| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Anderson, C M Milner, R G Cotton, R D Campbel. The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect. Journal of immunology (Baltimore, Md. : 1950). vol 148. issue 9. 1992-06-02. PMID:1573268. |
direct sequencing of a 4.4-kb region of the gene covering exons 17 to 31 and encoding the c4d fragment and most of the rest of the alpha chain of c4 revealed that the c4a6 allele encodes the a isotypic residues pro cys-leu asp at positions 1101, 1102, 1105, and 1106 and the same residues as the c4a3 alpha gene at the polymorphic positions 1054 (asp), 1157 (asn), 1182 (thr), 1188 (val), 1191 (leu) and 1267 (ala). |
1992-06-02 |
2023-08-11 |
human |
| L Y Lian, W C Chan, S D Morley, G C Roberts, B W Bycroft, D Jackso. Solution structures of nisin A and its two major degradation products determined by n.m.r. The Biochemical journal. vol 283 ( Pt 2). 1992-06-02. PMID:1575686. |
the conformations of nisin and two major degradation products, nisin-(1-32)-peptide (nisin1-32) and des-delta ala5-nisin1-32 (where delta ala is alpha beta-didehydroalanine), in aqueous solution have been determined from n.m.r. |
1992-06-02 |
2023-08-11 |
Not clear |
| G B Field. A model for interstitial collagen catabolism by mammalian collagenases. Journal of theoretical biology. vol 153. issue 4. 1992-05-13. PMID:1666905. |
mammalian collagenases cleave all three alpha chains of native, triple-helical types i, ii, and iii collagens after the gly residue of the partial sequence gly-[ile or leu]-[ala or leu] at a single locus approximately three-fourths from the amino terminus. |
1992-05-13 |
2023-08-11 |
Not clear |
| S H Phan, D E Gannon, P A Ward, S Karmio. Mechanism of neutrophil-induced xanthine dehydrogenase to xanthine oxidase conversion in endothelial cells: evidence of a role for elastase. American journal of respiratory cell and molecular biology. vol 6. issue 3. 1992-04-09. PMID:1540391. |
the elastase inhibitors, elastatinal, alpha 1-antitrypsin, and meo-suc-(ala)2-pro-val-ch2cl, significantly inhibited xanthine dehydrogenase to oxidase conversion by phorbol myristate acetate-stimulated neutrophils without inhibition of neutrophil adherence to the endothelial cell monolayer. |
1992-04-09 |
2023-08-11 |
Not clear |
| H Wajcman, J Kister, C Vasseur, Y Blouquit, J C Trastour, D Cottenceau, F Galactero. Structure of the EF corner favors deamidation of asparaginyl residues in hemoglobin: the example of Hb La Roche-sur-Yon [beta 81 (EF5) Leu----His]. Biochimica et biophysica acta. vol 1138. issue 2. 1992-04-03. PMID:1540659. |
deamidation has already been reported for two other variants of the ef corner, hb providence [beta 82 (ef6) lys----asn] and hb j singapore [alpha 79 (ef8) ala----gly]. |
1992-04-03 |
2023-08-11 |
Not clear |
| S Y Choi, B J Scherer, J Schnier, M V Davies, R J Kaufman, J W Hershe. Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. The Journal of biological chemistry. vol 267. issue 1. 1992-02-18. PMID:1346129. |
when either ser48 or ser51 is replaced by ala, the variants stimulate dihydrofolate reductase synthesis when the eif-2 alpha kinase, dai, is activated. |
1992-02-18 |
2023-08-11 |
human |
| M Babst, H Albrecht, I Wegmann, R Brunisholz, H Zube. Single amino acid substitutions in the B870 alpha and beta light-harvesting polypeptides of Rhodobacter capsulatus. Structural and spectral effects. European journal of biochemistry. vol 202. issue 2. 1992-02-11. PMID:1761033. |
thus, the three tryptophan exchanges at the position alpha 8 resulted in either the absence of a core complex (alpha trp8----leu), the absence of the core antenna (alpha trp8----ala) or a reduction in the carotenoid content (alpha trp8----tyr). |
1992-02-11 |
2023-08-11 |
Not clear |
| M Babst, H Albrecht, I Wegmann, R Brunisholz, H Zube. Single amino acid substitutions in the B870 alpha and beta light-harvesting polypeptides of Rhodobacter capsulatus. Structural and spectral effects. European journal of biochemistry. vol 202. issue 2. 1992-02-11. PMID:1761033. |
the strongest blue shift of the bacteriochlorophyll a (8-11 nm) was induced by substitutions of the trp at position alpha 43 (alpha trp43----ala, leu or tyr). |
1992-02-11 |
2023-08-11 |
Not clear |
| A J Mathews, J S Olson, J P Renaud, J Tame, K Naga. The assignment of carbon monoxide association rate constants to the alpha and beta subunits in native and mutant human deoxyhemoglobin tetramers. The Journal of biological chemistry. vol 266. issue 32. 1991-12-23. PMID:1939192. |
the alpha his58(e7) to gly and val62(e11) to ala substitutions caused 80- and 3-fold increases, respectively, in k'co for t-state alpha subunits, and the alpha val62(e11) to ile mutation caused a 3-fold decrease. |
1991-12-23 |
2023-08-11 |
human |
| S Sinha, J Knops, F Esch, E D Moyer, T Oltersdor. Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor. The Journal of biological chemistry. vol 266. issue 31. 1991-12-13. PMID:1939150. |
replacement of the p1' (ala) and p2' (met) residues of p1-val-mkd with the corresponding residues (ser, ile) from alpha 1-proteinase inhibitor resulted in an inactive protein, underscoring the mechanistic differences between the serpins from the kunitz-type protease inhibitor family. |
1991-12-13 |
2023-08-11 |
mouse |
| K E McLane, X D Wu, B M Conti-Troncon. Structural determinants within residues 180-199 of the rodent alpha 5 nicotinic acetylcholine receptor subunit involved in alpha-bungarotoxin binding. Biochemistry. vol 30. issue 44. 1991-12-12. PMID:1931993. |
in the present study, the effects of single amino acid substitutions of gly or ala for each residue of the rat alpha 5(180-199) sequence were tested, using a competition assay, in which peptides compete for 125i-alpha-btx binding with native torpedo nachr. |
1991-12-12 |
2023-08-11 |
rat |
| J Lavinha, P Faustino, L Osório-Almeida, Y Hattori, Y Ohba, M C Martin. Hb Himeji [alpha 2 beta 2(140)(H18)Ala----Asp] is linked to different haplotypes in Japanese and Portuguese families. Hemoglobin. vol 15. issue 1-2. 1991-10-31. PMID:1680833. |
hb himeji [alpha 2 beta 2(140)(h18)ala----asp] is linked to different haplotypes in japanese and portuguese families. |
1991-10-31 |
2023-08-11 |
Not clear |
| C Vasseur, A Francina, H Wajcman, F Galactéro. Two new cases of Hb Denmark Hill [alpha 95(G2)Pro----Ala] discovered in south-west France: electrophoretical and chromatographical considerations. Hemoglobin. vol 15. issue 1-2. 1991-10-31. PMID:1917529. |
two new cases of hb denmark hill [alpha 95(g2)pro----ala] discovered in south-west france: electrophoretical and chromatographical considerations. |
1991-10-31 |
2023-08-11 |
Not clear |
| S C Wong, M Tesanovic, M C Poo. Detection of two abnormal hemoglobins, Hb Manitoba and Hb G-Coushatta, during analysis of glycohemoglobin (A1c) by high-performance liquid chromatography. Clinical chemistry. vol 37. issue 8. 1991-09-19. PMID:1868612. |
structural studies determined the two hb variants to be hb manitoba (alpha 2 102 ser----arg beta 2) and hb g-coushatta (alpha 2 beta 2 22 glu----ala). |
1991-09-19 |
2023-08-11 |
Not clear |
| G Mar. Immunological monitoring of Fenton fragmentation of fibrinogen. Free radical research communications. vol 12-13 Pt 2. 1991-08-07. PMID:2060829. |
however, n-terminal amino acid analyses reveals the presence of 3 peptides terminating in ala (alpha chain fpa), glu (beta chain fpb) and ser/asp (unknown). |
1991-08-07 |
2023-08-11 |
Not clear |
| D J Tobias, C L Brook. Thermodynamics and mechanism of alpha helix initiation in alanine and valine peptides. Biochemistry. vol 30. issue 24. 1991-07-17. PMID:2043644. |
we used molecular dynamics simulations to study the folding/unfolding of one of turn of an alpha helix in ac-(ala)3-nhme and ac-(val)3-nhme. |
1991-07-17 |
2023-08-11 |
Not clear |
| D J Tobias, C L Brook. Thermodynamics and mechanism of alpha helix initiation in alanine and valine peptides. Biochemistry. vol 30. issue 24. 1991-07-17. PMID:2043644. |
the free energy difference between alpha helix and extended conformations, determined from the equilibrium constants for helix unfolding, is approximately -1 kcal/mol for ac-(ala)3-nhme and -5 kcal/mol for ac-(val)3-nhme. |
1991-07-17 |
2023-08-11 |
Not clear |
| K Skriver, W R Wikoff, P A Patston, F Tausk, M Schapira, A P Kaplan, S C Boc. Substrate properties of C1 inhibitor Ma (alanine 434----glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status. The Journal of biological chemistry. vol 266. issue 14. 1991-06-10. PMID:2026621. |
ala 434 of c1 inhibitor aligns with the p12 residue of the prototypical serpin alpha 1-antitrypsin. |
1991-06-10 |
2023-08-11 |
Not clear |
| S Ohsako, H Nakazawa, S Sekihara, A Ikai, T Yamauch. Role of threonine-286 as autophosphorylation site for appearance of Ca2(+)-independent activity of calmodulin-dependent protein kinase II alpha subunit. Journal of biochemistry. vol 109. issue 1. 1991-05-23. PMID:1849884. |
to confirm directly the role of thr-286 as the autophosphorylation site responsible for the appearance of ca2(+)-independent activity of ca2+/calmodulin-dependent protein kinase ii alpha subunit, we constructed two mutated cdnas of thr-286 to pro or ala using site-directed mutagenesis and introduced into chinese hamster ovary cells. |
1991-05-23 |
2023-08-11 |
Not clear |
| K Yutani, S Hayashi, Y Sugisaki, K Ogasahar. Role of conserved proline residues in stabilizing tryptophan synthase alpha subunit: analysis by mutants with alanine or glycine. Proteins. vol 9. issue 2. 1991-04-26. PMID:2008436. |
to study the role of pro residues in the conformation and conformational stability of a protein, nine mutant alpha subunits of tryptophan synthase from escherichia coli, in which ala or gly was substituted for each of six pro residues (positions 28, 57, 62, 96, 132, and 207) that are conserved in 10 microorganisms, were constructed by means of site-directed mutagenesis. |
1991-04-26 |
2023-08-11 |
Not clear |