| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Fisone, S X Cheng, A C Nairn, A J Czernik, H C Hemmings, J O Höög, A M Bertorello, R Kaiser, T Bergman, H Jörnval. Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis. The Journal of biological chemistry. vol 269. issue 12. 1994-04-21. PMID:7510709. |
we have now shown, using several experimental approaches, that a highly conserved seryl residue on the catalytic (alpha) subunit of na+,k(+)-atpase, corresponding to ser943 of the rat alpha 1 isoform, is the phosphorylation site for protein kinase a. cdnas corresponding to wild-type na+,k(+)-atpase and na+,k(+)-atpase in which ser943 was mutated to ala were transfected into cos cells. |
1994-04-21 |
2023-08-12 |
rat |
| D Y Kwo. Effects of negative charges of a model for bovine pancreatic trypsin inhibitor folding intermediate on the peptide folding. Bioscience, biotechnology, and biochemistry. vol 58. issue 2. 1994-04-11. PMID:7510152. |
four acidic groups in p alpha p beta: glu-49, asp-50, and c-termini at phe-33 and ala-58, were replaced individually with an ala (in case of glu and asp) and an amide group (for c-terminal carboxyl groups) to study the effects of these negative charged groups on folding structure in terms of thermal stability and ph dependence. |
1994-04-11 |
2023-08-12 |
cattle |
| D Y Kwo. Effects of negative charges of a model for bovine pancreatic trypsin inhibitor folding intermediate on the peptide folding. Bioscience, biotechnology, and biochemistry. vol 58. issue 2. 1994-04-11. PMID:7510152. |
substituting the glu-49 or asp-50 with ala and blocking the c-terminus carboxyl group of phe-33 in p beta destabilized the structure, but blocking the negative charge of c-terminus in ala-58 of p alpha stabilized the structure at neutral ph. |
1994-04-11 |
2023-08-12 |
cattle |
| A M Bergmans, H Tijssen, N Lardy, P Reeker. Complete nucleotide sequence of HLA-B*0703, a B7 variant (BPOT). Human immunology. vol 38. issue 2. 1994-03-22. PMID:8106270. |
the resulting amino acid substitutions in the alpha 1 domain of b703 at residues 69 (ala-->thr), 70 (gln-->asn), and 71 (ala-->thr) probably have their origin in a segmental exchange between b7 and other b alleles. |
1994-03-22 |
2023-08-12 |
Not clear |
| S Winitz, S K Gupta, N X Qian, L E Heasley, R A Nemenoff, G L Johnso. Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. The Journal of biological chemistry. vol 269. issue 3. 1994-02-25. PMID:8294438. |
overexpression of the wild-type alpha i2 polypeptide or the inactive mutant alpha i2g204a (gly204 mutated to ala) polypeptide had no effect on thrombin or atp receptor stimulation of arachidonic acid release. |
1994-02-25 |
2023-08-12 |
Not clear |
| b' S Tuzi, A Naito, H Sait\\xc3\\xb. A high-resolution solid-state 13C-NMR study on [1-13C]Ala and [3-13C]Ala and [1-13C]Leu and Val-labelled bacteriorhodopsin. Conformation and dynamics of transmembrane helices, loops and termini, and hydration-induced conformational change. European journal of biochemistry. vol 218. issue 3. 1994-02-14. PMID:8281935.' |
we have recorded 100.7-mhz high-resolution solid-state 13c-nmr spectra of [3-13c]ala, [1-13c]ala-labelled, leu-labelled and val-labelled bacteriorhodopsin (br), to analyze the conformation and dynamics of transmembrane alpha helices and hydration-induced conformational changes. |
1994-02-14 |
2023-08-12 |
Not clear |
| C Abeygunawardana, D J Weber, D N Frick, M J Bessman, A S Mildva. Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR. Biochemistry. vol 32. issue 48. 1994-01-06. PMID:8241161. |
they were confirmed by c alpha chemical shifts of ala residues uniquely identified by residual coupling to c beta resonances in constant time 1h[13c]hsqc experiments. |
1994-01-06 |
2023-08-12 |
Not clear |
| E D Anderson, L Thomas, J S Hayflick, G Thoma. Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. The Journal of biological chemistry. vol 268. issue 33. 1993-12-20. PMID:8227051. |
furthermore, the p4 arg in alpha 1-pdx greatly attenuates the thrombin inhibitory properties of this serpin (> 300-fold) compared with alpha 1-pit (which contains a p4 ala), thus increasing the selectivity of alpha 1-pdx for furin. |
1993-12-20 |
2023-08-12 |
human |
| V Divoky, M Svobodova, K Indrak, L Chrobak, T P Molchanova, T H Huisma. Hb Hradec Kralove (Hb HK) or alpha 2 beta 2 115(G17)Ala-->Asp, a severely unstable hemoglobin variant resulting in a dominant beta-thalassemia trait in a Czech family. Hemoglobin. vol 17. issue 4. 1993-12-01. PMID:7693620. |
hb hradec kralove (hb hk) or alpha 2 beta 2 115(g17)ala-->asp, a severely unstable hemoglobin variant resulting in a dominant beta-thalassemia trait in a czech family. |
1993-12-01 |
2023-08-12 |
human |
| Y Yamagishi, K Ikeda, J Takahara, S Irino, H Hasui, T Fujiwara, Y Kaji, T Harano, K Haran. Hb J-Guantanamo [alpha 2 beta 2 128(H6)Ala-->Asp] found in a Japanese family. Hemoglobin. vol 17. issue 4. 1993-12-01. PMID:8226098. |
hb j-guantanamo [alpha 2 beta 2 128(h6)ala-->asp] found in a japanese family. |
1993-12-01 |
2023-08-12 |
Not clear |
| J Pagnier, M T Bihoreau, V Baudin, S J Edelstein, C Poyar. [Polymerization and solubility of recombinant hemoglobins alpha 2 beta 2 6 Glu-->Ala (Hb Makassar) and alpha 2 beta 2 6 Glu-->Ala, 23 Val-->Ile]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 4. 1993-11-24. PMID:8402272. |
[polymerization and solubility of recombinant hemoglobins alpha 2 beta 2 6 glu-->ala (hb makassar) and alpha 2 beta 2 6 glu-->ala, 23 val-->ile]. |
1993-11-24 |
2023-08-12 |
Not clear |
| L K Lane, J M Feldmann, C E Flarsheim, C L Rybczynsk. Expression of rat alpha 1 Na,K-ATPase containing substitutions of "essential" amino acids in the catalytic center. The Journal of biological chemistry. vol 268. issue 24. 1993-09-16. PMID:8394354. |
to determine if the side chains of these amino acid residues are required for enzyme activity, rat alpha 1 cdnas containing the mutations cys-369-->ser, cys-658-->ala, lys-482-->ala, asp-712-->asn, and asp-716-->asn were prepared and stably expressed in hela cells, which normally cannot survive in medium containing microm concentrations of ouabain. |
1993-09-16 |
2023-08-12 |
rat |
| L K Lane, J M Feldmann, C E Flarsheim, C L Rybczynsk. Expression of rat alpha 1 Na,K-ATPase containing substitutions of "essential" amino acids in the catalytic center. The Journal of biological chemistry. vol 268. issue 24. 1993-09-16. PMID:8394354. |
expression of rat alpha 1 wild-type and the mutants cys-369-->ser, cys-658-->ala, and lys-482-->ala causes the appearance of hela cells that survive in medium containing 0.5 microm ouabain. |
1993-09-16 |
2023-08-12 |
rat |
| K Ishikawa, H Nakamura, K Morikawa, S Kimura, S Kanay. Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution. Biochemistry. vol 32. issue 28. 1993-09-03. PMID:8393706. |
another mutation within the alpha ii-helix, gly-77-->ala, reduces the stability by 0.9 kcal/mol. |
1993-09-03 |
2023-08-12 |
Not clear |
| T P Molchanova, Postnikov YuV, J B Wilson, B B Webber, L H Gu, H Sabio, P Waldron, T H Huisma. Hb Madrid or alpha 2 beta (2)115(G17)Ala-->Pro in a black teenager. Hemoglobin. vol 17. issue 3. 1993-08-19. PMID:8330978. |
hb madrid or alpha 2 beta (2)115(g17)ala-->pro in a black teenager. |
1993-08-19 |
2023-08-12 |
Not clear |
| B J Dzamba, H Wu, R Jaenisch, D M Peter. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. The Journal of cell biology. vol 121. issue 5. 1993-06-29. PMID:8501121. |
substitution of gln and ala at positions 774 and 777 of the alpha 1(i) chain for pro resulted in the formation of short fibronectin fibrils similar to what was observed in untransfected mov13 cells. |
1993-06-29 |
2023-08-12 |
Not clear |
| S O Brennan, J M Sheat, M Aiac. Circulating proalbumin associated with a second case of antitrypsin Pittsburgh. Clinica chimica acta; international journal of clinical chemistry. vol 214. issue 2. 1993-05-17. PMID:8472378. |
we report here the conclusive identification of circulating proalbumin of normal n-terminal sequence (arg gly val phe arg arg asp ala) in a second child with the alpha 1-antitrypsin pittsburgh 358 met-->arg mutation. |
1993-05-17 |
2023-08-12 |
Not clear |
| M E Kennedy, L E Limbir. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. The Journal of biological chemistry. vol 268. issue 11. 1993-05-06. PMID:8385131. |
this study demonstrates that the alpha 2aar incorporates [3h] palmitic acid in metabolic labeling studies and that mutation of cys-442 to ala or ser eliminates detectable 3h-palmitoylation. |
1993-05-06 |
2023-08-12 |
cattle |
| W C Wang, H Carter, H C Choitz, R Hall, T K Hine, D L Jue, W F Moo-Pen. Characterization of Hb Volga [beta 27(B9)Ala-->Asp] and Hb J-Wenchang-Wuming [alpha 11(A9)Lys-->Gln] in the population of the United States. Hemoglobin. vol 17. issue 1. 1993-04-16. PMID:8454471. |
characterization of hb volga [beta 27(b9)ala-->asp] and hb j-wenchang-wuming [alpha 11(a9)lys-->gln] in the population of the united states. |
1993-04-16 |
2023-08-12 |
Not clear |
| P Ferranti, A Parlapiano, A Malorni, P Pucci, G Marino, G Cossu, L Manca, B Masal. Hemoglobin Ozieri: a new alpha-chain variant (alpha 71(E20)Ala-->Val). Characterization using FAB- and electrospray-mass spectrometric techniques. Biochimica et biophysica acta. vol 1162. issue 1-2. 1993-04-13. PMID:8448185. |
hemoglobin ozieri: a new alpha-chain variant (alpha 71(e20)ala-->val). |
1993-04-13 |
2023-08-12 |
Not clear |