| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuping Tang, Pin Wu, Jinjin Su, Jun Xiang, Dingfang Cai, Qiang Don. Effects of Aquaporin-4 on edema formation following intracerebral hemorrhage. Experimental neurology. vol 223. issue 2. 2010-07-01. PMID:20132816. |
to date, little is known about the role of aqp4 (aquaporin-4), which is abundantly expressed in pericapillary astrocyte foot processes and in edema formation after intracerebral hemorrhage. |
2010-07-01 |
2023-08-12 |
mouse |
| Li-Hui Zhang, Jian-Bo Zho, Yan-Fang Wan. [Research advance in cysteinyl leukotriene receptors with brain injury]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 3. 2010-03-30. PMID:18546539. |
cyslt(1)receptor regulates the increased permeability of blood-brain barrier and the related vasogenic brain edema, astrocyte proliferation, and inflammatory responses after brain ischemia; while cyslt(2)receptor regulates aqp4 expression and the related cytotoxic brain edema, and astrocyte injury. |
2010-03-30 |
2023-08-12 |
Not clear |
| J-E Kim, H J Ryu, S-I Yeo, C H Seo, B C Lee, I-G Choi, D-S Kim, T-C Kan. Differential expressions of aquaporin subtypes in astroglia in the hippocampus of chronic epileptic rats. Neuroscience. vol 163. issue 3. 2010-01-14. PMID:19619613. |
aqp4 was expressed in astrocyte foot processes near blood vessels and in ependymal and pial surfaces in contact with cerebrospinal fluid. |
2010-01-14 |
2023-08-12 |
rat |
| Jeffrey L Bennett, Chiwah Lam, Sudhakar Reddy Kalluri, Philippe Saikali, Katherine Bautista, Cecily Dupree, Magdalena Glogowska, David Case, Jack P Antel, Gregory P Owens, Don Gilden, Stefan Nessler, Christine Stadelmann, Bernhard Hemme. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Annals of neurology. vol 66. issue 5. 2009-12-21. PMID:19938104. |
the serum of most neuromyelitis optica (nmo) patients contains autoantibodies (nmo-iggs) directed against the aquaporin-4 (aqp4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain. |
2009-12-21 |
2023-08-12 |
Not clear |
| Maria Grazia Mola, Grazia Paola Nicchia, Maria Svelto, David C Spray, Antonio Friger. Automated cell-based assay for screening of aquaporin inhibitors. Analytical chemistry. vol 81. issue 19. 2009-12-17. PMID:19705854. |
this system was validated using astrocyte primary cultures and fibroblasts that strongly express endogenous aqp4 and aqp1 proteins, respectively, as well as aqp4-transfected cells. |
2009-12-17 |
2023-08-12 |
Not clear |
| Shannon R Hinson, Andrew McKeon, James P Fryer, Metha Apiwattanakul, Vanda A Lennon, Sean J Pittoc. Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells. Archives of neurology. vol 66. issue 9. 2009-10-23. PMID:19752309. |
the nmo-igg binds in vitro to the extracellular domain of aqp4, activates complement, and causes astrocyte lesioning. |
2009-10-23 |
2023-08-12 |
Not clear |
| Lihua Li, Hua Zhang, A S Verkma. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC neuroscience. vol 10. 2009-10-01. PMID:19660138. |
the involvement of astrocyte water channel aquaporin-4 (aqp4) in autoimmune diseases of the central nervous system has been suggested following the identification of aqp4 autoantibodies in neuromyelitis optica, an inflammatory demyelinating disease. |
2009-10-01 |
2023-08-12 |
mouse |
| Geoffroy Noël, Daniel Kai Long Tham, Hakima Moukhle. Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes. The Journal of biological chemistry. vol 284. issue 29. 2009-09-25. PMID:19451651. |
a growing body of evidence points to a role for dystroglycan and its interaction with perivascular laminin in the targeting of the dystrophin complex and the water-permeable channel, aquaporin 4 (aqp4), at astrocyte endfeet. |
2009-09-25 |
2023-08-12 |
Not clear |
| Thomas Tourdias, Iulius Dragonu, Yasutaka Fushimi, Mathilde S A Deloire, Claudine Boiziau, Bruno Brochet, Chrit Moonen, Klaus G Petry, Vincent Dousse. Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological study. NeuroImage. vol 47. issue 2. 2009-09-03. PMID:19409501. |
aqp4 were first located on astrocyte endfeet, but later on the whole membrane of astrocytes that became hypertrophic in the most severe and chronic hydrocephalic rats. |
2009-09-03 |
2023-08-12 |
rat |
| S Saadoun, M J Tait, A Reza, D Ceri Davies, B A Bell, A S Verkman, M C Papadopoulo. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19345723. |
the glial cell water channel aquaporin-4 (aqp4) plays an important role in brain edema, astrocyte migration, and neuronal excitability. |
2009-08-24 |
2023-08-12 |
mouse |
| S Saadoun, M J Tait, A Reza, D Ceri Davies, B A Bell, A S Verkman, M C Papadopoulo. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19345723. |
here we describe a detailed characterization of baseline brain properties in our aqp4 null mice, including gross appearance, neuronal, astrocyte and oligodendrocyte characteristics, and blood-brain barrier integrity. |
2009-08-24 |
2023-08-12 |
mouse |
| S Saadoun, M J Tait, A Reza, D Ceri Davies, B A Bell, A S Verkman, M C Papadopoulo. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19345723. |
the ultrastructure of microvessels in the frontal cortex and caudate nucleus of wild type vs. aqp4 null mice was indistinguishable, with features including intact endothelial tight junctions, absence of perimicrovessel astrocyte foot process edema, and absence of horseradish peroxidase extravasation. |
2009-08-24 |
2023-08-12 |
mouse |
| Karen Wolburg-Buchholz, Andreas F Mack, Esther Steiner, Friederike Pfeiffer, Britta Engelhardt, Hartwig Wolbur. Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta neuropathologica. vol 118. issue 2. 2009-08-19. PMID:19533155. |
our data suggest that during eae, loss of beta-dystroglycan-mediated astrocyte foot process anchoring to the basement membrane leads to loss of polarized aqp4 localization in astrocytic endfeet, and thus to edema formation in eae. |
2009-08-19 |
2023-08-12 |
Not clear |
| Hartwig Wolburg, Susan Noell, Karen Wolburg-Buchholz, Andreas Mack, Petra Fallier-Becke. Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 15. issue 2. 2009-06-18. PMID:19307424. |
the aqp4 has an important impact on the homeostasis in the brain parenchyma; however, the mechanistic cascade from the composition of the astrocyte membrane to the maintenance of bbb properties in the endothelial cells, including their tight junction formation, is still completely unknown. |
2009-06-18 |
2023-08-12 |
Not clear |
| H Doi, T Matsushita, N Isobe, T Matsuoka, M Minohara, H Ochi, J I Kir. Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody. Multiple sclerosis (Houndmills, Basingstoke, England). vol 15. issue 3. 2009-05-22. PMID:19028829. |
because asian patients with opticospinal multiple sclerosis (osms) frequently have anti-aquaporin-4 (aqp4) antibody, complement-mediated disruption of astrocyte foot processes is proposed but not yet proven. |
2009-05-22 |
2023-08-12 |
Not clear |
| Jun-ichi Kir. [Search for the pathogenesis of multiple sclerosis from the bedside]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 11. 2009-04-08. PMID:19198121. |
research into the mechanisms of ms is rapidly progressing because of the discovery of th17 cells producing autoimmune diseases and of nmo-igg targeting aquaporin-4 (aqp4) on the astrocyte foot process. |
2009-04-08 |
2023-08-12 |
Not clear |
| Grazia Paola Nicchia, Andrea Rossi, Maria Grazia Mola, Giuseppe Procino, Antonio Frigeri, Maria Svelt. Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes. Glia. vol 56. issue 16. 2009-03-16. PMID:18649401. |
in this study, we differentiated primary astrocyte cultures with camp and lovastatin, both able to induce glial stellation through a reorganization of f-actin cytoskeleton, and obtained aqp4 selectively localized on the cell plasma membrane associated with an increase in the plasma membrane water transport level, but only camp induced an increase in aqp4 total protein expression. |
2009-03-16 |
2023-08-12 |
Not clear |
| Grazia Paola Nicchia, Andrea Rossi, Maria Grazia Mola, Giuseppe Procino, Antonio Frigeri, Maria Svelt. Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes. Glia. vol 56. issue 16. 2009-03-16. PMID:18649401. |
finally, aqp4 knockdown does not compromise the ability of astrocytes to stellate in the presence of camp, indicating that astrocyte stellation is independent of aqp4. |
2009-03-16 |
2023-08-12 |
Not clear |
| Zsolt Zador, Shirley Stiver, Vincent Wang, Geoffrey T Manle. Role of aquaporin-4 in cerebral edema and stroke. Handbook of experimental pharmacology. issue 190. 2009-03-03. PMID:19096776. |
during cerebral edema formation, the glial water channel aquaporin-4 (aqp4) has been show to facilitate astrocyte swelling ("cytotoxic swelling"). |
2009-03-03 |
2023-08-12 |
Not clear |
| Eli Gunnarson, Yutong Song, Jacob M Kowalewski, Hjalmar Brismar, Michael Brines, Anthony Cerami, Ulf Andersson, Marina Zelenina, Anita Aperi. Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 5. 2009-02-27. PMID:19164545. |
recent studies from our laboratory have shown that glutamate, acting on group i metabotropic glutamate receptors (mglurs), increases the permeability of astrocyte aqp4, which, in situations of hypoxia-ischemia, will increase astrocyte water uptake. |
2009-02-27 |
2023-08-12 |
mouse |