| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Friger. The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain. Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625560. |
it is strongly expressed at the astrocyte perivascular endfeet as a component of the supramolecular membrane complex, commonly called orthogonal array of particles (oap), together with the canonical isoforms m1 and m23 of aqp4. |
2022-05-28 |
2023-08-13 |
human |
| Tarapati Rana, Tapan Behl, Md Shamsuzzaman, Sukhbir Singh, Neelam Sharma, Aayush Sehgal, Asma M Alshahrani, Afaf Aldahis, Kumarappan Chidambaram, Hamad Ghaleb Dailah, Saurabh Bhatia, Simona Bunga. Exploring the role of astrocytic dysfunction and AQP4 in depression. Cellular signalling. 2022-05-21. PMID:35597427. |
aquaporin-4 (aqp4) is the water regulating channel found in the terminal processes of astrocytes in the brain and is implicated in regulating the astrocyte functions, whereas in neuropathologies, aqp4 performs an important role in astrocytosis and release of proinflammatory cytokines. |
2022-05-21 |
2023-08-13 |
Not clear |
| Chengfeng Sun, Luyi Lin, Lekang Yin, Xiaozhu Hao, Jiaqi Tian, Xiaoxue Zhang, Yan Ren, Chanchan Li, Yanmei Yan. Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia. Frontiers in immunology. vol 13. 2022-05-20. PMID:35592320. |
brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both involving aquaporin-4 (aqp4). |
2022-05-20 |
2023-08-13 |
human |
| Chengfeng Sun, Luyi Lin, Lekang Yin, Xiaozhu Hao, Jiaqi Tian, Xiaoxue Zhang, Yan Ren, Chanchan Li, Yanmei Yan. Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia. Frontiers in immunology. vol 13. 2022-05-20. PMID:35592320. |
studies revealed that acute inhibition of aqp4 after stroke diminishes brain edema, however, its effect on peri-infarct astrocyte reactivity and the subacute outcome is unclear. |
2022-05-20 |
2023-08-13 |
human |
| Nadia Skauli, Ekaterina Savchenko, Ole Petter Ottersen, Laurent Roybon, Mahmood Amiry-Moghadda. Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes. Frontiers in cellular neuroscience. vol 16. 2022-05-06. PMID:35518645. |
enhanced expression with concomitant mislocalization of aqp4 along astrocyte plasma membranes is a hallmark of several neurological conditions. |
2022-05-06 |
2023-08-13 |
mouse |
| José Luis Trillo-Contreras, Reposo Ramírez-Lorca, Javier Villadiego, Miriam Echevarrí. Cellular Distribution of Brain Aquaporins and Their Contribution to Cerebrospinal Fluid Homeostasis and Hydrocephalus. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454119. |
expression of aqp1 in the apical cell membrane of choroid plexus epithelial cells and of aqp4 in ependymal cells, glia limitans, and astrocyte processes in the pericapillary end foot is consistent with the involvement of both proteins in cerebrospinal fluid homeostasis. |
2022-04-23 |
2023-08-13 |
mouse |
| Aigli G Vakrakou, Maria-Evgenia Brinia, Ioanna Svolaki, Theodore Argyrakos, Leonidas Stefanis, Constantinos Kilidirea. Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases. Frontiers in neurology. vol 13. 2022-04-14. PMID:35418930. |
recent developments in immunopathology of central nervous system disease suggest that specific pathological immune features (type of demyelination, infiltrating cell type distribution, specific astrocyte pathology and complement deposition) can differentiate tumefactive lesions arising as part of ms, mog-associated disease, and aqp4 antibody-positive neuromyelitis optica spectrum disorder. |
2022-04-14 |
2023-08-13 |
Not clear |
| Xiao-Yu Zheng, Wen-Ting Song, Ye-Hao Zhang, Hui Cao, Jian-Xun Li. [Baicalin treats cerebral ischemia reperfusion-induced brain edema in rats by inhibiting TRPV4 and AQP4 of astrocytes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 4. 2022-03-14. PMID:35285204. |
the above results indicate that baicalin can effectively relieve the brain edema caused by cerebral ischemia reperfusion injury in rats, possibly by suppressing astrocyte swelling and trpv4 and aqp4. |
2022-03-14 |
2023-08-13 |
rat |
| Ali Mamivand, Shiva Bayat, Abolfazl Maghrouni, Sasan Shabani, Alireza Khoshnevisan, Hiva Saffar, Mina Tabriz. Data mining of bulk and single-cell RNA sequencing introduces OBI1-AS1 as an astrocyte marker with possible role in glioma recurrence and progression. Clinical epigenetics. vol 14. issue 1. 2022-03-09. PMID:35260196. |
our study indicated that lncrnas, like obi1-as1, could be extremely precise in identifying the astrocyte cluster in the single-cell transcriptome and demonstrating superiority to well-established astrocyte markers such as gfap, s100b, aldh1l1, and aqp4. |
2022-03-09 |
2023-08-13 |
Not clear |
| Hong Lu, Li Ai, Baoyue Zhan. TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis. Bioscience reports. 2022-03-09. PMID:35260880. |
primary astrocyte cultures were treated with different concentrations of tnf-α and the cell viability was assessed through cell counting kit-8 assay and aqp4 expression was detected by qpcr, western blots, and immunofluorescence assays. |
2022-03-09 |
2023-08-13 |
Not clear |
| Hong Lu, Li Ai, Baoyue Zhan. TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis. Bioscience reports. 2022-03-09. PMID:35260880. |
these experiments demonstrated that treatment with tnf-α can lead to astrocyte edema and an increase in aqp4 expression. |
2022-03-09 |
2023-08-13 |
Not clear |
| Hong Lu, Li Ai, Baoyue Zhan. TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis. Bioscience reports. 2022-03-09. PMID:35260880. |
the expression level of aqp4 was significantly decreased upon p65 interference, while the astrocyte viability was significantly increased compared to that in the tnf-α only group. |
2022-03-09 |
2023-08-13 |
Not clear |
| Hong Lu, Li Ai, Baoyue Zhan. TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis. Bioscience reports. 2022-03-09. PMID:35260880. |
in conclusion, tnf-α activated nf-κb pathway, which promoted the binding of p65 to the aqp4 gene promoter region, and enhanced aqp4 expression, ultimately reducing astrocyte viability and causing cell edema. |
2022-03-09 |
2023-08-13 |
Not clear |
| Onofrio Valente, Raffaella Messina, Giuseppe Ingravallo, Emilio Bellitti, Domenico Sergio Zimatore, Luigi de Gennaro, Pasqua Abbrescia, Roberta Pati, Claudia Palazzo, Grazia Paola Nicchia, Maria Trojano, Francesco Signorelli, Antonio Friger. Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-02-21. PMID:35187599. |
in peritumoral tissues, aqp4 expression was found altered in those perivascular astrocyte processes where aqp4ex appeared reduced and partially delocalized. |
2022-02-21 |
2023-08-13 |
human |
| Izabela Figiel, Ewa Bączyńska, Tomasz Wójtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Włodarczy. The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines. Scientific reports. vol 12. issue 1. 2022-02-16. PMID:35169214. |
we have also observed that the lack of dg evokes alterations in the morphological complexity of astrocytes accompanied by a decrease in the level of aquaporin 4 (aqp4), a protein located within astrocyte endfeet surrounding neuronal dendrites and synapses. |
2022-02-16 |
2023-08-13 |
rat |
| Shervin Banitalebi, Nadia Skauli, Samuel Geiseler, Ole Petter Ottersen, Mahmood Amiry-Moghadda. Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163040. |
aqp4 has adhesive properties and is assumed to facilitate astrocyte mobility by permitting rapid volume changes at the leading edges of migrating astrocytes. |
2022-02-15 |
2023-08-13 |
Not clear |
| Shiwu Guo, Zhiwen Song, Junsheng He, Gang Yin, Jianguo Zhu, Haifeng Liu, Lei Yang, Xubiao Ji, Xu Xu, Zhiyuan Liu, Jinbo Li. Akt/aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience. 2021-12-23. PMID:34942314. |
moreover, inhibition of aqp4 suppressed astrocyte activation both in the sdh and in primary cultures.similar to aqp4, we found that p-akt was also significantly elevated after snl. |
2021-12-23 |
2023-08-13 |
rat |
| Shiwu Guo, Zhiwen Song, Junsheng He, Gang Yin, Jianguo Zhu, Haifeng Liu, Lei Yang, Xubiao Ji, Xu Xu, Zhiyuan Liu, Jinbo Li. Akt/aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience. 2021-12-23. PMID:34942314. |
inhibition of akt with mk2206 suppressed aqp4 upregulation and astrocyte activation both in vivo and in vitro. |
2021-12-23 |
2023-08-13 |
rat |
| Antonio Cibelli, Randy Stout, Aline Timmermann, Laura de Menezes, Peng Guo, Karen Maass, Gerald Seifert, Christian Steinhäuser, David C Spray, Eliana Sceme. Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability. Scientific reports. vol 11. issue 1. 2021-12-22. PMID:34934080. |
these results showing altered distribution of some astrocyte nexus components (aqp4 and cx30) in cx43 null mice and in a truncation mutant, together with leakier cerebral vasculature, support the hypothesis that localization and mobility of gap junction proteins and their binding partners influences organization of astrocyte endfeet which in turn impacts bbb integrity of the nvu. |
2021-12-22 |
2023-08-13 |
mouse |
| Shreyas B Rao, Nadia Skauli, Nenad Jovanovic, Shirin Katoozi, Antonio Frigeri, Stanley C Froehner, Marvin E Adams, Ole Petter Ottersen, Mahmood Amiry-Moghadda. Orchestrating aquaporin-4 and connexin-43 expression in brain: Differential roles of α1- and β1-syntrophin. Biochimica et biophysica acta. Biomembranes. vol 1863. issue 8. 2021-11-18. PMID:33872576. |
aqp4 channels are anchored by α1-syntrophin to the perivascular astrocytic endfoot membrane domains where they control water flux at the blood-brain interface while connexins cluster at the lateral aspects of the astrocytic endfeet forming gap junctions that allow water and ions to dissipate through the astrocyte syncytium. |
2021-11-18 |
2023-08-13 |
mouse |