| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatsuro Misu, Romana Höftberger, Kazuo Fujihara, Isabella Wimmer, Yoshiki Takai, Shuhei Nishiyama, Ichiro Nakashima, Hidehiko Konno, Monika Bradl, Ferenc Garzuly, Yasuto Itoyama, Masashi Aoki, Hans Lassman. Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica. Acta neuropathologica. vol 125. issue 6. 2013-12-03. PMID:23579868. |
another pattern is characterized by clasmatodendrosis of astrocytes, defined by cytoplasmic swelling and vacuolation, beading and dissolution of their processes and nuclear alterations resembling apoptosis, which was associated with internalization of aqp4 and aqp1 and astrocyte apoptosis in the absence of complement activation. |
2013-12-03 |
2023-08-12 |
Not clear |
| Tatsuro Misu, Romana Höftberger, Kazuo Fujihara, Isabella Wimmer, Yoshiki Takai, Shuhei Nishiyama, Ichiro Nakashima, Hidehiko Konno, Monika Bradl, Ferenc Garzuly, Yasuto Itoyama, Masashi Aoki, Hans Lassman. Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica. Acta neuropathologica. vol 125. issue 6. 2013-12-03. PMID:23579868. |
only in a subset of lesions, in patients with aggressive disease, loss of aqp4 is observed in the initial stage of their formation, which is associated with retraction of astrocyte processes in the absence of complement deposition, granulocyte infiltration or loss of aqp1 or astrocytes. |
2013-12-03 |
2023-08-12 |
Not clear |
| Puay-Wah Phuan, Hua Zhang, Nithi Asavapanumas, Michael Leviten, Arnon Rosenthal, Lukmanee Tradtrantip, A S Verkma. C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica. Acta neuropathologica. vol 125. issue 6. 2013-12-03. PMID:23677375. |
the anti-c1q antibody prevented astrocyte damage and demyelination in mouse spinal cord slice cultures exposed to aqp4 autoantibody and human complement. |
2013-12-03 |
2023-08-12 |
mouse |
| Jungo Kato, Mariko Kato Hayashi, Shinnosuke Aizu, Yoshinori Yukutake, Junzo Takeda, Masato Yasu. A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn²⁺. The Biochemical journal. vol 454. issue 2. 2013-11-04. PMID:23772702. |
aqp4 (aquaporin-4), a water channel protein that is predominantly expressed in astrocyte end-feet, plays an important role in the brain oedema formation, and is thereby considered to be a potential therapeutic target. |
2013-11-04 |
2023-08-12 |
Not clear |
| Zhaohua Tang, Zhengbu Liao, Yanfeng Xie, Quanhong Shi, Chaohui He, Yan Zha. [Role of P38 signaling pathway in neonatal rat astrocyte swelling and aquaporin-4 expression after oxygen-glucose deprivation and recovery]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 32. issue 2. 2013-09-26. PMID:22381744. |
to explore the role of p38 signaling pathway in neonatal rat astrocyte swelling and the expression of aquaporin-4 (aqp4) after oxygen-glucose deprivation (ogd) and recovery (ogd/r). |
2013-09-26 |
2023-08-12 |
rat |
| Hayato Asai, Hiroki Kakita, Mineyoshi Aoyama, Yoshiaki Nagaya, Shinji Saitoh, Kiyofumi Asa. Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte. Cellular and molecular neurobiology. vol 33. issue 3. 2013-09-04. PMID:23322320. |
in conclusion, this study demonstrated that aqp4 is upregulated in astrocyte by proinflammatory cytokines, and that the addition of dcf further augments aqp4 production. |
2013-09-04 |
2023-08-12 |
rat |
| Leila Miguel Stavale, Edilene Siqueira Soares, Monique C P Mendonça, Silvia P Irazusta, Maria Alice da Cruz Höflin. Temporal relationship between aquaporin-4 and glial fibrillary acidic protein in cerebellum of neonate and adult rats administered a BBB disrupting spider venom. Toxicon : official journal of the International Society on Toxinology. vol 66. 2013-09-03. PMID:23419593. |
two astrocyte markers, the glial water channel aquaporin-4 (aqp4) and the glial fibrillary acidic protein (gfap), have been implicated in several physiological and pathological conditions in the central nervous system (cns) as well as in blood-brain barrier breakdown (bbbb). |
2013-09-03 |
2023-08-12 |
rat |
| Tatsuro Misu, Kazuo Fujihar. [Pathogenesis of neuromyelitis optica]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 5. 2013-08-22. PMID:23777089. |
neuromyelitis optica (nmo) is a disease characterized by severe optic neuritis and transverse myelitis with autoantibody against aquaporin 4 (aqp4), mainly localized at astrocyte foot processes. |
2013-08-22 |
2023-08-12 |
Not clear |
| Min-Hee Yi, Young Sook Lee, Joon Won Kang, Soo Jin Kim, Sang-Ha Oh, Yong Min Kim, Young Ho Lee, Sang Do Lee, Dong Woon Ki. NFAT5-dependent expression of AQP4 in astrocytes. Cellular and molecular neurobiology. vol 33. issue 2. 2013-08-08. PMID:23180003. |
our data demonstrate that nfat5 is necessary for the transcriptional regulation of aqp4 expression and for local astrocyte swelling with accompanying restriction of the neuropil extracellular space in vivo. |
2013-08-08 |
2023-08-12 |
rat |
| Andrea Rossi, Julien Ratelade, Marios C Papadopoulos, Jeffrey L Bennett, A S Verkma. Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly. Glia. vol 60. issue 12. 2013-08-05. PMID:22987455. |
neuromyelitis optica (nmo) is thought to be caused by immunoglobulin g autoantibodies (nmo-igg) against astrocyte water channel aquaporin-4 (aqp4). |
2013-08-05 |
2023-08-12 |
Not clear |
| Byung-Ju Jin, Hua Zhang, Devin K Binder, A S Verkma. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. The Journal of general physiology. vol 141. issue 1. 2013-07-01. PMID:23277478. |
deletion of astrocyte water channel aquaporin-4 (aqp4) in mice alters neuroexcitation by reducing ecs [k(+)] accumulation and slowing k(+) reuptake. |
2013-07-01 |
2023-08-12 |
mouse |
| Byung-Ju Jin, Hua Zhang, Devin K Binder, A S Verkma. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. The Journal of general physiology. vol 141. issue 1. 2013-07-01. PMID:23277478. |
the modeling showed that mechanisms b-d, together, can predict experimentally observed impairment in k(+) reuptake from the ecs in aqp4 deficiency, as well as altered k(+) accumulation in the ecs after neuroexcitation, provided that astrocyte water permeability is sufficiently reduced in aqp4 deficiency and that solute diffusion in astrocyte cytoplasm is sufficiently low. |
2013-07-01 |
2023-08-12 |
mouse |
| Lukmanee Tradtrantip, Nithi Asavapanumas, A S Verkma. Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase. Molecular pharmacology. vol 83. issue 6. 2013-07-01. PMID:23571414. |
neuromyelitis optica (nmo) is an inflammatory demyelinating disease of the central nervous system caused by binding of pathogenic igg autoantibodies (nmo-igg) to astrocyte water channel aquaporin-4 (aqp4). |
2013-07-01 |
2023-08-12 |
mouse |
| Tomoki Kaneyama, Sho Takizawa, Sayaka Tsugane, Satoshi Yanagisawa, Naoya Takeichi, Takashi Ehara, Motoki Ichikawa, Chang-Sung Ko. Downregulation of water channel aquaporin-4 in rats with experimental autoimmune encephalomyeritis induced by myelin basic protein. Cellular immunology. vol 281. issue 1. 2013-06-19. PMID:23510922. |
our findings suggest that aqp4 may be involved in forming edema in the inflammatory lesions of eae accompanying with up-regulation of reactive astrocyte. |
2013-06-19 |
2023-08-12 |
rat |
| Dean M Wingerchu. Neuromyelitis optica: potential roles for intravenous immunoglobulin. Journal of clinical immunology. vol 33 Suppl 1. 2013-06-14. PMID:22976554. |
it is distinct from multiple sclerosis and is associated with autoantibodies that target aquaporin-4 (aqp4), an astrocyte water channel. |
2013-06-14 |
2023-08-12 |
Not clear |
| Jihong Tong, Margaret M Briggs, Thomas J McIntos. Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. Biophysical journal. vol 103. issue 9. 2013-05-20. PMID:23199918. |
conversely, under ischemic conditions astrocyte membrane cholesterol content decreases, which could increase aqp4 permeability. |
2013-05-20 |
2023-08-12 |
Not clear |
| Dominique Promeneur, Lisa Kristina Lunde, Mahmood Amiry-Moghaddam, Peter Agr. Protective role of brain water channel AQP4 in murine cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 3. 2013-03-14. PMID:23277579. |
reduction of brain aqp4 protein was confirmed in cerebral malaria by quantitative immunogold em; however, polarized distribution of aqp4 at the perivascular and subpial astrocyte membranes was not altered. |
2013-03-14 |
2023-08-12 |
mouse |
| Esther Steiner, Gaby U Enzmann, Shuo Lin, Sharang Ghavampour, Melanie-Jane Hannocks, Benoît Zuber, Markus A Rüegg, Lydia Sorokin, Britta Engelhard. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia. vol 60. issue 11. 2013-02-14. PMID:22782669. |
loss of astrocyte foot process anchoring to the basement membrane (bm) accompanied by the loss of polarized localization of aqp4 to astrocytic endfeet has been shown to be associated with vasogenic/extracellular edema in neuroinflammation. |
2013-02-14 |
2023-08-12 |
mouse |
| Esther Steiner, Gaby U Enzmann, Shuo Lin, Sharang Ghavampour, Melanie-Jane Hannocks, Benoît Zuber, Markus A Rüegg, Lydia Sorokin, Britta Engelhard. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia. vol 60. issue 11. 2013-02-14. PMID:22782669. |
staining for the astrocyte endfoot anchorage protein β-dystroglycan (dg) was dramatically reduced in both the lesion core and the penumbra, and aqp4 and kir4.1 showed a loss of polarized localization to astrocytic endfeet. |
2013-02-14 |
2023-08-12 |
mouse |
| Esther Steiner, Gaby U Enzmann, Shuo Lin, Sharang Ghavampour, Melanie-Jane Hannocks, Benoît Zuber, Markus A Rüegg, Lydia Sorokin, Britta Engelhard. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia. vol 60. issue 11. 2013-02-14. PMID:22782669. |
taken together, these data indicate that the binding of dg to agrin embedded in the subjacent bm promotes polarized localization of aqp4 to astrocyte endfeet. |
2013-02-14 |
2023-08-12 |
mouse |