| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marios C Papadopoulos, A S Verkma. Potential utility of aquaporin modulators for therapy of brain disorders. Progress in brain research. vol 170. 2009-02-13. PMID:18655912. |
phenotype analysis of aqp4 knockout mice indicates the involvement of aqp4 in three distinct processes: brain water balance, astroglial cell migration and neural signal transduction. |
2009-02-13 |
2023-08-12 |
mouse |
| Jonathan M Crane, Alfred N Van Hoek, William R Skach, A S Verkma. Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Molecular biology of the cell. vol 19. issue 8. 2008-12-22. PMID:18495865. |
in several transfected cell types, including primary astrocyte cultures, the long n-terminal "m1" form of aqp4 diffused freely, with diffusion coefficient approximately 5 x 10(-10) cm(2)/s, covering approximately 5 microm in 5 min. |
2008-12-22 |
2023-08-12 |
Not clear |
| Shannon R Hinson, Shanu F Roemer, Claudia F Lucchinetti, James P Fryer, Thomas J Kryzer, Jayne L Chamberlain, Charles L Howe, Sean J Pittock, Vanda A Lenno. Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2. The Journal of experimental medicine. vol 205. issue 11. 2008-12-10. PMID:18838545. |
transport-competent eaat2 protein is up-regulated in differentiating astrocyte progenitors and in nonneural cells expressing aqp4 transgenically. |
2008-12-10 |
2023-08-12 |
Not clear |
| Bruce Cre. Neuromyelitis optica: diagnosis, pathogenesis, and treatment. Current neurology and neuroscience reports. vol 8. issue 5. 2008-10-16. PMID:18713580. |
that fact that the biomarker is an autoantibody that recognizes aquaporin 4 (aqp4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that nmo is a humorally mediated autoimmune disease. |
2008-10-16 |
2023-08-12 |
Not clear |
| Yi Fan, Hui Kong, Xueru Shi, Xiulan Sun, Jianhua Ding, Jie Wu, Gang H. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17353068. |
aquaporin 4 (aqp4) is a predominant water channel protein in mammalian brains, which is localized in the astrocyte plasma membrane. |
2008-08-21 |
2023-08-12 |
mouse |
| Eli Gunnarson, Marina Zelenina, Gustav Axehult, Yutong Song, Alexander Bondar, Patrik Krieger, Hjalmar Brismar, Sergey Zelenin, Anita Aperi. Identification of a molecular target for glutamate regulation of astrocyte water permeability. Glia. vol 56. issue 6. 2008-06-20. PMID:18286643. |
here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (aqp4) serine 111 residue, which is in a strategic position for control of the water channel gating. |
2008-06-20 |
2023-08-12 |
rat |
| L Vitellaro-Zuccarello, S Mazzetti, L Madaschi, P Bosisio, E Fontana, A Gorio, S De Bias. Chronic erythropoietin-mediated effects on the expression of astrocyte markers in a rat model of contusive spinal cord injury. Neuroscience. vol 151. issue 2. 2008-04-15. PMID:18065151. |
in the present study, to better understand rhepo-mediated effects on chronic astrocyte response to sci in rat, we have used immunocytochemical methods combined with confocal and electron microscopy to investigate, 1 month after injury, the effects of a single rhepo administration on the expression of a) aquaporin 4 (aqp4), the main astrocytic water channel implicated in edema development and resolution, and two molecules (dystrophin and syntrophin) involved in its membrane anchoring; b) glial fibrillary acidic protein (gfap) and vimentin as markers of astrogliosis; c) chondroitin sulfate proteoglycans of the extracellular matrix which are upregulated after sci and can inhibit axonal regeneration and influence neuronal and glial properties. |
2008-04-15 |
2023-08-12 |
human |
| Hiroshi Hibino, Yoshihisa Kurach. Distinct detergent-resistant membrane microdomains (lipid rafts) respectively harvest K(+) and water transport systems in brain astroglia. The European journal of neuroscience. vol 26. issue 9. 2008-03-14. PMID:17970725. |
immunolabeling showed that kir4.1 and aqp4 were occasionally distributed in close proximity but in distinct compartments of the astroglial cell membrane. |
2008-03-14 |
2023-08-12 |
Not clear |
| Matthew J Tait, Samira Saadoun, B Anthony Bell, Marios C Papadopoulo. Water movements in the brain: role of aquaporins. Trends in neurosciences. vol 31. issue 1. 2008-03-11. PMID:18054802. |
aqp4, found in astrocyte foot processes, glia limitans and ependyma, facilitates water movement into and out of the brain, accelerates astrocyte migration and alters neuronal activity. |
2008-03-11 |
2023-08-12 |
Not clear |
| Susan Noell, Petra Fallier-Becker, Cordian Beyer, Stephan Kröger, Andreas F Mack, Hartwig Wolbur. Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes. The European journal of neuroscience. vol 26. issue 8. 2008-02-01. PMID:17927773. |
freeze-fracture studies revealed a clustering of orthogonal arrays of particles, representing a structural equivalent of aqp4, when exogenous agrin was present in the astrocyte cultures. |
2008-02-01 |
2023-08-12 |
mouse |
| Jérôme Badaut, Stephen Ashwal, Beatriz Tone, Luca Regli, Hou Rou Tian, Andre Obenau. Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. Pediatric research. vol 62. issue 3. 2008-01-25. PMID:17622964. |
finally, induction of aqp4 on astrocyte end-feet could participate in tissue preservation after ischemia in the immature rat brain. |
2008-01-25 |
2023-08-12 |
rat |
| Jérôme Badaut, Jean-François Brunet, Luca Regl. Aquaporins in the brain: from aqueduct to "multi-duct". Metabolic brain disease. vol 22. issue 3-4. 2008-01-10. PMID:17701333. |
recently, aqp4 has been shown to be also involved in astrocyte migration during glial scar formation. |
2008-01-10 |
2023-08-12 |
Not clear |
| Xuemei Fu, Qiuping Li, Zhichun Feng, Dezhi M. The roles of aquaporin-4 in brain edema following neonatal hypoxia ischemia and reoxygenation in a cultured rat astrocyte model. Glia. vol 55. issue 9. 2007-07-25. PMID:17437301. |
the different roles of aqp4 during hi and reoxygenation suggest that aqp4 knockdown may protect against water influx in the formation of astrocyte swelling during hi, and may also delay water clearance in the resolution of astrocyte swelling during reoxygenation. |
2007-07-25 |
2023-08-12 |
rat |
| Marios C Papadopoulos, Alan S Verkma. Aquaporin-4 and brain edema. Pediatric nephrology (Berlin, Germany). vol 22. issue 6. 2007-07-03. PMID:17347837. |
aquaporin-4 (aqp4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (csf) and blood. |
2007-07-03 |
2023-08-12 |
mouse |
| Marios C Papadopoulos, Alan S Verkma. Aquaporin-4 and brain edema. Pediatric nephrology (Berlin, Germany). vol 22. issue 6. 2007-07-03. PMID:17347837. |
recently, aqp4 was also found to play a major role in processes unrelated to brain edema, including astrocyte migration and neuronal excitability. |
2007-07-03 |
2023-08-12 |
mouse |
| A S Verkman, Devin K Binder, Orin Bloch, Kurtis Auguste, Marios C Papadopoulo. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochimica et biophysica acta. vol 1758. issue 8. 2006-12-07. PMID:16564496. |
phenotype analysis of transgenic mice lacking aqp4 has provided compelling evidence for involvement of aqp4 in cerebral water balance, astrocyte migration, and neural signal transduction. |
2006-12-07 |
2023-08-12 |
mouse |
| A S Verkman, Devin K Binder, Orin Bloch, Kurtis Auguste, Marios C Papadopoulo. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochimica et biophysica acta. vol 1758. issue 8. 2006-12-07. PMID:16564496. |
aqp4 deficiency or knock-down slows astrocyte migration in response to a chemotactic stimulus in vitro, and aqp4 deletion impairs glial scar progression following injury in vivo. |
2006-12-07 |
2023-08-12 |
mouse |
| Didrik S Frydenlund, Anish Bhardwaj, Takashi Otsuka, Maria N Mylonakou, Thomas Yasumura, Kimberly G V Davidson, Emil Zeynalov, Oivind Skare, Petter Laake, Finn-Mogens Haug, John E Rash, Peter Agre, Ole P Ottersen, Mahmood Amiry-Moghadda. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938871. |
the aquaporin-4 (aqp4) pool in the perivascular astrocyte membranes has been shown to be critically involved in the formation and dissolution of brain edema. |
2006-10-19 |
2023-08-12 |
mouse |
| Didrik S Frydenlund, Anish Bhardwaj, Takashi Otsuka, Maria N Mylonakou, Thomas Yasumura, Kimberly G V Davidson, Emil Zeynalov, Oivind Skare, Petter Laake, Finn-Mogens Haug, John E Rash, Peter Agre, Ole P Ottersen, Mahmood Amiry-Moghadda. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938871. |
by freeze fracture we show that the loss of perivascular aqp4 is associated with the disappearance of the square lattices of particles that normally are distinct features of the perivascular astrocyte membrane. |
2006-10-19 |
2023-08-12 |
mouse |
| Marlise de Castro Ribeiro, Lorenz Hirt, Julien Bogousslavsky, Luca Regli, Jérôme Badau. Time course of aquaporin expression after transient focal cerebral ischemia in mice. Journal of neuroscience research. vol 83. issue 7. 2006-07-25. PMID:16511868. |
at 1 hr after occlusion, aqp4 expression was significantly increased on astrocyte endfeet in the core and in the border of the lesion. |
2006-07-25 |
2023-08-12 |
mouse |