| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahmood Amiry-Moghaddam, Anne Williamson, Maria Palomba, Tore Eid, Nihal C de Lanerolle, Erlend A Nagelhus, Marvin E Adams, Stanley C Froehner, Peter Agre, Ole P Otterse. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597704. |
the predominant water channel protein in brain, aquaporin-4 (aqp4), is concentrated in the astrocyte end-feet membranes adjacent to blood vessels in neocortex and cerebellum by association with alpha-syntrophin protein. |
2004-01-05 |
2023-08-12 |
mouse |
| Mahmood Amiry-Moghaddam, Anne Williamson, Maria Palomba, Tore Eid, Nihal C de Lanerolle, Erlend A Nagelhus, Marvin E Adams, Stanley C Froehner, Peter Agre, Ole P Otterse. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597704. |
we found that <10% of aqp4 immunogold labeling is retained in the perivascular astrocyte end-feet membranes of the alpha-syn-/- mice, whereas labeling of the inwardly rectifying k+ channel, kir4.1, is largely unchanged. |
2004-01-05 |
2023-08-12 |
mouse |
| Grazia Paola Nicchia, Antonio Frigeri, Grazia Maria Liuzzi, Maria Svelt. Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 11. 2003-08-11. PMID:12824287. |
recent studies indicate a key role of aquaporin (aqp) 4 in astrocyte swelling and brain edema and suggest that aqp4 inhibition may be a new therapeutic way for reducing cerebral water accumulation. |
2003-08-11 |
2023-08-12 |
Not clear |
| Grazia Paola Nicchia, Antonio Frigeri, Grazia Maria Liuzzi, Maria Svelt. Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 11. 2003-08-11. PMID:12824287. |
to understand the physiological role of aqp4-mediated astroglial swelling, we used 21-nucleotide small interfering rna duplexes (sirna) to specifically suppress aqp4 expression in astrocyte primary cultures. |
2003-08-11 |
2023-08-12 |
Not clear |
| Feng Gu, Ryuji Hata, Kazuko Toku, Lihua Yang, Yong-Jie Ma, Nobuji Maeda, Masahiro Sakanaka, Junya Tanak. Testosterone up-regulates aquaporin-4 expression in cultured astrocytes. Journal of neuroscience research. vol 72. issue 6. 2003-08-04. PMID:12774311. |
aquaporin-4 (aqp4) is located on astrocyte endfeet that face blood vessels in the brain and in the pia. |
2003-08-04 |
2023-08-12 |
Not clear |
| Masahiko Inoue, Yoshihiro Wakayama, Jian Wu Liu, Makoto Murahashi, Seiji Shibuya, Hiroaki Onik. Ultrastructural localization of aquaporin 4 and alpha1-syntrophin in the vascular feet of brain astrocytes. The Tohoku journal of experimental medicine. vol 197. issue 2. 2003-03-14. PMID:12233788. |
aquaporin 4 (aqp4) is a recently discovered membrane bound water-selective channel and has been described at the light microscopic level to be predominantly expressed in the astrocytes of the brain, especially at the perivascular astrocyte endfoot processes. |
2003-03-14 |
2023-08-12 |
mouse |
| Masahiko Inoue, Yoshihiro Wakayama, Jian Wu Liu, Makoto Murahashi, Seiji Shibuya, Hiroaki Onik. Ultrastructural localization of aquaporin 4 and alpha1-syntrophin in the vascular feet of brain astrocytes. The Tohoku journal of experimental medicine. vol 197. issue 2. 2003-03-14. PMID:12233788. |
aqp4 expression has been reported to be absent at the sarcolemma and the perivascular astrocyte endfoot processes of alpha1-syntrophin knockout mice. |
2003-03-14 |
2023-08-12 |
mouse |
| Masahiko Inoue, Yoshihiro Wakayama, Jian Wu Liu, Makoto Murahashi, Seiji Shibuya, Hiroaki Onik. Ultrastructural localization of aquaporin 4 and alpha1-syntrophin in the vascular feet of brain astrocytes. The Tohoku journal of experimental medicine. vol 197. issue 2. 2003-03-14. PMID:12233788. |
the results showed that aqp4 and alpha1-syntrophin colocalized frequently at the astrocyte membrane, especially at the perivascular astrocyte endfoot processes and suggested the presence of linkage between aqp4 and alpha1-syntrophin at the astrocyte plasma membrane. |
2003-03-14 |
2023-08-12 |
mouse |
| Ken-ichi Nakahama, Atsuko Fujioka, Mamoru Nagano, Shinsuke Satoh, Kei-ichi Furukawa, Hiroshi Sasaki, Yasufumi Shigeyosh. A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes. Genes to cells : devoted to molecular & cellular mechanisms. vol 7. issue 7. 2003-01-03. PMID:12081649. |
aquaporin 4 (aqp4) is a predominant water channel protein in mammalian brains, which is localized in the astrocyte plasma membrane. |
2003-01-03 |
2023-08-12 |
Not clear |
| Marios C Papadopoulos, Sanjeev Krishna, A S Verkma. Aquaporin water channels and brain edema. The Mount Sinai journal of medicine, New York. vol 69. issue 4. 2002-10-17. PMID:12357265. |
aqp4 is expressed in astrocyte foot processes near capillaries and in ependymal cells lining the ventricles -- key sites for water movement between the cellular, vascular, and ventricular compartments. |
2002-10-17 |
2023-08-12 |
mouse |
| Antonio Frigeri, Grazia Paola Nicchia, Silvia Repetto, Massimo Bado, Carlo Minetti, Maria Svelt. Altered aquaporin-4 expression in human muscular dystrophies: a common feature? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 9. 2002-07-23. PMID:12039847. |
recently, we have reported that the expression of aquaporin-4 (aqp4), a water-selective channel expressed in the sarcolemma of fast-twitch fibers and astrocyte end-feet, is drastically reduced in the muscle and brain of the mdx mouse, the animal model of dmd. |
2002-07-23 |
2023-08-12 |
mouse |
| S Saadoun, M C Papadopoulos, D C Davies, S Krishna, B A Bel. Aquaporin-4 expression is increased in oedematous human brain tumours. Journal of neurology, neurosurgery, and psychiatry. vol 72. issue 2. 2002-02-27. PMID:11796780. |
in rats, aqp4 is expressed in astrocyte foot processes and is important in brain water homeostasis. |
2002-02-27 |
2023-08-12 |
human |
| J D Neely, M Amiry-Moghaddam, O P Ottersen, S C Froehner, P Agre, M E Adam. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 24. 2002-01-08. PMID:11717465. |
the aquaporin-4 (aqp4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated. |
2002-01-08 |
2023-08-12 |
mouse |
| J D Neely, M Amiry-Moghaddam, O P Ottersen, S C Froehner, P Agre, M E Adam. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 24. 2002-01-08. PMID:11717465. |
high-resolution immunogold analyses revealed that aqp4 expression is markedly reduced in astrocyte endfeet membranes adjacent to blood vessels in cerebellum and cerebral cortex of alpha-syn(-/-) mice, but is present at higher than normal levels in membranes facing neuropil. |
2002-01-08 |
2023-08-12 |
mouse |
| G P Nicchia, A Frigeri, G M Liuzzi, M P Santacroce, B Nico, G Procino, F Quondamatteo, R Herken, L Roncali, M Svelt. Aquaporin-4-containing astrocytes sustain a temperature- and mercury-insensitive swelling in vitro. Glia. vol 31. issue 1. 2000-07-20. PMID:10816604. |
using southern blot pcr and western blot analysis, we demonstrate that primary astrocyte cultures from mouse express the aqp4 water channel at both the rna and protein levels. |
2000-07-20 |
2023-08-12 |
mouse |
| Z Vajda, D Promeneur, T Dóczi, E Sulyok, J Frøkiaer, O P Ottersen, S Nielse. Increased aquaporin-4 immunoreactivity in rat brain in response to systemic hyponatremia. Biochemical and biophysical research communications. vol 270. issue 2. 2000-05-08. PMID:10753653. |
immunocytochemistry and high-resolution immunogold electron microscopy revealed highly polarized labeling of aqp4 in astrocyte end-feet surrounding capillaries and forming the glia limitans. |
2000-05-08 |
2023-08-12 |
rat |
| K Nakahama, M Nagano, A Fujioka, K Shinoda, H Sasak. Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes. Glia. vol 25. issue 3. 1999-05-12. PMID:9932870. |
aquaporin 4 (aqp4) is a predominant water channel protein in mammalian brains, localized in the astrocyte plasma membrane. |
1999-05-12 |
2023-08-12 |
rat |
| J E Rash, T Yasumura, C S Hudson, P Agre, S Nielse. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 20. 1998-10-22. PMID:9751776. |
immunocytochemical analysis of the brain recently revealed that aqp4 has a highly polarized distribution, with marked expression in astrocyte end-feet that surround capillaries and form the glia limitans; however, the structural organization of aqp4 has remained unknown. |
1998-10-22 |
2023-08-12 |
rat |
| J E Rash, T Yasumura, C S Hudson, P Agre, S Nielse. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 20. 1998-10-22. PMID:9751776. |
in freeze-fracture replicas, astrocyte end-feet contain abundant square arrays of intramembrane particles that parallel the distribution of aqp4. |
1998-10-22 |
2023-08-12 |
rat |
| J E Rash, T Yasumura, C S Hudson, P Agre, S Nielse. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 20. 1998-10-22. PMID:9751776. |
to determine whether astrocyte and ependymocyte square arrays contain aqp4, we employed immunogold labeling of sds-washed freeze-fracture replicas and stereoscopic confirmation of tissue binding. |
1998-10-22 |
2023-08-12 |
rat |