauren M Fletcher, Murat H Digicaylioglu, Naomi L Sayr. Acetazolamide Treatment Prevents Redistribution of Astrocyte Aquaporin 4 after Murine Traumatic Brain Injury. Neuroscience journal. vol 2019. 2020-10-01. PMID:31187032. |
although understanding of factors that influence edema is incomplete, the astrocyte water channel aquaporin 4 (aqp4) has been identified as an important mediator and therefore attractive drug target for edema prevention. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yueying Zheng, Liqing Wang, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zh. Upregulation of miR-130b protects against cerebral ischemic injury by targeting water channel protein aquaporin 4 (AQP4). American journal of translational research. vol 9. issue 7. 2020-09-30. PMID:28804561. |
our results indicated knockdown of aqp4 could ameliorate astrocyte injury induced by ogd. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yueying Zheng, Liqing Wang, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zh. Upregulation of miR-130b protects against cerebral ischemic injury by targeting water channel protein aquaporin 4 (AQP4). American journal of translational research. vol 9. issue 7. 2020-09-30. PMID:28804561. |
finally, we found that mir-130b regulated astrocyte expression of aqp4, and rescue experiments further proved the protective role of mir-130b was mediated by aqp4 downregulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Thomas R Murphy, David Davila, Nicholas Cuvelier, Leslie R Young, Kelli Lauderdale, Devin K Binder, Todd A Fiacc. Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28979186. |
surprisingly, genetic deletion of aqp4 did not inhibit, but rather augmented, astrocyte swelling in severe hypoosmolar conditions. |
2020-09-30 |
2023-08-13 |
Not clear |
| S Nishiyama, T Misu, M Nuriya, R Takano, T Takahashi, I Nakashima, M Yasui, Y Itoyama, M Aoki, K Fujihar. Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis optica. Biochemistry and biophysics reports. vol 7. 2020-09-30. PMID:29114578. |
pathological studies on nmo have revealed extensive astrocytic damage, as evidenced by the loss of aqp4 and glial fibrillary acidic protein (gfap), specifically in perivascular regions with immunoglobulin and complement depositions, although other pathological patterns, such as a loss of aqp4 without astrocyte destruction and clasmatodendrosis, have also been observed. |
2020-09-30 |
2023-08-13 |
human |
| Yuji Suzuki, Hiroki Kitaura, Yukimi Nakamura, Akiyoshi Kakita, Vincent J Huber, Nicholas Capozzoli, Ingrid L Kwee, Tsutomu Nakad. Skull diploë is rich in aquaporin-4. Heliyon. vol 6. issue 1. 2020-09-28. PMID:32042979. |
aquaporin-4 (aqp4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ryan T Muir, Aditya Bharatha, Dalia Rotstei. Mirror-Image Lesions in Sequential Relapses of AQP4-Positive Neuromyelitis Optica Spectrum Disorder. Frontiers in neurology. vol 11. 2020-09-28. PMID:32477258. |
we hypothesize, using data from prior pathologic and epidemiologic studies, that mirror image lesions, where the same anatomic sites are affected on the contralateral side of the brain or spinal cord, may appear in subsequent attacks due to (i) areas of high remaining aqp4 density and/or (ii) local compromise of astrocyte or blood-brain barrier (bbb) function that persists after the initial inciting attack. |
2020-09-28 |
2023-08-13 |
Not clear |
| Irina Filchenko, Camille Blochet, Lara Buscemi, Melanie Price, Jerome Badaut, Lorenz Hir. Caveolin-1 Regulates Perivascular Aquaporin-4 Expression After Cerebral Ischemia. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32523952. |
in summary, we show for the first time that loss of cav-1 results in decreased aqp4 expression and impaired perivascular aqp4 covering after cerebral ischemia associated with altered reactive astrocyte morphology and enhanced brain swelling. |
2020-09-28 |
2023-08-13 |
mouse |
| Andrea Arighi, Andrea Di Cristofori, Chiara Fenoglio, Stefano Borsa, Marianna D'Anca, Giorgio Giulio Fumagalli, Marco Locatelli, Giorgio Carrabba, Anna Margherita Pietroboni, Laura Ghezzi, Tiziana Carandini, Annalisa Colombi, Marta Scarioni, Milena Alessandra De Riz, Maria Serpente, Paolo Maria Rampini, Elio Scarpini, Daniela Galimbert. Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease? Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156164. |
aquaporin4 (aqp4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in alzheimer's disease (ad) and normal pressure hydrocephalus (nph) pathophysiology. |
2020-09-18 |
2023-08-13 |
Not clear |
| Yuji Komaki, Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Biha. Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. PloS one. vol 15. issue 5. 2020-09-09. PMID:32437449. |
the contribution of astrocytes to the bold fmri and dfmri responses in visual cortex of mice following visual stimulation was investigated using tgn-020, an aquaporin 4 (aqp4) channel blocker, acting as an astrocyte function perturbator. |
2020-09-09 |
2023-08-13 |
mouse |
| Fabiana Galland, Marina Seady, Jessica Taday, Soraya Soubhi Smaili, Carlos Alberto Gonçalves, Marina Concli Leit. Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells. Neurochemistry international. vol 131. 2020-09-03. PMID:31430518. |
gfap, s100b, aqp4 and aldh1l1), although expressing them in less quantities then primary astrocyte cultures. |
2020-09-03 |
2023-08-13 |
Not clear |
| Su-Hyun Kim, Jae-Won Hyun, Ho Jin Ki. Individualized B cell-targeting therapy for neuromyelitis optica spectrum disorder. Neurochemistry international. vol 130. 2020-08-18. PMID:30513364. |
the majority of patients with nmosd are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (aqp4). |
2020-08-18 |
2023-08-13 |
Not clear |
| Silvia Ciappelloni, Delphine Bouchet, Nadège Dubourdieu, Eric Boué-Grabot, Blanka Kellermayer, Constance Manso, Romain Marignier, Stéphane H R Oliet, Thomas Tourdias, Laurent Gro. Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease. Cell reports. vol 27. issue 13. 2020-07-30. PMID:31242419. |
furthermore, human autoantibodies directed against aqp4 from neuromyelitis optica (nmo) patients impaired aqp4-m23 dynamic distribution and, consequently, astrocyte process and synaptic activity. |
2020-07-30 |
2023-08-13 |
human |