| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadine El-Khoury, Alex Braun, Furong Hu, Maya Pandey, Maiken Nedergaard, Edmund F Lagamma, Praveen Ballab. Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatric research. vol 59. issue 5. 2006-06-23. PMID:16627880. |
the expression of aqp4, a water channel molecule, in the astrocyte end-feet was not significantly different between premature and mature infants, suggesting similar risk of brain edema in preterm and term infants in pathologic conditions. |
2006-06-23 |
2023-08-12 |
Not clear |
| Grazia P Nicchia, Miduturu Srinivas, Wei Li, Celia F Brosnan, Antonio Frigeri, David C Spra. New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16103109. |
in a previous study, we used small interfering rna (sirna) to specifically knock down aqp4 in rat astrocyte primary cultures and found that together with reduced osmotic permeability, aqp4 knockdown (kd) led to altered cell morphology. |
2006-03-07 |
2023-08-12 |
mouse |
| Grazia P Nicchia, Miduturu Srinivas, Wei Li, Celia F Brosnan, Antonio Frigeri, David C Spra. New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16103109. |
in this study, we compared the effect of aqp4 kd in mouse, rat, and human astrocyte primary cultures and found that aqp4 kd in human astrocytes resulted in a morphological phenotype similar to that found in rat. |
2006-03-07 |
2023-08-12 |
mouse |
| Alejandra Bosco, Karen Cusato, Grazia P Nicchia, Antonio Frigeri, David C Spra. A developmental switch in the expression of aquaporin-4 and Kir4.1 from horizontal to Müller cells in mouse retina. Investigative ophthalmology & visual science. vol 46. issue 10. 2005-11-21. PMID:16186376. |
in adult retina, aquaporin-4 (aqp4) and inwardly rectifying k(+) (kir4.1) channels localize to astrocyte and müller cell membranes facing vascular and vitreous compartments, optimizing clearance of extracellular k(+) and water from the synaptic layers. |
2005-11-21 |
2023-08-12 |
mouse |
| Guillermo L Lehmann, Sergio A Gradilone, Raúl A Marinell. Aquaporin water channels in central nervous system. Current neurovascular research. vol 1. issue 4. 2005-11-14. PMID:16181079. |
the aqp4 is abundantly expressed in astrocyte foot processes and ependymocytes facing capillaries and brain-cerebrospinal fluid (csf) interfaces, whereas aqp9 is localized in tanycytes and astrocytes processes. |
2005-11-14 |
2023-08-12 |
Not clear |
| Marios C Papadopoulos, A S Verkma. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15695511. |
meningitis produced marked astrocyte foot process swelling in wild type but not aqp4 null mice, and slowed diffusion of an inert macromolecule in brain extracellular space. |
2005-06-21 |
2023-08-12 |
mouse |
| Mayka Tomás-Camardiel, José L Venero, R M de Pablos, I Rite, Alberto Machado, Josefina Can. In vivo expression of aquaporin-4 by reactive microglia. Journal of neurochemistry. vol 91. issue 4. 2005-05-25. PMID:15525343. |
aqp4 is particularly enriched in plasma membranes of ependymal cells and astrocyte membrane domains facing blood vessels and pia. |
2005-05-25 |
2023-08-12 |
Not clear |
| E A Nagelhus, T M Mathiisen, O P Otterse. Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561407. |
thus, immunogold analyses have revealed an enrichment of aqp4 in endfeet membranes in contact with brain microvessels or subarachnoidal space and a low but significant concentration in non-endfeet membranes, including those astrocyte membranes that ensheath glutamate synapses. |
2005-03-29 |
2023-08-12 |
Not clear |
| G P Nicchia, B Nico, L M A Camassa, M G Mola, N Loh, R Dermietzel, D C Spray, M Svelto, A Friger. The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture models. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561409. |
aquaporin-4 (aqp4) is the major water channel expressed in brain perivascular astrocyte processes. |
2005-03-29 |
2023-08-12 |
mouse |
| J E Rash, K G V Davidson, T Yasumura, C S Furma. Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561408. |
most of that efflux is through aqp4 water channels concentrated in astrocyte endfeet that surround capillaries and form the glia limitans. |
2005-03-29 |
2023-08-12 |
human |
| J E Rash, K G V Davidson, T Yasumura, C S Furma. Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561408. |
this report extends the ultrastructural and immunocytochemical characterizations of the crystalline aggregates of intramembrane proteins that comprise the aqp4 "square arrays" of astrocyte and ependymocyte plasma membranes. |
2005-03-29 |
2023-08-12 |
human |
| E Gunnarson, M Zelenina, A Aperi. Regulation of brain aquaporins. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561410. |
the assembly between aqp4 and syntrophin is required for the proper localization of aqp4 in the astrocyte plasma membrane that faces capillaries. |
2005-03-29 |
2023-08-12 |
Not clear |
| M Amiry-Moghaddam, D S Frydenlund, O P Otterse. Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience. vol 129. issue 4. 2005-03-29. PMID:15561415. |
data suggest that the perivascular pool of aqp4 plays a role in edema formation and that this pool (through its serial coupling with the aqp4 pools in other astrocyte membranes) is involved in k(+) siphoning. |
2005-03-29 |
2023-08-12 |
mouse |
| Tore Eid, Tih-Shih W Lee, Marion J Thomas, Mahmood Amiry-Moghaddam, Lars P Bjørnsen, Dennis D Spencer, Peter Agre, Ole P Ottersen, Nihal C de Laneroll. Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 4. 2005-03-01. PMID:15657133. |
experimental studies have shown that clearance of extracellular k+ is compromised by removal of the perivascular pool of the water channel aquaporin 4 (aqp4), suggesting that an efficient clearance of k+ depends on a concomitant water flux through astrocyte membranes. |
2005-03-01 |
2023-08-12 |
human |
| Tore Eid, Tih-Shih W Lee, Marion J Thomas, Mahmood Amiry-Moghaddam, Lars P Bjørnsen, Dennis D Spencer, Peter Agre, Ole P Ottersen, Nihal C de Laneroll. Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 4. 2005-03-01. PMID:15657133. |
there was no difference in the density of aqp4 on the astrocyte membrane facing the neuropil. |
2005-03-01 |
2023-08-12 |
human |
| Tore Eid, Tih-Shih W Lee, Marion J Thomas, Mahmood Amiry-Moghaddam, Lars P Bjørnsen, Dennis D Spencer, Peter Agre, Ole P Ottersen, Nihal C de Laneroll. Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 4. 2005-03-01. PMID:15657133. |
because anchoring of aqp4 to the perivascular astrocyte endfoot membrane depends on the dystrophin complex, the localization of the 71-kda brain-specific isoform of dystrophin was assessed by immunohistochemistry. |
2005-03-01 |
2023-08-12 |
human |
| Marios C Papadopoulos, Geoffrey T Manley, Sanjeev Krishna, A S Verkma. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 11. 2005-02-08. PMID:15208268. |
aquaporin-4 (aqp4) is the major water channel in the brain, expressed predominantly in astroglial cell membranes. |
2005-02-08 |
2023-08-12 |
mouse |
| Mahmood Amiry-Moghaddam, Rong Xue, Finn-Mogens Haug, John D Neely, Anish Bhardwaj, Peter Agre, Marvin E Adams, Stanley C Froehner, Susumu Mori, Ole P Otterse. Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14734638. |
here we show by high-resolution immunogold analysis of the blood-brain-barrier that aqp4 is expressed in brain endothelial cells as well as in the perivascular membranes of astrocyte endfeet. |
2004-06-01 |
2023-08-12 |
Not clear |
| Arne Warth, Stephan Kröger, Hartwig Wolbur. Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta neuropathologica. vol 107. issue 4. 2004-05-24. PMID:14735305. |
since alpha-dystroglycan operates as a binding protein for agrin, these observations support the suggestions that (1) aqp4 is tightly associated with the dystrophin-dystroglycan complex, and (2) agrin is necessary for the polarized distribution of aqp4 in the astrocyte. |
2004-05-24 |
2023-08-12 |
human |
| C Sue Furman, Daniel A Gorelick-Feldman, Kimberly G V Davidson, Thomas Yasumura, John D Neely, Peter Agre, John E Ras. Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoforms. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597700. |
perivascular astrocyte end-feet contain distinctive orthogonal lattices (square arrays) assembled from 4- to 6-nm intramembrane particles (imps) corresponding to individual aqp4 tetramers. |
2004-01-05 |
2023-08-12 |
Not clear |