| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luka Vlahovic, Jamie McDonald, Jessica Hinman, Anna Tomczak, Christopher Lock, Chella A Palmer, Lawrence J Cook, Michael R Yeaman, Melinda K Burnett, Gayle K Deutsch, Lorene M Nelson, May H Ha. Prevalence, Demographic, and Clinical Factors Associated With Cognitive Dysfunction in Patients With Neuromyelitis Optica Spectrum Disorder. Neurology. vol 102. issue 1. 2024-01-02. PMID:38165361. |
neuromyelitis optica spectrum disorder (nmosd) is a chronic cns demyelinating autoimmune disorder targeting the astrocyte antigen aquaporin-4 (aqp4), typically presenting with optic neuritis, transverse myelitis, and brain syndromes. |
2024-01-02 |
2024-01-05 |
Not clear |
| Sigal Liraz Zaltsman, Shirley Sharabi, David Guez, Diann Daniels, Itzik Cooper, Chen Shemesh, Dana Atrakchi, Orly Ravid, Liora Omesi, Daniel Rand, Abigail Livny, Michal Schnaider Beeri, Yael Friedman-Levi, Esther Shohami, Yael Mardor, David Las. Application of Delayed Contrast Extravasation Magnetic Resonance Imaging for Depicting Subtle Blood-Brain Barrier Disruption in a Traumatic Brain Injury Model. Journal of neurotrauma. 2023-12-06. PMID:37776183. |
at each time point, 2-6 animals were sacrificed and their brains were extracted, sectioned, and stained for bbb biomarkers including: blood microvessel coverage by astrocyte using gfap, aqp4, zo-1 gaps, and igg leakage. |
2023-12-06 |
2023-12-10 |
mouse |
| Juliana Cazzaniga, Cesar E Jara Silva, Jonathan Quinonez, Samir Ruxmohan, Melissa M Leyva, Abrahim Fah. Neuromyelitis Optica Spectrum Disorder. Cureus. vol 15. issue 11. 2023-12-04. PMID:38046734. |
the primary target in nmosd is the aquaporin-4 (aqp4) protein, predominantly located on astrocyte surfaces. |
2023-12-04 |
2023-12-10 |
Not clear |
| Juliana Cazzaniga, Cesar E Jara Silva, Jonathan Quinonez, Samir Ruxmohan, Melissa M Leyva, Abrahim Fah. Neuromyelitis Optica Spectrum Disorder. Cureus. vol 15. issue 11. 2023-12-04. PMID:38046734. |
antibodies binding to aqp4 can lead to astrocyte dysfunction and damage, contributing to nmosd's distinctive pathology. |
2023-12-04 |
2023-12-10 |
Not clear |
| Dan-Dan Zhu, Yue-Lin Huang, Song-Yu Guo, Na Li, Xue-Wei Yang, Ao-Ran Sui, Qiong Wu, Yue Zhang, Yue Kong, Qi-Fa Li, Ting Zhang, Wen-Fei Zheng, Ai-Ping Li, Jian Yu, Tong-Hui Ma, Shao L. AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting Nav1.6-Mediated Astrocyte Autophagy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 10. issue 30. 2023-10-26. PMID:37883742. |
aqp4 aggravates cognitive impairment in sepsis-associated encephalopathy through inhibiting nav1.6-mediated astrocyte autophagy. |
2023-10-26 |
2023-11-08 |
Not clear |
| Cloé Moëlo, Alicia Quillévéré, Lucas Le Roy, Serge Timsi. (S)-roscovitine, a CDK inhibitor, decreases cerebral edema and modulates AQP4 and α1-syntrophin interaction on a pre-clinical model of acute ischemic stroke. Glia. 2023-10-13. PMID:37828900. |
aquaporin-4 (aqp4), a water-channel polarized at the astrocyte endfoot, is known to be highly implicated in cerebral edema. |
2023-10-13 |
2023-10-15 |
Not clear |
| Cloé Moëlo, Alicia Quillévéré, Lucas Le Roy, Serge Timsi. (S)-roscovitine, a CDK inhibitor, decreases cerebral edema and modulates AQP4 and α1-syntrophin interaction on a pre-clinical model of acute ischemic stroke. Glia. 2023-10-13. PMID:37828900. |
immunofluorescence analysis of aqp4 distribution in astrocytes revealed that (s)-roscovitine decreased the non-perivascular pool of aqp4 by 53% and drastically increased aqp4 clusters in astrocyte perivascular end-feet (671%, t test p = .005) compared to vehicle. |
2023-10-13 |
2023-10-15 |
Not clear |
| Cloé Moëlo, Alicia Quillévéré, Lucas Le Roy, Serge Timsi. (S)-roscovitine, a CDK inhibitor, decreases cerebral edema and modulates AQP4 and α1-syntrophin interaction on a pre-clinical model of acute ischemic stroke. Glia. 2023-10-13. PMID:37828900. |
α1-syntrophin, aqp4 anchoring protein, was colocalized with aqp4 in astrocyte endfeet, and this colocalization was maintained in ischemic area as observed on confocal microscopy. |
2023-10-13 |
2023-10-15 |
Not clear |
| Wei Jiang, Fan Zhu, Huiming Xu, Li Xu, Haoyang Li, Xin Yang, Shabbir Khan Afridi, Shuiqing Lai, Xiusheng Qiu, Chunxin Liu, Huilu Li, Youming Long, Yuge Wang, Kevin Connolly, Jack A Elias, Chun Geun Lee, Yaxiong Cui, Yu-Wen Alvin Huang, Wei Qiu, Changyong Tan. CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation. Science advances. vol 9. issue 39. 2023-09-27. PMID:37756391. |
nmo is an astrocyte disease caused by autoantibodies targeting the astroglial protein aquaporin 4 (aqp4) and leads to vision loss, motor deficits, and cognitive decline. |
2023-09-27 |
2023-10-07 |
mouse |
| Sedat Sen, Asli Tuncer, Murat Terzi, Sena Destan Bunul, Pinar Ozen-Acar, Burcu Altunrende, Serkan Ozakbas, Melih Tutuncu, Ugur Uygunoglu, Gulsen Akman-Demir, Rana Karabudak, Husnu Efendi, Aksel Siv. Severe disease reactivation in seropositive neuromyelitis optica spectrum disorders patients after stopping eculizumab treatment. Multiple sclerosis and related disorders. vol 79. 2023-09-07. PMID:37678131. |
most nmosd patients have autoantibodies against the astrocyte water channel protein aquaporin-4 (aqp4). |
2023-09-07 |
2023-10-07 |
Not clear |
| Hiroshi Hasegawa, Mari Kond. Astrocytic Responses to Binge Alcohol Intake in the Mouse Hindbrain. Biological & pharmaceutical bulletin. vol 46. issue 9. 2023-09-04. PMID:37661398. |
another astrocyte marker, aquaporin 4 (aqp4), was also increased in the sttn with a pattern similar to that of gfap. |
2023-09-04 |
2023-09-07 |
mouse |
| Lin Zhang, Dongna Li, Pengrong Yi, Jiangwei Shi, Mengqing Guo, Qingsheng Yin, Dingbin Liu, Pengwei Zhuang, Yanjun Zhan. Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment. Acta pharmaceutica Sinica. B. vol 13. issue 7. 2023-07-31. PMID:37521866. |
the glymphatic system dysfunction mediated by aquaporin-4 (aqp4) loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment (dci). |
2023-07-31 |
2023-08-14 |
Not clear |
| Lin Zhang, Dongna Li, Pengrong Yi, Jiangwei Shi, Mengqing Guo, Qingsheng Yin, Dingbin Liu, Pengwei Zhuang, Yanjun Zhan. Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment. Acta pharmaceutica Sinica. B. vol 13. issue 7. 2023-07-31. PMID:37521866. |
we focused on exosomal mirnas that could induce low aqp4 expression and redistribution in perivascular astrocyte endfeet, which could provide an interorgan communication pathway to illustrate the pathogenesis of dci. |
2023-07-31 |
2023-08-14 |
Not clear |
| Ying Gao, Kangding Liu, Jie Zh. Glymphatic system: an emerging therapeutic approach for neurological disorders. Frontiers in molecular neuroscience. vol 16. 2023-07-24. PMID:37485040. |
the glymphatic pathway consists of periarterial influx of csf, astrocyte-mediated interchange between isf and csf supported by aquaporin-4 (aqp4) on the endfeet of astrocyte around the periarterioles, and perivenous efflux of csf. |
2023-07-24 |
2023-08-14 |
Not clear |
| Li Xu, Huiming Xu, Siqi Chen, Wei Jiang, Shabbir Khan Afridi, Yuge Wang, Xin Ren, Yipeng Zhao, Shuiqing Lai, Xiusheng Qiu, Yu-Wen Alvin Huang, Yaxiong Cui, Hui Yang, Wei Qiu, Changyong Tan. Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases. Molecular therapy : the journal of the American Society of Gene Therapy. 2023-07-23. PMID:37481702. |
the pathogenic serum igg antibody against the aquaporin 4 (aqp4) on astrocytes triggers the activation of the complement cascade, causing astrocyte injury, followed by oligodendrocyte injury, demyelination, and neuronal loss. |
2023-07-23 |
2023-08-14 |
mouse |
| Yan-Yan Chen, Zhi-Cheng Gong, Mei-Mei Zhang, Zhao-Hui Huan. Brain-Targeting Emodin Mitigates Ischemic Stroke via Inhibiting AQP4-Mediated Swelling and Neuroinflammation. Translational stroke research. 2023-06-28. PMID:37380800. |
furthermore, we demonstrated that aqp4, the most abundant water transporter subunit expressed in astrocytes, plays a crucial role in mediating the mechanisms by which emodin inhibits astrocyte swelling, neuroinflammatory blood-brain barrier (bbb) breakdown in vivo and in vitro, and brain edema in general. |
2023-06-28 |
2023-08-14 |
Not clear |
| Shu Feng, Chongyun Wu, Peibin Zou, Qianting Deng, Zhe Chen, Meng Li, Ling Zhu, Fanghui Li, Timon Cheng-Yi Liu, Rui Duan, Luodan Yan. High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization. Theranostics. vol 13. issue 10. 2023-06-23. PMID:37351177. |
high-intensity interval training ameliorates alzheimer's disease-like pathology by regulating astrocyte phenotype-associated aqp4 polarization. |
2023-06-23 |
2023-08-14 |
Not clear |
| Jesse A Stokum, Bosung Shim, Serban Negoita, Natalya Tsymbalyuk, Orest Tsymbalyuk, Svetlana Ivanova, Kaspar Keledjian, Joseph Bryan, Mordecai P Blaustein, Ruchira M Jha, Kristopher T Kahle, Volodymyr Gerzanich, J Marc Simar. Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke. Science signaling. vol 16. issue 788. 2023-06-06. PMID:37279286. |
cation flux through sur1-trpm4 and ncx1 in astrocyte endfeet induces water influx through aqp4 and brain swelling after ischemic stroke. |
2023-06-06 |
2023-08-14 |
mouse |
| Rongchun Xing, Jin Cheng, Jiangtao Yu, Shaoping Li, Haoli Ma, Yan Zha. Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells. International journal of medical sciences. vol 20. issue 6. 2023-05-22. PMID:37213674. |
in this study, the immunofluorescence co-localization analysis revealed that the area and intensity covered by aquaporin4 (aqp4) on the surface of brain cells (astrocyte endfeet) increased significantly after tbi. |
2023-05-22 |
2023-08-14 |
rat |
| Rongchun Xing, Jin Cheng, Jiangtao Yu, Shaoping Li, Haoli Ma, Yan Zha. Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells. International journal of medical sciences. vol 20. issue 6. 2023-05-22. PMID:37213674. |
this finding showed that tfp inhibited aqp4 accumulation on the surface of brain cells (astrocyte endfeet). |
2023-05-22 |
2023-08-14 |
rat |