| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Collongues, J B Chanson, F Blanc, J Steibel, C D Lam, A Shabbir, E Trifilieff, J Honnorat, D Pham-Dinh, M S Ghandour, J de Sez. The Brown Norway opticospinal model of demyelination: does it mimic multiple sclerosis or neuromyelitis optica? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22634288. |
increasing attention has recently focused on astrocyte markers, aquaporin-4 (aqp4) and glial fibrillary acidic protein (gfap) in these diseases. |
2013-02-05 |
2023-08-12 |
rat |
| N Collongues, J B Chanson, F Blanc, J Steibel, C D Lam, A Shabbir, E Trifilieff, J Honnorat, D Pham-Dinh, M S Ghandour, J de Sez. The Brown Norway opticospinal model of demyelination: does it mimic multiple sclerosis or neuromyelitis optica? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22634288. |
the overexpression of aqp4 was particularly pronounced in the spinal cord and was concomitant with demyelination and astrocyte apoptosis. |
2013-02-05 |
2023-08-12 |
rat |
| A M Fukuda, V Pop, D Spagnoli, S Ashwal, A Obenaus, J Badau. Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: possible role in edema resolution? Neuroscience. vol 222. 2013-01-24. PMID:22728101. |
immunohistochemical analysis of aqp4 in perivascular astrocyte endfeet was increased in the lesion at 3 and 7days post-injury as edema resolved. |
2013-01-24 |
2023-08-12 |
rat |
| Donald E Kimbler, Jessica Shields, Nathan Yanasak, John R Vender, Krishnan M Dhandapan. Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815977. |
notably, p2x7 localized within astrocytic end feet and administration of bbg decreased the expression of glial fibrillary acidic protein (gfap), a reactive astrocyte marker, and attenuated the expression of aquaporin-4 (aqp4), an astrocytic water channel that promotes cellular edema. |
2013-01-16 |
2023-08-12 |
mouse |
| Megumi Yamamoto, Motohiro Takeya, Hiroko Ikeshima-Kataoka, Masato Yasui, Yasuaki Kawasaki, Mitsuya Shiraishi, Eiji Majima, Seiji Shiraishi, Yasuhito Uezono, Masanori Sasaki, Komyo Et. Increased expression of aquaporin-4 with methylmercury exposure in the brain of the common marmoset. The Journal of toxicological sciences. vol 37. issue 4. 2012-12-18. PMID:22863855. |
these results indicate that aqp4 expression might be stimulated by mehg exposure in astrocytes in the occipital lobe and cerebellum, suggesting a role for aqp4 in mehg neurotoxicity via astrocyte dysfunction. |
2012-12-18 |
2023-08-12 |
marmoset |
| Julien Ratelade, A S Verkma. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. The international journal of biochemistry & cell biology. vol 44. issue 9. 2012-11-29. PMID:22713791. |
based on the initiating pathogenic role of aqp4-igg binding to astrocyte aqp4 in nmo, selective blocker therapies are under development in which aqp4-targeted monoclonal antibodies or small molecules block binding of aqp4-igg to astrocytes and consequent downstream pathology. |
2012-11-29 |
2023-08-12 |
Not clear |
| Wen-Zhen Shi, Ling-Ling Qi, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing We. Aggravated chronic brain injury after focal cerebral ischemia in aquaporin-4-deficient mice. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22634625. |
the water channel aquaporin-4 (aqp4) is important in brain water homeostasis, and is also involved in astrocyte growth and glial scar formation. |
2012-10-04 |
2023-08-12 |
mouse |
| Wen-Zhen Shi, Ling-Ling Qi, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing We. Aggravated chronic brain injury after focal cerebral ischemia in aquaporin-4-deficient mice. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22634625. |
furthermore, astrocyte proliferation and glial scar formation were impaired in aqp4(-/-) mice. |
2012-10-04 |
2023-08-12 |
mouse |
| Wen-Zhen Shi, Ling-Ling Qi, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing We. Aggravated chronic brain injury after focal cerebral ischemia in aquaporin-4-deficient mice. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22634625. |
therefore, aqp4 deficiency complicated by astrocyte dysfunction aggravates chronic brain injury after focal cerebral ischemia, suggesting that aqp4 may be important in the chronic phase of the post-ischemic recovery process. |
2012-10-04 |
2023-08-12 |
mouse |
| Katsuhisa Masaki, Satoshi O Suzuki, Takuya Matsushita, Tomomi Yonekawa, Takeshi Matsuoka, Noriko Isobe, Kyoko Motomura, Xiao-Mu Wu, Takeshi Tabira, Toru Iwaki, Jun-ichi Kir. Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22438105. |
autopsied specimens from four cases that provided seven actively demyelinating concentric lesions infiltrated with numerous cd68(+) macrophages were immunohistochemically examined for the astrocyte markers glial fibrillary acidic protein (gfap), aqp4, cx43, cx30 and megalencephalic leukoencephalopathy with subcortical cyst 1 (mlc1). |
2012-09-24 |
2023-08-12 |
Not clear |
| Takuya Matsushita, Katsuhisa Masaki, Satoru Suzuki, Takeshi Matsuoka, Tomomi Yonekawa, Xiao-Mu Wu, Takeshi Tabira, Toru Iwaki, Jun-Ichi Kir. [Astrocytopathy in neuromyelitis optica, multiple sclerosis and Baló's disease]. Rinsho shinkeigaku = Clinical neurology. vol 51. issue 11. 2012-09-18. PMID:22277409. |
an antibody for aquaporin-4 (aqp4), which is a water channel located in astrocyte foot process, is specifically positive for nmo and antibody and complement dependent astrocytic damage is thought to be a main cause of nmo. |
2012-09-18 |
2023-08-12 |
Not clear |
| Yutong Song, Eli Gunnarso. Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling. PloS one. vol 7. issue 4. 2012-09-04. PMID:22493723. |
potassium kinetics can be modulated by aquaporin-4 (aqp4), the essential water channel for astrocyte water permeability regulation. |
2012-09-04 |
2023-08-12 |
rat |
| Yutong Song, Eli Gunnarso. Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling. PloS one. vol 7. issue 4. 2012-09-04. PMID:22493723. |
studies were performed on rat primary astrocytes and a rat astrocyte cell line transfected with aqp4. |
2012-09-04 |
2023-08-12 |
rat |
| Yutong Song, Eli Gunnarso. Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling. PloS one. vol 7. issue 4. 2012-09-04. PMID:22493723. |
in conclusion, we find that elevation of extracellular potassium regulates aqp4 and astrocyte water permeability via intracellular signaling involving camp. |
2012-09-04 |
2023-08-12 |
rat |
| Wei Yang, Qi Wu, Chan Yuan, Junying Gao, Ming Xiao, Minxia Gu, Jiong Ding, Gang H. Aquaporin-4 mediates astrocyte response to β-amyloid. Molecular and cellular neurosciences. vol 49. issue 4. 2012-08-27. PMID:22365952. |
it has been demonstrated that the water channel protein aquaporin-4 (aqp4) plays an important role in astrocyte plasticity in response to a variety of injuries or stimuli. |
2012-08-27 |
2023-08-12 |
mouse |
| Wei Yang, Qi Wu, Chan Yuan, Junying Gao, Ming Xiao, Minxia Gu, Jiong Ding, Gang H. Aquaporin-4 mediates astrocyte response to β-amyloid. Molecular and cellular neurosciences. vol 49. issue 4. 2012-08-27. PMID:22365952. |
however, the potential role of aqp4 in astrocyte response to β-amyloid (aβ) has not been studied. |
2012-08-27 |
2023-08-12 |
mouse |
| Wei Yang, Qi Wu, Chan Yuan, Junying Gao, Ming Xiao, Minxia Gu, Jiong Ding, Gang H. Aquaporin-4 mediates astrocyte response to β-amyloid. Molecular and cellular neurosciences. vol 49. issue 4. 2012-08-27. PMID:22365952. |
aqp4 gene knockout reduced aβ(1-42)-induced astrocyte activation and apoptosis, which was associated with a reduction in the uptake of aβ via decreased upregulation of low-density lipoprotein receptor related protein-1. |
2012-08-27 |
2023-08-12 |
mouse |
| Marios C Papadopoulos, A S Verkma. Aquaporin 4 and neuromyelitis optica. The Lancet. Neurology. vol 11. issue 6. 2012-07-25. PMID:22608667. |
the discovery of circulating igg1 antibodies against the astrocyte water channel protein aquaporin 4 (aqp4) and the evidence that aqp4-igg is involved in the development of neuromyelitis optica revolutionised our understanding of the disease. |
2012-07-25 |
2023-08-12 |
Not clear |
| Puay-Wah Phuan, Julien Ratelade, Andrea Rossi, Lukmanee Tradtrantip, A S Verkma. Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays. The Journal of biological chemistry. vol 287. issue 17. 2012-07-17. PMID:22393049. |
neuromyelitis optica (nmo) is an inflammatory demyelinating disease of the central nervous system in which binding of pathogenic autoantibodies (nmo-igg) to astrocyte aquaporin-4 (aqp4) causes complement-dependent cytotoxicity (cdc) and inflammation. |
2012-07-17 |
2023-08-12 |
Not clear |
| Lukmanee Tradtrantip, Hua Zhang, Marc O Anderson, Samira Saadoun, Puay-Wah Phuan, Marios C Papadopoulos, Jeffrey L Bennett, A S Verkma. Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22319008. |
neuromyelitis optica (nmo) is an inflammatory demyelinating disease of spinal cord and optic nerve caused by pathogenic autoantibodies (nmo-igg) against astrocyte aquaporin-4 (aqp4). |
2012-06-29 |
2023-08-12 |
mouse |