| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A S Verkman, Andrea Rossi, Jonathan M Cran. Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion. Methods in enzymology. vol 504. 2012-06-19. PMID:22264543. |
aqp4 is involved in brain water balance, neuroexcitation, astrocyte migration, and neuroinflammation and is the target of pathogenic autoantibodies in neuromyelitis optica. |
2012-06-19 |
2023-08-12 |
Not clear |
| Tetsuryu Mitsuyama, Taku Yoneyama, Sakiko Suzuki, Mizuo Kagawa, Takakazu Kawamat. [Neuromyelitis optica spectrum disorder: a case report]. No shinkei geka. Neurological surgery. vol 40. issue 4. 2012-06-19. PMID:22466233. |
it is presumed to be an antibody-mediated disorder and the target antigen is the water channel aquaporin-4 (aqp4) on astrocyte cell membranes. |
2012-06-19 |
2023-08-12 |
Not clear |
| Andrea Rossi, Florian Baumgart, Alfred N van Hoek, A S Verkma. Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays. Traffic (Copenhagen, Denmark). vol 13. issue 1. 2012-06-11. PMID:21981006. |
post-golgi and membrane curvature-dependent oap assembly may be important for vesicle transport of aqp4 in the secretory pathway and aqp4-facilitated astrocyte migration, and suggests a novel therapeutic approach for neuromyelitis optica. |
2012-06-11 |
2023-08-12 |
Not clear |
| Lukmanee Tradtrantip, Hua Zhang, Samira Saadoun, Puay-Wah Phuan, Chiwah Lam, Marios C Papadopoulos, Jeffrey L Bennett, A S Verkma. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Annals of neurology. vol 71. issue 3. 2012-05-16. PMID:22271321. |
circulating autoantibodies (nmo-immunoglobulin [ig]g) against astrocyte water channel aquaporin-4 (aqp4) cause complement- and cell-mediated astrocyte damage with consequent neuroinflammation and demyelination. |
2012-05-16 |
2023-08-12 |
Not clear |
| Samira Saadoun, Patrick Waters, Claire MacDonald, B Anthony Bell, Angela Vincent, A S Verkman, Marios C Papadopoulo. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Annals of neurology. vol 71. issue 3. 2012-05-16. PMID:22374891. |
neuromyelitis optica (nmo) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (aqp4). |
2012-05-16 |
2023-08-12 |
mouse |
| Jing Yang, Lisa K Lunde, Paworn Nuntagij, Tomohiro Oguchi, Laura M A Camassa, Lars N G Nilsson, Lars Lannfelt, Yuming Xu, Mahmood Amiry-Moghaddam, Ole Petter Ottersen, Reidun Tor. Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21891870. |
astrocytic endfoot membranes exhibit tenfold higher densities of aqp4 than non-endfoot membranes, making aqp4 an excellent marker of astrocyte polarization. |
2012-04-16 |
2023-08-12 |
mouse |
| Jing Yang, Lisa K Lunde, Paworn Nuntagij, Tomohiro Oguchi, Laura M A Camassa, Lars N G Nilsson, Lars Lannfelt, Yuming Xu, Mahmood Amiry-Moghaddam, Ole Petter Ottersen, Reidun Tor. Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21891870. |
here we investigate by a combination of light and electron microscopic immunocytochemistry whether amyloid deposition is associated with a loss of astrocyte polarization, using aqp4 as a marker. |
2012-04-16 |
2023-08-12 |
mouse |
| Julien Ratelade, Jeffrey L Bennett, A S Verkma. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22069320. |
autoantibodies against astrocyte water channel aquaporin-4 (aqp4) are thought to be pathogenic in neuromyelitis optica (nmo). |
2012-02-27 |
2023-08-12 |
mouse |
| Julien Ratelade, Jeffrey L Bennett, A S Verkma. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22069320. |
however, little or no internalization of nmo-igg, aqp4, or eaat2 was found in primary astrocyte cultures, nor was glutamate uptake affected by nmo-igg exposure. |
2012-02-27 |
2023-08-12 |
mouse |
| Julien Ratelade, Jeffrey L Bennett, A S Verkma. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22069320. |
following injection of nmo-igg into mouse brain, nmo-igg binding and aqp4 expression showed a perivascular astrocyte distribution, without detectable cellular internalization over 24 h. we conclude that astrocyte endocytosis of nmo-igg, aqp4, and eaat2 is not a significant consequence of aqp4 autoantibody in vivo, challenging generally accepted views about nmo pathogenesis. |
2012-02-27 |
2023-08-12 |
mouse |
| Ryuichi Katada, Yoko Nishitani, Osamu Honmou, Keisuke Mizuo, Shunichiro Okazaki, Kenji Tateda, Satoshi Watanabe, Hiroshi Matsumot. Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure. The American journal of pathology. vol 180. issue 1. 2012-02-17. PMID:22051773. |
in the ethanol-pretreated group, aqp4 was accumulated, particularly in astrocyte end feet, 24 hours after tbi. |
2012-02-17 |
2023-08-12 |
rat |
| Hua Zhang, Jeffrey L Bennett, A S Verkma. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. Annals of neurology. vol 70. issue 6. 2012-02-09. PMID:22069219. |
neuromyelitis optica (nmo) is a neuroinflammatory disease of spinal cord and optic nerve associated with serum autoantibodies (nmo-immunoglobulin g [igg]) against astrocyte water channel aquaporin-4 (aqp4). |
2012-02-09 |
2023-08-12 |
Not clear |
| Nadia Nabil Haj-Yasein, Gry Fluge Vindedal, Martine Eilert-Olsen, Georg Andreas Gundersen, Øivind Skare, Petter Laake, Arne Klungland, Anna Elisabeth Thorén, John Michael Burkhardt, Ole Petter Ottersen, Erlend Arnulf Nagelhu. Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 43. 2011-12-19. PMID:21990350. |
glial-conditional deletion of aquaporin-4 (aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. |
2011-12-19 |
2023-08-12 |
mouse |
| Xiang-Nan Huang, Wei-Zhi Wang, Jin Fu, Hua-Bing Wan. The relationship between aquaporin-4 expression and blood-brain and spinal cord barrier permeability following experimental autoimmune encephalomyelitis in the rat. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 1. 2011-11-07. PMID:21157915. |
aquaporin 4(aqp4) is a water channel protein strongly expressed in the central nervous system in perimicrovessel astrocyte foot processes, the glia limitans, and ependyma. |
2011-11-07 |
2023-08-12 |
rat |
| Alan S Verkman, Julien Ratelade, Andrea Rossi, Hua Zhang, Lukmanee Tradtranti. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta pharmacologica Sinica. vol 32. issue 6. 2011-09-30. PMID:21552296. |
phenotype analysis of aqp4-null mice indicates the involvement of aqp4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. |
2011-09-30 |
2023-08-12 |
mouse |
| Alan S Verkman, Julien Ratelade, Andrea Rossi, Hua Zhang, Lukmanee Tradtranti. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta pharmacologica Sinica. vol 32. issue 6. 2011-09-30. PMID:21552296. |
each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in aqp4 deficiency. |
2011-09-30 |
2023-08-12 |
mouse |
| Alan S Verkman, Julien Ratelade, Andrea Rossi, Hua Zhang, Lukmanee Tradtranti. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta pharmacologica Sinica. vol 32. issue 6. 2011-09-30. PMID:21552296. |
aqp4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica (nmo), where autoantibodies (nmo-igg) targeting aqp4 produce astrocyte damage and inflammation. |
2011-09-30 |
2023-08-12 |
mouse |
| Jennifer M Rutkowsky, Breanna K Wallace, Phyllis M Wise, Martha E O'Donnel. Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. American journal of physiology. Cell physiology. vol 301. issue 1. 2011-09-06. PMID:21471464. |
effects of estradiol on ischemic factor-induced astrocyte swelling and aqp4 protein abundance. |
2011-09-06 |
2023-08-12 |
rat |
| Kakulavarapu V Rama Rao, Pichili V B Reddy, Kevin M Curtis, Michael D Norenber. Aquaporin-4 expression in cultured astrocytes after fluid percussion injury. Journal of neurotrauma. vol 28. issue 3. 2011-07-25. PMID:21204635. |
silencing the aqp4 gene by sirna resulted in a significant reduction in trauma-induced astrocyte swelling, indicating a critical role of aqp4 in this process. |
2011-07-25 |
2023-08-12 |
Not clear |
| Cheng Zhang, Laura Asnaghi, Celine Gongora, Bonnie Patek, Stacey Hose, Bo Ma, Masoud Aghsaei Fard, Lawrence Brako, Kamaljeet Singh, Morton F Goldberg, James T Handa, Woo-Kuen Lo, Charles G Eberhart, J Samuel Zigler, Debasish Sinh. A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21354650. |
aquaporin 4 (aqp4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. |
2011-07-11 |
2023-08-12 |
human |