| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jernej Jorgačevski, Robert Zorec, Maja Potoka. Insights into Cell Surface Expression, Supramolecular Organization, and Functions of Aquaporin 4 Isoforms in Astrocytes. Cells. vol 9. issue 12. 2021-07-08. PMID:33297299. |
the membrane of astrocyte processes, which align brain capillaries and pia, is particularly rich in aqp4. |
2021-07-08 |
2023-08-13 |
human |
| Benjamin C Reeves, Jason K Karimy, Adam J Kundishora, Humberto Mestre, H Mert Cerci, Charles Matouk, Seth L Alper, Iben Lundgaard, Maiken Nedergaard, Kristopher T Kahl. Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus. Trends in molecular medicine. vol 26. issue 3. 2021-07-02. PMID:31959516. |
inph and alzheimer's disease (ad) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (aqp4). |
2021-07-02 |
2023-08-13 |
human |
| Shuisheng Lei, Yan He, Ziting Zhu, Zhongrui Liu, Yuwan Lin, Yuehua He, Sheng Du, Xiang Chen, Pingyi Xu, Xiaoqin Zh. Inhibition of NMDA Receptors Downregulates Astrocytic AQP4 to Suppress Seizures. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32107753. |
aquaporin 4 (aqp4), a water-specific channel protein locating on the astrocyte membrane, has been found to be antagonist, agonist and undergone closely related to epilepsy. |
2021-06-21 |
2023-08-13 |
rat |
| Sven Olaf Rohr, Theresa Greiner, Sarah Joost, Sandra Amor, Paul van der Valk, Christoph Schmitz, Markus Kip. Aquaporin-4 Expression during Toxic and Autoimmune Demyelination. Cells. vol 9. issue 10. 2021-06-18. PMID:32998402. |
we show that during toxin-induced demyelination, diffuse aqp4 expression increases, while polarized aqp4 expression at the astrocyte endfeet decreases. |
2021-06-18 |
2023-08-13 |
mouse |
| Lulu An, Yi Shen, Michael Chopp, Alex Zacharek, Poornima Venkat, Zhili Chen, Wei Li, Yu Qian, Julie Landschoot-Ward, Jieli Che. Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094639. |
compared to corresponding sham mice, bcas in wild-type (wt) and enos-/- mice significantly: 1) induces short term, long term memory loss, spatial learning and memory deficits; 2) decreases cbf, increases ischemic cell damage, including apoptosis, white matter (wm) and axonal damage; 3) increases blood brain barrier (bbb) leakage, decreases aquaporin-4 (aqp4) expression and vessel density; 4) increases microglial, astrocyte activation and oxidative stress in the brain; 5) increases inflammatory factor interleukin-1 receptor-associated kinase-1(irak-1) and amyloid beta (aβ) expression in brain; 6) increases il-6 and irak4 expression in brain. |
2021-06-08 |
2023-08-13 |
mouse |
| Xiao Zhang, Paul O'Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping L. Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33971986. |
hpa-tg brains presented with thicker vbms and swollen perivascular astrocyte endfeet, as well as elevated expression of the bbb-associated water-pump protein aquaporin 4 (aqp4). |
2021-06-07 |
2023-08-13 |
mouse |
| Jacqueline Palace, Dean M Wingerchuk, Kazuo Fujihara, Achim Berthele, Celia Oreja-Guevara, Ho Jin Kim, Ichiro Nakashima, Michael Levy, Murat Terzi, Natalia Totolyan, Shanthi Viswanathan, Kai-Chen Wang, Amy Pace, Marcus Yountz, Larisa Miller, Róisín Armstrong, Sean Pittoc. Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial. Multiple sclerosis and related disorders. vol 47. 2021-05-14. PMID:33310418. |
antibodies to the aquaporin-4 (aqp4) water channel in neuromyelitis optica spectrum disorder (nmosd) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury. |
2021-05-14 |
2023-08-13 |
Not clear |
| Antonio Cibelli, Sandra Veronica Lopez-Quintero, Sean Mccutcheon, Eliana Scemes, David C Spray, Randy F Stout, Sylvia O Suadicani, Mia M Thi, Marcia Urban-Maldonad. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Frontiers in cellular neuroscience. vol 15. 2021-05-11. PMID:33790744. |
aqp4, the water channel that is found in high abundance in astrocyte end-feet, was expressed at moderately high levels in early passages, and its mrna and protein declined to low but still detectable levels by p10. |
2021-05-11 |
2023-08-13 |
mouse |
| Shay Gur, Michal Taler, Gil Bormant, Dori Blattberg, Uri Nitzan, Adi Vaknin-Dembinsky, Livnat Brill, Amir Krivoy, Abraham Weizman, Eldar Hochma. Lack of association between unipolar or bipolar depression and serum aquaporin-4 autoantibodies. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32380273. |
aquaporin-4 (aqp4), an astrocyte water channel protein, is the target antigen of serum immunoglobulin g (igg) autoantibody in neuromyelitis optica spectrum disorders (nmosd), a group of inflammatory, demyelinating diseases of the central nervous system. |
2021-04-27 |
2023-08-13 |
Not clear |
| Chloé Richard, Anne Ruiz, Sylvie Cavagna, Maxime Bigotte, Sandra Vukusic, Katsuhisa Masaki, Toshihiko Suenaga, Jun-Ichi Kira, Pascale Giraudon, Romain Marignie. Connexins in neuromyelitis optica: a link between astrocytopathy and demyelination. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32889550. |
neuromyelitis optica, a rare neuroinflammatory demyelinating disease of the cns, is characterized by the presence of specific pathogenic autoantibodies directed against the astrocytic water channel aquaporin 4 (aqp4) and is now considered as an astrocytopathy associated either with complement-dependent astrocyte death or with astrocyte dysfunction. |
2021-02-16 |
2023-08-13 |
Not clear |
| E Liu, Xianlong Peng, Haowen Ma, Yan Zhang, Xiaomei Yang, Yixuan Zhang, Linlin Sun, Junhao Ya. The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage. Frontiers in aging neuroscience. vol 12. 2021-02-13. PMID:33574749. |
aquaporin-4 (aqp4) is highly expressed on the astrocyte foot processes and facilitates the interstitial fluid (isf) transportation in the gs system. |
2021-02-13 |
2023-08-13 |
Not clear |
| Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhäuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghadda. Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms. Cells. vol 9. issue 2. 2021-02-12. PMID:32046059. |
uncoupling of the astrocyte syncytium differentially affects aqp4 isoforms. |
2021-02-12 |
2023-08-13 |
mouse |
| Zahra Moinfar, Scott S Zamvi. Microglia complement astrocytes in neuromyelitis optica. The Journal of clinical investigation. vol 130. issue 8. 2021-01-28. PMID:32568215. |
nmo-igg alone caused astrocyte activation and aqp4 loss. |
2021-01-28 |
2023-08-13 |
Not clear |
| Tianjiao Duan, Lukmanee Tradtrantip, Puay-Wah Phuan, Jeffrey L Bennett, Alan S Verkma. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology. vol 162. 2021-01-06. PMID:31654702. |
we previously developed an antibody blocking approach for potential therapy of nmo in which an engineered, monoclonal, anti-aqp4 antibody lacking cytotoxicity effector functions (called aquaporumab) blocked binding of nmo autoantibodies to astrocyte aqp4 (tradtrantip et al. |
2021-01-06 |
2023-08-13 |
human |
| Kenji Kawaguchi, Jonghyuk Park, Takahiro Masaki, Yoshihiro Mezaki, Sae Ochi, Tomokazu Matsuur. Comprehensive gene expression profiling of human astrocytes treated with a hepatic encephalopathy-inducible factor, alpha 1-antichymotripsin. Biochemistry and biophysics reports. vol 24. 2020-12-11. PMID:33299931. |
act induces astrocyte swelling by upregulating aquaporin 4 (aqp4); however, the causal connection between these proteins is not clear yet. |
2020-12-11 |
2023-08-13 |
human |
| Arno Vandebroek, Masato Yasu. Regulation of AQP4 in the Central Nervous System. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32111087. |
aqp4 is densely expressed in astrocyte end-feet, and is an important factor in cns water and potassium homeostasis. |
2020-12-08 |
2023-08-13 |
Not clear |
| Shinji Naganawa, Toshiaki Taok. The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 2020-11-30. PMID:33250472. |
in this hypothesis, cerebrospinal fluid (csf) enters the periarterial spaces, enters the interstitial space of the brain parenchyma via aquaporin-4 (aqp4) channels in the astrocyte end feet, and then exits through the perivenous space, thereby clearing waste products. |
2020-11-30 |
2023-08-13 |
Not clear |
| Claudia Palazzo, Pasqua Abbrescia, Onofrio Valente, Grazia Paola Nicchia, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Maria Trojano, Antonio Friger. Tissue Distribution of the Readthrough Isoform of AQP4 Reveals a Dual Role of AQP4ex Limited to CNS. International journal of molecular sciences. vol 21. issue 4. 2020-11-23. PMID:32102323. |
without the readthrough isoform, aqp4 assemblies are mis-localized, being uniformly distributed on the astrocyte processes facing the neuropile. |
2020-11-23 |
2023-08-13 |
mouse |
| Serge Nata. The Demonstration of an Aqp4/Tgf-beta 1 Pathway in Murine Astrocytes Holds Implications for Both Neuromyelitis Optica and Progressive Multiple Sclerosis. International journal of molecular sciences. vol 21. issue 3. 2020-11-17. PMID:32033173. |
the role exerted by aquaporin 4 (aqp4) as a regulator of astrocyte immune functions has been poorly explored. |
2020-11-17 |
2023-08-13 |
Not clear |
| Heyu Zhang, Yanzhe Wang, Ling Lian, Cheng Zhang, Zhiyi H. Glycine-Histidine-Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt/miR-146a-3p/AQP4 Pathway. Frontiers in neuroscience. vol 14. 2020-11-17. PMID:33192260. |
furthermore, the effects of ghk on astrocyte were associated with the upregulation of mirna-146a-3p, which partially regulated the expression of aqp4. |
2020-11-17 |
2023-08-13 |
human |