| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Huang, Junwen Li, Chao Feng, Xi Huang, Liping Wong, Xueyuan Liu, Zhiyu Nie, Gangming X. Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4. BioMed research international. vol 2018. 2018-09-20. PMID:29682525. |
astrocyte polarity was assessed by visualizing the distribution of aqp4 on astrocyte end-feet membranes. |
2018-09-20 |
2023-08-13 |
Not clear |
| Jing Huang, Junwen Li, Chao Feng, Xi Huang, Liping Wong, Xueyuan Liu, Zhiyu Nie, Gangming X. Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4. BioMed research international. vol 2018. 2018-09-20. PMID:29682525. |
at 3 days after 2vo, aqp4 and agrin displayed the most opposite expression with the former increasing and the latter decreasing; at the same time, brain edema reached high point as well as bbb permeability, and astrocyte polarity was degeneration. |
2018-09-20 |
2023-08-13 |
Not clear |
| Jing Huang, Junwen Li, Chao Feng, Xi Huang, Liping Wong, Xueyuan Liu, Zhiyu Nie, Gangming X. Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4. BioMed research international. vol 2018. 2018-09-20. PMID:29682525. |
in accordance with that, agrin and aqp4 expression decreased significantly with astrocyte polarity reducing. |
2018-09-20 |
2023-08-13 |
Not clear |
| Jing Huang, Junwen Li, Chao Feng, Xi Huang, Liping Wong, Xueyuan Liu, Zhiyu Nie, Gangming X. Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4. BioMed research international. vol 2018. 2018-09-20. PMID:29682525. |
we speculated that agrin and aqp4 played key roles in development of wml by mediating bbb damage in cch, and bbb dysfunction due to reduced astrocyte polarity is the starting point of wmh. |
2018-09-20 |
2023-08-13 |
Not clear |
| Alan S Verkman, Lukmanee Tradtrantip, Alex J Smith, Xiaoming Ya. Aquaporin Water Channels and Hydrocephalus. Pediatric neurosurgery. vol 52. issue 6. 2018-08-27. PMID:27978530. |
aqp4 is expressed in astrocyte foot processes and ependymal cells lining ventricles, where it appears to facilitate the transport of excess water out of the brain. |
2018-08-27 |
2023-08-13 |
mouse |
| Jesse A Stokum, Min S Kwon, Seung K Woo, Orest Tsymbalyuk, Rudi Vennekens, Volodymyr Gerzanich, J Marc Simar. SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia. vol 66. issue 1. 2018-07-02. PMID:28906027. |
sur1-trpm4 and aqp4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. |
2018-07-02 |
2023-08-13 |
Not clear |
| Jesse A Stokum, Min S Kwon, Seung K Woo, Orest Tsymbalyuk, Rudi Vennekens, Volodymyr Gerzanich, J Marc Simar. SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia. vol 66. issue 1. 2018-07-02. PMID:28906027. |
mechanisms proffered to explain astrocyte swelling emphasize the importance of either aquaporin-4 (aqp4), an astrocyte water channel, or of na |
2018-07-02 |
2023-08-13 |
Not clear |
| Mootaz M Salman, Philip Kitchen, M Nicola Woodroofe, James E Brown, Roslyn M Bill, Alex C Conner, Matthew T Conne. Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism. The European journal of neuroscience. vol 46. issue 9. 2018-06-20. PMID:28925524. |
hypothermia is known to cause astrocyte swelling in culture, but the precise role of aqp4 in this process is unknown. |
2018-06-20 |
2023-08-13 |
human |
| Mohd Jamil Mohamed Mokhtarudin, Stephen J Payn. The study of the function of AQP4 in cerebral ischaemia-reperfusion injury using poroelastic theory. International journal for numerical methods in biomedical engineering. vol 33. issue 1. 2018-06-12. PMID:26991256. |
brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (aqp4), which are found in the astrocyte endfeet. |
2018-06-12 |
2023-08-13 |
Not clear |
| Mohd Jamil Mohamed Mokhtarudin, Stephen J Payn. The study of the function of AQP4 in cerebral ischaemia-reperfusion injury using poroelastic theory. International journal for numerical methods in biomedical engineering. vol 33. issue 1. 2018-06-12. PMID:26991256. |
aqp4 allows the movement of water between astrocyte and the ecs and the microvessels. |
2018-06-12 |
2023-08-13 |
Not clear |
| Cordula Rakers, Matthias Schmid, Gabor C Petzol. TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model. Glia. vol 65. issue 9. 2018-04-12. PMID:28639721. |
aqp4 neither influenced pid-related calcium signals nor pid-related edema of astrocyte somata. |
2018-04-12 |
2023-08-13 |
mouse |
| Hui Wang, Shiqi Wang, Kang Zhang, Hua Wang, Liting Lan, Xiaoyun Ma, Xiaoyan Liu, Shuzhuo Zhang, Jianquan Zheng, Xiaoli Wei, Haitao Ya. Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28341892. |
these findings may help to reveal the mechanism that aqp4, glt-1, and mor form protein complex and participate in morphine dependence, and deeply understand the reason that aqp4 deficiency maintains extracellular glutamate homeostasis and attenuates morphine dependence, moreover emphasizes the function of astrocyte in morphine dependence. |
2018-03-06 |
2023-08-13 |
Not clear |
| Jing Yang, Rui Zhang, Changhe Shi, Chengyuan Mao, Zhihua Yang, Zhenhe Suo, Reidun Torp, Yuming X. AQP4 Association with Amyloid Deposition and Astrocyte Pathology in the Tg-ArcSwe Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 57. issue 1. 2018-02-26. PMID:28222512. |
aqp4 association with amyloid deposition and astrocyte pathology in the tg-arcswe mouse model of alzheimer's disease. |
2018-02-26 |
2023-08-13 |
mouse |
| Jing Yang, Rui Zhang, Changhe Shi, Chengyuan Mao, Zhihua Yang, Zhenhe Suo, Reidun Torp, Yuming X. AQP4 Association with Amyloid Deposition and Astrocyte Pathology in the Tg-ArcSwe Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 57. issue 1. 2018-02-26. PMID:28222512. |
in addition, the astrocyte marker, glial fibrillary acidic protein (gfap), was studied in association with aqp4. |
2018-02-26 |
2023-08-13 |
mouse |
| Jing Yang, Rui Zhang, Changhe Shi, Chengyuan Mao, Zhihua Yang, Zhenhe Suo, Reidun Torp, Yuming X. AQP4 Association with Amyloid Deposition and Astrocyte Pathology in the Tg-ArcSwe Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 57. issue 1. 2018-02-26. PMID:28222512. |
this suggests that aqp4 expression was associated with amyloid deposition and astrocyte pathology in the tg-arcswe mouse model of ad. |
2018-02-26 |
2023-08-13 |
mouse |
| Manuela De Bellis, Francesco Pisani, Maria Grazia Mola, Stefania Rosito, Laura Simone, Cinzia Buccoliero, Maria Trojano, Grazia Paola Nicchia, Maria Svelto, Antonio Friger. Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport. Glia. vol 65. issue 5. 2018-02-06. PMID:28206694. |
translational readthrough generates new astrocyte aqp4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport. |
2018-02-06 |
2023-08-13 |
Not clear |
| Meiyan Sun, Jie Wang, Yue Zhou, Zijian Wang, Yong Jiang, Miao L. Isotetrandrine Reduces Astrocyte Cytotoxicity in Neuromyelitis Optica by Blocking the Binding of NMO-IgG to Aquaporin 4. Neuroimmunomodulation. vol 23. issue 2. 2018-02-05. PMID:27064690. |
research over the last decade revealed that the binding of nmo-igg to the water channel protein astrocyte aquaporin 4 (aqp4) might be the primary cause of nmo pathogenesis. |
2018-02-05 |
2023-08-13 |
Not clear |
| Heling Chu, Xiaobo Yang, Chuyi Huang, Zidan Gao, Yuping Tang, Qiang Don. Apelin-13 Protects against Ischemic Blood-Brain Barrier Damage through the Effects of Aquaporin-4. Cerebrovascular diseases (Basel, Switzerland). vol 44. issue 1-2. 2018-01-08. PMID:28402976. |
aquaporin-4 (aqp4) has a close link with bbb due to the high concentration in astrocyte foot processes and regulation of astrocytes function. |
2018-01-08 |
2023-08-13 |
Not clear |
| Xiaoming Yao, Alan S Verkma. Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta neuropathologica communications. vol 5. issue 1. 2017-12-19. PMID:28750658. |
complement regulator cd59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin g. pathogenesis in aquaporin-4 immunoglobulin g (aqp4-igg) seropositive neuromyelitis optica spectrum disorders (herein called nmo) involves complement-dependent cytotoxicity initiated by aqp4-igg binding to astrocyte aqp4. |
2017-12-19 |
2023-08-13 |
rat |
| Lukmanee Tradtrantip, Xiaoming Yao, Tao Su, Alex J Smith, Alan S Verkma. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta neuropathologica. vol 134. issue 1. 2017-12-11. PMID:28567523. |
injury to oligodendrocytes, which do not express aqp4, links the initiating pathogenic event of aqp4-igg binding to astrocyte aqp4 to demyelination. |
2017-12-11 |
2023-08-13 |
rat |