| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoming Yao, Alex J Smith, Byung-Ju Jin, Zsolt Zador, Geoffrey T Manley, A S Verkma. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. vol 63. issue 10. 2016-05-03. PMID:25944186. |
the astrocyte water channel aquaporin-4 (aqp4) regulates extracellular space (ecs) k(+) concentration ([k(+)]e) and volume dynamics following neuronal activation. |
2016-05-03 |
2023-08-13 |
mouse |
| Shuling Zhou, Karolina Szczesna, Anna Ochalek, Julianna Kobolák, Eszter Varga, Csilla Nemes, Abinaya Chandrasekaran, Mikkel Rasmussen, Susanna Cirera, Poul Hyttel, András Dinnyés, Kristine K Freude, Hasan X Avc. Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem cells international. vol 2016. 2016-01-22. PMID:26798357. |
furthermore, the 3d propagation method for npcs resulted in a significant higher expression of the astrocyte markers gfap and aquaporin 4 (aqp4) in the differentiated cells. |
2016-01-22 |
2023-08-13 |
human |
| Jesse A Stokum, David B Kurland, Volodymyr Gerzanich, J Marc Simar. Mechanisms of astrocyte-mediated cerebral edema. Neurochemical research. vol 40. issue 2. 2015-12-30. PMID:24996934. |
following the discovery of aquaporins, passive conduits of water flow, aquaporin 4 (aqp4) was identified as the predominant astrocyte water channel. |
2015-12-30 |
2023-08-13 |
human |
| Reza Khorooshi, Nasrin Asgari, Marlene Thorsen Mørch, Carsten Tue Berg, Trevor Owen. Hypersensitivity Responses in the Central Nervous System. Frontiers in immunology. vol 6. 2015-10-27. PMID:26500654. |
serum-derived autoantibodies with predominant specificity for the astrocyte water channel aquaporin-4 (aqp4) are implicated as inducers of pathology in neuromyelitis optica (nmo), a central nervous system (cns) demyelinating disease where activated neutrophils infiltrate, unlike in ms. |
2015-10-27 |
2023-08-13 |
mouse |
| Fengyin Liang, Chuanming Luo, Guangqing Xu, Fengjuan Su, Xiaofei He, Simei Long, Huixia Ren, Yaning Liu, Yanqing Feng, Zhong Pe. Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice. Neuroscience letters. vol 598. 2015-09-14. PMID:25957560. |
aquaporin-4 (aqp4) is a water channel expressed in astrocyte end-feet, which plays an important role in brain edema. |
2015-09-14 |
2023-08-13 |
mouse |
| Fengyin Liang, Chuanming Luo, Guangqing Xu, Fengjuan Su, Xiaofei He, Simei Long, Huixia Ren, Yaning Liu, Yanqing Feng, Zhong Pe. Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice. Neuroscience letters. vol 598. 2015-09-14. PMID:25957560. |
our results indicate that aqp4 deletion reduced cell death, water content, astrocyte swelling and lesion volume during the acute stage of micro tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Masato Yasu. [Roles of Aquaporins in Brain Disorders]. Brain and nerve = Shinkei kenkyu no shinpo. vol 67. issue 6. 2015-09-08. PMID:26062588. |
in the mammalian central nervous system (cns), aqp4 is specifically expressed in the astrocyte membranes lining the perivascular and periventricular structures. |
2015-09-08 |
2023-08-13 |
human |
| Lu He, Xiaoyang Zhang, Xianfeng Wei, Yunsheng L. Progesterone attenuates aquaporin-4 expression in an astrocyte model of ischemia/reperfusion. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25200987. |
these results indicate that progesterone exerts the protective effects and attenuates aqp4 expression in an astrocyte model of ischemia/reperfusion depending on the pkc signal pathway. |
2015-07-29 |
2023-08-13 |
rat |
| Miho Akaza, Keiko Tanaka, Masami Tanaka, Teruhiko Sekiguchi, Tamako Misawa, Kazutaka Nishina, Izumi Kawachi, Masatoyo Nishizawa, Hidehiro Mizusawa, Takanori Yokot. Can anti-AQP4 antibody damage the blood-brain barrier? European neurology. vol 72. issue 5-6. 2015-07-23. PMID:25323016. |
aquaporin 4 (aqp4) is a water-channel protein predominantly expressed in astrocyte end feet that make up the blood-brain barrier (bbb). |
2015-07-23 |
2023-08-13 |
Not clear |
| Laurentiu Mogoanta, Marius Ciurea, Ionica Pirici, Claudiu Margaritescu, Cristiana Simionescu, Daniela A Ion, Daniel Piric. Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke. Brain pathology (Zurich, Switzerland). vol 24. issue 5. 2015-06-29. PMID:24571080. |
aquaporin-4 (aqp4) and glutamate transporter-1 (glt-1) represent the major water and glutamate astrocyte buffering gateways in the brain. |
2015-06-29 |
2023-08-12 |
human |
| Xiaoming Yao, Nikita Derugin, Geoffrey T Manley, A S Verkma. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neuroscience letters. vol 584. 2015-06-26. PMID:25449874. |
aquaporin-4 (aqp4) is a water channel expressed in astrocyte end-feet lining the blood-brain barrier. |
2015-06-26 |
2023-08-13 |
mouse |
| Raphaël Bernard-Valnet, Romain Marignie. [Evolution of Devic's neuromyelitis optica spectrum disorders]. Presse medicale (Paris, France : 1983). vol 44. issue 4 Pt 1. 2015-06-25. PMID:25535163. |
in vitro and ex vivo experiments showed that aqp4-ab can induce either direct astrocyte loss through complement activation (neuroinflammation) or astrocyte changes via internalization of aqp4 (neuromodulation). |
2015-06-25 |
2023-08-13 |
Not clear |
| Kunihiko Asakura, Akihiro Ueda, Sayuri Shima, Tomomasa Ishikawa, Chika Hikichi, Seiko Hirota, Takao Fukui, Shinji Ito, Tatsuro Muto. Targeting of aquaporin 4 into lipid rafts and its biological significance. Brain research. vol 1583. 2015-06-05. PMID:25128605. |
in this study, we generated a fluorescent epitope-tagged aqp4 m1 and m23 co-expressing astrocyte cell line and examined the subcellular targeting of aqp4. |
2015-06-05 |
2023-08-13 |
Not clear |
| Christina R Marmarou, Xiuyin Liang, Naqeeb H Abidi, Shanaz Parveen, Keisuke Taya, Scott C Henderson, Harold F Young, Aristotelis S Filippidis, Clive M Baumgarte. Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury. Brain research. vol 1581. 2015-05-21. PMID:24933327. |
we therefore tested whether vasopressin 1a receptor (v1ar) inhibition would suppress astrocyte aqp4, reduce astrocytic edema, and thereby diminish tbi-induced edematous changes. |
2015-05-21 |
2023-08-13 |
rat |
| Jeffrey L Bennett, Kevin C O'Connor, Amit Bar-Or, Scott S Zamvil, Bernhard Hemmer, Thomas F Tedder, H-Christian von Büdingen, Olaf Stuve, Michael R Yeaman, Terry J Smith, Christine Stadelman. B lymphocytes in neuromyelitis optica. Neurology(R) neuroimmunology & neuroinflammation. vol 2. issue 3. 2015-05-15. PMID:25977932. |
a majority (approximately 75%) of patients with nmo are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (aqp4). |
2015-05-15 |
2023-08-13 |
Not clear |
| Jeffrey L Bennett, Kevin C O'Connor, Amit Bar-Or, Scott S Zamvil, Bernhard Hemmer, Thomas F Tedder, H-Christian von Büdingen, Olaf Stuve, Michael R Yeaman, Terry J Smith, Christine Stadelman. B lymphocytes in neuromyelitis optica. Neurology(R) neuroimmunology & neuroinflammation. vol 2. issue 3. 2015-05-15. PMID:25977932. |
these autoantibodies are predominantly igg1, and considerable evidence supports their pathogenicity, presumably by binding to aqp4 on cns astrocytes, resulting in astrocyte injury and inflammation. |
2015-05-15 |
2023-08-13 |
Not clear |
| Jasmine Vella, Christian Zammit, Giuseppe Di Giovanni, Richard Muscat, Mario Valentin. The central role of aquaporins in the pathophysiology of ischemic stroke. Frontiers in cellular neuroscience. vol 9. 2015-04-23. PMID:25904843. |
other roles ascribed to aqp4 include facilitation of astrocyte migration, glial scar formation, modulation of inflammation and signaling functions. |
2015-04-23 |
2023-08-13 |
mouse |
| Petra Fallier-Becker, Jörg P Vollmer, Hans-C Bauer, Susan Noell, Hartwig Wolburg, Andreas F Mac. Onset of aquaporin-4 expression in the developing mouse brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 36. 2015-03-02. PMID:24915007. |
we used immunocytochemistry against aqp4, zonula occludens protein-1, glial fibrillary acidic protein, and β-dystroglycan to follow astrocyte development in e15 to p3 nmri mouse brains, and expression of aqp4. |
2015-03-02 |
2023-08-13 |
mouse |
| Lei Liu, Yushan Lu, Hui Kong, Liu Li, Charles Marshall, Ming Xiao, Jiong Ding, Junying Gao, Gang H. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. The international journal of neuropsychopharmacology. vol 15. issue 1. 2015-01-22. PMID:21281561. |
a growing body of evidence indicates that water channel aquaporin-4 (aqp4) is a potential molecular target for the regulation astrocyte function. |
2015-01-22 |
2023-08-12 |
mouse |
| Lei Liu, Yushan Lu, Hui Kong, Liu Li, Charles Marshall, Ming Xiao, Jiong Ding, Junying Gao, Gang H. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. The international journal of neuropsychopharmacology. vol 15. issue 1. 2015-01-22. PMID:21281561. |
therefore, regulation of astrocyte function by aqp4 may attenuate oxidative damage, offering a promising therapeutic strategy for ad. |
2015-01-22 |
2023-08-12 |
mouse |