| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeffrey L Bennett, Kevin C O'Connor, Amit Bar-Or, Scott S Zamvil, Bernhard Hemmer, Thomas F Tedder, H-Christian von Büdingen, Olaf Stuve, Michael R Yeaman, Terry J Smith, Christine Stadelman. B lymphocytes in neuromyelitis optica. Neurology(R) neuroimmunology & neuroinflammation. vol 2. issue 3. 2015-05-15. PMID:25977932. |
a majority (approximately 75%) of patients with nmo are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (aqp4). |
2015-05-15 |
2023-08-13 |
Not clear |
| Jeffrey L Bennett, Kevin C O'Connor, Amit Bar-Or, Scott S Zamvil, Bernhard Hemmer, Thomas F Tedder, H-Christian von Büdingen, Olaf Stuve, Michael R Yeaman, Terry J Smith, Christine Stadelman. B lymphocytes in neuromyelitis optica. Neurology(R) neuroimmunology & neuroinflammation. vol 2. issue 3. 2015-05-15. PMID:25977932. |
these autoantibodies are predominantly igg1, and considerable evidence supports their pathogenicity, presumably by binding to aqp4 on cns astrocytes, resulting in astrocyte injury and inflammation. |
2015-05-15 |
2023-08-13 |
Not clear |
| Jasmine Vella, Christian Zammit, Giuseppe Di Giovanni, Richard Muscat, Mario Valentin. The central role of aquaporins in the pathophysiology of ischemic stroke. Frontiers in cellular neuroscience. vol 9. 2015-04-23. PMID:25904843. |
other roles ascribed to aqp4 include facilitation of astrocyte migration, glial scar formation, modulation of inflammation and signaling functions. |
2015-04-23 |
2023-08-13 |
mouse |
| Petra Fallier-Becker, Jörg P Vollmer, Hans-C Bauer, Susan Noell, Hartwig Wolburg, Andreas F Mac. Onset of aquaporin-4 expression in the developing mouse brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 36. 2015-03-02. PMID:24915007. |
we used immunocytochemistry against aqp4, zonula occludens protein-1, glial fibrillary acidic protein, and β-dystroglycan to follow astrocyte development in e15 to p3 nmri mouse brains, and expression of aqp4. |
2015-03-02 |
2023-08-13 |
mouse |
| Lei Liu, Yushan Lu, Hui Kong, Liu Li, Charles Marshall, Ming Xiao, Jiong Ding, Junying Gao, Gang H. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. The international journal of neuropsychopharmacology. vol 15. issue 1. 2015-01-22. PMID:21281561. |
a growing body of evidence indicates that water channel aquaporin-4 (aqp4) is a potential molecular target for the regulation astrocyte function. |
2015-01-22 |
2023-08-12 |
mouse |
| Lei Liu, Yushan Lu, Hui Kong, Liu Li, Charles Marshall, Ming Xiao, Jiong Ding, Junying Gao, Gang H. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. The international journal of neuropsychopharmacology. vol 15. issue 1. 2015-01-22. PMID:21281561. |
therefore, regulation of astrocyte function by aqp4 may attenuate oxidative damage, offering a promising therapeutic strategy for ad. |
2015-01-22 |
2023-08-12 |
mouse |
| Tatsuro Mis. [In vivo experimental models of neuromyelitis optica]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 11. 2015-01-08. PMID:25518375. |
neuromyelitis optica (nmo) is autoimmune disease targeting against water channel aquaporin 4 (aqp4), mainly located at astrocyte foot processes in the central nervous system (cns). |
2015-01-08 |
2023-08-13 |
Not clear |
| Gökhan Akdemir, Julien Ratelade, Nithi Asavapanumas, A S Verkma. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neuroscience letters. vol 574. 2014-12-18. PMID:24717641. |
astrocyte water channel aquaporin-4 (aqp4) facilitates water movement across the blood-brain barrier and into injured astrocytes. |
2014-12-18 |
2023-08-13 |
mouse |
| Ming Xiao, Gang H. Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders. CNS neuroscience & therapeutics. vol 20. issue 5. 2014-12-08. PMID:24712483. |
aquaporin 4 (aqp4) is the main water channel in the central nervous system (cns) and specifically localized to astrocyte processes. |
2014-12-08 |
2023-08-13 |
Not clear |
| Ming Xiao, Gang H. Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders. CNS neuroscience & therapeutics. vol 20. issue 5. 2014-12-08. PMID:24712483. |
this review summarizes recent findings and highlights the involvement of aqp4 in astrocyte function and neuropsychiatric disorders. |
2014-12-08 |
2023-08-13 |
Not clear |
| Hossein Mostafavi, Mojtaba Khaksarian, Mohammad Taghi Joghataei, Gholamreza Hassanzadeh, Masoud Soleimani, Sanaz Eftekhari, Mansooreh Soleimani, Kazem Mousavizadeh, Mahmoud Reza Hadjighasse. Fluoxetin upregulates connexin 43 expression in astrocyte. Basic and clinical neuroscience. vol 5. issue 1. 2014-12-01. PMID:25436087. |
this study aimed to investigate possible acute effects of fluoxetine on cx43 and aqp4 expression in astrocyte. |
2014-12-01 |
2023-08-13 |
Not clear |
| Charles L Howe, Tatiana Kaptzan, Setty M Magaña, Jennifer R Ayers-Ringler, Reghann G LaFrance-Corey, Claudia F Lucchinett. Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures. Glia. vol 62. issue 5. 2014-11-24. PMID:24492996. |
we hypothesize that binding of the nmo igg to aqp4 induces a cellular response that results in transcriptional and translational events within the astrocyte that are consistent with a reactive and inflammatory phenotype. |
2014-11-24 |
2023-08-12 |
rat |
| Ryuichi Katada, Kana Sugimoto, Motonori Yoshida, Hiroshi Matsumot. Ethanol increases astrocyte aquaporin-4 expression under hyper-sodium condition. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 49. issue 3. 2014-10-16. PMID:25223087. |
astrocyte aqp4 expression was increased in hypo-sodium exposure. |
2014-10-16 |
2023-08-13 |
rat |
| Ryuichi Katada, Kana Sugimoto, Motonori Yoshida, Hiroshi Matsumot. Ethanol increases astrocyte aquaporin-4 expression under hyper-sodium condition. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 49. issue 3. 2014-10-16. PMID:25223087. |
hyper-sodium changing increased astrocyte aqp4 expression under etoh exposure. |
2014-10-16 |
2023-08-13 |
rat |
| Nithi Asavapanumas, Julien Ratelade, Marios C Papadopoulos, Jeffrey L Bennett, Marc H Levin, Alan S Verkma. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24468108. |
most nmo patients are seropositive for immunoglobulin g autoantibodies (nmo-igg) against the astrocyte water channel aquaporin-4 (aqp4). |
2014-09-16 |
2023-08-12 |
mouse |
| Claudia F Lucchinetti, Yong Guo, Bogdan F Gh Popescu, Kazuo Fujihara, Yasuto Itoyama, Tatsuro Mis. The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica. Brain pathology (Zurich, Switzerland). vol 24. issue 1. 2014-08-29. PMID:24345222. |
additionally, recent experimental studies showed that aqp4 antibody is pathogenic, resulting in selective astrocyte destruction and dysfunction in vitro, ex vivo and in vivo. |
2014-08-29 |
2023-08-12 |
Not clear |
| A S Verkman, Puay-Wah Phuan, Nithi Asavapanumas, Lukmanee Tradtranti. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain pathology (Zurich, Switzerland). vol 23. issue 6. 2014-06-05. PMID:24118484. |
phenotype analysis of aqp4 knockout mice indicates the involvement of aqp4 in water movement into and out of the brain, astrocyte migration, glial scar formation and neuroexcitatory phenomena. |
2014-06-05 |
2023-08-12 |
mouse |
| Tae-Joon Park, Jeong-Hyun Kim, Ho Jin Kim, Joon Seol Bae, Hyun Sub Cheong, Byung Lae Park, Hyoung Doo Shi. Lack of association between AQP4 polymorphisms and risk of inflammatory demyelinating disease in a Korean population. Gene. vol 536. issue 2. 2014-04-28. PMID:24361961. |
aquaporin 4 (aqp4) is a commonly distributed water channel in astrocytes of the cns, and its expression is decreased in nmo lesions due to astrocyte cytotoxicity. |
2014-04-28 |
2023-08-12 |
Not clear |
| Grazyna Rajkowska, Craig A Stockmeie. Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Current drug targets. vol 14. issue 11. 2014-04-14. PMID:23469922. |
this review summarizes evidence from human postmortem tissue showing alterations in the expression of protein and mrna for astrocyte markers such as glial fibrillary acidic protein (gfap), gap junction proteins (connexin 40 and 43), the water channel aquaporin-4 (aqp4), a calcium-binding protein s100b and glutamatergic markers including the excitatory amino acid transporters 1 and 2 (eaat1, eaat2) and glutamine synthetase. |
2014-04-14 |
2023-08-12 |
human |
| Alex J Smith, Byung-Ju Jin, Julien Ratelade, Alan S Verkma. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. The Journal of cell biology. vol 204. issue 4. 2014-04-08. PMID:24515349. |
the astrocyte water channel aquaporin-4 (aqp4) is expressed as heterotetramers of m1 and m23 isoforms in which the presence of m23-aqp4 promotes formation of large macromolecular aggregates termed orthogonal arrays. |
2014-04-08 |
2023-08-12 |
Not clear |