| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lukmanee Tradtrantip, Xiaoming Yao, Tao Su, Alex J Smith, Alan S Verkma. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta neuropathologica. vol 134. issue 1. 2017-12-11. PMID:28567523. |
here, we report evidence for a complement 'bystander mechanism' to account for early oligodendrocyte injury in nmo in which activated, soluble complement proteins following aqp4-igg binding to astrocyte aqp4 result in deposition of the complement membrane attack complex (mac) on nearby oligodendrocytes. |
2017-12-11 |
2023-08-13 |
rat |
| Alan S Verkman, Alex J Smith, Puay-Wah Phuan, Lukmanee Tradtrantip, Marc O Anderso. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert opinion on therapeutic targets. vol 21. issue 12. 2017-11-16. PMID:29072508. |
however, a biologic ('aquaporumab') is in development for neuromyelitis optica, an autoimmune inflammatory demyelinating disease where cns pathology is initiated by binding of anti-aqp4 autoantibodies to astrocyte aqp4. |
2017-11-16 |
2023-08-13 |
mouse |
| Domenico Alberga, Daniela Trisciuzzi, Gianluca Lattanzi, Jeffrey L Bennett, Alan S Verkman, Giuseppe Felice Mangiatordi, Orazio Nicolott. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochimica et biophysica acta. Biomembranes. vol 1859. issue 8. 2017-10-23. PMID:28477975. |
neuromyelitis optica (nmo) is an inflammatory demyelinating disease of the central nervous system in which most patients have serum autoantibodies (called nmo-igg) that bind to astrocyte water channel aquaporin-4 (aqp4). |
2017-10-23 |
2023-08-13 |
Not clear |
| Heling Chu, Yuping Tang, Qiang Don. Protection of Vascular Endothelial Growth Factor to Brain Edema Following Intracerebral Hemorrhage and Its Involved Mechanisms: Effect of Aquaporin-4. PloS one. vol 8. issue 6. 2017-10-20. PMID:23805198. |
furthermore, we assessed the possible signal transduction pathways activated by vegf to regulate aqp4 expression via astrocyte cultures. |
2017-10-20 |
2023-08-12 |
mouse |
| Yiting Liu, Danielle E Harlow, Katherine S Given, Gregory P Owens, Wendy B Macklin, Jeffrey L Bennet. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. Journal of neuroinflammation. vol 13. issue 1. 2017-10-10. PMID:27905992. |
studies of neuromyelitis optica (nmo), an autoimmune disease of the central nervous system (cns), have demonstrated that autoantibodies against the water channel aquaporin-4 (aqp4) induce astrocyte damage through complement-dependent cytotoxicity (cdc). |
2017-10-10 |
2023-08-13 |
mouse |
| Mengmeng Xu, Ming Xiao, Shao Li, Baoxue Yan. Aquaporins in Nervous System. Advances in experimental medicine and biology. vol 969. 2017-09-07. PMID:28258567. |
aqp4, the predominant water channel in the cns, is involved both in the astrocyte swelling of cytotoxic edema and the resolution of vasogenic edema, and is of pivotal importance in the pathology of brain disorders such as neuromyelitis optica , brain tumors and alzheimer's disease. |
2017-09-07 |
2023-08-13 |
Not clear |
| Jeffrey L Bennet. Finding NMO: The Evolving Diagnostic Criteria of Neuromyelitis Optica. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. vol 36. issue 3. 2017-09-01. PMID:27529327. |
due to the identification of a specific autoantibody response against the astrocyte water channel aquaporin-4 (aqp4) in the vast majority of affected individuals, the clinical spectrum of nmo has greatly expanded necessitating the development of new international criteria for the diagnosis of nmo spectrum disorder (nmosd). |
2017-09-01 |
2023-08-13 |
Not clear |
| Daniel Kai Long Tham, Bharat Joshi, Hakima Moukhle. Aquaporin-4 Cell-Surface Expression and Turnover Are Regulated by Dystroglycan, Dynamin, and the Extracellular Matrix in Astrocytes. PloS one. vol 11. issue 10. 2017-06-23. PMID:27788222. |
our data therefore indicate that the dual interation of dg with laminin and dynamin is involved in the regulation of aqp4 internalization, leading to its asymmetric enrichment at perivascular astrocyte endfeet. |
2017-06-23 |
2023-08-13 |
Not clear |
| Izumi Kawachi, Hans Lassman. Neurodegeneration in multiple sclerosis and neuromyelitis optica. Journal of neurology, neurosurgery, and psychiatry. vol 88. issue 2. 2017-05-26. PMID:27671902. |
the target antigen of autoimmunity in nmo is the water channel aquaporin-4 (aqp4), and antibodies directed against this antigen result in astrocyte damage. |
2017-05-26 |
2023-08-13 |
Not clear |
| Grazia Paola Nicchia, Francesco Pisani, Laura Simone, Antonio Cibelli, Maria Grazia Mola, Massimo Dal Monte, Antonio Frigeri, Paola Bagnoli, Maria Svelt. Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina. Experimental eye research. vol 146. 2017-05-25. PMID:27018215. |
to investigate for gliotic responses caused by aqp4 deletion, müller cells and astrocytes were analysed by immunofluorescence and western blot, using the müller cell marker glutamine synthetase (gs) and the astrocyte marker gfap. |
2017-05-25 |
2023-08-13 |
mouse |
| Grazia Paola Nicchia, Francesco Pisani, Laura Simone, Antonio Cibelli, Maria Grazia Mola, Massimo Dal Monte, Antonio Frigeri, Paola Bagnoli, Maria Svelt. Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina. Experimental eye research. vol 146. 2017-05-25. PMID:27018215. |
interestingly, no gfap altered expression was found in aqp4 sirna treated astrocyte primary cultures. |
2017-05-25 |
2023-08-13 |
mouse |
| Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, Devin K Binde. Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27155358. |
regulation of astrocyte glutamate transporter-1 (glt1) and aquaporin-4 (aqp4) expression in a model of epilepsy. |
2017-05-05 |
2023-08-13 |
mouse |
| H Sun, R Liang, B Yang, Y Zhou, M Liu, F Fang, J Ding, Y Fan, G H. Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease. Neuroscience. vol 317. 2016-10-24. PMID:26774050. |
similarly, aqp4 deficiency augmented the activation of the nf-κb pathway and the production of il-1β and tnf-α in midbrain astrocyte cultures treated with mpp(+) (1-methyl-4-phenylpyridinium). |
2016-10-24 |
2023-08-13 |
mouse |
| H Sun, R Liang, B Yang, Y Zhou, M Liu, F Fang, J Ding, Y Fan, G H. Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease. Neuroscience. vol 317. 2016-10-24. PMID:26774050. |
our data provide the first evidence that aqp4 modulates astrocyte-to-microglia communication in neuroinflammation, although its effect on astrocyte inflammatory activation remains to be explored. |
2016-10-24 |
2023-08-13 |
mouse |
| Maria Grazia Mola, Angelo Sparaneo, Concetta Domenica Gargano, David C Spray, Maria Svelto, Antonio Frigeri, Eliana Scemes, Grazia Paola Nicchi. The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins. Glia. vol 64. issue 1. 2016-10-20. PMID:26413835. |
using biophysical techniques to measure water flux through the plasma membrane of wild-type (wt) and aqp4 knockout (ko) astrocytes and of an astrocyte cell line (di tnc1) transfected with aqp4 or aqp1, we here show that aqp-mediated fast swelling kinetics play a key role in triggering and accelerating rvd. |
2016-10-20 |
2023-08-13 |
Not clear |
| Alex J Smith, Alan S Verkma. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophysical journal. vol 109. issue 12. 2016-09-21. PMID:26682810. |
native aqp4 in mouse cortex, where both isoforms are expressed, was enriched in astrocyte foot-processes adjacent to microcapillaries; clusters in perivascular regions of the cortex were larger than in parenchymal regions, demonstrating size-dependent subcellular segregation of aqp4 clusters. |
2016-09-21 |
2023-08-13 |
mouse |
| Masakazu Nakamura, Manabu Araki, Takashi Yamamur. [Plasmablast in the pathology of multiple sclerosis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. vol 38. issue 5. 2016-09-01. PMID:26725862. |
interestingly, an ms-like autoimmune disease neuromyelitis optica (nmo) is exclusively resistant to this therapy and mediated by il-6-dependnet pbs via producing a disease-specific autoantibody against aquaporin 4 (aqp4) on astrocyte. |
2016-09-01 |
2023-08-13 |
Not clear |
| Mahdi Asgari, Diane de Zélicourt, Vartan Kurtcuogl. How astrocyte networks may contribute to cerebral metabolite clearance. Scientific reports. vol 5. 2016-08-15. PMID:26463008. |
the astrocyte networks are connected through aquaporin-4 (aqp4) water channels with a parallel, extracellular route carrying metabolites. |
2016-08-15 |
2023-08-13 |
Not clear |
| Xiaoming Yao, Kazuyoshi Uchida, Marios C Papadopoulos, Zsolt Zador, Geoffrey T Manley, Alan S Verkma. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. Journal of neurotrauma. vol 32. issue 19. 2016-07-06. PMID:25790314. |
prior indirect evidence has suggested the involvement of astrocyte water channel aquaporin-4 (aqp4) in the pathogenesis of tbi. |
2016-07-06 |
2023-08-13 |
mouse |
| Xiaoming Yao, Kazuyoshi Uchida, Marios C Papadopoulos, Zsolt Zador, Geoffrey T Manley, Alan S Verkma. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. Journal of neurotrauma. vol 32. issue 19. 2016-07-06. PMID:25790314. |
transmission electron microscopy showed reduced astrocyte foot-process area in aqp4(-/-) mice at 24 h after cci, with greater capillary lumen area. |
2016-07-06 |
2023-08-13 |
mouse |