| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun Hong, He JianCheng, Wu JiaWen, Zhan ShuQin, Zhang GuiLian, Wu HaiQin, Zhang Ru, Gao Zhen, Ren HongWe. Losartan inhibits development of spontaneous recurrent seizures by preventing astrocyte activation and attenuating blood-brain barrier permeability following pilocarpine-induced status epilepticus. Brain research bulletin. vol 149. 2020-07-20. PMID:31077774. |
as the changes of aqp4 expression were closely related to astrocyte activation and bbb permeability, the antiepileptic action of losartan likely relates to its effects on astrocyte activation and bbb permeability. |
2020-07-20 |
2023-08-13 |
rat |
| Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Biha. Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor. PloS one. vol 15. issue 5. 2020-07-20. PMID:32413082. |
a key component of the gs and brain tissue water circulation is the astrocyte which is regulated by acquaporin-4 (aqp4), a membrane-bound water channel on the astrocytic end-feet. |
2020-07-20 |
2023-08-13 |
mouse |
| Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Biha. Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor. PloS one. vol 15. issue 5. 2020-07-20. PMID:32413082. |
here we investigated the potential of diffusion mri to monitor astrocyte activity in a mouse brain model through the inhibition of aqp4 channels with tgn-020. |
2020-07-20 |
2023-08-13 |
mouse |
| Xue Xue, Weiwei Zhang, Jifeng Zhu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Gang Hu, Chuan S. Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease. Journal of cellular and molecular medicine. vol 23. issue 4. 2020-07-15. PMID:30680924. |
aquaporin-4 (aqp4), the main water-selective membrane transport protein in the brain, is localized to the astrocyte plasma membrane. |
2020-07-15 |
2023-08-13 |
mouse |
| Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Hamed Jafarpour, Zatollah Asem. Aquaporin 4: A key player in Parkinson's disease. Journal of cellular physiology. vol 234. issue 12. 2020-06-05. PMID:31127615. |
given that a sequence of cellular and molecular mechanisms, including oxidative stresses, apoptosis, inflammatory pathways, microglia, astrocyte activation, and aquaporin 4 (aqp4) are associated with initiation and the progression of pd. |
2020-06-05 |
2023-08-13 |
Not clear |
| Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Hamed Jafarpour, Zatollah Asem. Aquaporin 4: A key player in Parkinson's disease. Journal of cellular physiology. vol 234. issue 12. 2020-06-05. PMID:31127615. |
aqp4 may affect various pathways (i.e., α-synuclein, inflammatory pathways, and microglia and astrocyte activation). |
2020-06-05 |
2023-08-13 |
Not clear |
| Zhihong Zhong, Yuhao Sun, Baofeng Wang, Qingfang Sun, Guoyuan Yang, Liuguan Bia. Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology. vol 73. 2020-04-27. PMID:30914277. |
primary cultures of astrocytes were exposed to ferrous iron, and the expression of aqp4 as well as the swelling of astrocyte were determined. |
2020-04-27 |
2023-08-13 |
mouse |
| Zhihong Zhong, Yuhao Sun, Baofeng Wang, Qingfang Sun, Guoyuan Yang, Liuguan Bia. Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology. vol 73. 2020-04-27. PMID:30914277. |
ferrous iron exposure induced astrocyte death as well as cell swelling, and increased aqp4 expression. |
2020-04-27 |
2023-08-13 |
mouse |
| Zhihong Zhong, Yuhao Sun, Baofeng Wang, Qingfang Sun, Guoyuan Yang, Liuguan Bia. Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology. vol 73. 2020-04-27. PMID:30914277. |
aqp4 gene silencing after sirna transfection attenuated ferrous iron-induced astrocyte death. |
2020-04-27 |
2023-08-13 |
mouse |
| Zhihong Zhong, Yuhao Sun, Baofeng Wang, Qingfang Sun, Guoyuan Yang, Liuguan Bia. Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology. vol 73. 2020-04-27. PMID:30914277. |
mapks were activated after ferrous iron treatment, and inhibitors of erk and p38-mapk relieved aqp4 expression upregulation as well as astrocyte death. |
2020-04-27 |
2023-08-13 |
mouse |
| Zhihong Zhong, Yuhao Sun, Baofeng Wang, Qingfang Sun, Guoyuan Yang, Liuguan Bia. Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology. vol 73. 2020-04-27. PMID:30914277. |
mapks activation may play important roles in ferrous iron-induced astrocyte death through upregulation of aqp4 expression. |
2020-04-27 |
2023-08-13 |
mouse |
| Alex J Smith, Tianjiao Duan, Alan S Verkma. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31068220. |
redistribution of the water channel aquaporin-4 (aqp4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of alzheimer's disease (ad) and other neurological conditions with prominent astrogliosis. |
2020-04-21 |
2023-08-13 |
mouse |
| Alex J Smith, Tianjiao Duan, Alan S Verkma. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31068220. |
aqp4 deficient 5xfad mice also showed a significant reduction in the density of gfap labeled peri-plaque astrocyte processes. |
2020-04-21 |
2023-08-13 |
mouse |
| Alex J Smith, Tianjiao Duan, Alan S Verkma. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31068220. |
on the basis of these findings, we propose that redistribution of aqp4 into the parenchymal processes facilitates astrocyte structural plasticity and the formation of a reactive glial net around plaques that protects neurons from the deleterious effects of aβ aggregates. |
2020-04-21 |
2023-08-13 |
mouse |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
this study was designed to evaluate the roles of hmgb1 on the regulation of early spinal cord edema, astrocyte activation, and aquaporin-4 (aqp4) expression in a rat sci model. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
the effects of hmgb1 inhibition on the early spinal cord edema, astrocyte activation (glial fibrillary acidic protein [gfap] expression), and aqp4 expression after sci (12 h-3 days) were analyzed. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
these results implicate that hmgb1 inhibition improved locomotor function and reduced early spinal cord edema, which was associated with a downregulation of astrocyte activation (gfap expression) and aqp4 expression in sci rats. |
2020-04-10 |
2023-08-13 |
rat |
| Claudia Palazzo, Cinzia Buccoliero, Maria Grazia Mola, Pasqua Abbrescia, Grazia Paola Nicchia, Maria Trojano, Antonio Friger. AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30935410. |
aqp4ex is crucial for the anchoring of aqp4 at the astrocyte end-feet and for neuromyelitis optica antibody binding. |
2020-03-30 |
2023-08-13 |
Not clear |
| Brittany Short, Lindsay Kozek, Hannah Harmsen, Bo Zhang, Michael Wong, Kevin C Ess, Cary Fu, Robert Naftel, Matthew M Pearson, Robert P Carso. Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex. Neurobiology of disease. vol 129. 2020-03-24. PMID:31078684. |
we hypothesized that aberrant expression of the astrocyte protein aquaporin-4 (aqp4) may be present in tsc and contribute to disease pathology. |
2020-03-24 |
2023-08-13 |
mouse |
| Brittany Short, Lindsay Kozek, Hannah Harmsen, Bo Zhang, Michael Wong, Kevin C Ess, Cary Fu, Robert Naftel, Matthew M Pearson, Robert P Carso. Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex. Neurobiology of disease. vol 129. 2020-03-24. PMID:31078684. |
our findings in both tsc epileptogenic cortex and in a variety of astrocyte culture models demonstrate for the first time that aqp4 expression is dysregulated in tsc. |
2020-03-24 |
2023-08-13 |
mouse |