| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geoffroy Noël, Sarah Stevenson, Hakima Moukhle. A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes. PloS one. vol 6. issue 3. 2011-07-05. PMID:21408176. |
aquaporin-4 (aqp4) constitutes the principal water channel in the brain and is clustered at the perivascular astrocyte endfeet. |
2011-07-05 |
2023-08-12 |
mouse |
| Geoffroy Noël, Sarah Stevenson, Hakima Moukhle. A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes. PloS one. vol 6. issue 3. 2011-07-05. PMID:21408176. |
a growing body of evidence points to a role of the dystroglycan complex and its interaction with perivascular laminin in the clustering of aqp4 at perivascular astrocyte endfeet. |
2011-07-05 |
2023-08-12 |
mouse |
| Geoffroy Noël, Sarah Stevenson, Hakima Moukhle. A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes. PloS one. vol 6. issue 3. 2011-07-05. PMID:21408176. |
indeed, mice lacking components of this complex or in which laminin-dystroglycan interaction is disrupted show a delayed onset of brain edema due to a redistribution of aqp4 away from astrocyte endfeet. |
2011-07-05 |
2023-08-12 |
mouse |
| Jonathan M Crane, Chiwah Lam, Andrea Rossi, Tripta Gupta, Jeffrey L Bennett, A S Verkma. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21454592. |
autoantibodies against astrocyte water channel aquaporin-4 (aqp4) are highly specific for the neuroinflammatory disease neuromyelitis optica (nmo). |
2011-07-01 |
2023-08-12 |
human |
| Lihua Li, Hua Zhang, Michel Varrin-Doyer, Scott S Zamvil, A S Verkma. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21257712. |
adenovirus-mediated expression of aqp4, or of an unrelated aquaporin, aqp1, increased cytokine secretion in astrocyte and nonastrocyte cell cultures, supporting the involvement of aquaporin water permeability in cytokine secretion. |
2011-06-28 |
2023-08-12 |
mouse |
| Lihua Li, Hua Zhang, Michel Varrin-Doyer, Scott S Zamvil, A S Verkma. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21257712. |
our data suggest an intrinsic proinflammatory role of aqp4 involving aqp4-dependent astrocyte swelling and cytokine release. |
2011-06-28 |
2023-08-12 |
mouse |
| Ling-Ling Qi, San-Hua Fang, Wen-Zhen Shi, Xue-Qin Huang, Xia-Yan Zhang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing We. CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes. Life sciences. vol 88. issue 1-2. 2011-01-21. PMID:21055410. |
we previously reported that cysteinyl leukotriene receptor 2 (cyslt(2)) mediates ischemic astrocyte injury, and leukotriene d(4)-activated cyslt(2) receptor up-regulates the water channel aquaporin 4 (aqp4). |
2011-01-21 |
2023-08-12 |
rat |
| T Matsushita, N Isobe, M Kawajiri, M Mogi, K Tsukuda, M Horiuchi, Y Ohyagi, J Kir. CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity. Journal of the neurological sciences. vol 295. issue 1-2. 2011-01-18. PMID:20541774. |
anti-aquaporin-4 (aqp4) antibody targets perivascular astrocyte foot processes, which contain abundant angiotensinogen, a precursor of angiotensin ii, angiotensin-converting enzyme (ace) and ace2. |
2011-01-18 |
2023-08-12 |
Not clear |
| Marina Zelenin. Regulation of brain aquaporins. Neurochemistry international. vol 57. issue 4. 2010-12-22. PMID:20380861. |
aqp4, the predominant brain water channel, is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of ranvier. |
2010-12-22 |
2023-08-12 |
Not clear |
| Toru Gohara, Kazuyoshi Ishida, Kazuhiko Nakakimura, Mitsuyoshi Yoshida, Shiro Fukuda, Mishiya Matsumoto, Takefumi Sakab. Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats. Journal of anesthesia. vol 24. issue 2. 2010-11-15. PMID:20111877. |
we investigated brain damage in relationship to temporal profiles of water channel aquaporin 4 (aqp4) and astrocyte response to fat embolism in rats. |
2010-11-15 |
2023-08-12 |
rat |
| Tatsuro Misu, Toshiyuki Takahashi, Shuhei Nishiyama, Rina Takano, Ichiro Nakashima, Kazuo Fujihara, Yasuto Itoyam. [New insights into the pathogenesis of neuromyelitis optica]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 9. 2010-11-09. PMID:20844303. |
now it is indispensable to check the aqp4 antibody,and is important to reconsider the role of astrocyte in demyelinating disorders. |
2010-11-09 |
2023-08-12 |
human |
| Kakulavarapu V Rama Rao, Arumugam R Jayakumar, Pichili V B Reddy, Xiaoying Tong, Kevin M Curtis, M D Norenber. Aquaporin-4 in manganese-treated cultured astrocytes. Glia. vol 58. issue 12. 2010-11-04. PMID:20648640. |
as aquaporin-4 (aqp4) is important in the mechanism of astrocyte swelling, we examined the effect of manganese on aqp4 protein levels in cultured astrocytes. |
2010-11-04 |
2023-08-12 |
Not clear |
| Kakulavarapu V Rama Rao, Arumugam R Jayakumar, Pichili V B Reddy, Xiaoying Tong, Kevin M Curtis, M D Norenber. Aquaporin-4 in manganese-treated cultured astrocytes. Glia. vol 58. issue 12. 2010-11-04. PMID:20648640. |
aqp4 gene silencing by small interfering ribonucleic acid resulted in a marked reduction in astrocyte swelling by manganese. |
2010-11-04 |
2023-08-12 |
Not clear |
| Kakulavarapu V Rama Rao, Arumugam R Jayakumar, Pichili V B Reddy, Xiaoying Tong, Kevin M Curtis, M D Norenber. Aquaporin-4 in manganese-treated cultured astrocytes. Glia. vol 58. issue 12. 2010-11-04. PMID:20648640. |
inhibitors of erk1/2 and p38-mapk (but not of jnk) blocked (40-60%) the manganese-induced increase in aqp4 protein content and astrocyte swelling, suggesting the involvement of these kinases in the increased aqp4 content. |
2010-11-04 |
2023-08-12 |
Not clear |
| S Saadoun, M C Papadopoulo. Aquaporin-4 in brain and spinal cord oedema. Neuroscience. vol 168. issue 4. 2010-10-14. PMID:19682555. |
a water channel protein, aquaporin-4 (aqp4), is found in astrocyte foot processes (blood-brain border), the glia limitans (subarachnoid cerebrospinal fluid-brain border) and ependyma (ventricular cerebrospinal fluid-brain border). |
2010-10-14 |
2023-08-12 |
mouse |
| Y Yukutake, M Yasu. Regulation of water permeability through aquaporin-4. Neuroscience. vol 168. issue 4. 2010-10-14. PMID:19850109. |
aquaporin-4 (aqp4) is a predominant water channel protein in mammalian brains that is distributed with the highest density in the perivascular and subpial astrocyte end-feet. |
2010-10-14 |
2023-08-12 |
Not clear |
| Gavin Wright, Robin Soper, Heather F Brooks, Vanessa Stadlbauer, Balasubramaniyan Vairappan, Nathan A Davies, Fausto Andreola, Stephen Hodges, Raymond F Moss, D Ceri Davies, Rajiv Jala. Role of aquaporin-4 in the development of brain oedema in liver failure. Journal of hepatology. vol 53. issue 1. 2010-09-20. PMID:20451280. |
we aimed to determine whether aquaporin-4 (aqp4), an astrocyte endfeet bi-directional water channel, is associated with the brain oedema of he. |
2010-09-20 |
2023-08-12 |
Not clear |
| Yasui Masat. [Regulation, structure and function of brain aquaporin]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030210. |
in mammalian brain, aquaporin-4 (aqp4) is the main water channel and is distributed with highest density in the perivascular and subpial astrocyte end-feet. |
2010-09-02 |
2023-08-12 |
drosophila_melanogaster |
| Miao Xu, Wei Su, Qiu-ping X. Aquaporin-4 and traumatic brain edema. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 13. issue 2. 2010-08-04. PMID:20356447. |
aquaporin-4 (aqp4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid and blood. |
2010-08-04 |
2023-08-12 |
Not clear |
| Daniele Tomassoni, Vincenzo Bramanti, Francesco Ament. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Brain research. vol 1325. 2010-07-19. PMID:20156423. |
aqp4 is expressed by astrocyte foot processes near blood vessels. |
2010-07-19 |
2023-08-12 |
rat |