| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lukmanee Tradtrantip, Michael R Yeaman, A S Verkma. Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder. Scientific reports. vol 11. issue 1. 2021-11-13. PMID:34753987. |
most nmosd patients are seropositive for immunoglobulin g (igg) autoantibodies against astrocyte water channel aquaporin-4 (aqp4), called aqp4-igg. |
2021-11-13 |
2023-08-13 |
human |
| Matthew MacGregor Sharp, Jordan Cassidy, Thomas Thornton, James Lyles, Abby Keable, Maureen Gatherer, Masato Yasui, Yoichiro Abe, Shinsuke Shibata, Roy O Weller, Dariusz C Górecki, Roxana O Carar. The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix-significance for protein elimination failure arteriopathies. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34674769. |
alpha-dystrobrevin (α-db) is a key dystrophin associated protein within perivascular astrocyte endfeet; its deficiency leads to a reduction in other dystrophin associated proteins, loss of aqp4 and altered ecm. |
2021-11-05 |
2023-08-13 |
mouse |
| Alex J Smith, Gokhan Akdemir, Meetu Wadhwa, Dan Song, Alan S Verkma. Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake. The Journal of general physiology. vol 153. issue 8. 2021-10-15. PMID:34128962. |
the "glymphatic" mechanism proposes that the astrocyte water channel aquaporin-4 (aqp4) is a major determinant of solute transport between the csf and the interstitial space; however, this is controversial in part because of wide variance in experimental data on interstitial uptake of cisternally injected solutes. |
2021-10-15 |
2023-08-13 |
mouse |
| Jian Li, Zhiqiang Jia, Qiangqiang Zhang, Junyu Dai, Jundong Kong, Zhongkai Fan, Gang L. Inhibition of ERK1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats. Brain research bulletin. vol 170. 2021-10-07. PMID:33592275. |
interestingly, the sci-induced elevation of aqp4 expression was downregulated by p-erk1/2 inhibition, suggesting that blocking erk1/2 phosphorylation could attenuate astrocyte activation and inflammatory processes through negative regulation of aqp4. |
2021-10-07 |
2023-08-13 |
rat |
| Siyi Li, Bingjian Jiang, Huanhuan Lu, Shuxuan Huang, Binglin Fan, Zhi Chen, Yanhua L. Inhibition of CAMK II modulates water permeability by reducing AQP4 expression in astrocytes after oxygen-glucose deprivation. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34232129. |
ogd increased astrocytic swelling and expression of camk ii and aqp4, and it decreased astrocyte viability. |
2021-09-20 |
2023-08-13 |
Not clear |
| Siyi Li, Bingjian Jiang, Huanhuan Lu, Shuxuan Huang, Binglin Fan, Zhi Chen, Yanhua L. Inhibition of CAMK II modulates water permeability by reducing AQP4 expression in astrocytes after oxygen-glucose deprivation. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34232129. |
inhibition of camk ii resulted in reduced astrocyte water permeability and aqp4 expression. |
2021-09-20 |
2023-08-13 |
Not clear |
| Siyi Li, Bingjian Jiang, Huanhuan Lu, Shuxuan Huang, Binglin Fan, Zhi Chen, Yanhua L. Inhibition of CAMK II modulates water permeability by reducing AQP4 expression in astrocytes after oxygen-glucose deprivation. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34232129. |
we concluded that the upregulation of camk ii promoted astrocyte swelling by increasing the expression of aqp4 after ogd. |
2021-09-20 |
2023-08-13 |
Not clear |
| Edgar Carnero Contentti, Jorge Correal. Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies. Journal of neuroinflammation. vol 18. issue 1. 2021-09-19. PMID:34530847. |
it binds to aqp4 channels on astrocytes, triggering activation of the classical complement cascade, causing granulocyte, eosinophil, and lymphocyte infiltration, culminating in injury first to astrocyte, then oligodendrocytes followed by demyelination and neuronal loss. |
2021-09-19 |
2023-08-13 |
Not clear |
| Carmen Falcone, Elisa Penna, Tiffany Hong, Alice F Tarantal, Patrick R Hof, William D Hopkins, Chet C Sherwood, Stephen C Noctor, Verónica Martínez-Cerdeñ. Cortical Interlaminar Astrocytes Are Generated Prenatally, Mature Postnatally, and Express Unique Markers in Human and Nonhuman Primates. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-09-16. PMID:32930323. |
we showed that the density and morphological complexity of ilas increase with age, and that ilas express multiple markers that are expressed by rg cells (pax6, sox2, and nestin), specific to inner and outer rg cells (cryab and hopx), and astrocyte markers (s100β, aqp4, and glast) in prenatal stages and in adult. |
2021-09-16 |
2023-08-13 |
mouse |
| Dongyang Li, Tong Li, Jiawei Yu, Xiaoyu Liu, Shuwei Jia, Xiaoran Wang, Ping Wang, Yu-Feng Wan. Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams with Pup-Deprivation at Different Stages of Lactation. Neurochemical research. vol 46. issue 10. 2021-09-14. PMID:32930948. |
they also significantly increased the expression of glial fibrillary acidic protein (gfap) in western blots while increased gfap filaments and the colocalization of gfap filaments with aquaporin 4 (aqp4) puncta in astrocyte processes surrounding oxytocin neuronal somata in immunohistochemistry in the supraoptic nucleus. |
2021-09-14 |
2023-08-13 |
rat |
| Zhong-Fang Shi, Qing Fang, Ye Chen, Li-Xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-Xuan Wang, Yu-Jiao Wang, Xu Yan, Li-Ping Dong, Fang Yua. Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression. Acta pharmacologica Sinica. vol 42. issue 3. 2021-09-09. PMID:32665706. |
in a cell swelling model established in cultured rat astrocyte exposed to glutamate (1 mm), we consistently found that mb (10 μm) attenuated cell swelling, aqp4 increases and erk1/2 activation. |
2021-09-09 |
2023-08-13 |
rat |
| Zhong-Fang Shi, Qing Fang, Ye Chen, Li-Xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-Xuan Wang, Yu-Jiao Wang, Xu Yan, Li-Ping Dong, Fang Yua. Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression. Acta pharmacologica Sinica. vol 42. issue 3. 2021-09-09. PMID:32665706. |
these results demonstrate that mb improves brain edema and astrocyte swelling, which may be mediated by the inhibition of aqp4 expression via erk1/2 pathway, suggesting that mb may be a potential choice for the treatment of brain edema. |
2021-09-09 |
2023-08-13 |
rat |
| Francesco Pisani, Laura Simone, Maria Grazia Mola, Manuela De Bellis, Antonio Frigeri, Grazia Paola Nicchia, Maria Svelt. Regulation of aquaporin-4 expression in the central nervous system investigated using M23-AQP4 null mouse. Glia. vol 69. issue 9. 2021-08-18. PMID:34038017. |
in astrocyte primary cultures, ddx17 knockdown upregulated aqp4 protein expression and increased cell swelling, leaving aqp4 mrna levels unchanged. |
2021-08-18 |
2023-08-13 |
mouse |
| Nithi Asavapanumas, Lukmanee Tradtrantip, Alan S Verkma. Targeting the complement system in neuromyelitis optica spectrum disorder. Expert opinion on biological therapy. vol 21. issue 8. 2021-07-29. PMID:33513036. |
in aqp4-igg seropositive nmosd, circulating immunoglobulin g (igg) autoantibodies against astrocyte water channel aquaporin-4 (aqp4) cause tissue injury. |
2021-07-29 |
2023-08-13 |
Not clear |
| Manuela de Bellis, Antonio Cibelli, Maria Grazia Mola, Francesco Pisani, Barbara Barile, Maria Mastrodonato, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Pasqua Abbrescia, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchi. Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain. Glia. vol 69. issue 2. 2021-07-28. PMID:32946135. |
astrocyte endfeet are endowed with aquaporin-4 (aqp4)-based assemblies called orthogonal arrays of particles (oaps) whose function is still unclear. |
2021-07-28 |
2023-08-13 |
mouse |
| Manuela de Bellis, Antonio Cibelli, Maria Grazia Mola, Francesco Pisani, Barbara Barile, Maria Mastrodonato, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Pasqua Abbrescia, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchi. Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain. Glia. vol 69. issue 2. 2021-07-28. PMID:32946135. |
blue native (bn)/sds-page and western blot performed on oap-null brain and primary astrocyte cultures showed the complete depletion of aqp4 assemblies, the selective expression of m1-aqp4-based tetramers, and a substantial reduction in aqp4 total expression level. |
2021-07-28 |
2023-08-13 |
mouse |
| Manuela de Bellis, Antonio Cibelli, Maria Grazia Mola, Francesco Pisani, Barbara Barile, Maria Mastrodonato, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Pasqua Abbrescia, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchi. Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain. Glia. vol 69. issue 2. 2021-07-28. PMID:32946135. |
fluorescence quenching and super-resolution microscopy experiments showed that aqp4 tetramers were functionally expressed in astrocyte plasma membrane and their dimensions were reduced compared to wild-type assemblies. |
2021-07-28 |
2023-08-13 |
mouse |
| Manuela de Bellis, Antonio Cibelli, Maria Grazia Mola, Francesco Pisani, Barbara Barile, Maria Mastrodonato, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Pasqua Abbrescia, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchi. Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain. Glia. vol 69. issue 2. 2021-07-28. PMID:32946135. |
finally, as shown by light and electron microscopy, oap depletion resulted in a massive reduction in aqp4 expression and a loss of perivascular aqp4 staining at astrocyte endfeet, with only sparse labeling throughout the brain areas analyzed. |
2021-07-28 |
2023-08-13 |
mouse |
| Wenli Zhu, Yaling Zhang, Zhen Wang, Ying Fu, Yaping Ya. Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside. Neuroscience bulletin. vol 36. issue 10. 2021-07-27. PMID:32533450. |
the binding of nmo-igg with astrocytic aquaporin-4 (aqp4) functions directly in the pathogenesis of >60% of nmosd patients, and causes astrocyte loss, secondary inflammatory infiltration, demyelination, and neuron death, potentially leading to paralysis and blindness. |
2021-07-27 |
2023-08-13 |
Not clear |
| Rehab E Abo El Gheit, Marwa Mohamed Atef, Ghada A Badawi, Walaa M Elwan, H A Alshenawy, Marwa Nagy Ema. Role of serine protease inhibitor, ulinastatin, in rat model of hepatic encephalopathy: aquaporin 4 molecular targeting and therapeutic implication. Journal of physiology and biochemistry. vol 76. issue 4. 2021-07-20. PMID:32794154. |
aquaporin-4 (aqp4), the principal astrocyte water channel, is primarily involved in brain edema development. |
2021-07-20 |
2023-08-13 |
human |