| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
we showed that ast potentially improved the recovery of motor function and inhibited the spinal cord edema via maintaining the integrity of bscb, reducing the expression of hmgb1, tlr4, and nf-κb, mmp-9 as well as downregulation of astrocyte activation (gfap) and aqp4 expression. |
2023-05-05 |
2023-08-14 |
rat |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
these effects are mediated by suppression of the hmgb1/tlr4/nf-κb signaling pathway, suppressing post-sci astrocyte activation, and decreasing aqp4 and mmp-9 expression. |
2023-05-05 |
2023-08-14 |
rat |
| María García-Bonilla, Betsaida Ojeda-Pérez, Kirill Shumilov, Luis-Manuel Rodríguez-Pérez, Dolores Domínguez-Pinos, Javier Vitorica, Sebastián Jiménez, Reposo Ramírez-Lorca, Miriam Echevarría, Casimiro Cárdenas-García, Teresa Iglesias, Antonia Gutiérrez, James P McAllister, David D Limbrick, Patricia Páez-González, Antonio J Jiméne. Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982724. |
in the cerebral tissue, mrna overexpression of nerve growth factor (ngf), vascular endothelial growth factor (vegf), hypoxia-inducible factor-1 (hif1α), and transforming growth factor beta 1 (tgfβ1) could be related to the regulation of the astrocyte reaction and aqp4 expression. |
2023-03-29 |
2023-08-14 |
mouse |
| María García-Bonilla, Betsaida Ojeda-Pérez, Kirill Shumilov, Luis-Manuel Rodríguez-Pérez, Dolores Domínguez-Pinos, Javier Vitorica, Sebastián Jiménez, Reposo Ramírez-Lorca, Miriam Echevarría, Casimiro Cárdenas-García, Teresa Iglesias, Antonia Gutiérrez, James P McAllister, David D Limbrick, Patricia Páez-González, Antonio J Jiméne. Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982724. |
in conclusion, bm-msc treatment in hydrocephalus can stimulate a key developmental process such as the periventricular astrocyte reaction, where aqp4 overexpression could be implicated in tissue recovery. |
2023-03-29 |
2023-08-14 |
mouse |
| Dan-Dan Zhu, Yue-Lin Huang, Song-Yu Guo, Na Li, Xue-Wei Yang, Ao-Ran Sui, Qiong Wu, Yue Zhang, Yue Kong, Qi-Fa Li, Ting Zhang, Wen-Fei Zheng, Ai-Ping Li, Jian Yu, Tong-Hui Ma, Shao L. AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting Na Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-03-16. PMID:36922751. |
furthermore, the data suggest that aqp4 deletion could attenuate learning and memory impairment, attributing to activation of astrocytic autophagy, inactivation of astrocyte and downregulate the expression of proinflammatory cytokines induced by clp or lipopolysaccharide (lps). |
2023-03-16 |
2023-08-14 |
mouse |
| Dan-Dan Zhu, Yue-Lin Huang, Song-Yu Guo, Na Li, Xue-Wei Yang, Ao-Ran Sui, Qiong Wu, Yue Zhang, Yue Kong, Qi-Fa Li, Ting Zhang, Wen-Fei Zheng, Ai-Ping Li, Jian Yu, Tong-Hui Ma, Shao L. AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting Na Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-03-16. PMID:36922751. |
furthermore, the activation effect of aqp4 knockout on clp or lps-induced ppar-γ inhibiting in astrocyte is related to intracellular ca |
2023-03-16 |
2023-08-14 |
mouse |
| Hongen Li, Mo Yang, Honglu Song, Mingming Sun, Huanfen Zhou, Junxia Fu, Di Zhou, Wenhao Bai, Biyue Chen, Mengying Lai, Hao Kang, Shihui We. ACT001 Relieves NMOSD Symptoms by Reducing Astrocyte Damage with an Autoimmune Antibody. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36771078. |
we neutralized the aqp4-igg from nmosd patient sera using synthesized aqp4 extracellular epitope peptides and found that the severe cytotoxicity produced by aquaporin-4 immunoglobin (aqp4-igg) could be blocked by aqp4 extracellular mimotope peptides of loop a and loop c in astrocyte protection and animal models. |
2023-02-11 |
2023-08-14 |
mouse |
| Chiliang Xu, Feixiang Wang, Can Su, Xiao Guo, Jiang Li, Jingyan Li. Restoration of aquaporin-4 polarization in the spinal glymphatic system by metformin in rats with painful diabetic neuropathy. Neuroreport. 2023-01-31. PMID:36719843. |
immunofluorescence was used to detect the localization of perivascular aqp4 in astrocyte endfeet. |
2023-01-31 |
2023-08-14 |
rat |
| Ming Xiao, Jiaoyu Hou, Mengmeng Xu, Shao Li, Baoxue Yan. Aquaporins in Nervous System. Advances in experimental medicine and biology. vol 1398. 2023-01-30. PMID:36717489. |
aqp4, the predominant water channel in the cns, is involved both in the astrocyte swelling of cytotoxic edema and the resolution of vasogenic edema and is of pivotal importance in the pathology of brain disorders such as neuromyelitis optica, brain tumors, and neurodegenerative disorders. |
2023-01-30 |
2023-08-14 |
Not clear |
| Xiaohui Sun, Qing Tian, Zhengjie Yang, Yumei Li, Chengqian Li, Binghui Hou, Anmu Xi. Association of AQP4 single nucleotide polymorphisms (rs335929 and rs2075575) with Parkinson's disease: a case-control study. Neuroscience letters. 2023-01-10. PMID:36626962. |
the glymphatic system plays an important role in brain waste removal and is functionally and structurally dependent on astrocyte aquaporin-4 (aqp4). |
2023-01-10 |
2023-08-14 |
Not clear |
| Mario A Mireles-Ramírez, Fermín P Pacheco-Moises, Héctor A González-Usigli, Nayeli A Sánchez-Rosales, Martha R Hernández-Preciado, Daniela L C Delgado-Lara, José J Hernández-Cruz, Genaro Gabriel Orti. Neuromyelitis optica spectrum disorder: Pathophysiological approach. The International journal of neuroscience. 2022-12-01. PMID:36453541. |
here, we review the main pathological findings of nmosd associated with the presence of autoantibodies to aqp4 as well as the mechanisms of astrocyte dysfunction and demyelination. |
2022-12-01 |
2023-08-14 |
Not clear |
| Francesca R Buccellato, Marianna D'Anca, Maria Serpente, Andrea Arighi, Daniela Galimbert. The Role of Glymphatic System in Alzheimer's and Parkinson's Disease Pathogenesis. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140362. |
aquaporin-4 (aqp4), a water channel located in the endfeet of astrocyte membrane, is considered a primary driver of the glymphatic clearance system, and defective aqp4-mediated glymphatic drainage has been linked to proteinopathies. |
2022-09-23 |
2023-08-14 |
Not clear |
| Jiajun Cai, Jundong Kong, Song Ma, Yaozu Ban, Jian Li, Zhongkai Fa. Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression. Brain research bulletin. 2022-09-17. PMID:36115513. |
upregulation of trpc6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing aqp4 expression. |
2022-09-17 |
2023-08-14 |
rat |
| Jiajun Cai, Jundong Kong, Song Ma, Yaozu Ban, Jian Li, Zhongkai Fa. Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression. Brain research bulletin. 2022-09-17. PMID:36115513. |
this work investigates the effects and mechanisms of inhibiting trpc6 (a non-selective cation channel) downregulation on rat astrocyte activation and proliferation following spinal cord injury (sci) by suppressing aqp4 expression. |
2022-09-17 |
2023-08-14 |
rat |
| Zhaohua Tang, Gang Yang, Zhengbu Liao, Feilan Chen, Song Chen, Wentao Wang, Gang Huo, Xiaochuan Sun, Xiaoshu Wan. Tanshinone IIA reduces AQP4 expression and astrocyte swelling after OGD/R by inhibiting the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis. Scientific reports. vol 12. issue 1. 2022-08-18. PMID:35982135. |
tanshinone iia reduces aqp4 expression and astrocyte swelling after ogd/r by inhibiting the hmgb1/rage/nf-κb/il-6 pro-inflammatory axis. |
2022-08-18 |
2023-08-14 |
Not clear |
| Zhaohua Tang, Gang Yang, Zhengbu Liao, Feilan Chen, Song Chen, Wentao Wang, Gang Huo, Xiaochuan Sun, Xiaoshu Wan. Tanshinone IIA reduces AQP4 expression and astrocyte swelling after OGD/R by inhibiting the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis. Scientific reports. vol 12. issue 1. 2022-08-18. PMID:35982135. |
tso iia significantly reduced astrocyte swelling after ogd/r injury in vitro, via blocking the activation of the hmgb1/rage/nf-κb/il-6 pro-inflammatory axis and thereby decreasing the expression of aqp4 in the plasma membrane. |
2022-08-18 |
2023-08-14 |
Not clear |
| Fei-Xiang Wang, Chi-Liang Xu, Can Su, Jiang Li, Jing-Yan Li. β-Hydroxybutyrate Attenuates Painful Diabetic Neuropathy Frontiers in neuroscience. vol 16. 2022-07-28. PMID:35898407. |
in the cns, α-syntrophin (snta1) directly or indirectly anchors aqp4 in astrocyte membranes facing blood vessels. |
2022-07-28 |
2023-08-14 |
mouse |
| Yuan Liu, Zongqi Wang, Chang Cao, Zhongmou Xu, Jinxin Lu, Haitao Shen, Xiang Li, Haiying Li, Jiang Wu, Gang Che. Aquaporin 4 Depolarization-Enhanced Transferrin Infiltration Leads to Neuronal Ferroptosis after Subarachnoid Hemorrhage in Mice. Oxidative medicine and cellular longevity. vol 2022. 2022-06-28. PMID:35761873. |
aqp4, a water channel protein located at the astrocyte foot, has been reported to regulate blood-brain barrier integrity, and its polarization is disrupted after sah. |
2022-06-28 |
2023-08-14 |
mouse |
| Jenny I Szu, Devin K Binde. Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy. Frontiers in cellular neuroscience. vol 16. 2022-06-23. PMID:35734218. |
one key protein involved in such processes is the astrocyte water channel aquaporin-4 (aqp4). |
2022-06-23 |
2023-08-14 |
Not clear |
| Jenny I Szu, Devin K Binde. Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy. Frontiers in cellular neuroscience. vol 16. 2022-06-23. PMID:35734218. |
studies have revealed that perivascular aqp4 redistributes away from astrocyte endfeet and toward the neuropil in both clinical and preclinical studies. |
2022-06-23 |
2023-08-14 |
Not clear |